| 5:56 PM (2 hours ago) | |||
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#DrVivekBuch, thanks https://stanford.cloud-cme.
#DrVivekBuch, thanks https://t.co/9O08xo3qV5 How to improve #BrainAnatomyMapping (beyond #LanguageOfElectricity) & @ #Gcell, #Gmolecule levels eg for tremor, & in a #RVEforBrainCircuits, a #RealisticVirtualEarthForSurgery #RVEforYogaAsana (re #GStreetView w #GTimeSlider, #GMaps)?
— QuakerYogaMacFlower (@Q_YogaMacFlower) August 26, 2026
https://x.com/Q_YogaMacFlower/
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https://x.com/WorldUnivAndSch/
https://x.com/scottmacleod/
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https://x.com/TheOpenBand/
https://share.google/aimode/
- Scott GK MacLeod
Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki,
World University & School (WUaS)
- USPS US Post Office, PO Box 132, General Delivery, Canyon, CA 94516
1) non-profit 501(c)(3) Public Charity
building on CC-4 licensed MIT OCW in 7 languages -
http://
2) for profit general stock company WUaS Corporation in CA - http://
- wuas_ceo@
https://wiki.
World University & School Innovation Research -
- http://scottmacleod.com
- https://twitter.com/
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* *
- Weight-Bearing and Isometric Poses (e.g., Phalakasana / Plank, Utkatasana / Chair Pose):
- Inversions (e.g., Viparita Karani / Legs-up-the-Wall, Adho Mukha Svanasana / Downward Dog):
- Mechanism: Alters baroreceptor activity, increases vagal tone, and shifts the autonomic nervous system into a parasympathetic state.
- Electrical Target: Drives strong Alpha (8–12 Hz) and Theta (4–8 Hz) microstates across frontocentral networks, counteracting the hyper-arousal that exacerbates tremors. [1, 2, 3]
- Seated, Braced Postures with Restorative Framing (e.g., Bhadrasana / Bound Angle with supports):
- Mechanism: Minimizes gravity-induced postural demands.
- Electrical Target: Isolates baseline brainwave shifts during Pranayama (breath control), suppressing erratic Beta oscillations linked with motor stress. [1]
- Mobile, High-Density EEG: Use a dry-sensor or gel-based wireless EEG cap (e.g., 32 or 64 channels) that is stable during movement.
- Synchronized Electromyography (EMG): Place surface EMG sensors on the affected muscle groups (e.g., wrist extensors).
- Data Isolation: Run Corticomuscular Coherence (CMC) analysis to calculate the exact mathematical alignment between the brain's motor cortex rhythms and the hand's tremor frequency.
[R21 Exploratory Grant] ──> [R33 Implementation Phase] ──> [U01 / R01 Definitive RCT]
(Mechanistic / Feasibility) (Biomarker Validation) (Large-Scale Clinical Efficacy)
- Phase II: Efficacy Testing (NIH R01 or R33 Mechanism):
- Focus: A randomized, controlled trial (RCT) comparing a standardized 12-week Yoga Asana protocol against an active control group (e.g., basic stretching or light calisthenics).
- Primary Outcomes: Quantitative tremor reduction using the The Essential Tremor Rating Assessment Scale (TETRAS) alongside calibrated accelerometer data. [1, 2]
- Phase II: Efficacy Testing (NIH R01 or R33 Mechanism):
- Yoga as an Adjuvant (Combination Protocol): You can propose a trial evaluating if yoga alters cortical excitability, effectively increasing the efficacy of lower pharmaceutical doses. This minimizes drug side effects while optimizing tremor control. []
- FDA Mobile/Software Regulation: If you develop an app that uses wearable sensors to guide patients into specific asanas based on real-time tremor frequencies (biofeedback), the software component may require FDA clearance as a Software as a Medical Device (SaMD).
- Draft a Pilot Protocol: Outline a 4-week, 3-pose protocol specifically tailored for individuals with postural hand tremors. [1]
- Search Existing Frameworks: Review open grants on the NIH RePORTER database using keywords like "NCCIH movement disorder" to see how comparable mind-body mechanics achieved federal funding.
Investigating how specific yoga asanas modulate central electrical oscillations to address Essential Tremor (ET) requires bridging high-density neuroimaging with structured clinical trial protocols. Because ET is primarily driven by hyper-synchronous oscillatory activity in the cerebello-thalamo-cortical loop (typically presenting as 4–12 Hz kinetic and postural tremors), evaluating yoga's potential to damp this circuit involves a clear multi-phase roadmap.
Phase 1: Mapping Asana to Electrophysiological Signals
To isolate the "electrical language" of the brain during specific movement or stillness profiles, design a laboratory-based observational protocol.
1. Neuroimaging Instrumentation
- Mobile High-Density EEG (64+ Channels): Use active-electrode, motion-artifact-compensated EEG caps equipped with accelerometry and electromyography (EMG) on tremor-affected muscle groups (e.g., forearm extensors/flexors).
- Signal Demixing: Apply Independent Component Analysis (ICA) and Artifact Subspace Reconstruction (ASR) to clean motion artifacts induced by movement or the tremor itself.
-
Target Biomarkers:
- Cerebellar & Sensorimotor Rhythms (Mu / Beta band, 13–30 Hz): Measure power spectral density and functional connectivity between the primary motor cortex (M1) and supplementary motor area (SMA).
- Alpha (8–12 Hz) & Theta (4–7 Hz) Synchronization: Track how restorative, supported postures influence central autonomic regulation and corticomuscular coherence (CMC).
2. Asana Categorization Framework
Categorize postures by their motor-unit recruitment and autonomic impact rather than just tradition:
Chart
|
Asana Category |
Biomechanical Focus |
Target Electrical / Neuromuscular Shift |
|---|---|---|
|
Supported Restorative (e.g., Supta Baddha Konasana with props) |
Down-regulation of sympathetic drive; passive spinal elongation. |
Increase in global Alpha/Theta power; reduction of central hyper-excitability. |
|
Weight-Bearing Isometric (e.g., Bharadvajasana or mild plank variations) |
Co-contraction, proprioceptive resetting, and joint stabilization. |
Modulations in Beta-band desynchronization (ERD) over motor areas. |
|
Dynamic Slow Flow (e.g., Marjaryasana-Bitilasana / Cat-Cow) |
Rhythmic spinal articulation paired with paced respiration (0.1\text{ Hz}). |
Phase-locking of vagal nerve tone with cortical slow-wave dynamics. |
Phase 2: Hypothesis & Proposed Mechanism of Action
Your trial design should center on testing specific physiological mechanisms:
- Corticomuscular Uncoupling: Does down-regulating stress via slow breathing (Pranayama) and supported grounding postures reduce the gain in the cerebello-thalamo-cortical circuit, decoupling central oscillatory drivers from peripheral EMG output?
- Neuroplastic Cortical Inhibition: Post-intervention, does consistent practice restore GABAergic intracortical inhibition—which is frequently deficient in essential tremor populations?
Phase 3: Developing a Rigorous Clinical Trial (NIH Alignment)
To meet the standards of the National Institutes of Health (NIH)—specifically National Center for Complementary and Integrative Health (NCCIH) or National Institute of Neurological Disorders and Stroke (NINDS)—follow a staged trial trajectory.
Step A: Phase I / Feasibility Pilot Study (R21 / R34 Grant Pathway)
- Design: Single-arm or small 2-arm pilot (n = 20\text{–}30) assessing feasibility, safety, and preliminary signal.
- Primary Outcomes: Adherence rates, safety logs, and change on the TETRAS (The Essential Tremor Rating Assessment Scale).
- Secondary Outcomes: Quantitative kinematic tremor metrics (via 3D accelerometers) and electrophysiological shifts (pre/post intervention EEG power spectral density).
Step B: Phase II Multi-Center RCT (U01 / R01 Grant Pathway)
-
Design: Three-arm Randomized Controlled Trial (n = 100+) comparing:
- Standardized Yoga Intervention (e.g., 8–12 weeks of structured prop-supported Asana + Pranayama).
- Active Control (e.g., light-stretching or seated upper-extremity physical therapy).
- Waitlist / Usual Care Control.
- Blinding: Blind the neurological assessors and EEG data analysts to group assignments (single-blind design).
-
Clinical Endpoints:
- Primary: Change in TETRAS performance and activities of daily living (ADL) scores.
- Secondary: Sensorimotor EEG coherence, Quality of Life (QUEST score), and resting-state fMRI functional connectivity.
Practical Next Steps for Research Design
- IRB Protocol Preparation: Secure Institutional Review Board clearance for non-invasive electrophysiological recording during mild physical activity.
- Form a Cross-Disciplinary Team: Partner with a movement disorder neurologist, a biomedical engineer specializing in signal processing/EEG, and an experienced yoga researcher or physical therapist.
- Register the Protocol: Register the finalized study design on ClinicalTrials.gov prior to recruitment to establish transparency and institutional credibility
* * *
ADDED to https://wiki.worlduniversityandschool.org/wiki/Yoga the following using this citation form -
MacLeod, Scott GK. 2026. [https://scott-macleod.blogspot.com/2026/08/lotus-maculatus-restorative-yoga.html Lotus maculatus: Restorative Yoga explorations' classes' Blog posts since December 2025 with 'Yoga' blog label too here - https://scott-macleod.blogspot.com/2026/08/lotus-maculatus-restorative-yoga.html & https://scott-macleod.blogspot.com/search/label/Yoga ~]. (Thursday, August 13). SF East Bay, CA: https://scott-macleod.blogspot.com/2026/08/lotus-maculatus-restorative-yoga.html.
* * *
Lisa Nevara, ex sister-in-law to Ann Brown questions about Larry Gill’s story about his run in with the Manson's - in The Dalles, Oregon - and a #RealsiticVirtualEarth #ForHistory, and #ForCounterculture
12:58 PM
Chat with Lisa. Details
Scotty Macleod, this is Lisa Nevara, ex sister-in-law to Ann Brown. I'm listening to a NPR program about the Merry prankster’s psychedelic bus coming down to San Francisco for an exhibition. It reminds me of the stories Larry told of that era. I remember you taped a piece of Larry Gill’s story about his run in with the Manson's. I've been thinking about piecing together some of his stories/travels, but it's so hard to remember how to tell with his voice. Do you by any chance still have that?? if so, maybe you can forward it on? It might be easier by email?? Anyway, if it works out: lisanevara@gmail.com
Hi Lisa, How are you? Greetings from Berkeley, California, near to Canyon CA 94516. Are you still living in The Dalles, Oregon or nearby? I don't recall much about taping or writing about Larry Gill's story (except possibly that I wished I had recorded it) ... but I may have written something about this in my daily blog, having an ongoing academic focus on counterculture, the 1960s and '70s and their aftermath - and in a realistic virtual earth for history even ... and there may be something here findable in these blog labels - https://scott-macleod.
1:13 PM
Yes, of course if I get enough interesting pieces put together. I will forward to you. Thanks so much. I think it might’ve been 2015 or later over there about
I now live in Lincoln city Oregon left the dry side
1:16 PM
Thanks for your texts Lisa ... Just emailed you in case it went into spam ... More later
are you on LinkedIn or TwitterX ? And when did we see each other near the swimming spot? Fond regards, Scotty (with parallels to https://scott-macleod.*
12:58 PM
Hi Lisa, How are you? Greetings from Berkeley, California, near to Canyon CA 94516. Are you still living in The Dalles, Oregon or nearby? I don't recall much about taping or writing about Larry Gill's story (except possibly that I wished I had recorded it) ... but I may have written something about this in my daily blog, having an ongoing academic focus on counterculture, the 1960s and '70s and their aftermath - and in a realistic virtual earth for history even ... and there may be something here findable in these blog labels - https://scott-macleod.
1:13 PM
Yes, of course if I get enough interesting pieces put together. I will forward to you. Thanks so much. I think it might’ve been 2015 or later over there about
I now live in Lincoln city Oregon left the dry side
1:16 PM
Thanks for your texts Lisa ... Just emailed you in case it went into spam ... More later
are you on LinkedIn or TwitterX ? And when did we see each other near the swimming spot? Fond regards, Scotty (with parallels to https://scott-macleod.Thanks for your text message just now, and below in the PS.Am wondering if this far-reaching and fascinating conversation could even have been recorded 'externally' - e.g. by the US federal government or the state of Oregon or similar ... and how to access this ... brainstorming-wise ...How might we add such a conversation even to an emerging realistic virtual earth for history and think Google Street View with a time slider ... (and regarding Rajneeshi's in Oregon too ... and re Tim's working at that museum or historical society too not far from The Dalles)My reply to you -Hi Lisa, How are you? Greetings from Berkeley, California, near Canyon CA 94516. Are you still living in The Dalles, Oregon or nearby? I don't recall much about taping or writing about Larry Gill's story (except possibly that I wished I had recorded it) ... but I may have written something about this in my daily blog, having an ongoing academic focus on counterculture, the 1960s and '70s and their aftermath - and in a realistic virtual earth for history even ... and there may be something here findable in these blog labels - https://scott-macleod.blogspot.com/search/label/ Counterculture or https://scott-macleod. blogspot.com/search/label/ Oregon - or in an email ... Do you remember the year and / or month we might have been having a meal at Annie Brown's house in The Dalles regarding this interesting history, if I remember correctly where this happened. Will email you too, Friendly regards, Scotty (And see the history and counterculture wiki subjects at wiki World University and School, building on MIT OCW in 7 languages, here - https://wiki. worlduniversityandschool.org/ wiki/Subjects ... Might we add what you write or piece together as a kind of wiki-teaching to one of these or related wiki-subjects at WUaS) ScottyPSTuesday August 25, 2026Scotty Macleod, this is Lisa Nevara, ex sister-in-law to Ann Brown. I'm listening to a NPR program about the Merry prankster’s psychedelic bus coming down to San Francisco for an exhibition. It reminds me of the stories Larry told of that era. I remember you taped a piece of Larry Gill’s story about his run in with the Manson's. I've been thinking about piecing together some of his stories/travels, but it's so hard to remember how to tell with his voice. Do you by any chance still have that?? If so, maybe you can forward it on? It might be easier by email?? Anyway, if it works out: lisanevara@gmail.com--Society, Information Technology, and the Global University, (forthcoming, Academic Press at World University and School, 2026)Scottish Small Piping album #2 - Honey Piobaireachd (2022)- https://twitter.com/TheOpenBand (Berkeley) Scottish Small Piping album #1 Honey in the Bag ~ Out of the Air tune (2020)Order Book #4 To the Dance or the Pools? ~ Virtually! How different it is to soak at Harbin Hot Springs, than to realize it in virtual reality (2019, Academic Press at WUaS)Order Book #3 Winding Road Rainbow: Harbin, Wandering & the Poetry of Loving Bliss (2018, Academic Press at WUaS)Order Actual-Virtual Ethnographic Book #1: Naked Harbin Ethnography (2016, Academic Press at World University and School)
- Scott GK MacLeod
Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki,
World University & School (WUaS)
- USPS US Post Office, PO Box 132, General Delivery, Canyon, CA 94516
1) non-profit 501(c)(3) Public Charity
building on CC-4 licensed MIT OCW in 7 languages -https://ocw.mit.edu/ & https://opencw.aprende.org/courses/ translated-courses/ -
http://worlduniversityandschool.org
2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/ AcademicPress.html
- wuas_ceo@worlduniversityandschool.org https://wiki.worlduniversityandschool.org/ wiki/Nation_States (planning ~200 countries' WUaS world class universities in their main languages, per the Olympics, for free-to-students' WUaS degrees from home)
https://wiki.worlduniversityandschool.org/ wiki/Languages (planning to be in all 7159 living languages, each as or with wiki schools for open people-to-people wiki-teaching and wiki-learning, e.g. from here - https://wiki. worlduniversityandschool.org/ wiki/Subjects)
World University & School Innovation Research -
- http://scottmacleod.com
- https://twitter.com/scottmacleod
- https://x.com/Q_YogaMacFlower/status/ 1815700381474689273
- http://www.linkedin.com/in/scottgkmacleod
- https://twitter.com/sgkmacleod (all 7,159 known living languages at WUaS)
- https://scott-macleod.blogspot.com/search/label/ global%20university
- https://worlduniversityandschool. blogspot.com/search/label/ global%20university
* *
| from: | Scott MacLeod sgkmacleod@worlduniversityandschool.org | ||
|---|---|---|---|
| to: |
| ||
| date: | Aug 26, 2026, 9:43 AM | ||
| subject: | Re: Lisa Nevara, ex sister-in-law to Ann Brown questions about Larry Gill’s story about his run in with the Manson's - in The Dalles, Oregon, I think | ||
| mailed-by: | worlduniversityandschool.org |
https://scott-macleod.
* * *
Quakers Friends Family Cuttyhunk - M 8/24/26 & 8/31/26 open best STEAM Creative Commons' licensed OpenCourseWare wiki World Univ & Sch WUaS News and Q&A, with Zoom URL ~ unsubscribe & 2 Friendly Quaker wiki schools and subjects at Friendly-informed World University and School for open wiki-teaching and wiki-learning, with a Friendly invitation to teach to these, if lead ...
Carl Anderson referenced here -
TVC in the News
Calling for Change
April 21, 2022
Source: The Independent
https://trivalleycares.org/
C 2
And with
Carl Anderson speaking here at ~42:25 minutes -
Good Friday at LLNL 2022
https://youtu.be/-y-ueGhv-3c
https://trivalleycares.org/
And with
Carl Anderson speaking here at 42:24 minutes -
Good Friday at LLNL 2022
https://youtu.be/-y-ueGhv-3c
Sierra Azul, Santa Cruz mountains, CA: M 8/24/26 Recording of @WorldUnivAndSch @WUaSPress #WUaSWBM #
M 8/24/26 Recording of @WorldUnivAndSch @WUaSPress #WUaSWBM #
https://youtu.be/xEakun3HXRE
https://
-https://scott-macleod.
using 8/17 #WUaSAgenda
-https://
-https://scott-macleod.
-https://www.youtube.com/@
Unsubscribe- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -Carl Anderson- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
* * *
SF Bay Area again from Massachusetts 2026 - Canyon 94516 ? ~ Kristin B. Connelly (she/her), Contra Costa county Clerk-Recorder and Registrar of Voters -
& signing the property deed for 670 Ridgecrest Road, Canyon 94516
Automatic reply: WUaS News and Q&A - AA - M 8/24/26 & 8/31/26 open best STEAM Creative Commons' licensed OpenCourseWare wiki World Univ & Sch WUaS News and Q&A, with Zoom URL
| Christine Carducci | Sun, Aug 23, 10:55 PM (2 days ago) | ||
- Scott GK MacLeod
Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki,
World University & School (WUaS)
- USPS US Post Office, PO Box 132, General Delivery, Canyon, CA 94516
1) non-profit 501(c)(3) Public Charity
building on CC-4 licensed MIT OCW in 7 languages -
http://
2) for profit general stock company WUaS Corporation in CA - http://
- wuas_ceo@
Hi Byron, Sid, Ed, Jane, Peter, Elizabeth, Kristin, all, how are you? Just returned to the SF Bay Area from Massachusetts ... and received this further MIT Alumni Startups NorCal in SF message from Shuja Keen MIT '99 BS in the Sloan School of Business, from Pakistan -Will #MassachusettsInstituteOfTechno logy @MIT #AlumniStartups #MITAS #NorCal #CoWorkingSessions in SF this fall https://giqqp.r.a.d.sendibm1. com/mk/mr/sh/ 1t6AVsd2XFnIGIVb9qIATOtvkQ1WCv /phUUZ9SozoAm lead to @WorldUnivAndSch, since ~2007 & with #MITOCW in 7 langs, matriculating students from all 200 countries for #FreeWUaSdegrees on M 1/4/27? ... No sign of international organized crime on Cuttyhunk or en route this year ... WUaS abolition movement seems to be growing ... and after the precipitating? gunshot to Sienna minivan on M 5/18/26 and a myriad of death threats sadly on both coasts in recent years ... Is international organized crime diminishing in the SF east bay and Canyon 94516 do you think?Regards, Scott(re MITAS - https://scott-macleod.blogspot.com/2026/08/marsur- rock-hussainabad-skardu- valley.html?m=0) --Society, Information Technology, and the Global University, (forthcoming, Academic Press at World University and School, 2026)Scottish Small Piping album #2 - Honey Piobaireachd (2022)- https://twitter.com/TheOpenBand (Berkeley) Scottish Small Piping album #1 Honey in the Bag ~ Out of the Air tune (2020)Order Book #4 To the Dance or the Pools? ~ Virtually! How different it is to soak at Harbin Hot Springs, than to realize it in virtual reality (2019, Academic Press at WUaS)Order Book #3 Winding Road Rainbow: Harbin, Wandering & the Poetry of Loving Bliss (2018, Academic Press at WUaS)Order Actual-Virtual Ethnographic Book #1: Naked Harbin Ethnography (2016, Academic Press at World University and School)
- Scott GK MacLeod
Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki,
World University & School (WUaS)
- USPS US Post Office, PO Box 132, General Delivery, Canyon, CA 94516
1) non-profit 501(c)(3) Public Charity
building on CC-4 licensed MIT OCW in 7 languages -https://ocw.mit.edu/ & https://opencw.aprende.org/courses/ translated-courses/ -
http://worlduniversityandschool.org
2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/ AcademicPress.html
- wuas_ceo@worlduniversityandschool.org https://wiki.worlduniversityandschool.org/ wiki/Nation_States (planning ~200 countries' WUaS world class universities in their main languages, per the Olympics, for free-to-students' WUaS degrees from home)
https://wiki.worlduniversityandschool.org/ wiki/Languages (planning to be in all 7159 living languages, each as or with wiki schools for open people-to-people wiki-teaching and wiki-learning, e.g. from here - https://wiki. worlduniversityandschool.org/ wiki/Subjects)
World University & School Innovation Research -
- http://scottmacleod.com
- https://twitter.com/scottmacleod
- https://x.com/Q_YogaMacFlower/status/ 1815700381474689273
- http://www.linkedin.com/in/scottgkmacleod
- https://twitter.com/sgkmacleod (all 7,159 known living languages at WUaS)
- https://scott-macleod.blogspot.com/search/label/ global%20university
- https://worlduniversityandschool. blogspot.com/search/label/ global%20university
*
https://en.wikipedia.org/wiki/Western_honey_bee
https://commons.wikimedia.org/wiki/Category:Apis_mellifera
https://species.wikimedia.org/wiki/Apis_mellifera
....

, Thank you for your message. I value on-going communication and will gladly respond to your e-mail upon my return to work the week of September 7. St
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