Saturday, February 7, 2026

Kadamba flower: Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:)? ~ Yoga explorations further in this Restorative Yoga class on this Saturday 2/7/26 at around 8 am PT, 11 am ET, 8:30 pm India Time * Here's George Church in a video titled "The End of Aging ... " https://youtu.be/2b5xDVCNkTU (2025) And here's the minute-long 60 Minutes aging reversal interview with George Church with Scott Pelley: "How soon could humans reverse the aging process with genetic engineering?" https://youtu.be/bnCEIPQFNnk (2019) * 3 restorative poses Sitting in crosslegged pose, half lotus (ardha padmasana) or on a chair ... Explore these again - Xmas Yoga video ... 'open free Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:) 12/25/25' https://youtu.be/F61foSTThsY (2025) * * fascinating further Gemini AI responses regarding Yoga meditation and asana genetics and scientific experimentation directions .. and with avatar agent electronic health records in a realistic virtual earth ...and see the PS especially ...

 


Sat 2/7/26
open free Restorative Yoga class on Saturdays & in the mornings (and as we may live to 150 and well beyond:)? - Sat 2/7/26 https://scott-macleod.blogspot.com/2026/02/kadamba-flower.html
12/25/25
https://youtu.be/F61foSTThsY
12/27/25
https://youtu.be/AIKPYP939q8
https://www.youtube.com/@ScottMacLeodWorldUniversity/videos
#YogaAndLongevityGeneticsConvo #WUaSYoga~



AND 
12/25/25 & 12/27/25

Twitter - open free Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:) & an #YogaAndLongevityGeneticsConvo #WUaSYoga ~




AND

12/27/26


12/27/25

#OpenFreeRestorativeYogaClass on Sats (as we may live to 150 & well beyond:) & conversation 12/27/25 (online at 8am PT)
Namaste,
Scott 
@ewarren @WorldUnivAndSch
(See also 12/25










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Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:)? ~ Yoga explorations further in this Restorative Yoga class on this Saturday 2/7/26 at around 8 am Pacific Time, 11 am ET, 8:30 pm India Time


Dear Annie, Alden, Donna, George and Maitreyi (both professors in Harvard Medical School), Ma/Janie, Byron, Yogis & Yogi scientists, All, 

Warm greetings!
 
Yoga explorations further in this Restorative Yoga class on this Saturday 2/7/26 at around 8 am PT, 11 am ET, 8:30 pm India Time (and as we may live to 150 and well beyond:)


! How are you doing? How are your hip and knee healing, Annie and Alden? How are (y)our individual explorations of restorative Yoga poses going? I find much to learn from Yogini Angela Farmer re last week's video (35 mins - 42 mins) ~ 

Here's the Yoga meditation again with Angela - 

Angela Farmer : Living Fully In Our Bodies (Full Class)

https://youtu.be/wCJfXwm97rw (2022)



Here's George Church in a video titled 
"The End of Aging ... " 


And here's the minute-long 60 Minutes aging reversal interview with George Church with Scott Pelley: 
"How soon could humans reverse the aging process with genetic engineering?"

How might we explore the results of this science in the form of vaccines or similar from a Yoga science perspective now and in the future?


3 restorative poses 

Sitting in crosslegged pose, half lotus (ardha padmasana) or on a chair ... 

Explore these again -
Xmas Yoga video ...
'open free Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:) 12/25/25' 


You'll find here also the restorative Yoga poses in pictures from Kaiser Permanente health care - http://scott-macleod.blogspot.com/2025/12/eagle-cap-wilderness-in-wallowa.html Explore these exploratorily to go deeper with restorative yoga pose explorations  ? 


Angela & Victor's Yoga (from the outside) 


And a Yoga philosophical exploration into consciousness (subjective experience) creating reality on 2/3/26 - 
" ... consciousness > reality re #Yoga
Asked #GeminiAIrePhilosophy where has #YogaPhilosophy ..."
And how does 8 limb yoga inform consciousness ?- 
"Yoga philosophy, specifically the Eight Limbs ..."


Yoga philosophy, specifically the Eight Limbs (Ashtanga), originates from Patañjali’s Yoga Sutras. It provides a structured framework for living a purposeful, ethical, and disciplined life aimed at spiritual liberation.

The Eight Limbs
Yamas: Ethical restraints (non-violence, truthfulness).

Niyamas: Personal observances (purity, contentment).

Asana: Physical postures.

Pranayama: Breath control.

Pratyahara: Sensory withdrawal.

Dharana: Concentration.

Dhyana: Meditation.

Samadhi: Enlightenment or oneness.

Would you like me to break down the specific meanings of the Yamas and Niyamas?



 



Seeking to teach this Restorative Yoga class live in a Zoom Yoga hall video call on Saturdays at 8 am Pacific time soon - and from 670 Ridgecrest Rd in Canyon ! Stay tuned ...

Namaste,
Scott 
(Am updating these Yoga web pages newly - with the free Filezilla FTP and Seamonkey ... if interested in how to make web pages, please let me know) ~ 




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San Francisco Bay Area - East Bay Hills & Online

415 480 4577

World University and School's wiki, 'Yoga,' subject page - https://wiki.worlduniversityandschool.org/wiki/Yoga :) - with an invitation to 'edit this page' to learn or teach and explore yoga. 


Yoga ideas
#QuakerYogaMacFlower
#DesiderataWUaS
~#ToolifyAIWUaS #WUaSBliss 
~#YogaNotationsWUaS
~#YogaWUaS @
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#WUaSabolition in #RealisticVirtualEarth #WUaSYoga ~

with pic of partner child pose - supported backbend 




Please reply with unsubscribe in the subject line if you do not want to receive these yoga emails. Namaste.






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Dear Annie, Alden, Donna, George and Maitreyi (both professors in Harvard Medical School), Ma/Janie, Byron, Yogis, All,  

Greetings ... Looking forward to gathering individually for restorative Yoga poses exploration in about 12 hours from now - and as we may live to 150 years old and well beyond - and all exploring Yoga asana independently from home, or where we are ... I blogged about this today here -


Recalling also that, for me, first Yoga meditation in a cross legged pose, then half lotus Yoga pose into a forward bend head to floor (Yoga mudrasana) daily can be wonderful for de-stressing ... And if you are finding yourself stressed or worried, I've also just recalled that flax-seed-oil such as in capsule form, or as seeds baked into corn, tomato and spinach chips can be a very positive and great way to destress  ...

Here again are steps to explore the relaxation response inner releasing action meditation - https://scott-macleod.blogspot.com/2008/09/arc-steps-to-elicit-relaxation-response.html - and out of the Harvard Medical School, and derived from a scientific study of meditation.

Happy Yoga, best regards, Namaste, 
Scott

Want to wiki-teach Yoga in some of these regards, or even longevity or aging reversal genetics regarding Yoga potentially? Please explore wiki-teaching here - 


of









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Sunday, February 8, 2026


fascinating further Gemini AI responses regarding Yoga meditation and asana genetics and scientific experimentation directions .. and with avatar agent electronic health records  in a realistic virtual earth ...and see the PS especially ...

Annie, Alden, Donna, George and Maitreyi (both professors in Harvard Medical School), Ma/Janie, Byron, Peter Norvig, Yogis, All,  
 
Some fascinating further Gemini AI responses regarding Yoga meditation and asana genetics and scientific experimentation directions ... and with avatar agent electronic health records  in a realistic virtual earth ...and see the PS especially ...

Sat 2/7/26
open free Restorative Yoga class on Saturdays & in the mornings (and as we may live to 150 and well beyond:)? - Sat 2/7/26 https://scott-macleod.blogspot.com/2026/02/kadamba-flower.html
12/25/25
https://youtu.be/F61foSTThsY
12/27/25
https://youtu.be/AIKPYP939q8
https://www.youtube.com/@ScottMacLeodWorldUniversity/videos
#YogaAndLongevityGeneticsConvo #WUaSYoga~



AND
See some of you, I hope, in the HTGAA synthetic biology class 2026 on Tuesday at 11am PT ..

Until next Saturday, 2/14/26 ... and Happy Valentine's Day too 

Yogically, warm regards, Namaste,
Scott
Will further add here on Sat 2/7/26 - 


PS



AND 

How might we do further research in a realistic virtual Earth for molecules and a realistic virtual Earth for genetics on Yoga asana & the Yoga relaxation response meditation and other genes that for example George Church is focusing on in aging reversal genetics and extreme longevity genetics? 

To conduct research into the intersection of Yoga Asana, the Relaxation Response (RR), and George Church’s aging reversal genetics, we can move beyond static data and build a Virtual Earth for Genetics.

By transitioning from Electronic Health Records (EHR) to Avatar Agents and finally to Digital Twins, we can simulate the "synergy" between ancient mind-body practices and cutting-edge synthetic biology.

1. The Research Framework: From Record to Agent

A "Virtual Earth" allows us to simulate millions of lives simultaneously to see how behavioral changes (Yoga) interact with genetic interventions (Church).

Phase A: Data Foundation (EHR)

  • The Baseline: Use EHR data to identify "epigenetic signatures" in long-term yoga practitioners versus non-practitioners.

  • Target Genes: Focus on Church’s primary longevity targets—FGF21 (metabolism), sTGFβR2 (anti-fibrosis), and α-Klotho (kidney/brain protection)—and see how their baseline expression correlates with yoga frequency.

Phase B: The Avatar Agent (The Experimental Proxy)

Before building a 1:1 molecular "Twin," create Avatar Agents. These are AI-driven representatives of different genetic "types."

  • The "Practice" Variable: Program agents to perform different "Virtual Asana" routines (e.g., restorative vs. vigorous) in a simulated environment.

  • The "Intervention" Variable: Introduce "Digital Church Therapies" (simulated AAV gene delivery) to these agents.

  • Hypothesis: Does the reduced inflammation (NF-κB downregulation) from a "Yoga Agent" increase the success rate of the FGF21 gene therapy by reducing cellular "noise" or stress?

Phase C: The Digital Twin (Molecular Simulation)

This is the high-fidelity stage where we model the actual molecular docking and protein folding.

  • Molecular Dynamics: Simulate how the α-Klotho protein, enhanced by gene therapy, interacts with the lower cortisol and higher BDNF levels found in the "Relaxation Response" state.

  • In Silico Aging: Run the Digital Twin at 100x speed to observe "epigenetic drift" over a simulated 150-year lifespan.

2. Key Genetic Targets for the Simulation

Your research in this Virtual Earth would track the interaction between these two "toolkits":

The "Yoga/RR" Genetic ToolkitGeorge Church's "Aging Reversal" Toolkit
NF-κB: Downregulated to stop chronic inflammation ("inflammaging").FGF21: Overexpressed to reverse obesity and metabolic decline.
Telomerase: Increased activity to protect chromosomal "caps."sTGFβR2: Repressed to stop heart and lung tissue scarring (fibrosis).
SIRT1: Upregulated for mitochondrial health and DNA repair.α-Klotho: Increased to protect cognitive function and kidney health.
BDNF: Increased for neuroplasticity and brain aging reversal.TFAM: Enhanced to boost mitochondrial "biogenesis" (energy).

3. Designing the "Virtual Earth" Experiment

In a realistic virtual world, you can test scenarios that are impossible in real-life clinical trials:

  1. The "Synergy" Test:

    • Group A: Gene Therapy alone.

    • Group B: Yoga Asana alone.

    • Group C: Combined "Avatar" receiving both.

    • Virtual Earth Finding: You might find that Group C reaches "longevity escape velocity" 20% faster because the RR stabilizes the environment for the new genes.

  2. Environmental Stressors:

    • Introduce "Virtual Pollution" or "High Stress" into the Earth. Observe if the Relaxation Response acts as a "buffer" that prevents the synthetic genes (like FGF21) from being prematurely silenced by epigenetic "tags" (methylation).

  3. Cross-Generational Modeling:

    • Simulate the "Avatar Agent" having offspring to see if the epigenetic benefits of the Yoga RR + Church Genetics are heritable in the virtual environment.

Next Step

Would you like me to generate a detailed technical simulation roadmap for an Avatar Agent that combines Hatha Yoga asanas with the α-Klotho gene therapy?



AND 
Yoga asana, realistic virtual earth with avatar agent electronic health records, & George Church's aging reversal and longevity genetics ' gene therapies, experiments (at World Univ & Sch building on MIT OCW in 7 languages) ?

Yoga meditation as relaxation response and Yoga asana

Research from Harvard Medical School indicates that the Relaxation Response (RR) alters the expression of genes involved in energy metabolism, insulin secretion, and inflammatory pathways.

Specifically, the response influences:

NF-κB: Downregulates genes linked to the pro-inflammatory response and stress-related signaling.

Mitochondrial Resilience: Enhances genes associated with ATP synthesis and insulin pathways to improve energy stability.

Telomere Maintenance: Some studies suggest positive effects on genes related to cellular aging and DNA repair.

Would you like me to find a specific study citation for these genetic markers?

how might we do further research in a realistic virtual Earth for molecules and a realistic virtual Earth for genetics on the relaxation response meditation and other genes that for example George Church is focusing on in aging reversal genetics and extreme longevity genetics
To research the relaxation response and longevity genetics within a "virtual Earth" framework, we can leverage Digital Twins and In Silico modeling to simulate molecular interactions at scale.

1. Digital Twins for Personalized Meditation
Researchers can create a digital twin—a virtual mathematical replica—of a person’s biological system. By feeding real-time data from wearables (heart rate variability, cortisol levels) into the twin, scientists can simulate how the Relaxation Response (RR) influences gene expression in that specific individual.

Targeting NF-κB: Virtual models can predict how different meditation durations "downregulate" inflammatory pathways in real-time.

Environmental Feedback: A "Virtual Earth" allows researchers to test how different simulated environments (e.g., a digital forest vs. deep space) optimize the RR at a genetic level.

2. Virtual Genetic Perturbation for Longevity
For the work of George Church and aging reversal, we use virtual cell models to perform "genetic perturbation." Instead of years of lab trials, AI simulates the effects of editing master genes across an entire virtual population.

Multi-Gene Interaction: Longevity is rarely about one gene. Virtual Earths allow us to simulate the "cocktail effect" of Church’s focus areas—like FGF21, sTGFβR2, and α-Klotho—interacting simultaneously.

Simulated Evolutionary Pressure: Researchers can observe how "extreme longevity" genes perform over virtual centuries within varied environmental stressors.

Comparison of Research Approaches
Method Physical Lab Virtual Earth / Digital Twin
Speed Years/Decades Minutes/Hours (via AI)
Scale Limited samples Millions of virtual "twins"
Risk High (in vivo testing) Zero (in silico simulation)
Complexity Single-pathway focus Holistic, multi-gene interaction
Would you like me to generate a summary of the specific "longevity cocktail" genes George Church is currently testing in his Rejuvenate Bio research?

how many further examine do research with hypotheses and experiments on the effects of yoga Asana and George Church's focus in aging reversal genetics and extreme longevity genetics and in a realistic virtual Earth for genetics for aging reversal for extreme longevity and Beyond digital twins as Avatar agent electronic health records building from the electronic health record to Avatar agents first before possibly digital Twins or in a separate Direction
To research the intersection of yoga asana, George Church’s aging reversal genetics, and virtual Earth modeling, you can follow this multi-stage framework that transitions from data records to active simulations.

1. Hypothesis Formulation: Convergence of Bio-Markers
You can test the hypothesis that Yoga Asana acts as a "behavioral epigenetic regulator" that synergizes with Church's longevity gene therapies (like FGF21, sTGFβR2, and α-Klotho).

Hypothesis: Regular asana practice reduces systemic inflammation (downregulating NF-κB), creating a more receptive cellular environment for Church’s AAV-delivered gene therapies to reverse tissue fibrosis.

Experiment: Use "Virtual Earth" simulations to model how reduced cortisol from yoga interacts with the metabolic efficiency provided by FGF21 over a 50-year simulated lifespan.

2. The Developmental Pipeline: EHR to Avatar to Digital Twin
Instead of jumping straight to a high-fidelity Digital Twin, building in stages allows for a more realistic "Avatar Agent" that acts as a bridge:

Step 1: Electronic Health Record (EHR)

Action: Aggregate multi-modal data (genomics, blood panels, yoga frequency).

Focus: Passive history and baseline biological age.

Step 2: Avatar Agent (The "Active" Proxy)

Action: Create a goal-driven AI agent representing the patient. This agent "lives" in the Virtual Earth, testing different yoga routines and dosage timings for gene therapies.

Value: Unlike a static twin, the agent can proactively "negotiate" with virtual environments to find the path of least biological resistance.

Step 3: Digital Twin (The "Predictive" Model)

Action: Once the Avatar Agent identifies successful patterns, the Digital Twin runs high-fidelity molecular simulations (e.g., protein folding of α-Klotho) to confirm the physical viability of the aging reversal.

3. Virtual Earth Research Tools
Using a Virtual Earth for Genetics, you can scale experiments beyond human limitations:

Simulated Populations: Run 100,000 Avatar Agents with different genetic backgrounds to see which groups respond best to the combination of yoga and FGF21 therapy.

Extreme Longevity Modeling: Simulate "Super Ager" genetics (like those studied by Nir Barzilai) alongside George Church’s synthetic edits to identify if yoga can prevent the "adverse interactions" Church observed when combining certain longevity genes.

Would you like me to draft a specific research protocol for simulating the interaction between Hatha Yoga and the α-Klotho gene in an Avatar Agent?






PPS

While I can conceive of Yoga genetics and regarding aging reversal and extreme longevity genetic drug therapies emerging  as self-study or self-experimentation ... 'svadhyaya' in the Sanskrit in 8 Limbs of Yoga,  ...


How does George Church self-experiment?

Femini AI 

George Church self-experiments by applying his genetic engineering and synthetic biology research directly to his own body to test safety and efficacy, most notably by taking a DIY COVID-19 vaccine. As a pioneer of the Personal Genome Project, he has made his own genomic, health, and trait data public.
Key ways George Church engages in self-experimentation include:
  • DIY COVID-19 Vaccine: In 2020, Church took a do-it-yourself coronavirus vaccine developed by a former student, mixing the ingredients himself and administering two doses to test its safety.
  • Personal Genomics and Data Sharing: Church founded the Personal Genome Project (PGP), where he was the first to make his own genome sequence, medical records, and lab values public to accelerate research.
  • Age Reversal Research: Church is heavily involved in studies aimed at reversing aging through genetic modification, often testing concepts related to cellular rejuvenation.
  • Technological Validation: He often tests technologies developed in his lab, such as new, highly accurate, and inexpensive genome sequencing methods.
His approach is driven by a belief that high-risk, high-reward innovations—ranging from synthetic biology to de-extinction—can be accelerated by pioneering researchers taking the first steps themselves



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http://www.flowersofindia.net/catalog/slides/Kadam.html



https://en.wikipedia.org/wiki/Neolamarckia_cadamba

https://commons.wikimedia.org/wiki/Category:Neolamarckia_cadamba

https://species.wikimedia.org/wiki/Neolamarckia_cadamba


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