To a global, virtual, free, open, {future degree- & credit-granting}, multilingual University & School for the developing world and everyone, as well as loving bliss ~ scottmacleod.com
Harvard Crimson by Corey Becker '26 (& Friends Select School '22) - "Fifteen Questions: David Sinclair on Age Reversal, Exercise, and Immortal Yeast Cells"
Dear George and David, Corey and McKenna, David (Sun Kong), Byron, Friend David (Matchett), Peter (Norvig, Google AI Director), All,
Thanks so much for publishing "Fifteen Questions: David Sinclair on Age Reversal, Exercise, and Immortal Yeast Cells" in the Harvard Crimson by Corey Becker '26 (& Friends Select School '22) -
In adding this article to the free-to-students' CC-4 licensed MIT OCW- centric wiki World University and School's fairly new Aging Reversal Genetics' wiki school or subject page (planned in all 200 countries and in their main languages too), WUaS continues to seek open-licensed OCW-like Aging Reversal Genetics' and Extreme Longevity genetics' and related courses ... and regarding WUaS seeking to develop a #PhyaicalDigital #RealisticVirtualEarth #ForAgingReversal #RealisticVirtualEarthForAgingReversal, and think Google Street View with time slider, Google Maps, TensorFlowAI, and at the Google Cell View and Molecular view levels, and AlphaFold3Server, and even with the Nabla Bio AI's "Nabla Bio’s AI design and human-relevant wet-lab capabilities" and regarding the related Tweet by Harvard and MIT professor of Genetics George Church in the Harvard Medical School, in the PPS below/.
George and David, Corey and McKenna, all: do you know of any such OCW-related Aging Reversal Genetics' courses - or even how we might create such courseware in a #RealisticVirtualEarthForGenetics - a project Reed College friend Byron Hann MD PhD and I are seeking to develop in the shop at 670 Ridgecrest Rd, Canyon 94516 beginning soon? Thanks again George and David (Sun Kong) for the stellar How to Grow (Almost) Anything synthetic biology class online in which I was a global listener (and created a blog label for HTGAA too - https://scott-macleod.blogspot.com/search/label/HTGAA - in daily blog). The Academic Press at WUaS (planned in all 7159 living languages) is also seeking to make publishing of scientific papers possible in a brand new way from something like Google Street View with time slider, from #TextInTheSidebar. Please stay tuned.
How best also to grow new researchers in Aging Reversal Genetics and Extreme Longevity genetic drug therapies emerging at MIT OCW-centric wiki World University and School and from our WUaS eventual STEAM graduates ... and out of Harvard, and the Scottish-Celtic worlds / networks / cultures, and out of unprogrammed Friends' Quaker worlds (UU too), and in all ~200 countries and in their languages too ?
Thnx @geochurch for retweet & how best could @WorldUnivAndSch dev a #RealisticVirtualEarthForProteins #ForAgingReversal re "Nabla Bio’s AI design and human-relevant wet-lab capabilities" to deploy "across Takeda’s early-stage development programs" w #WUaSunivs collab w both cos? AAAB https://x.com/WorldUnivAndSch/status/1978467720053367098
We’re excited to share a new multi-year collaboration with @TakedaPharma, building on the success of our first engagement. Under the agreement, Nabla will receive double-digit millions in upfront and research payments and is eligible for success-based payments exceeding $1 billion.
The partnership deploys Nabla’s AI-driven JAM platform across Takeda’s early-stage programs to include de novo design of antibodies in parallel for multiple targets, multispecifics, challenging targets, and other custom therapeutics.
How best could @WorldUnivAndSch dev #DigitalTwinRobotics #DigitalTwins w #LegoSpikePrimeRoboticsKits #WUaSLegoRobotics in a #RealisticVirtualEarthForRobotics & for #WUaShomeRobotics? 8:50 min - Augmented Reality for Digital Twins: from LEGO to Buildings
How best could @WorldUnivAndSch dev #DigitalTwinRobotics #DigitalTwins w #LegoSpikePrimeRoboticsKits #WUaSLegoRobotics in a #RealisticVirtualEarthForRobotics & for #WUaShomeRobotics? 8:50 min - Augmented Reality for Digital Twins: from LEGO to Buildings https://youtu.be/HHAFIflmJJU?si=7BVCtP-hZgSh8eC- ?
How best could @ help in developing #DigitalTwinRobotics #DigitalTwins w #LegoSpikePrimeRoboticsKits #WUaSLegoRobotics in a #RealisticVirtualEarthForRobotics & for #WUaShomeRobotics? Begin coding a Realistic Virtual Earth for Robotics AND a #RealisticVirtualEarthForArchitecture with 8:50 min -
Great adaptation of a MIT OCW course with our Intro to Computer Science & Python. 2025. and thanks! If it's ok with you, I have added it as a resource and reference to
Thanks so so much, and for the amazing engagement and adaptation with a MIT OCW in a new way, and World University and School's wiki pages in a sense ... I am wondering if Mwende Volcano Evande in Cameroon, West Africa might be interested for example.
Gemini, how best to invite people to wiki-teach and wiki-learn at MIT OCW-centric wiki World University and School, possibly using artificial intelligence besides this "What citation format do I use for adding what I teach or a resource to a WUaS wiki subject?
Gemini AI, how best to invite people to #wikiTeach & #wikiLearn @ #MITOCWcentric wiki @WorldUnivAndSch poss. using AI besides: "What citation format do I use for adding what I teach or a resource to a #WUaSwikiSubject?
GeminiAI, how best to invite people to wiki-teach and wiki-learn at MIT OCW-centric wiki World University and School, possibly using artificial intelligence besides this "What citation format do I use for adding what I teach or a resource to a WUaS wiki subject? https://wiki.worlduniversityandschool.org/wiki/Frequently_Asked_Questions
Gemini, how best to invite people to wiki-teach and wiki-learn at MIT OCW-centric wiki World University and School, possibly using artificial intelligence besides this "What citation format do I use for adding what I teach or a resource to a WUaS wiki subject?
Answer:
The general idea for the WUaS wiki schools in terms of citation practice begins with -
last name, first name. year. [URL title of link]. (extra items - eg like accessed online). place of publication: publisher.
Example:
JudgeAI. 2024. JudgeAI Demo (with upgraded UI). (A Stanford Law CodeX presentation on Th Sep 12, 2024 online - https://x.com/CodeXStanford/status/1833289582131220941). Yerevan, Armenia: https://judgeai.space/." from the Frequently Asked Questions wiki page - https://wiki.worlduniversityandschool.org/wiki/Frequently_Asked_Questions so as to grow the number of WUaS wiki-teachers and wiki-learmers making GREAT contributions at WUaS in all 200 countries and their languages with parallels to but different from Wikipedia's Editors and curators etc)? Reach out via email or advertise or? How to get to 1000 active editors or WUaS wiki teachers by the emd of 2025 and see also this set of TwitterX posts from this morning - How best @ #WikiWUaS free & open @WorldUnivAndSch to cultivate #WUaSWikiUsers #WUaSvolunteers #WUaSUniversitians ... ?
How best @ #WikiWUaS free & open @WorldUnivAndSch to cultivate #WUaSWikiUsers #WUaSvolunteers #WUaSUniversitians @ https://wiki.worlduniversityandschool.org/wiki/User who will #WikiAdd or #WikiTeach great #TeachingResources #LearningResources in all ~200 countries, all 7159 langs & in coding for 7.9B peops?
Achieving your goal of reaching 1,000 active WUaS wiki teachers/editors by the end of 2025 requires a multi-faceted strategy that leverages both traditional outreach and innovative use of AI, focusing on cultivating a passionate, supported, and rewarded community.
The best approach involves a combination of targeted outreach (email/social media), strategic partnerships, and AI-powered tooling to streamline contributions and support the community.
1. AI-Powered Contribution and Support
Artificial Intelligence can be a powerful force multiplier for recruiting and retaining wiki contributors, especially by simplifying the barrier to entry and enhancing productivity.
* AI-Assisted Content Generation & Formatting:
* Drafting Tools: Implement an AI assistant that can take a teaching resource (e.g., a lecture transcript, a PDF summary, a video link) and generate a structured wiki draft. This drastically lowers the effort required to go from a resource to a formatted wiki page.
* Citation Bot: Directly address the citation question you provided by using an AI bot that can take standard bibliographic information or a URL and automatically format it into the required WUaS citation style (e.g., the "JudgeAI" example format) for easy insertion.
* Language Translation/Adaptation: Use AI to help automatically translate existing English content into the other 7,159 languages you target, or to adapt content to a local context, fulfilling your mission in all 200 countries. This makes it easier for non-English speakers to contribute and use material.
* AI-Guided Onboarding and Mentorship:
* Interactive Tutorial/Game: Develop an AI-driven, gamified "Wiki Adventure" tutorial (similar to Wikipedia's) that guides a new user step-by-step through the process of creating their first page, including proper citation, formatting, and linking.
* Contextual Help Chatbot: Deploy a support chatbot that lives on the wiki's "Edit" pages. New users can ask questions like "How do I make a heading?" or "Where should I link this resource?" and get instant, context-specific answers.
* AI for Quality Control and Moderation (Retention):
* Content Vetting: Use AI to flag potential issues like broken links, plagiarism, or content that significantly deviates from the established quality standards, allowing human moderators to focus on more complex editorial decisions. This ensures high-quality contributions, which is key for retaining serious teachers/learners.
2. Targeted Recruitment and Outreach
To reach 1,000 active contributors, a continuous and diverse outreach plan is crucial.
* Direct Email and Social Media Outreach:
* Targeted Faculty/Educator Lists: Create lists of faculty and educators interested in Open Educational Resources (OER) and open pedagogy, particularly those affiliated with MIT OCW, Creative Commons, and similar initiatives. Email them directly, highlighting the benefit of global reach for their existing materials.
* Personalized Social Media Campaigns (e.g., X/Twitter): Continue using platforms like X, but focus posts on a clear call-to-action and a specific benefit. Use hashtags that reach educators (e.g., #OpenEd, #OER, #GlobalEd, #EdTech, #WikiEdu). Example: "Amplify your best lecture! #WikiTeach on WUaS and reach students in 200 countries. AI tools make formatting a snap. Link in bio."
* Strategic Partnerships and University Programs:
* Wiki Education Program Model: Emulate the Wiki Education Foundation's model by actively recruiting university instructors to assign their students to contribute content (e.g., write a module, curate a reading list, create a cited resource page) to WUaS as a course assignment. This creates a pipeline of hundreds of contributors per semester.
* Librarians and OER Advocates: Partner with university librarians, who are often central figures in OER adoption. They can promote WUaS as a destination for sharing and discovering open resources.
* Incentives and Recognition (The "Why"):
* Professional Recognition: Emphasize that contributing is a form of scholarly output and professional service. Offer digital badges, certificates, or even official letters of appreciation for contributions (e.g., "WUaS Global Wiki Teacher"). This is a form of non-monetary "reward" crucial for academic volunteers.
* Featured Contributors: Highlight the best contributors and their work prominently on the main page and in social media to provide prestige and visibility.
* Community Building: Host regular virtual "Wiki-Sprints" or "Edit-a-thons" focused on specific subjects or languages. This fosters a sense of community and provides a dedicated time for mass contributions.
3. Emphasizing the Value Proposition
To compete with other platforms, you must clearly articulate what makes WUaS unique.
* Global, Multilingual Reach: Stress that WUaS is explicitly focused on all 200 countries and a vast number of languages, offering a unique opportunity to impact global education that platforms like a local university's courseware cannot match.
* Structured OCW-Centric Curricula: Position WUaS as a platform where contributions aren't random but build toward structured, high-quality, and potentially degree-like learning pathways, similar to the MIT OCW philosophy.
* The "5R" OER Permissions: Emphasize that your platform is a place where teachers can truly exercise the 5Rs of OER—Retain, Reuse, Revise, Remix, and Redistribute—with a clear citation standard to give credit. This appeals to the core OER community.
How will a #Realistic Virtual Earth For Viruses in 1 iterating #Realistic Virtual Earth help with approaches to curing the common cold? #CuringTheCommonColdWUaS? -#IncredibleGeminiAIreply: ...
How will a #RealisticVirtualEarthForViruses in 1 iterating #RealisticVirtualEarthWUaS #ForViruses help with approaches to #CuringTheCommonColdWUaS? -#IncredibleGeminiAIreply: https://gemini.google.com/share/c1222c7ffc2e
*
How will a #Realistic Virtual Earth For Viruses in 1 iterating #Realistic Virtual Earth help with approaches to curing the common cold?
AI Overview
A #Realistic Virtual Earth, or a massive, iterative simulation of Earth's biological and environmental systems, would be an unprecedented tool for developing common cold cures. By integrating data on viral genetics, transmission, and human immune responses, such a model could help scientists identify universal weaknesses in cold viruses that have so far eluded traditional research methods.
Addressing the common cold's core challenges
The common cold is caused by over 200 different viruses, primarily rhinoviruses, with new strains constantly emerging. A cure has been difficult to find because a single drug is unlikely to work against all of them. A virtual Earth could help solve this in several ways:
Identify conserved viral features: While cold viruses mutate constantly, a virtual model could process vast datasets to find molecular structures or functions that all rhinoviruses share, but that are absent from host cells. A drug targeting one of these "conserved" features could neutralize a wide variety of cold viruses at once.
Model viral evolution in real-time: By iterating the simulation over time, scientists could observe how different viral strains evolve, how they interact with each other, and where new pandemic-level threats might arise. This would allow researchers to predict and prepare for future viral shifts.
Predict drug effectiveness: Researchers could "test" new antiviral drug candidates in the virtual Earth before human trials. By modeling the drug's interaction with multiple viral strains, they could quickly see if it works, predict how the virus might develop resistance, and iterate on the drug's design.
Insights from other virtual biology projects
Several projects have already shown the promise of virtual biology, suggesting what a full-scale virtual Earth could accomplish:
Agent-based epidemic models: Agent-based models that use supercomputers to simulate the movement and interactions of millions of individuals have already been used to understand the spread of diseases like COVID-19. A virtual Earth would scale this up to a global level, including data like weather patterns and travel routes, to track and stop cold virus outbreaks.
Atomically detailed molecular simulations: Projects studying viruses like HIV and SARS-CoV-2 have used supercomputers to simulate viral protein dynamics at the atomic level. A virtual Earth could scale this approach, allowing researchers to simulate how all known strains of rhinovirus function and how they might be neutralized.
Virtual lab collaboration: The ViroLab Project for HIV, and similar "virtual labs" for cancer research, allow geographically-distributed scientists to collaborate in a single virtual space. A virtual Earth would expand this, allowing virologists worldwide to work together to hunt for a common cold cure.
Potential applications for the common cold
Beyond finding a cure, an iterating virtual Earth could help with many other aspects of common cold research:
Accelerated antiviral development: Instead of designing a new drug for every viral strain, a virtual Earth could identify a universal target shared by many cold viruses. For example, a 2013 study used a 3D model of rhinovirus C to find that previous drug candidates failed because they did not account for differences in viral surfaces. A virtual Earth could have detected this, saving time and resources.
Understand human-viral interactions: By modeling the complexity of human behavior, a virtual Earth could help predict how cold viruses spread within and between populations. For instance, data from real-world virtual games have shown that human unpredictability, like panic and non-compliance with quarantine, can dramatically alter disease spread. A virtual Earth could provide realistic data on this behavior to inform disease models.
Improve public health measures: Just as existing simulations have helped modelers and public health officials understand COVID-19 spread, a virtual Earth would allow testing different health interventions to see what would most effectively reduce the burden of the common cold.
Training for new pandemics: A realistic, iterative virtual Earth would be a powerful training ground for preparing for the next major pandemic. It could help researchers and public health officials anticipate viral dynamics and test control strategies before an outbreak occurs.
By simulating complex interactions between viruses, host immunity, and human behavior on an unprecedented scale, a virtual Earth would fundamentally transform our ability to understand, predict, and ultimately find a cure for the common cold.
* *
Feel a cold coming on? How could #AvatarAgentElectronicHealthRecords #WUaSinteroperable #WITHa #RealisticVirtualEarth be brought to Bear to end cold early (e.g. via a #eRapidSensor) & re approaches to #CuringTheCommonColdWUaS?#IncredibleGeminiAIreply: https://g.co/gemini/share/73335257eb65 ~
how could MIT open courseware Centric Wiki World University and school and I develop a realistic virtual Earth for genetics and at the Google Street View level with time slider Google sell view level Google molecule of you levels and connected to our Avatar agent electronic health records and to cure the common cold such that if I felt a cold coming on I could bring this Avatar agent electronic health record of mine in an realistic virtual Earth to Bear to end the cold early
This complex vision requires massive, multi-disciplinary collaboration across MIT OpenCourseWare (OCW) and World University and School (WUaS), Google, genetics research, and healthcare technology.
* Develop the Virtual Earth and Data Layers:
* MIT OCW/WUaS could establish the framework for a "Genetics Earth" using open-source tools and educational content, potentially building on Google Earth's time slider and Street View capabilities for visualization.
* Integrate "Google Street View level" to visualize environmental/geographic factors (pollutants, population density, climate) and their correlation with disease incidence.
* Add "Google Molecule View level" to display real-time, global genetic and proteomic data (e.g., rhinovirus strain distribution from wastewater or patient data, as research is already sequencing all strains).
* Implement a "time slider" to track the evolution of genetic data (e.g., viral mutations) and correlate with health outcomes and environmental changes.
* Connect Personal Health Data:
* Create a secure, privacy-preserving standard (like a federated learning model) to connect the Virtual Earth's genetic data to the Avatar Agent/Electronic Health Record (EHR).
* The Avatar Agent would be a computational, personalized "digital twin" of your biology (genetics, immune history, current health status from your EHR), a concept already explored in precision medicine.
* Cure the Common Cold:
* Your Avatar Agent, upon detecting early cold symptoms (from your EHR/wearables), would query the Virtual Earth's real-time viral-strain and environmental data.
* It would leverage research findings (like disabling the SETD3 protein needed for rhinovirus replication, a concept already published) and your unique genetic makeup to simulate the most effective, personalized intervention (drug, gene therapy, or prophylactic measure) to "end the cold early."
* MIT OCW/WUaS's educational platform would host the open-source algorithms and knowledge base driving the Avatar Agent's recommendation system.
* * *
Happy birthday, Jen MacLeod Murray - M October 13, 2025 ~ and remembering Harvard physics' student Franny MacLeod, and Jen's father Quaker Bruce MacLeod, and their brother too Gordon MacLeod (my father)
Jen Happy birthday Jen! All,
And thanks for your nice note in the PS and remembrance of your great dad Bruce, one of my favorite uncles (who was a member of Abington Friends' Meeting) who helped open the way to my becoming a student for 3 terms at Pendle Hill Quaker center for Study and Contemplation in Wallingford, PA (near Swarthmore College), and then my working in the Pendle Hill Bookstore / Publishing for about 3 1/2 years total beginning in the late 1980s), I hope you're having a great long birthday, Jen! Your writing about your dad and in my exploring further about aging reversal genetic drug therapies emerging, and Harvard (re Harvard And MIT professor of Genetics' George Church and see the PPS) and re Harvard too, reminded me of our uncle Franny "Francis" MacLeod, who as I've heard, went to Harvard College from Boston Latin School, planning to be a physics' major (and re another Harvard College physics' major who went to Friends Select School in Philadelphia and wrote the aging reversal article in the Harvard Crimson school paper below) and then was drafted into WW2 and died at the age of around 20 in the Vosges mountains in France in around 1943. Mark and Brad may know more specifics but see too - http://scottmacleod.com/ScottMacLeodFamilyHistory.htm. Interestingly, Jen, with you still teaching in a Quaker school in the Philadelphia area, and my having been active with unprogrammed Friends' Quakers since the mid-1970s (in about 15 unprogrammed Friends' Quaker Meetings ... some in 3D virtual worlds), and family history-wise, when I was living and studying in Germany for a year in 1981-1982 (through a Reed College program in Munich), I was active in a little unprogrammed Friends' Quaker Meeting there (living at the end of my 13 months there with a Quaker family, the Kruegers in Garching, for 2.5 months), and the husband one of the women who attended Meeting, Diete Jehle, came to Meeting a couple of times, Herbert Jehle, and he had taught physics at Harvard College in the 1940s and REMEMBERED Franny (And when my father Gordon and mother Janie, above, came to visit me I was glad my father GKM MD and Herbert Jehle met)... I don't recall asking your father, my uncle, Bruce, about why he became a member of the Religious Society of Friends but I wonder if the Friends' Peace Testimony from the 1660s (which in its briefest form, you'll find here, searching on 'testimony - https://scott-macleod.blogspot.com/2025/10/western-capercaillie.html - in my daily blog, along with the most inspiring Quaker writing I know the Nobel Peace Prize address to Quakers in 1947) could be part of this (and re what happened to our Uncle Franny in WW2) ... Am an appreciator of Friends Quaker Silent Meeting and re a kind of group meditation - and in Yoga meditating daily first thing upon rising ... Happy, happy birthday, Jen!
Any MacLeods here interested in free online MIT OCW-centric wiki in a #GrowWithGoogleWUaS program World University and School degrees as WUaS accredits further, or wiki-teaching in our free open WUaS wiki schools? Please let me know.
Thank you for the thoughtful birthday wishes! Thanks also for the kind memory of my dad. I still work in a Quaker school and enjoy my colleagues and (most of) the students.
Thank you again, for reaching out. It was really nice to hear from you.
Got a bounceback from jenmurray@comcast.com, so Mark / cousins, could you please forward this happy birthday greetings to her new email address? (I also got bounce backs from these Jennifer MacLeod Murray e-birthday party celebrants - jm@jenmacleod.com, bridget.macleod@ndus.edu, macl0105@crk.umn.edu - so could you please include their new possible email addresses in this birthday greetings to Jen (and I'd love to be able to stay in communication with these family members as well)).
Happy birthday, and are you 'back home' in Glenside, Philadelphia, Pennsylvania?
With extreme longevity and aging reversal genetic drug therapies emerging, and FDA approved, (as heralded by Harvard and MIT professor of genetics' George Church in the Harvard Medical School), we may be celebrating your birthday for centuries even to come!
Warm regards, best wishes, Friendly Quaker greetings (like from your father Bruce, too - and thanks to him for connecting when I was a Pendle Hill Quaker center for Study and Contemplation in Wallingford, PA, for about 4 years beginning in the late 1980s), Have a great birthday!
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