How for @WorldUnivAndSch with #WUaSAIandML to develop #CC4 #MITOCW in 7 languages ... https://opencw.aprende.org/
How for @WorldUnivAndSch with #WUaSAIandML to develop #CC4 #MITOCW in 7 languages https://opencw.aprende.org/
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How for @WorldUnivAndSch with #WUaSAIandML to develop #CC4 #MITOCW in 7 languages https://t.co/rpVT6bUIc9 & https://t.co/OEqcLjPOd8 into the other ~175 countries' main langs for #freeWUaSdegrees & while growing #ForProfitInCA @WUaSPress w #MITAS #NorCal -https://t.co/4mA0y9JCGt ?
— WorldUnivandSch (@WorldUnivAndSch) September 9, 2026
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Society, Information Technology, and the Global University, (forthcoming, Academic Press at World University and School, 2026)
Scottish Small Piping album #2 - Honey Piobaireachd (2022)
- https://twitter.com/
Scottish Small Piping album #1 Honey in the Bag ~ Out of the Air tune (2020)
Order Book #4 To the Dance or the Pools? ~ Virtually! How different it is to soak at Harbin Hot Springs, than to realize it in virtual reality (2019, Academic Press at WUaS)
Order Book #3 Winding Road Rainbow: Harbin, Wandering & the Poetry of Loving Bliss (2018, Academic Press at WUaS)
Order Actual-Virtual Ethnographic Book #1: Naked Harbin Ethnography (2016, Academic Press at World University and School)
- Scott GK MacLeod
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at / of best STEAM CC licensed OCW, Wiki,
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#Rentosertib for IPF & #ER100 for Glaucoma, in clinical trials, 2 of the most groundbreaking experimental therapies in medicine; Both drugs use #CellularRejuvenation & #AntiAgingScience to treat severe diseases w/o cure so far
#Rentosertib for IPF (https://www.nature.com/
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#Rentosertib for IPF (https://t.co/9uYCG2Oc2E), & #ER100 for Glaucoma, in clinical trials, 2 of the most groundbreaking experimental therapies in medicine; Both drugs use #CellularRejuvenation & #AntiAgingScience to treat severe diseases w/o cure so far https://t.co/JEejKqItn5 ~
— WorldUnivandSch (@WorldUnivAndSch) September 9, 2026
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Did Pharma.AI - https://pharma.ai/ - design Rentosertib for IPF?
Yes -
Yes, Insilico Medicine used its generative AI platform, Pharma.AI, to discover and design Rentosertib (formerly ISM001-055) specifically for idiopathic pulmonary fibrosis (IPF). [1, 2, 3]
As reported in Nature Medicine, “Our approach resulted in the first antifibrotic, small-molecule TNIK inhibitor, rentosertib (formerly ISM001-055), for the treatment of IPF designed by generative AI.”
How the AI Designed the Drug
- Target Discovery: The AI platform used data to find a new target called TNIK that causes lung scarring and aging.
- Molecule Creation: The system used generative AI to build a brand new small molecule that fits into the TNIK protein.
Clinical Progress
- Phase IIa Trials: Tests showed the drug is safe and helps improve lung function in patients.
- Phase III Studies: The treatment has moved into large-scale late-stage clinical trials.
- Read full details on the study from Nature Biotechnology.
Would you like to know more about how Phase III trials work or how AI is used to target aging?
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Rentosertib for IPF (https://www.nature.com/
Rentosertib for IPF, and ER-100 for 2 glaucoma conditions
Rentosertib and ER-100 are two of the most groundbreaking experimental therapies in medicine. Both drugs use cellular rejuvenation and anti-aging science to treat severe diseases that currently have no cure: Idiopathic Pulmonary Fibrosis (IPF) and Glaucoma. [1, 2, 3]
While they target different parts of the body, they both represent a massive shift from just managing symptoms to actually rewinding the biological clock of damaged cells. [1]
Rentosertib for IPF (Idiopathic Pulmonary Fibrosis)Idiopathic Pulmonary Fibrosis (IPF) is a serious lung disease where the lungs become scarred and stiff, making it hard to breathe. Rentosertib (previously called ISM001-055) is an oral pill designed to stop this scarring. [1, 2, 3]
- The AI Connection: Rentosertib is famous for being the world’s first fully AI-designed drug to reach late-stage human trials. Artificial intelligence was used to discover both the biological target and the chemical structure of the drug from scratch. [1, 2, 3, 4]
- How It Works: It blocks a specific protein called TNIK, which is heavily involved in lung tissue scarring, chronic inflammation, and cell aging. [1]
- The "Age Reversal" Discovery: Data published in Nature Biotechnology shows that Rentosertib actually reversed the biological age of patients. When scientists tested patients' blood using "aging clocks" (tools that measure cellular wear and tear), those taking Rentosertib showed a noticeable reduction in biological age markers. [1, 2, 3]
- Current Status: After successful Phase IIa trials where it significantly improved lung function compared to a placebo, Rentosertib has officially entered Phase III clinical trials. [1, 2]
ER-100 for GlaucomaGlaucoma is an eye condition where pressure damages the optic nerve, killing off retinal ganglion cells (the neurons that send pictures from your eye to your brain). Once these cells die, the vision loss has historically been permanent. ER-100 aims to change that. [1]
- The Science of Rejuvenation: Co-developed by famed Harvard molecular biologist David Sinclair, ER-100 is a type of epigenetic reprogramming therapy. It is built on the concept that aging cells haven't lost their original blueprints; they just forgot how to read them due to chemical clutter (methylation) on the DNA. [1, 2]
- How It Works: A modified, harmless virus is injected directly into the eye. This virus delivers three specific genes—known as Yamanaka factors (OSK)—into the damaged eye cells. These factors wipe away the "clutter," essentially resetting the cells to a much younger, healthier state so they can repair themselves. [1, 2, 3]
- The Safety Switch: To keep the cells from rolling back too far (which could cause tumors), the treatment is only active when the patient takes a common antibiotic called doxycycline. Doctors can turn the therapy on and off simply by controlling the antibiotic intake. [1]
- Current Status: ER-100 is the first-ever cellular rejuvenation therapy of its kind cleared by the FDA for human testing. It is currently in a Phase 1 clinical trial with human patients to test its safety and see if it can successfully restore lost vision. [1, 2]
Summary Comparison| Feature | Rentosertib | ER-100 |
|---|---|---|
| Primary Target Disease | Idiopathic Pulmonary Fibrosis (IPF) | Open-Angle Glaucoma & NAION |
| How It is Taken | Oral pill (by mouth) | Intravitreal injection (into the eye) |
| Core Technology | Generative AI & TNIK inhibition | Epigenetic reprogramming (OSK genes) |
| Anti-Aging Effect | Lowers systemic biological age markers | Rewinds optic nerve cells to a youthful state |
| Current Clinical Phase | Phase III (Large-scale efficacy testing) | Phase I (Initial human safety testing) |
| Developer | Insilico Medicine | Life Biosciences |
Please note that both of these treatments are highly experimental and are not yet available to the general public outside of controlled clinical trials. [1, 2]
Are you looking into these therapies for a specific medical condition, or are you researching them for their longevity and anti-aging properties? Let me know so I can give you more targeted information or help you look up active clinical trial registries!
https://scott-macleod.blogspot.com/2026/09/blog-post.html
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Began thread with 'Chase bank branch, Shadyside community in Pgh PA, M 12/11/23' ~ On Wed, Sep 9, 2026 at 12:09 PM Scott MacLeod <sgkmacleod@
Dear JP Morgan Chase bank CEO Jamie Dimon, US Senator and former Harvard Law professor Elizabeth Warren, "faux obituary?" former FBI director Bob Mueller (and please forward), All,Greetings from World Univ & Sch / WUaS, and in continuing to grow a worldwide abolition movement to protect people, and in WUaS seeking to code for all 7.9 billion people on the planet ...
Dear JP Morgan Chase bank CEO Jamie Dimon, US Senator and former Harvard Law professor Elizabeth Warren, "faux obituary?" former FBI director Bob Mueller (and please forward), All,
On Wed, Sep 9, 2026 at 12:09 PM Scott MacLeod <sgkmacleod@
Dear JP Morgan Chase bank CEO Jamie Dimon, US Senator and former Harvard Law professor Elizabeth Warren, "faux obituary?" former FBI director Bob Mueller (and please forward), All,Greetings from World Univ & Sch / WUaS, and in continuing to grow a worldwide abolition movement to protect people, and in WUaS seeking to code for all 7.9 billion people on the planet - https://wiki.worlduniversityandschool.org/ wiki/You_at_World_University - with Pi cryptocurrency - https://minepi.com/sgkmac (and to end poverty worldwide), and after both the murder word spoken to me in Chase bank shadyside pittsburgh, pa, by chase vp shauna mcnally, while I was in asylum (in 2 houses in pittsburgh pa, from about July 2022 - Dec 2024). And my chase credit card is still not reactivated, which I learned from a trader joe's on Penn Avenue in Pittsburgh, on 2/28/24, fairly close to chase bank Wilkinsburg Pittsburgh on Penn Avenue too ... meaning too that I can't seek asylum from international organized crime for example to other countries ... I would say I sought further asylum on the west coast again from the murder word spoken to me in Chase bank shadyside pittsburgh, pa, by chase vp shauna mcnally,, and a murderous run through attempt of me in 2nd asylum house in pgh by craven psychopath?? Swiss French EPFL or Lebanese soldier??? cmu undergraduate at the time frederic khayat in April of 2023 ... With a fairly recent gunshot to my 2025 leased Toyota Sienna vehicle in Oakland, CA, on M May 18, 2026, and 5 tesla-companies' related death threats earlier in 2026 ... WUaS and I are continuing to grow a worldwide abolition movement to abolish the wrongful buying and selling of people in the illegal sex, drugs, violence, car theft, military targeting industries internationally and their latent violence networks ... as I seek to move forward with the WUaS Academic Medical Center into a newly safe vacant with property deed 670 Ridgecrest Rd, Canyon 94516 (which I lived for 13 years until calling the local police in Sep 2020, then moving into a 'safe house' or unsafe house north of Berkeley, in El Cerrito, then fleeing for my life to the eastern seaboard) ... Will I move in there soon with US federal and state of California and Contra Costa county law working effectively together in new ways and with AI and ML and GPS tracking iterating?Recently received a Chase email to check my credit score ... which I just did and it's 713 (which I think is good ... is 800 the highest one can get?) ... and also confirmed my General Delivery Canyon 94516 address regarding the US federal post office there (with Firefox browser, since both Chrome and Edge browsers don't work with https://www.chase.com/ I read).How please to get my Chase credit card with 1% or so cash back, or similar, reactivated ... and so I could for example move to asylum in another country if necessary due to international organized crime criminal activity, until the FBI and CIA are able to knock back international organized crime successfully eg in the SF East Bay, and the SF Bay Area?Abolition, World University and School WUaS is growing, building on MIT OCW in 7 languages, staying alive, Friendly NtF Quaker and Unitarian Universalist church greetings, kindly,ScottScott Gordon K MacLeod
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https://www.cycad.org/publications/illustrated_glossary.htm
https://en.wikipedia.org/wiki/Encephalartos_macrostrobilus
https://species.wikimedia.org/wiki/Encephalartos_macrostrobilus
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