https://med.stanford.edu/news/all-news/2020/03/old-human-cells-rejuvenated-with-stem-cell-technology.html How, with ever expanding data sets, & #MachineLearning?
"Old #HumanCellsRejuvenated with stem cell technology ... become more youthful by coaxing them to briefly express proteins used to make #inducedPluripotentCells, .. implications for aging research"https://t.co/Nj9Rzk6Wz8 How, with ever expanding data sets, & #MachineLearning?
— WorldUnivandSch (@WorldUnivAndSch) December 6, 2021
https://twitter.com/WorldUnivAndSch/status/1467736225847005184?s=20
Mechanism of rejuvenation via #inducedPluripotentCells - #AgingReversal genetic drug therapies, in #StreetView w #TimeSlider at cell & molecule levels? How do particles & molecules rearrange as #AgeReversal hypothetically takes place, with #ExpandingDataSets, & #MachineLearning? https://t.co/xy9sQhOhwx
— WorldUnivandSch (@WorldUnivAndSch) December 6, 2021
https://twitter.com/WorldUnivAndSch/status/1467737611007520772?s=20
— george church (@geochurch) December 2, 2021
https://twitter.com/geochurch/status/1466395250637918210?s=20
* *
Amazing examples of Actual-Virtual, Physical-Digital, biology-machine learning developments, and re companies, scientists, law, countries, and centers for Genetic and Artificial Intelligence excellence, and for emerging Aging Reversal Genetic Drug Therapies, from Harvard and MIT Professor of Genetics' George Church -
george church
@geochurch
Dec 6, 2021
As therapeutics become more complex with more functional domains, the role of AI in development will become critical.
As therapeutics become more complex with more functional domains, the role of AI in development will become critical. https://t.co/Pd09I2lNQu
— george church (@geochurch) December 6, 2021
https://twitter.com/geochurch/status/1467881501022994439?s=20
george church
@geochurch
Dec 2, 2021
— george church (@geochurch) December 2, 2021
https://twitter.com/geochurch/status/1466395250637918210?s=20
*
Did George Church and Peter Norvig talk with each other, and per this WUaS Monthly Business Meeting Agenda and News' item from 10/16/21 - https://worlduniversityandschool.blogspot.com/2021/10/wuas-agenda-news-for-101621wuas-agenda.html and http://scott-macleod.blogspot.com/2021/10/ceropegia.html ?
* * *
Hi Ma, (Hugh, Lillian, All),
Merry Xmas and happy New Years!
Really nice to talk with you just now, and sorry you can't come out here to the west coast for Xmas, where it would be warmer (but a very different trip too ... than your travels from Pennsylvania to Maine for Thanksgiving) ... and thank you for the lovely invitation to come to Pittsburgh to visit you over Xmas. I'll look into a flight for 4 nights or so, say from Th 23 Dec - M 27 Dec. :)
Your HD opera this afternoon, Orpheus and Eurydice, from The Met sounds great too. Am eager to hear more about it!
(Hugh, and Lillian, - any chance you'll be in Pittsburgh over Xmas, visiting your Mom, Jean?:)
Am hoping that aging reversal drugs are more within reach than ever, per Harvard and MIT's Prof of Genetics' George Church here (in the WUaS Minutes for 11/20/21) - http://scott-macleod.blogspot.com/2021/11/hypericum-montanum.html - thanks to the advancements in vaccine developments over the past 18 months or so.
Love, Scott
https://worlduniversityandschool.blogspot.com/2021/11/112021-wuas-minutes.html
http://scott-macleod.blogspot.com/search/label/longevity
http://scott-macleod.blogspot.com/search/label/genes
--
- Scott GK MacLeod
Founder, President, CEO & Professor
World Univ & Sch (WUaS) - PO Box 442, Canyon, CA 94516
1) non-profit World University and School - http://worlduniversityandschool.org
2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html
(o) 415 480 4577 - sgkmacleod@worlduniversiryandschool.org
(m) 412 478 0116 - sgkmacleod@gmail.com
World Univ & Sch Innovation Research - scottmacleod.com
*
Ma, All,
Seasons Greetings and Happy New Years (many ahead?):) Found these 2 articles about aging reversal and regarding genetic drug therapies emerging recently ... Am NoT SuRe iF THiS IS A GIft OR NOT ...:)
"Turning Back the Clock on Aging Cells
Researchers report that they can rejuvenate human cells by reprogramming them to a youthful state."
By Nicholas Wade
March 24, 2020
https://www.nytimes.com/2020/03/24/scnce/aging-dna-epigenetics-cells.html
Old human cells rejuvenated with stem cell technology
Old human cells can become more youthful by coaxing them to briefly express proteins used to make induced pluripotent cells, Stanford researchers and their colleagues have found. The finding may have implications for aging research.
March 24, 2020 - By Krista Conger
Happy Xmas! And see some of you soon? In Pittsburgh? Even possibly in DC between Xmas and New Years? AND pER MY EMAIL AT BOTtOM TO REEd COLLEGe FRIEND IN ThESe REGaRDs ...
WArMLY, SCOTt
Thanks Tym, so much! ...
just emailed you, minutes ago, and friends another email ... Am doing alright ... how are you? And hoping your trip goes well ... as I continue to live in a 'safe house' and which hopefully stay safe! How best to make it 'stay safe' per recent emails today? How is that you'll be out of the country, as this recall re ca gov is going on? Is this interesting timing? Hoping you have a very good and productive trip, and hope we can continue to stay in touch while you're away. Ok to include your state department email in some of my missives, and thinking? Sending love ... happy and safe travels!
Love, Scott
--
- Scott GK MacLeod
Founder, President, CEO & Professor
World Univ & Sch (WUaS) - PO Box 442, Canyon, CA 94516
1) non-profit World University and School - http://worlduniversityandschool.org
2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html
(o) 415 480 4577 - sgkmacleod@worlduniversiryandschool.org
(m) 412 478 0116 - sgkmacleod@gmail.com
World Univ & Sch Innovation Research - scottmacleod.com
IMPORTANT NOTICE: This transmission and any attachments are intended only for the use of the individual or entity to which they are addressed and may contain information that is privileged, confidential, or exempt from disclosure under applicable federal or state laws. If the reader of this transmission is not the intended recipient, you are hereby notified that any use, dissemination, distribution, or copying of this communication is strictly prohibited. If you have received this transmission in error, please notify me immediately by email or telephone.
Show quoted text
Hi Tym,
Would rather be checking in to actual Harbin Hot Springs, - but perhaps after California gets its act together and even regarding abolition of the illegal sex industry ... which I don't see happening for the next few years ... so maybe I can facilitate getting a realistic virtual Harbin going before then for sociality, meditation and the home bathtub! Wanna check in together, Tym?
Love, Scott
--
- Scott GK MacLeod
Founder, President, CEO & Professor
World Univ & Sch (WUaS) - PO Box 442, Canyon, CA 94516
1) non-profit World University and School - http://worlduniversityandschool.org
2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html
(o) 415 480 4577 - sgkmacleod@worlduniversiryandschool.org
(m) 412 478 0116 - sgkmacleod@gmail.com
World Univ & Sch Innovation Research - scottmacleod.com
IMPORTANT NOTICE: This transmission and any attachments are intended only for the use of the individual or entity to which they are addressed and may contain information that is privileged, confidential, or exempt from disclosure under applicable federal or state laws. If the reader of this transmission is not the intended recipient, you are hereby notified that any use, dissemination, distribution, or copying of this communication is strictly prohibited. If you have received this transmission in error, please notify me immediately by email or telephone.
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How are you doing Tym? Sending love, Scott
Checking out the site line, but or by installing a motion-sensor video camera that works well at 200 yards? Who knows?
Agenda News World University and School is done ... http://scott-macleod.blogspot.com/search/label/Business%20Meeting ...
9/18/21 Agenda & News for World Univ & Sch & WUaS Corporation
https://scott-macleod.blogspot.com/2021/09/eriogonum-alpinum-91821-agenda-and-news.html
https://scott-macleod.blogspot.com/2021/09/eriogonum-alpinum-91821-agenda-and-news.html
Meet and connect with a life partner through the UU CHURCH thanks to my mother, and Cuttyhnker UUs' Rev Betsy and daughter Laura Tabor's extended circles too? A MD in the SF Bay Area? Pretty & 28 yo? Could be good...
How was your day? :)
Love you ❤️, Scott
A Church in which to find a partner (but not Harbin Hot Springs!) UU Church with its abolitionist history (or Quaker too?)
Love, Scott
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Tym!
Welcome home about now!
Sending care, Scott
PS
Very glad the WUaS Corporation's tax return for 2017, our 3rd legal entity, is re-filed in the state of California for a second time this year, with the California FTB ... where the 3 WUaS legal entities together are a bit bodacious in their own regards.
More about this Bodacious Bay email thread in these 2 recent blog posts -
http://scott-macleod.blogspot.com/2021/09/emigrant-wilderness-area_0606112083.html
http://scott-macleod.blogspot.com/2021/09/john-muir-wilderness-backpackiing-where.html
But how both to expedite gene function decline reversal re George Church here - http://scott-macleod.blogspot.com/2021/09/borneo-orangutan-pongo-pygmaeus_072504751.html - and could new genetic tools in a realistic virtual earth for genetics at WUaS help? And in a related vein, also in a 2nd blog post from today, how to further develop video gaming for mental health (and regarding the MIT example here, & newly at bottom of this post above), and here too - http://scott-macleod.blogspot.com/2021/09/sumatran-orangutan-pongo-abelii.html ...
And regarding an iterating approach to 'ethno-wiki-virtual-world-graphy' social theory, and a new methodology, how best can we all build out an actual-virtual, physical-digital, realistic, virtual Harbin (Universe too) -https://twitter.com/scottmacleod/status/1434309190596448259?s=19 - for STEAM research (and at the street view, cellular and molecular levels with realistic Avatar Bots - eventually for tele-robotic surgery even)?
All the best,
Scott
amazon.com/author/scottmacleodworlduniversity
http://scott-macleod.blogspot.com/search/label/virtual%20Harbin
http://scott-macleod.blogspot.com/search/label/ethno-wiki-virtual-world-graphy
--
- Scott GK MacLeod
Founder, President, CEO & Professor
World Univ & Sch (WUaS) - PO Box 442, Canyon, CA 94516
1) non-profit World University and School - http://worlduniversityandschool.org
2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html
(o) 415 480 4577 - sgkmacleod@worlduniversiryandschool.org
(m) 412 478 0116 - sgkmacleod@gmail.com
World Univ & Sch Innovation Research - scottmacleod.com
IMPORTANT NOTICE: This transmission and any attachments are intended only for the use of the individual or entity to which they are addressed and may contain information that is privileged, confidential, or exempt from disclosure under applicable federal or state laws. If the reader of this transmission is not the intended recipient, you are hereby notified that any use, dissemination, distribution, or copying of this communication is strictly prohibited. If you have received this transmission in error, please notify me immediately by email or telephone.
Show quoted text
Dear Tym,
When are we going to check in to Harbin together again? Am missing Harbin only a bit, because I still don't think it's safe to head back there (even after receiving 2 email invitations from Deirdre Davis a year or two ago - who might be a kind of managing director - MD - there, sardonically construed even). It was fun to travel there with you in 2012.
How are you, and how are you settling in, world traveler, after your recent trip to the ME? Just shared the following with my younger brother, and my mother, -and since you're a younger brother (of Bill), I'd thought I'd share it with you too. More context in the blog post (and some other recent blog posts too).
Am also wondering where I'm going to live in spring of 2022 when my lease in this 'safe house' north of Berkeley is over ... and as a whistle-blower. Am considering exploring a kind of political asylum - on the east coast, or even in Scotland, Germany, or another German speaking country (since I speak German, and think that ethics, and regarding the nation state, are more intact and are working there, and even enforceable with laws that are effective).
Here's today's WUaS News and Q&A -
WUaS News and Q&A M 9/27/21 recording - https://drive.google.com/file/d/1xX51k_ty0RzD1My9Oxi3BmVT0JX9xbm8/view - with an invitation to join the conversation - Collaborating further with Google? Wiki best STEAM CC-4 http://ocw.mit.edu
@WorldUnivAndSch (& @WUaSPress) for free-to-students' degrees, planned first in English
https://twitter.com/WorldUnivAndSch/status/1442549320478199811?s=20
Hoping this finds you well and settling into the greater DC area, Tym! See you over Xmas or New Year, if by some good change, I head back to Pittsburgh to see my mother? That would be wonderful!
Warmly, Scott
Su, Sep 26, 2021
Sandy, Ma, All,
I just added some of this "Please be careful" thread to this blog post - http://scott-macleod.blogspot.com/2021/09/banyan-tree-stammtisch.html?m=0 - as a heads' up for others too. As scary as spiked vaccines, for example, might be for some, in this society of 330 million in the USA, and a history of somewhat decent legal and medical systems, I think it'll be a long time yet before we find out what actually happened, and who died and why and how, and who made the decisions - let alone that they might be brought to justice, and especially social justice. For example, Ma just mailed me an NYT's article by Ross Douthat from the Sunday, September 19, 2021 NYT, which said that 670,000 people have died from Covid-19 (670 happens too, - coincidentally or not - to be the same number of the house in Canyon 94516 I lived in for about 13 years, after a number change part way through), and the Op Ed also continued, for example, that "Yes, there does seem to be a notable tendency for right-wing talk radio hosts to die of the disease -- " ... which seems to me like these deaths could possibly have been kinds of political killings even! So please be careful (if for example there's also been a major failing of psychiatry and the law too, in the USA, and in many countries around the world, to successfully protect victims, for example, of the intl. illegal sex industry, and its latent culture of violence too), and as a kind of internet ecology' (a concept I'm developing potentially re karma and dharma and ethics, etc.) swings around in a different direction. I just talked with Pin Mazumdar on the phone this evening from the UU Church of Kensington Berkeley, and I think he said the Covid-19 pandemic isn't over yet. He had returned from Madison Wisconsin, driving there with his wife.
Thinking of you - per the 2 younger brother potential warnings I've heard directly from 2 people who won't be involved in World Univ & Sch.
Love, and abolition-ally yours, Scott
(Please remember too that that 2nd dose of the Pfizer vaccine may have damaged the far left of my left eye ... and possibly due to lack of testing by the FDA, and therefore to experimenting somehow on humans, with echoes of law breaking from the 1940s, tragically again). Please be careful ... it would be great, if aging reversal genetic drug therapies emerge, if we could all be talking together long into the future.
https://scott-macleod.blogspot.com/search/label/genes
https://scott-macleod.blogspot.com/search/label/longevity
AND ... this morning, M. Sep 27, 2021
Hi Ma,
Nice to hear your human voice at the beginning of our conversation with your warmth - 'hi' - and at its close too, with your understanding and compassion - 'I really hope you have a good week' (recognizing perhaps that my whistle-blowing is stressful). We are living in strange times, with this fabricated alienating coronavirus pandemic, and having lived in 'sick Canyon' renting from mentally ill, psychiatrically sick former landlord t.w. - and among Canyon related sickness, relating to, hypothetically, a very old culture of perpetrators, offenders, purveyors, drug dealers, scofflaws, outlaws, racists (learned of a hanging tree, for ex., a mile down the road, from Jono in a trailer, a few years before he died) ... and probably most anything sick under the sun people can think up. Similar illegal sex industry and psychiatric issues with the SF Quaker Meeting and possibly all of Pacific Yearly Meeting (Quaker) + with a big plus ... And California still hasn't gotten its act together, I think, there in Canyon, ... but maybe it is doing so in this time of Covid-19 pandemic change (having had that (a) telephone hearing with a California judge about health insurance before I moved out of Canyon, for example, in the spring of 2020) ... To be seen ...
I'd prefer to continue to live on the west coast or east coast of the USA - since my actual virtual Harbin Ethnography project is somehow similarly both amazingly wondrous, and alienating (re Harbin's potential latent culture of violence - and since Sunheart, friend and informant, died there last autumn 2020), ... and my Harbin projects' meditation focus, and soaking in the warm pool with people, esp affords deep centering (actually and virtually) - and not somehow go into a curious whistle-blown political asylum in Germany or Scotland for example, but a lot depends on California's ability to clean up its act, and as I continue to call for abolition of the illegal sex industry, (following on the abolition of slavery).
One other item from our conversation ... re the NYT article on academic tenure you mentioned falling asleep over :) ... and the many World Univ & Sch considerations about this complex issue include not only about faculty so people in 200 countries' major online planned universities, and their many languages' cultures, but also the possibility of aging reversal genetic drug therapies making tenure for 3 centuries for example seem to me untenable or unviable at this point. Further research needed.
So it was really nice to hear your connection 🙂 in voice ... which I'm seeking more of ... and perhaps in finding a talking friend and possibly a long term partner with whom to begin a family. Returning some to The Desiderata, but also to family - you, and Sandy (but about whom I'm concerned too regarding possibly the illegal s x trade in New England ... And these recent mentions of a younger brother dying, or not doing well after a vaccine), so until he possibly cleans up his act, it's not easy to talk with him. And regarding these possible 'political killings' mentioned in the NYT Ross Douthat article due the Covid-19 pandemic disease diagnosis, of conservative talk show hosts - which is further alienating to me. Change is possible, through teaching even - and at World University and School ... But this is a long process. I'd think as an aside that Angela Merkel could well help facilitate growing World Univ & Sch as a conversation re her shaping the political discourse in Germany so remarkably over the past 16 years - highlighting certain actors, and structuring the conversation among constituencies ... All germane for WUaS.
So, developing a human voice in World University and School, and in my own life, in somewhat alienated SF Bay Area (with so many people deeply retreated in their homes and languages, and not really with much of a constructive civil discourse possibility in the air) leaves a lot of opportunities for this very diverse work world we're now moving more deeply into.
Love, Scott
http://scott-macleod.blogspot.com/search/label/care
virtual Harbin - http://scott-macleod.blogspot.com/search/label/virtual%20Harbin
http://scott-macleod.blogspot.com/search/label/global%20university
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You're inspiring, Tym, and you're travels sound great, social, family-oriented, and to be worthy in their peace goals. Yemen and Saudi Arabia are places I'd like to get to know in a realistic virtual earth for traveling, and history ... https://twitter.com/sgkmacleod/status/1436337341325398019?s=19 - https://twitter.com/scottmacleod/status/1431692763884503042?s=19 !
Am missing Harbin a bit and hope we can head back there soon (when we might get an invite even). Are you by any chance in touch with Sajjad Wynne, of Harbin, whom we met in the office there, he wearing his yellow-lensed glasses? His Harbin book "The big bang and the Harbin experience" made me laugh -
https://www.amazon.com/big-bang-Harbin-experience/dp/0944202101 (and I wrote the Brautigan reference:).
May explore hiking much of both the California Coastal Trail and the PCT, thanks to you, with my avuncular Alden (south of SF), and Ed ... Could or might we invite you or friends along if they emerge. A woman who might be interested in beginning a family even?
All the best, Scott
https://www.amazon.com/Naked-Harbin-Ethnography-Counterculture-Clothing-Optionality/dp/0692646132
Glad to have sent out the Work World Univ & Sch 9/18/21 Minutes just before your email came too :)~
http://scott-macleod.blogspot.com/2021/09/calendula-officinalis-minutes-for-91821.html?m=0
New hiking inspired resources - & maps :)
The California Coastal Trail is a 1,200-mile, multi-use route stretching along the Pacific coastline from Mexico to Oregon.
https://coasttrails.org/wctprcaliforniatrail.html
California Coastal Trail
2.4 miles - (3.9 ) kilometers
https://www.presidio.gov/trails/california-coastal-trail
California Coastal Trail: Lands End to Golden Gate Bridge on AllTrails - 4.4 miles
https://www.alltrails.com/trail/us/california/california-coastal-trail-lands-end-to-golden-gate-bridge
The Pacific Crest Trail is 100-150 miles east of the Pacific ocean, and is 2650 long -
https://www.fs.usda.gov/detail/pct/home/?cid=stelprdb5310782#:~:text=The%20Pacific%20Crest%20National%20Scenic,Is%20the%20trail%20finished%3F
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That was a fun Canyon-Harbin-Canyon trip, and thanks for coming to visit!
Harbin is open apparently, and Sajjad@Harbin.org is/was his email address, which may be buried in your inbox even. With an invite from Sajjad or Eric Richardson, I think it would be safe to visit Harbin again.
A realistic virtual Harbin for Ethnographic (& STEM research) study informs my actual virtual, physical digital realistic virtual earth / universe thinking. Motivation-wise, these come out of my virtual St.Kilda / Hirta, Scotland study of 2003-2004 at the University of Edinburgh (http://scott-macleod.blogspot.com/2021/09/hirta.html?m=0).
Let's plan a trip on the PCT - maybe for next summer, and possibly with pack animals too. Took a great trip in the Olympic wilderness area, and orienteering off trail on top of the world, with a Reed College friend too, on the way to my second year of hiking the PCT from Manning Park 100 miles inland, in Canada, south thru half of Washington state, in 1982. Wanna hike on the PCT there in 2023? :)
Happy travels!
Fondly,
Scott
Interesting poetry reading Tweet from Laura Ashe, Oxford University Professor - https://twitter.com/AsheLaura/status/1443330848913231878?s=19
My reply ... And regarding aging reversal genetic drug therapies emergent -
https://twitter.com/TheOpenBand/status/1443449810011320325?s=19
May email her, and even regarding reading my poetry -
https://twitter.com/HarbinBook/status/1366814117034557440?s=19
https://twitter.com/scottmacleod/status/1366811917956706304?s=19 :)
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Dear Tym,
Thanks for the emails again and your kind words, including -
"Are you able to develop a social life in your new environs and with the pandemic still wreaking havoc? Music, yoga, meditation, hiking, reading groups could be fertile ground for new friendships."
Open Band Scottish Country Dancing is still shutdown, and not necessarily an opportunity to meet new friends. I do Yoga and meditation on my own, beneficially, but don't think teaching or taking classes are a good idea or way to meet friends. I've inquired with avuncular Alden (in his 80s and a favorite) about hiking the California Coastal Trail first in SF Bay Area - thanks to you - but haven't heard back yet. And don't know of any reading groups whatsoever in Bay Area ...
But thanks to you too, I took a chance and reached out to Sajjad and others (since there's strength in numbers) about checking into Harbin - http://scott-macleod.blogspot.com/2021/10/zinnia-peruviana-non.html?m=0 (with related analysis about some whistle blowing I'm continuing to do and regarding World University and School) - and may not here back for awhile. Apologies for including you in a large group email, but think you could make it work, and safely. Traveling to Harbin somewhat regularly for next Ethnographic project would change dramatically the self-quarantine isolation hangover aspect of coronavirus pandemic (after a kind of isolation in the spring somewhat sick culture of Canyon 94516), but wouldn't necessarily lead to new friends in the curious culture of California for me.
Appreciate much your thinking of me ... And sending love on your world travels and good work.
Love, Scott
3am Scotland Fettes College Annual General Meeting in a few hours per WUaS Minute #2 - http://scott-macleod.blogspot.com/2021/09/calendula-officinalis-minutes-for-91821.html?m=0 - and could WUaS even somehow get awarded some of this money mentioned in this Finnish paper article which also made me wonder about Scotland in other ways re whistle blowing ... (Finnish paper Pic - could this have implications for World Univ & Sch too & my planning to attend the 3am Fettes College AGM tomorrow 10/2 ... & any illegal implications too re EU students, and is this a Dutch woman's bonnet?)
"Scottish government announces new £2.25 million scholarship programme for EU students"
https://www.helsinkitimes.fi/world-int/20071-scottish-government-announces-new-2-25-million-scholarship-programme-for-eu-students.html ...
Setting the alarm for 2:30 am this morning ...
Tym,
Online World Univ & Sch hasn't lead yet to meeting too many new friends in person, but it could if I begin to travel to get the word out.
On with the Desiderata here, -
https://www.desiderata.com/desiderata.html -
as I continue to seek a friend to spend time with, and then we might begin a family.
Sending love, Scott
Show quoted text
Tym, how are you, and where are you? :)
Here are some hypothetical amusing questions and regarding an email I just sent to my mother, then to friends -
If Harbin went in the direction of a California police person on property - right out of CA Police academy - what would she or he wear in the warm pool? :) Armed even and nothing else? :) Gun on the head 😂? (And what would CA police academy official Harbin uniform and vehicles be - energy-wise, and different from Harbin's security vehicles)?
Have too many Harbin security people been insecure and passed away, knowing a bit too much even ? - on the not amusing side ... Speculatively
And divergent from Harbin's countercultural history, might having a police person on property be better CA insurance-wise? (A different kind of insurance than it's quite broad Hippy community with their own economies).
In one of those Harbin ironies, Rosemary Cordova, Harbin office manager (and friend), and mom of Lazarus, was married to the Chief of Police in the area, not living together. Rosemary drove me into SF a couple of times back I think in 2004 ... When I was a Harbin resident for 4.5 months ... And exploring the idea of writing a Harbin Ethnography (just back from UNI EDINBURGH Scotland for a year, and after 2 years before that at UC Santa Barbara in Anthropology related academic disciplines, and before traveling on Semester at Sea in autumn 2005). Was HCC founder Ishvara snortling that Rosemary's son's father was the local chief of police? (Is there a long history of police corruption in California and how has this played out re the white Latino Hispanic 'divides' even)?
I think people in Harbin's culture would be safer with a CA police on property, but keeping the camping cost down at the gate would be key to attracting younger folks who don't have much money, and are open to a pick up place with alternative thinking - and re the open naked hippy energy of Harbin's warm pool area which informs its countercultural energy coming out of the 1960s and '70s as it does ... And with the continuity of Ishvara Bob Hartley still being around re unfolding vision and even Harbin Pubs (as vile, violent, difficult and sick as he may be) . He'd balk a lot at no-corruption naked CA cops on property, but might come around re insurance questions, and given the devastating valley fire of 2015.
Shall we visit Harbin again in the 2022 spring, if we get the green light from Sajjad or Eric - to CHECK IN by checking out liminally of society modernity 'internetity' for a spell at that 'nudie place' - which is what UC BERKELEY Anthro Prof Aiwha Ong called Harbin to me years ago - that institutionalized the hippy party sociologically / anthropologically :)?
Fondly, Scott
PLEASE BE CAREFUL thread
Sandy, Ma, All,
Happy Birthday, Sandy, on 10/5, soon! :) Am putting a wee gift in the mail for you, for you to celebrate over the days ahead.
Hoping you can remain safe, Sandy - with the 2 recent harmed younger brother narratives I've heard, and the suggestion of political killings' from the Covid-19 disease diagnosis & vaccine, which NYT Ross Douthat article Ma sent me on pay through the mail. Just shared this with Ma in some of these regards -
Good to hear from you, Ma,
Regarding living in a 'safe house,' and seeking a new place to live in the spring, am wondering about living on Cuttyhunk even for the April to Thanksgiving 'cool shoulder summer season' ... and with an attractive life partner re beginning a family.
Would having a police person at Harbin Hot Springs change its counterculture forever, & regarding its 'in house' Harbin security which doesn't do the same thing as the state of CA? Would having a federal police person on Cuttyhunk make Cuttyhunk safe and good again? I'd still mediate in the warm pool at Harbin and write Ethnography, my next Actual-Virtual Physical-Digital anthropological Harbin book project in Text in the Sidebar from Google Street View with Time Slider ... And yes, I think a federal police person on Cuttyhunk could make it safe And Good again. (Last possible year for anyone staying illegally in our MacLeod house on Cuttyhunk in the autumn?)
Something to think about, abolition-wise esp.
Sending love and hope you have a good time in the UU Church sphere this morning.
Love, Scott
Doesn't seem likely that I'll meet a life partner out here (given history), or ... But where and how to meet ? - and it's up to me to meet her ...
Abolition-ally yours, Scott
http://scott-macleod.blogspot.com/2021/10/zinnia-peruviana-non.html?m=0
Have a great birthday, Sandy, - and many, many more, if aging reversal genetic drug therapies emerge! :)
Love, Scott
--
- Scott GK MacLeod
Founder, President, CEO & Professor
World Univ & Sch (WUaS) - PO Box 442, Canyon, CA 94516
1) non-profit World University and School - http://worlduniversityandschool.org
2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html
(o) 415 480 4577 - sgkmacleod@worlduniversiryandschool.org
(m) 412 478 0116 - sgkmacleod@gmail.com
World Univ & Sch Innovation Research - scottmacleod.com
More emails in a related vein -
Dear Tym,
Thanks for the emails again and your kind words, including -
"Are you able to develop a social life in your new environs and with the pandemic still wreaking havoc? Music, yoga, meditation, hiking, reading groups could be fertile ground for new friendships."
Open Band Scottish Country Dancing is still shutdown, and not necessarily an opportunity to meet new friends. I do Yoga and meditation on my own, beneficially, but don't think teaching or taking classes are a good idea or way to meet friends. I've inquired with avuncular Alden (in his 80s and a favorite) about hiking the California Coastal Trail first in SF Bay Area - thanks to you - but haven't heard back yet. And don't know of any reading groups whatsoever in Bay Area ...
But thanks to you too, I took a chance and reached out to Sajjad and others (since there's strength in numbers) about checking into Harbin - http://scott-macleod.blogspot.com/2021/10/zinnia-peruviana-non.html?m=0 (with related analysis about some whistle blowing I'm continuing to do and regarding World University and School) - and may not hear back for awhile. Apologies for including you in a large group email, but think you could make it work, and safely. Traveling to Harbin somewhat regularly for next Ethnographic project would change dramatically the self-quarantine isolation hangover aspect of coronavirus pandemic (after a kind of isolation - in the spring - in the somewhat sick culture of Canyon 94516), but wouldn't necessarily lead to new friends in the curious culture of California for me.
Appreciate much your thinking of me ... And sending love on your world travels and good work.
Love, Scott
3am Scotland Fettes College Annual General Meeting in a few hours per WUaS Minute #2 - http://scott-macleod.blogspot.com/2021/09/calendula-officinalis-minutes-for-91821.html?m=0 - and could WUaS even somehow get awarded some of this money mentioned in this Finnish paper article which also made me wonder about Scotland in other ways re whistle blowing ... (Finnish paper Pic - could this have implications for World Univ & Sch too & my planning to attend the 3am Fettes College AGM tomorrow 10/2 ... & any illegal implications too re EU students, and is this a Dutch woman's bonnet?)
"Scottish government announces new £2.25 million scholarship programme for EU students"
https://www.helsinkitimes.fi/world-int/20071-scottish-government-announces-new-2-25-million-scholarship-programme-for-eu-students.html ...
Setting the alarm for 2:30 am this morning ...
Tym,
Online World Univ & Sch hasn't lead yet to meeting too many new friends in person, but it could if I begin to travel to get the word out.
On with the Desiderata here, -
https://www.desiderata.com/desiderata.html -
as I continue to seek a friend to spend time with, and then we might begin a family.
Sending love, Scott
Appreciate Tym's thinking about friends and friendships in California culture, which doesn't seem that conducive to making friends ... Perhaps given where I've lived here in recent years, Ma ... As I've mentioned before, this might be a reason to move back to Pittsburgh, Massachusetts, or Hanover NH in the spring even.
Any thoughts about how to hear back from Alden?
Thoughts questions ideas suggestions?
Love ❣️ Scott
--
- Scott GK MacLeod
Founder, President, CEO & Professor
World Univ & Sch (WUaS) - PO Box 442, Canyon, CA 94516
1) non-profit World University and School - http://worlduniversityandschool.org
2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html
(o) 415 480 4577 - sgkmacleod@worlduniversiryandschool.org
(m) 412 478 0116 - sgkmacleod@gmail.com
World Univ & Sch Innovation Research - scottmacleod.com
Show quoted text
Hi Tym,
Re
Checking in {to Harbin again?} ...
http://scott-macleod.blogspot.com/2021/10/mount-rainier-abolition.html?m=0
Just noticed (again?) that your mom grew up in Hamden CT ... AND my family lived there for about 6 years from ~1966-'72
https://adventfuneral.com/tribute-ajax/print-obituary.html?id=175581
Just shared this with my mother, re checking in too ... How are you, Tym, checking-in wise?
Dear Ma,
I woke up deep in the morning feeling a little isolated (and for biology reasons too - to go to rest room), wondering about staying in the SF Bay Area or exploring spending
3 months a year in the Boston area? Then received two civil emails from Cambridge Univ Phil and European Anthropology groups re online academic reading and groups, and that my abstract was accepted for the Harvard 'Smartphone's .…' Data science Symposium (re Harbin Hot Springs' STEAM projects) - thanks Jukka-Pekka Onnela ... (http://scott-macleod.blogspot.com/2021/10/turritopsis-dohrnii-immortal-jellyfish.html) ...blogging daily is interesting envisioning too ... And received another possible "Keep your focus ... " 'bemail' from Interfolio which was part of my MIT Media Lab Faculty position application not long ago ... so, psychology-wise, consciousness-wise esp., am still seeking significant positive sociality, social gatherings, friends' groups, partner - with Work World & Univ Sch too - but isolation dissipates a bit ... So ...
Live in Boston 3 months a year near the Emerald Necklace or Arnold Arboretum for most Green areas and forests, while living daily in a great city (rather than Lexington or Concord)? Or live in Cambridge, close to Harvard? Best! Brookline near the Robb's whom I've known since I was a baby? ... But in a house?
Or get a house here in the SF Bay Area, and more simple home in Boston ?
And revisiting ... I think I'm more likely to meet a 25-28 yo ...like, female understanding-wise, a MIT's Diane Henderson (whom I read would have liked to have a family), or a Nancy Larson or Anke Starke or Susan Taylor in the Boston area than most other places I can think of ... :)
Regarding female understanding and energy, am especially appreciative of MIT Shakespeare Prof Diana Henderson
https://twitter.com/DianaHe23732776/status/1446311155174101000 (re Elinor Karlsson's energy too), both now in Massachusetts, and Diana is from the DC AREA and does a kind of 'aikido' in all kinds of ways on Twitter in her brilliance and interest in theater. I think she has Scottish forebears, and is very progressive ... A 27 year old Diana, energy-wise, seeking a partner, and friends' wise too, would be great. She's kinda wonderful 😊
Is she a friend of Tym, also from the DC Area (where we lived too)?
Am appreciating too my 7 week drive much in Massachusetts this summer, and regarding its visionary smart culture, even especially in its embrace of diversity.
Aging reversal genetic drug therapies emergence -
http://scott-macleod.blogspot.com/2021/10/greenland-shark.html (which blog post grows, and contains interesting IDEAS - see the LARGE TYPE for example) - could rewrite questions of having kids even - and am also wondering about heading back to Massachusetts in early November, for more than a weekend ... But am not clear where I'd stay ...
Am appreciating too some Cambridge University women I'm seeing online who are post docs like Jess Whittlestone - https://twitter.com/jesswhittles/status/1439901759837704195 - (here writing about short stories) and how normal and attractive these women are ... :)
Appreciate too Diana's Twitter ... DianaHe (re feminist thinking - Reed College thesis in Religion even)
Saw Wellesley UU CHURCH and Quaker Meeting look somewhat good (or civil) too ...
"Enjoy your achievements as well as your plans. Keep interested in your own career, however humble; it is a real possession in the changing fortunes of time."
https://www.desiderata.com/desiderata.html
I think I'd like to find a partner somehow LIKE me (albeit younger in her 20s early 30s) ...(continuing to call for abolition) ... The Ycleptance idea
"It has its phyletic basis in likeness and unlikeness between individual and group attributes" - http://scottmacleod.com/JohnMoneyConceptsOfDeterminism.html
The love and community on Cuttyhunk in 70s, when head sailing instructor in '79, in '80s and beyond, socially, still ripples through and may be evokable or elicitable in different ways today and into the (long) future ahead:)
Love, Scott
--
- Scott GK MacLeod
Founder, President, CEO & Professor
World Univ & Sch (WUaS) - PO Box 442, Canyon, CA 94516
1) non-profit World University and School - http://worlduniversityandschool.org
2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html
(o) 415 480 4577 - sgkmacleod@worlduniversiryandschool.org
(m) 412 478 0116 - sgkmacleod@gmail.com
World Univ & Sch Innovation Research - scottmacleod.com
IMPORTANT NOTICE: This transmission and any attachments are intended only for the use of the individual or entity to which they are addressed and may contain information that is privileged, confidential, or exempt from disclosure under applicable federal or state laws. If the reader of this transmission is not the intended recipient, you are hereby notified that any use, dissemination, distribution, or copying of this communication is strictly prohibited. If you have received this transmission in error, please notify me immediately by email or telephone.
Show quoted text
Tym,
checking in wise, further, then I saw a #RealisticVirtualEarthForGenetics' Tweet I had posted (https://twitter.com/WorldUnivAndSch/status/1337519210809856001 ... ) ReTweeting about 'the night,' last year, and retweeted this ... But opened just now to my Yoga Mac Flower Gmail (now above) ... And wonder how the creation of a realistic virtual earth for history can be both beautiful, and facilitate mental health strategies for dealing with illegal, criminal stuff (abolition movement-wise even) ...
Re my
#RealisticVirtualEarthForGenetics' Tweets /sim yesterday ...
Can #TimeSlider be an '#AIDeliveryShuttle' in #StreetView in a #RealisticVirtualEarthForGenetics See #RealisticVirtualHarbin & SHUTTLE between 2007 & 2015 HERE @ #HarbinGateHouse in #GoogleStreetView: https://t.co/8F7i8x7dSD (ON LAPTOP) ~ @HarbinBook see
http://scott-macleod.blogspot.com/2021/10/greenland-shark.html?m=0 ~
https://twitter.com/HarbinBook/status/1447745969374695426
What is #TimeSlider in #GoogleStreetView in #RealisticVirtualHarbin ? Move the '#AIDeliveryShuttle' @ #HarbinGateHouse HERE: https://t.co/8h3ggSUQdt ~ @HarbinBook ~ https://t.co/9lNZZn3xLt ~ & even for a #RealisticVirtualEarthForSurgery & #Genetics See: http://scott-macleod.blogspot.com/2021/10/greenland-shark.html ~
https://twitter.com/sgkmacleod/status/1447742635255369731
With focus on #AIDeliveryShuttle (and this idea I found here - https://www.lifeextension.com/magazine/2020/9/george-church-age-reversal and is here too http://scott-macleod.blogspot.com/2021/10/greenland-shark.html
... And Harbin in Street View, and TIME slider ...
So, what is checking into actual Harbin these days ... If one of my book's central theses is 'Hippies to the Hot Springs ... ' ('Naked Harbin Ethnography') ... and if I were to check in again to both actual & separately virtual Harbin in 2022 ... with writing a 2nd Harbin Ethnography in Street View itself in mind, text in the sidebar, brain wave data about meditation in the warm pool wifi streaming into our avatar Bot Electronic Medical Records in Google Street View grown up 'Pegman' too?
... So how excellent an experience could aging reversal or living beyond 122 yo be with iterating vaccines? What will checking into Harbin be like again? Will I never want to go back a second time re what I see, (& for ex., since Sunheart died last year)? How safe could Harbin become, re all the risks I've mentioned in recent email? (What's abolition of the illegal sex industry in CA mean, (following the abolition of slavery)? How to navigate the ethics of all of this too, virtually especially?
Appreciate your checking in email, Tym (when Works World University and School still hasn't become financially operational after around 14 years) . . . 🙏 Thank you!
Love,
Scott
Show quoted text
Good day, Tym,
How are you?
What's up with https://twitter.com/John_Hudson/status/1450501047542239234
Which Pranshu just Tweeted
https://twitter.com/pranshuverma_/status/1392530915235147781
And with whom I was in a new Boston Globe Twitter conversation recently.
Warmly, Scott
Show quoted text
Tym,
Here's a related Tweet -
All @LenderkingTim @pranshuverma_ @ampressman What's up with the US State Dept - https://twitter.com/John_Hudson/status/1450501047542239234 - Which Pranshu just Tweeted https://twitter.com/pranshuverma_/status/1392530915235147781
And with whom I was in a new Boston Globe Twitter conversation recently re @WorldUnivAndSch MBM http://scott-macleod.blogspot.com/2021/10/ceropegia.html?m=0 ?
Scott
https://twitter.com/WorldUnivAndSch/status/1450610018147979264
https://twitter.com/scottmacleod/status/1450610654302199813
https://twitter.com/HarbinBook/status/1450610555765477378
https://twitter.com/sgkmacleod/status/1450610607917453316
https://twitter.com/TheOpenBand/status/1450610505647726595
https://twitter.com/WUaSPress/status/1450610451738345472
Show quoted text
Tym,
Warm greetings!
How are you? How were your trips to Yemen recently? What are you up to this weekend? Have you been hiking yet recently PA-, VA-, or other-wise?
Here's a photo from friend & colleague (and helping supporter) Jim Spohrer 'Curious Hawk' - https://twitter.com/JimSpohrer/status/1450961594632925189 - re learning about nature, other animals, California, - looks like Canyon a bit - and even regarding the fascinating stag picture I took (which seemed to be listening to the Allman Brothers in 1973 at Cow Palace SF music I was listening to, at top here - http://scott-macleod.blogspot.com/2021/10/california-mule-deer-stag-allman-bros-r.html). Appreciate Jim's sharing the picture !
TYM, am wondering too if Jim's pic could somehow refer to this Ret. Gen. Douglas Fraser who recently Twitter messaged me, in the middle of the night apparently, a picture of sunflowers, and I replied with the messages herein - http://scott-macleod.blogspot.com/2021/10/Sierra%20columbine%20Re%20News%20in%20England%20%20Abolition%20.html - Douglas Malcolm Fraser is involved in his Iridium satellite company ... and his knowledge ... (see video, which I was impressed with, re conscience and conscientiousness ... in part, as one in the uniformed services; I also found his video interesting for learning about DC society - coats and ties, some Scots- heritage people, somehow many 'birds of a feather') ... could be helpful for a realistic virtual earth (and for tele-robotic surgery ... re robots esp too) and universe projects (and Harbin esp too). Would be interesting to talk about this. Here's one of his 2 Twitter feeds ... https://twitter.com/Douglas90576032/status/1449248071792185346 - and while he's single newly, this picture may include his family at a ball game, where fully enclosed stadiums for virtual earth & even VR film sets are a wild idea. (Am I seeking a ~25-30 year old woman like the one on the left, a MD, and feminine too? C'est possible!:)
Do you happen to know Douglas Fraser?
What can we learn from animals and nature (I wanna hike on the PCT again, and hike more otherwise, maybe with Alden in November, thanks in part to you) - regarding the above - and even in a realistic virtual earth, and at WUaS too re - https://wiki.worlduniversityandschool.org/wiki/Interspecies_Communications ? Animals connect, are conscious, ... And re the stag picture where he touched his antlers to my window twice, am wondering if I will connect with a life partner somehow in this way ... via music, (paralleling this Allman Bros' music which I like) even ... or similar code :)
How are you doing? How to navigate the possibility of aging reversal genetic drug therapies ahead? Let's talk about this too.
Fond regards,
Scott
With email to you, and in the Reed College label -
http://scott-macleod.blogspot.com/2021/10/so-how-excellent-experience-could-aging.html
:)
How can I be of support to you - https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.linkedin.com/in/tim-lenderking-8011b5155&ved=2ahUKEwix-M-trd7zAhX6qpUCHYyzBpAQFnoECA4QAQ&sqi=2&usg=AOvVaw33PXR3nVUECKfcMcPqm-o9
-
as ...
'tim lenderking - Deputy Assistant Secretary of State'
... Tym?
Warm regards, Scott
Show quoted text
Congrats on your work anniversary, Tym!!! 28 years at the US State Department!
How are you doing?
(Interesting Harvard medical school Smartphones, Wearables and Health conference on 11/5/21 which abstract was accepted, and here's the first draft of the 1 slide presentation - http://scott-macleod.blogspot.com/2021/10/uluru.html?m=0 - which is Harbin and brainwave headset research focused:)
Warm regards, Scott
(the WUaS Corp just got its very first tax bill ... allowing us to begin to grow! :)
http://scott-macleod.blogspot.com/2021/10/Ceropegia%20stapeliiformis%20Minutes%20for%20101621%20W.html -
--
- Scott GK MacLeod
Founder, President, CEO & Professor
World Univ & Sch (WUaS) - PO Box 442, Canyon, CA 94516
1) non-profit World University and School - http://worlduniversityandschool.org
2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html
(o) 415 480 4577 - sgkmacleod@worlduniversiryandschool.org
(m) 412 478 0116 - sgkmacleod@gmail.com
World Univ & Sch Innovation Research - scottmacleod.com
IMPORTANT NOTICE: This transmission and any attachments are intended only for the use of the individual or entity to which they are addressed and may contain information that is privileged, confidential, or exempt from disclosure under applicable federal or state laws. If the reader of this transmission is not the intended recipient, you are hereby notified that any use, dissemination, distribution, or copying of this communication is strictly prohibited. If you have received this transmission in error, please notify me immediately by email or telephone.
Show quoted text
Hi Tym,
How are you? Just checking in again. Apologies again for including you in that WUaS Monthly Business Meeting Minutes for 10/16/21 yesterday with other Reedies. Will seek to share these Minutes with Reed College folks in BCC in the future.
Here attached is a nice little checking-in pic -
Mt Tamalpais and little hills above low clouds PXL_20211028.jpg
And you might enjoy this, to my mother, and other friends, just now -
Waiting for an email invitation from Harvard to talk there, or similar, makes much sense (re the upcoming Harvard university Smartphone Symposium on F 11/5/21, - http://scott-macleod.blogspot.com/2021/10/uluru.html?m=0 - which I'm planning to attend online, but probably not with being able to try out the waterproof Wearables and Smartphones effectively, for Actual-Virtual Harbin Hot Springs' Ethnographic field research) ..
... WUAS Corporation waited until we got a 3 year tax bill from the CA FTB before paying 800 per year plus late fees and penalties totally on 10/26/21, totaling $2930.98 (instead of 2400 total, paid annually) ... and engagement with the state of California as a kind of 'tax bill as invitation' to network together financially ... Go figure. ...
Sitting on the garden patio with Mt Tam beautiful in the distance (see pic), and 2 or 3 tops of forested hills as islands above low clouds, in the foreground, both spires of the Golden Gate Bridge are very clear and visible ... Beautiful morning ... My meditation world every morning first thing upon rising centering and central (Yogically ... & re ethical attunement as an individual somehow too, - philosophically even, NtQuaker silent Meeting sitting-wise too and abolition-wise ) ... Seeking to study meditation further in Harbin's warm pool and scientifically with Wearables beyond the inner releasing action as a measurable biological response (re 'The Relaxation Response' book from 1972).
Thanks for talking last night, Ma. Communicating with you helps focus my mind, bodymind beneficially ...
Took a multivitamin capsule or pill with iron this morning and my eyes are not fuzzy (but it"s also morning, and I'm also outside looking at both my smartphone and into the distance) ... As an ovo lacto vegetarian, iron, & vitamin B 12 are potentially lacking in my diet ... And I think the other nutrients are helpful too. Seeking to take one with iron on Sundays and a different multivitamin daily otherwise again (seems not to be harmful too :) Experimenting on self (a Yogic India idea too) based on experience may be working ... difficult or possibly impossible to find the scientific literature about evidence for and against multivitamins in 2021 to parse the signal from the noise :) curious about aging reversal genetic drug therapies and capsules in these regards in the future too.
Abolitionally yours, Scott
http://scott-macleod.blogspot.com/2021/10/svartifoss-iceland_01887283290.html
How are you d
...
[Message clipped] View entire message
Scott MacLeod <sgkmacleod@gmail.com>
2:55 PM (6 hours ago)
to Janie
Ma,
Just checked SW AIR for flights on Th 12/23 and M 12/27/21 ... $677 each way. .... (Expensive but available still)
Have emailed David Thurston and Tym Lenderking to find out if they might be in DC over holidays too ... Could be great to see them ... Wanna plan a trip together, and see other people? Or?
Or if I went by myself, I could get out of your way, for that busy season ...
Just put together a Scottish Small Pipes' flyer for prospective students ... (May seek to update my website ...
http://scottmacleod.com/piping.htm
... Long time needed ... A little hassle prone but also creative .. )
Talk with you soon.
Love, Scott
* *
| 11:01 AM (10 hours ago) |  | ||
| ||||
Turning Back the Clock on Aging Cells
Researchers report that they can rejuvenate human cells by reprogramming them to a youthful state.
By Nicholas Wade
March 24, 2020
https://www.nytimes.com/2020/
Old human cells can become more youthful by coaxing them to briefly express proteins used to make induced pluripotent cells, Stanford researchers and their colleagues have found. The finding may have implications for aging research.
March 24, 2020 - By Krista Conger
https://med.stanford.edu/news/
Researchers report that they can rejuvenate human cells by reprogramming them to a youthful state.
A scanning electron micrograph of a human embryonic stem cell.
A scanning electron micrograph of a human embryonic stem cell.Credit...David Scharf/Science Source
By Nicholas Wade
March 24, 2020
Researchers at Stanford University report that they can rejuvenate human cells by reprogramming them back to a youthful state. They hope that the technique will help in the treatment of diseases, such as osteoarthritis and muscle wasting, that are caused by the aging of tissue cells.
A major cause of aging is thought to be the errors that accumulate in the epigenome, the system of proteins that packages the DNA and controls access to its genes. The Stanford team, led by Tapash Jay Sarkar, Dr. Thomas A. Rando and Vittorio Sebastiano, say their method, designed to reverse these errors and walk back the cells to their youthful state, does indeed restore the cells’ vigor and eliminate signs of aging.
In their report, published on Tuesday in Nature Communications, they described their technique as “a significant step toward the goal of reversing cellular aging” and could produce therapies “for aging and aging-related diseases.”
Leonard P. Guarente, an expert on aging at M.I.T., said the method was “one of the most promising areas of aging research” but that it would take a long time to develop drugs based on RNA, the required chemical.
The Stanford approach utilizes powerful agents known as Yamanaka factors, which reprogram a cell’s epigenome to its time zero, or embryonic state.
Embryonic cells, derived from the fertilized egg, can develop into any of the specialized cell types of the body. Their fate, whether to become a skin or eye or liver cell, is determined by chemical groups, or marks, that are tagged on to their epigenome.
In each type of cell, these marks make accessible only the genes that the cell type needs, while locking down all other genes in the DNAs. The pattern of marks thus establishes each cell’s identity.
As the cell ages, it accumulates errors in the marking system, which degrade the cell’s efficiency at switching on and off the genes needed for its operations.
In 2006 Dr. Shinya Yamanaka, a stem-cell researcher at Kyoto University, amazed biologists by showing that a cell’s fate could be reversed with a set of four transcription factors — agents that activate genes — that he had identified. A cell dosed with the Yamanaka factors erases the marks on the epigenome, so the cell loses its identity and reverts to the embryonic state. Erroneous marks gathered during aging are also lost in the process, restoring the cell to its state of youth. Dr. Yamanaka shared the 2012 Nobel Prize in medicine for the work.
In 2006, Dr. Shinya Yamanaka, a stem cell researcher and Nobel laureate, identified four transcription factors that can be manipulated to reverse aging in cells.
Credit...Shizuo Kambayashi/Associated Press
But the Yamanaka factors are no simple panacea. Applied to whole mice, the factors made cells lose their functions and primed them for rapid growth, usually cancerous; the mice all died.
In 2016, Juan Carlos Izpisua Belmonte, of the Salk Institute for Biological Studies in San Diego, found that the two effects of the Yamanaka factors — erasing cell identity and reversing aging — could be separated, with a lower dose securing just age reversal. But he achieved this by genetically engineering mice, a technique not usable in people.
In their paper on Tuesday, the Stanford team described a feasible way to deliver Yamanaka factors to cells taken from patients, by dosing cells kept in cultures with small amounts of the factors.
If dosed for a short enough time, the team reported, the cells retained their identity but returned to a youthful state, as judged by several measures of cell vigor.
Dr. Sebastian said the Yamanaka factors appeared to operate in two stages, as if they were raising the epigenome’s energy to one level, at which the marks of aging were lost, and then to a higher level at which cell identity was erased.
The Stanford team extracted aged cartilage cells from patients with osteoarthritis and found that after a low dosage of Yamanaka factors the cells no longer secreted the inflammatory factors that provoke the disease. The team also found that human muscle stem cells, which are impaired in a muscle-wasting disease, could be restored to youth. Members of the Stanford team have formed a company, Turn Biotechnologies, to develop therapies for osteoarthritis and other diseases.
The study is “definitively a step forward in the goal of reversing cellular aging,” Dr. Izpisua Belmonte said.
* * *
! #ScienceExperiments? Newly #ActualVirtual, #PhysicalDigital experiments' history? A #ScientificLiteratureReview, Comparative papers? in many disciplines of 'basic science'? And what we could learn from this in a #RealisticVirtualEarthForSTEM for #Genetics? #WUaSAgingReversal ?
! #ScienceExperiments? Newly #ActualVirtual, #PhysicalDigital experiments' history? A #ScientificLiteratureReview, Comparative papers? in many disciplines of 'basic science'? And what we could learn from this in a #RealisticVirtualEarthForSTEM for #Genetics? #WUaSAgingReversal ? https://t.co/gsuv2vCFOX
— Scott_GK_MacLeod_WUaS_worlduniversityandschool.org (@scottmacleod) December 5, 2021
https://twitter.com/scottmacleod/status/1467621890793492484?s=20
https://twitter.com/WorldUnivAndSch/status/1467621163870289924?s=20
https://twitter.com/sgkmacleod/status/1467621732139749377?s=20
https://twitter.com/HarbinBook/status/1467621598123290631?s=20
https://twitter.com/WUaSPress/status/1467621479818747910?s=20
https://twitter.com/TheOpenBand/status/1467621353096302593?s=20
https://twitter.com/RohitChotai/status/1467454820751609861?s=20
* * *
*
https://en.wikipedia.org/wiki/Turritopsis_dohrnii
https://commons.wikimedia.org/wiki/Category:Turritopsis_dohrnii
...
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