Wednesday, May 22, 2024

Tongass National Forest, AK: Shady Side Academy (high school in 2nd half of the 1970s) friends! * And here's the Harvard Medical School article - SCIENCE & TECH Science is making anti-aging progress. But do we want to live forever? Nobel laureate details new book, which surveys research, touches on larger philosophical questions * Continuing to be fascinated by generating a #RealisticVirtualEarth as classrooms and field sites (re my Physical-Digital Harbin Hot Springs' ethnographic field site) - and re Peter Norvig's incredible #ToolifyAIWUaS article - https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306 - AND THANKS TO SSA PRESIDENT BART GRIFFITH FOR EXPLORING SOME OF THIS A BIT IN RECENT 'Beyond the Quad' + emails especially ...


Shady Side Academy (high school in 2nd half of the 1970s) friends! 


Scott MacLeod sgkmacleod@worlduniversityandschool.org

May 21, 2024, 4:41 PM (2 days ago)
to mawileylarrylawheadGregHenryShawnEdwardStephenShawnNancySidPinJanieJoanJohnSarahBruceCharlesGeorgeBart

Hi Mike, Larry and Greg, Pin, Henry, Steve, Shawn, Nancy, All, 

Shady Side Academy friends from the 2nd half of the 1970s, with Linked Ins I've found  - 









Nancy Gormley (Bevilaqua Reed College writer Hoboken NY Shady Side Academy) (NY)



Sid Mazumdar (Harvard College, now 9n Baltimore) (MD)



Greetings from the near the SSA senior school campus ...

Best Regards, Scott 


PS
next open #MITOCW -centric wiki @WorldUnivAndSch @WUaSPress #WUaSNewsAndQA meets M 5/27/24 and re -


The next open #MITOCW -centric wiki @WorldUnivAndSch @WUaSPress #WUaSNewsAndQA meets M 5/20/24 at 07:00 AM Pacific Time, 10:AM Eastern Time (US/Canada), 7:30 PM India Time but please check your time converter from your time zone 











re my next and 6th book - 


World Univ & Sch 

'global university' blog label too -





Society, Information Technology, and the Global University (2024, forthcoming)

- Scott GK MacLeod  
Founder, President, CEO & Professor
CC-4 licensed MIT OCW-centric, Wiki, 
World University & School (WUaS) 
- PO Box 442, Canyon, CA 94516 
- 5816 Callowhill St., Pittsburgh, PA 15206

1) non-profit 501(c)(3) Public Charity 
MIT OCW-centric, 
 World University and School - http://worlduniversityandschool.org  

2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html

(m) 412 478 0116 - sgkmacleod@gmail.com 


World Univ & Sch Innovation Research -  scottmacleod.com 




Hi Mike, Larry and Greg (with your somewhat Scottish last names:), Pin, Henry, Steve, Shawn, Nancy, AND John (Hill), Mary, Jamie,  Marc, Jan, Bill, - Jim, John (Parran), Mike, & Scott (with no email addresses - please forward) - Jeff, Catherine, Michael, Eric John (Dix), 


Good morning! I've found the  Linked Ins of Shady Side Academy friends from the 2nd half of the 1970s, as a followup on yesterday's email to you ... (and fantastic news: MIT OCW-centric wiki World Univ & Sch, of which I'm the founder, the head, president, CEO and a professor at, just received an email from the Middle States Commission on Higher Education, with offices in the greater Philadelphia area, that WUaS can proceed with accreditation via a video call ... and possibly in collaboration with Shady Side and its heads' Trixie Sabundayo and Bart Griffith even ... And check this INCREDIBLE #ToolifyAIWUaS article - https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306  :))

How are you all doing in the middle of the information technology revolution? :)

Lt John Tadler in Linked In 















 


(PA)




And what do you all think of #AgingReversalGenetics' therapies emerging - https://wiki.worlduniversityandschool.org/wiki/Aging_Reversal_Genetics - early ones possibly FDA approved around 2030 (and see related #TwitterHashtags eg re also a #RealisticVirtualEarthForAgingReversal and #RealisticVirtualEarthForGenetics in 1 #RealistiVirtualEarth )? 

Are any of you, who are in Pittsburgh, up for a hike or similar (like a chamber music concert, if there are some over the summer) some weekend - and before I potentially move the WUaS Academic Medical Center with WUaS Longevity Genetics' Institute forward to a newly safe open Canyon 94516 (where I lived for about 13 years until September 2020, about 6 months into the non-SARS CoV2 pandemic) in 2024 potentially? After writing "Society, Information Technology and the Global University" book this year, I'd like to write a second Harbin Hot Springs' ethnographic book - and potentially even publish it at the WUaS Press newly from a #RealisticVirtualHarbin Hot Springs in something like Google Street View with time slider, Maps, Earth, TensorFlow AI with little Pegman becoming avatar agents of you and I (and #AvatarAgentElectronicHealthRecords) from text in the sidebar to 1) a brand new invention of the book in digital formats, and to 2) paper too.

It would be great to see you Shady Side A friends for a mini-reunion get togethers (and great to run into you Shawn a few days before SSA Homecoming in September 2022, I think, on Ivy St. in Shadyside not far from your law offices:).

Friendly Regards, 
Scott





PS
A little news here re an email I just sent to friends and family, yesterday Tue 5/22/24 - 

Ma, Pin, Shawn (Flaherty, attorney), Lt. John Tadler, US Senator and former Harvard Law teacher Elizabeth Warren, Peter Norvig, All, 

Greetings, and good morning (from an asylum place of western Pennsylvania, as a whistle blower and having called the police in the two asylum houses I've lived in in Pgh PA since August 2022, and in Canyon 94516 in August 2020)! 

Glad the US has a fairly well-functioning US federal government working with states' laws (e.g. PA and CA) in new ways ... 

and re, for example, tampering with US federal mails re the Resources' check sent to me, delivered on M May 20, 2024 regarding the paper letter to me being out of my locked mailbox at 5816 Callowhill Street #7 Pgh 15206, which the US Postal Service carrier would have a key for, but other people too (and after I put the paper letter addressed to Natalia Morgan-Long at #7, previous resident I think, back into my locked mailbox with "Return to Sender" OR "Please Forward" on it ... and could the person who put the resources' check to me on top of the opposite metal mail boxes have been somehow shocked or startled when s'he saw the paper letter to Morgan-Long, as evidence especially, newly in my box? ... And was this possibly the person in the luminous green vest with ladder initially, or even a new manager at lobos management bryant street rentals ... POSSIBLY navigating past lobos management Bryant street rentals  crimes? ... OR ?) ... By whom? (But glad I GOT 'RESOURCES' PAPER LETTER' with all this illegal US federal mails' tampering ... and I still am not getting the MIT OCW-centric wiki World University and School mail from the WUaS PO Box 442 Canyon CA 94516 after some 1 3/4 years ... and hope to get it again from the US Post Office in Canyon 94516 late this year).  

How to get my Chase credit card reactivated (deactivated on W 2/28/24), (and as the flagship physical-digital WUaS bookstore Chase bank loans with an initial invitation to WUaS from Stanford LBAN to meet with Curated Coaching TAP partnering with JP Morgan Chase bank)  ...I realize this may take time re Possible US federal investigation eg Into Chase bank Wilkinsburg Pgh PA 15221 and Chase bank Moraga 94556, and re the Target store near the trader joe's (where I first heard that "Your account is closed" Gordon name tag on the manager's name tag) ... and in growing a WUaS Abolition movement worldwide ... as right conduct, or ethical conduct or correct conduct ? I appreciate that Pittsburgh may seek to provide for its citizens ... and that Stanford Law CodeX (Roland Vogl is the executive director, and of which I'm a member) could possibly be looking into these interoperating companies' wrongful credit card closures in a complex way.


Seeking to move the WUaS Academic Medical Center with WUaS Longevity Genetics' Institute into Canyon 94516 in 2024 - and in growing this worldwide abolition movement ... (could an arrest warrant have been issued for alice sowaal at one time of the sf quajer meeting - and regarding international organized crime with kids even tragically? ... received some smartphone postings' yesterday, possibly suggestive of this, re a small middle eastern country's leader being sought for crimes ... and potentially re his arrest too).

Appreciating in an ongoing way this incredible TOOLIFY AI WUaS World Univ & Sch article from Peter Norvig

Thoughts, questions, ideas, suggestions? 

Thanks, regards, abolitionally, Friendly regards,  
Scott 


PS


Seems like with possible #AgingReversalGenetics & #ExtremeLongevity #GeneTherapies emerging, questions of How to live well & long are emerging:
Desiderata (1927)
"Take kindly the counsel of the years"









Retweeting - 

Harvard Medical School
@harvardmed
·
May 17
Nobel laureate Venki Ramakrishnan discusses current scientific understanding of aging and death






PPS
And here's the Harvard Medical School article - 

SCIENCE & TECH

Science is making anti-aging progress. But do we want to live forever?

Nobel laureate details new book, which surveys research, touches on larger philosophical questions

Anne J. Manning

 Harvard Staff Writer

May 14, 2024 4 min read

Mayflies live for only a day. Galapagos tortoises can reach up to age 170. The Greenland shark holds the world record at over 400 years of life. 

Venki Ramakrishnan, Nobel laureate and author of the newly released “Why We Die: The New Science of Aging and the Quest for Immortality,” opened his packed Harvard Science Book Talk last week by noting the vast variabilities of lifespans across the natural world. Death is certain, so far as we know. But there’s no physical or chemical law that says it must happen at a fixed time, which raises other, more philosophical issues.

The “why” behind these enormous swings, and the quest to harness longevity for humans, have driven fevered attempts (and billions of dollars in research spending) to slow or stop aging. Ramakrishnan’s book is a dispassionate journey through current scientific understanding of aging and death, which basically comes down to an accumulation of chemical damage to molecules and cells.

“The question is whether we can tackle aging processes, while still keeping us who we are as humans,” said Ramakrishnan during his conversation with Antonio Regalado, a writer for the MIT Technology Review. “And whether we can do that in a safe and effective way.”

Even if immortality — or just living for a very, very long time — were theoretically possible through science, should we pursue it? Ramakrishnan likened the question to other moral ponderings.

“There’s no physical or chemical law that says we can’t colonize other galaxies, or outer space, or even Mars,” he said. “I would put it in that same category. And it would require huge breakthroughs, which we haven’t made yet.”

In fact, we’re a lot closer to big breakthroughs when it comes to chasing immortality. Ramakrishnan noted the field is moving so fast that a book like his can capture but a snippet. He then took the audience on a brief tour of some of the major directions of aging research. And much of it, he said, started in unexpected places.

Take rapamycin, a drug first isolated in the 1960s from a bacterium on Easter Island found to have antifungal, immunosuppressant, and anticancer properties. Rapamycin targets the TOR pathway, a large molecular signaling cascade within cells that regulates many functions fundamental to life. Rapamycin has garnered renewed attention for its potential to reverse the aging process by targeting cellular signaling associated with physiological changes and diseases in older adults.

Other directions include mimicking the anti-aging effects of caloric restriction shown in mice, as well as one particularly exciting area called cellular reprogramming. That means taking fully developed cells and essentially turning back the clock on their development.

The most famous foundational experiment in this area was by Kyoto University scientist and Nobel laureate Shinya Yamanaka, who showed that just four transcription factors could revert an adult cell all the way back to a pluripotent stem cell, creating what are now known as induced pluripotent stem cells.

Ramakrishnan, a scientist at England’s MRC Laboratory of Molecular Biology, won the 2009 Nobel Prize in chemistry for uncovering the structure of the ribosome. He said he felt qualified to write the book because he has “no skin in the game” of aging research. As a molecular biologist who has studied fundamental processes of how cells make proteins, he had connections in the field but wasn’t too close to any of it.

While researching the book, he took pains to avoid interviewing scientists with commercial ventures tied to aging.

The potential for conflicts of interest abound.

The world has seen an explosion in aging research in recent decades, with billions of dollars spent by government agencies and private companies. And the consumer market for products is forecast to hit $93 billion by 2027.

As a result, false or exaggerated claims by companies promising longer life are currently on the rise, Ramakrishnan noted. He shared one example: Supplements designed to lengthen a person’s telomeres, or genetic segments that shrink with age, are available on Amazon.

“Of course, these are not FDA approved. There are no clinical trials, and it’s not clear what their basis is,” he said.

But still there appears to be some demand.

https://news.harvard.edu/gazette/story/2024/05/science-is-making-anti-aging-progress-but-do-we-want-to-live-forever/






On Tue, May 21, 2024 at 4:41 PM Scott MacLeod <sgkmacleod@worlduniversityandschool.org> wrote:

Hi Mike, Larry and Greg, Pin, Henry, Steve, Shawn, Nancy, All, 

Shady Side Academy friends from the 2nd half of the 1970s, with Linked Ins I've found  - 









Nancy Gormley (Bevilaqua Reed College writer Hoboken NY Shady Side Academy) (NY)


Sid Mazumdar (Harvard College, now in Baltimore) (MD)


Greetings from near the SSA senior school campus ...

Best Regards, Scott 


PS
next open #MITOCW -centric wiki @WorldUnivAndSch @WUaSPress #WUaSNewsAndQA meets M 5/27/24 and re -


The next open #MITOCW -centric wiki @WorldUnivAndSch @WUaSPress #WUaSNewsAndQA meets M 5/20/24 at 07:00 AM Pacific Time, 10:AM Eastern Time (US/Canada), 7:30 PM India Time but please check your time converter from your time zone 











re my next and 6th book - 


World Univ & Sch blog - 


--
World University and School is sending you this because of your interest in free, online, higher education. If you don't want to receive these, please reply with 'unsubscribe' in the body of the email, leaving the subject line intact. Thank you. 







Marc Lhormer

Wed, May 22, 3:11 PM (17 hours ago)
to memawileylarrylawheadGregHenryShawnEdwardStephenShawnNancySidSidJanieJoanJohnSarahBruceCharlesGeorgeBartCatherineJohnMaryjimJohnJanBilljlplaw15217padrdeatJohn
Powerful and exciting (and head-spinning) stuff … Scott … thank you for sharing!

Wishing you and everyone all the best through these times of great challenge and opportunity.

Marc




Almost as exciting as Marc's Oscar-nominated films!!  

Jeff Pollock (law)




Scott MacLeod sgkmacleod@worlduniversityandschool.org

4:40 PM (16 hours ago)
to MarcmawileylarrylawheadGregHenryShawnEdwardStephenShawnNancySidSidJanieJoanJohnSarahBruceCharlesGeorgeBartCatherineJohnMaryjimJohnJanBilljlplaw15217padrdeatJohn
Shady Side Academy friends, Marc, Jeff, Mary Ellen Chesley, All, 

Thanks for your emails - and conversation esp!  And thanks Marc! And glad Mary Ellen Chesley???? connected somehow via LinkedIn - 


And here's Bart Griffith's LinkedIn too (with email above)

So a #RealisticVirtualEarthForFilm (https://x.com/scottmacleod/status/1522300997598859264 and https://x.com/WorldUnivAndSch/status/1338730477566365699) and a #RealisticVirtualEarthForLaw (eg https://x.com/WorldUnivAndSch/status/1323725177302081536) in one iterating #RealisticVirtualEarth ? (Produce an Oscar winning film out of a #Realistic Virtual Earth possibly? )


And Scott Holquist checked in on my LI in LinkedIn too - thanks to whomever forwarded these emails - to them (... if ...). And what are our other Shady Side friends' emails in some of these regards (who didn't put their emails into LinkedIN ... and like Michael Hooper's email said for business only ) ... and please unsubscribe too if you wish not to receive emails in this thread. And please add other SSA friends from our time there, if you wish. 


I continue to be fascinated by generating a #RealisticVirtualEarth as classrooms and field sites (re my Physical-Digital Harbin Hot Springs' ethnographic field site) - and re Peter Norvig's incredible #ToolifyAIWUaS article - https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306 - AND THANKS TO SSA PRESIDENT BART GRIFFITH FOR EXPLORING SOME OF THIS A BIT IN RECENT 'Beyond the Quad' + emails especially ...
 

In these regards, MIT OCW-centric wiki World Univ & Sch is interested in exploring building an #AgingReversalMachine as #WUaSHospitalRooms #WUaSMultimediaBarns - and think Google Street View with TIME SLIDER with #GCellView , #GAtomView - and N-Dimensionally inside rooms, and see (all fascinating ideas ... and building to some degree or coming into conversation with Harvard and MIT Professor of Genetics' George Church, who's a lead voice in heralding Aging Reversal and Extreme Longevity Genetic therapies - https://youtu.be/bnCEIPQFNnk) - and see, for example: 

view: #GStreetViewRoom https://youtu.be/q9FBhEAXRY4 with #timeslider >An #AgingReversalMachine from these 8 Tweets w #FlywireFly @amplesa @geochurch #PeterNorvig & think in #GStreetView w #GCellView #GAtomView in #RealisticVirtualEarthForGenomics #RealisticVirtualEarthForGenetics ?

https://twitter.com/WorldUnivAndSch/status/1775874497704243374







Retweeting -

Can we reverse aging?
7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, https://biorxiv.org/content/10.1101/2023.11.13.566787v1 we used 🧬 screens to find new rejuvenation factors🧵1/8

https://twitter.com/amplesa/status/1737852952407326906


"How to view Google Street View in a smart meeting room" (Igloo Vision)
 - as potential #AgingReversalMachine in Hospital Rooms 

and regarding #AgingReversalGenetics in #RealisticVirtualEarthForAgingReversal and #AvatarAgentElectronicHealthRecords. 

AlphaFold 3 predicts the structure and interactions of all of life’s molecules 


WOW: "#AlphaFold3 takes us beyond proteins to a broad spectrum of biomolecules. This leap could unlock more transformative science" - to accelerate #WUaSDrugDesign & #WUaSgenomics research"-Steps to #RealisticVirtualEarthFor #ForProteins #ForPharmaceuticals #AgingReversalMachine?







Retweeting - 

1.8M+ researchers have used @GoogleDeepMind’s AlphaFold protein predictions in their work on vaccine development, cancer treatment + more. AlphaFold 3 is the latest breakthrough, predicting the structures + interactions of all of life’s molecules with unprecedented accuracy. We’re sharing access to these capabilities through AlphaFold Server to enable other scientific discoveries. blog.google/technology/ai/…




Exploring as MIT OCW-centric wiki World Univ & Sc accredits with MSCHE offering a co-listed WUaS course (which course so far doesn't exist as far as I know - does it?) on aging reversal genetics potentially with Harvard and Stanford if at all possible https://wiki.worlduniversityandschool.org/wiki/Aging_Reversal_Genetics .

Will we all be talking in 5 centuries from now, thanks to aging reversal and extreme longevity genetic therapies, and possibly as 25 year olds  in 482 year old bodyminds? Until the possible first aging reversal genetic drug therapies are FDA approved (in 2030?) - Desiderata? : "Take kindly the counsel of the years ... " :) - https://www.desiderata.com/desiderata.html -  makes sense to me ... 

Wishing you and everyone all the best through the years, and possibly centuries and millennia + ahead (... if ... :)

Best regards, abolitionally, nice to be in communication, 
Scott 










https://www.ktoo.org/2019/10/15/after-months-of-speculation-forest-service-recommends-lifting-roadless-rule-for-the-tongass/ 


















https://en.wikipedia.org/wiki/Tongass_National_Forest

https://commons.wikimedia.org/wiki/Category:Tongass_National_Forest


https://www.nationalforests.org/blog/seven-largest-national-forests


https://en.wikipedia.org/wiki/Misty_Fjords_National_Monument

https://commons.wikimedia.org/wiki/Category:Misty_Fjords_National_Monument


...



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