Monday, October 5, 2026

Wuyi Mountains, China: Sunday 10/4/26 open @WorldUnivAndSch #WUaSNewsAndQA @WUaSPress #WUaSWBM #HarvardAARD #VirtualCellInTime

 

Sunday 10/4/26 open @WorldUnivAndSch #WUaSNewsAndQA @WUaSPress #WUaSWBM #HarvardAARD #VirtualCellInTime 

https://youtu.be/lf77X55TTIE 





Recording of (newly) SUNDAY 10/4/26 open @WorldUnivAndSch #WUaSNewsAndQA @WUaSPress #WUaSWBM
-https://youtu.be/lf77X55TTIE
-https://worlduniversityandschool.blogspot.com/2026/09/sacajawea-peak-wallowa-mountains-or-m.html
-https://scott-macleod.blogspot.com/2026/09/sacajawea-peak-wallowa-mountains-or.html
-https://www.youtube.com/@ScottMacLeodWorldUniversity/videos #HarvardAARD #VirtualCellInTime #AvatarAgentEHR #DigitalHealthTwins #MITOCWinRVE ?

https://x.com/WorldUnivAndSch/status/2106902274186621149

https://x.com/WUaSPress/status/2106902555859312964

https://x.com/sgkmacleod/status/2106902497269096568

https://x.com/Q_YogaMacFlower/status/2106902416985833931

https://x.com/HarbinBook/status/2106902641410535788

https://x.com/scottmacleod/status/2106904103871824286 








* * * * 


Dear Universitians, World University and School networks & friends, World Universitians, all,  


Friendly NtF (Nontheist Friends) Quaker & Yoga (as in 8 limbs of Yoga) greetings! How are you? 

Glad to be traveling from the SF Bay Area to the Harvard Aging Research and Drug Development (ARDD) conference in Boston, from Thursday, 10/1-10/3/26 - https://agingpharma.org/program2026 - and staying at the Friends' Meeting House at Cambridge. 

I'm planning to hold the next open World Univ & Sch Weekly Business Meeting WUaS News and Q & A on Sunday afternoon October 4, 2026 at 4pm Eastern Time (1pm Pacific Time) ... and potentially or possibly in conversation with the Harvard Quaker Chaplin John Bach there. 


Here are a possible Sun 10/4/26 WUaS Agenda and News, and the Zoom URL for this -


Topic: Sun 10/04/26 open best STEAM Creative Commons' licensed OpenCourseWare wiki World Univ & Sch WUaS News and Q&A, with Zoom URL
Time: Oct 4, 2026 04:00 PM Eastern Time (US and Canada)

Join Zoom Meeting
https://us04web.zoom.us/j/72834561360?pwd=paJIK8N8TPKSnBFUAAw9SC4hdZMjTn.1

Meeting chat link
https://us04web.zoom.us/launch/jc/72834561360

Meeting ID: 728 3456 1360
Passcode: 722MMJ




AND 

here is the WUaS Agenda for M September 28, 2026 - 


Topic: M 9/28/26 open best STEAM Creative Commons' licensed OpenCourseWare wiki World Univ & Sch WUaS News and Q&A, with Zoom URL
Time: Sep 28, 2026 10:00 AM Pacific Time (US and Canada)

Join Zoom Meeting
https://us04web.zoom.us/j/71228313741?pwd=xUnQd2lQ4K4dvIASJTgZqZUCWTYDmQ.1

Meeting chat link
https://us04web.zoom.us/launch/jc/71228313741

Meeting ID: 712 2831 3741
Passcode: V9GckN



World University & School is growing daily, and Weekly Business Meeting by Weekly Business Meeting - https://worlduniversityandschool.blogspot.com/search/label/Business%20Meeting AND https://scott-macleod.blogspot.com/search/label/Business%20Meeting - (and before these, with WUaS Monthly Business Meeting by Monthly Business Meeting, loosely conducted in the Manner of unprogrammed Friends NtFs Quakers) and blog post by blog post too ... And waiting, I think, for accreditation opportunities to further develop, and in WUaS seeking to Deploy with the Full US Federal Toolkit as well. 



And WUaS is waiting for money ... from Grants.gov initially or https://simpler.grants.gov/? ...  or some other grant somehow ? (MacArthur foundation, Nobel foundation, or?)  And how to grow a flourishing, engaged and engaging research community online? MIT and Harvard's "How to Grow Almost Anything" synthetic biology course online as a model - https://worlduniversityandschool.blogspot.com/search/label/HTGAA and https://scott-macleod.blogspot.com/search/label/HTGAA? 


And how best to grow an engaged and engaging WUaS wiki-teaching and wiki-learning community - with wiki-teachers and wiki-learners teaching and learning in any of these subjects - https://wiki.worlduniversityandschool.org/wiki/Subjects - or beginning new wiki subjects (first in English but then in all 200 countries' main languages, and then for speakers of all 7159 living languages to do this, in all these languages, and again with wiki-subjects one can create ... for example about what one loves to do, teach or learn about) - and both online with a 2D-3D computer screen & in our homes in a developing realistic virtual earth in VR goggles, and digital glasses and similar hardware AND especially in WUaS Multimedia Rooms (in our homes and which we create or eventually are able to purchase), a WUaS Hospital Multimedia Room, & at the WUaS Academic Medical Center, (eg out of 670 Ridgecrest Rd, Canyon 94516 potentially too)?  And see: "Google Earth in an Immersive Meeting Room" 
https://youtu.be/KjUHngd5fDk - 


AND for a #RealisticVirtualHarbin Hot Springs as ethnographic and STEM field sites, and classrooms -  


... enter into this #RealisticVirtualEarth here at the Harbin Hot Springs' gate house - 
{and see Peter Norvig's INCREDIBLE #ToolifyAIWUaS article Revolutionizing Education with Machine Learning and AI - https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306 - which mentions a RVE for the first time other than WUaS that I know of} 

and with a #RealisticVirtualEarth a #RealisticVirtualEarthFor, a #RVEforSTEM, a #RVEforIndustrialProduction, a #RVEforAgenticAI, a #RVEforEverything ... and see 

Experience the real power of Industrial AI with Siemens

https://youtu.be/O3Sj0Ab9q3s



All the best, abolition-ally - and with ~50 million people enslaved or caught in human  trafficking  - https://www.modernslaverycommission.org/ &  https://share.google/aimode/Wi9Zp8zsytD4mU08C (a best STEAM Creative Commons' licensed OpenCourseWare wiki @WorldUnivAndSch #WUaSabolition movement continues to grow to protect people ... https://worlduniversityandschool.blogspot.com/2025/10/eagle-aquila-world-university-and.html 
... and in WUaS seeking to code for all 7.9 billion people on the planet from here -https://wiki.worlduniversityandschool.org/wiki/You_at_World_University - to facilitate wiki free universal education, and potentially to end poverty worldwide), Yogically (8 limbs of Yoga & see tree of 8 limbs of yoga picture - https://x.com/Q_YogaMacFlower/status/2044848212360753480), Friendly NtF NtQ Quaker (& re Quaker SPICES - https://www.friendsjournal.org/s-p-i-c-e-s-quaker-testimonies/) & Unitarian Universalist church (re 7 or 8 UU Principles' https://www.uua.org/beliefs/what-we-believe/principles) greetings, kind regards, 

Scott
Scott GK MacLeod
Founder, President, CEO & Professor, Yoga teacher, Presiding and Recording Clerk (loosely in the manner of unprogrammed NtF Friends / Quakers), 

Recording will be posted here -




TwitterX and LinkedIN - 

Announcement - 

Announcement - 

#HarvardAARD #VirtualCellInTime to #AvatarAgentEHR as #DigitalTwins for 7.9B people in #RealisticVirtualEarthForGenetics ...at #WUaSunivs







* * * * 

World University and School / WUaS 


1st of 2 WUaS wings - 

World Univ & Sch wing - 
a 501 c 3 / similar non-profit - 
building on CC licensed best STEAM OpenCourseWare and which is wiki:  


World University and School 
http://worlduniversityandschool.org/ (and see both exempt legal entities' tax IDs at bottom here)




Agenda item 0 
As video minutes - 


Monday, September 21, 2026
Anamudi mountain, India: M 9/21/26 recording of @WorldUnivAndSch @WUaSPress #WUaSNewsAndQA #WUaSWBM #MITAS #MITAlumniStartups * (was - M 9/21/26 & M 9/28/26 open best STEAM Creative Commons' licensed OpenCourseWare wiki World Univ & Sch WUaS News and Q&A, with Zoom URL)
 


M 9/21/26 recording of @WorldUnivAndSch @WUaSPress #WUaSNewsAndQA #WUaSWBM #MITAS #MITAlumniStartups

https://youtu.be/cJkMi9pPOqk

-https://worlduniversityandschool.blogspot.com/2026/09/anamudi-mountain-india-m-92126-m-92826.html

-https://scott-macleod.blogspot.com/2026/09/anamudi-mountain-india.html

w Tue 9/14 #WUaSAgenda

-https://worlduniversityandschool.blogspot.com/2026/09/tushar-mountains-ut-m-91426-m-92126.html

-https://scott-macleod.blogspot.com/2026/09/tushar-mountains-ut.html

-https://www.youtube.com/@ScottMacLeodWorldUniversity/videos

#MITAS #MITAlumniStartups




*

M 9/21/26 recording of @WorldUnivAndSch @WUaSPress #WUaSNewsAndQA #WUaSWBM
-https://youtu.be/cJkMi9pPOqk
-https://worlduniversityandschool.blogspot.com/2026/09/anamudi-mountain-india-m-92126-m-92826.html
-https://scott-macleod.blogspot.com/2026/09/anamudi-mountain-india.html
w M 9/14 #WUaSAgenda
-https://worlduniversityandschool.blogspot.com/2026/09/tushar-mountains-ut-m-91426-m-92126.html
-https://scott-macleod.blogspot.com/2026/09/tushar-mountains-ut.html
-https://www.youtube.com/@ScottMacLeodWorldUniversity/videos

#MITAS #MITAlumniStartups ~


https://x.com/WorldUnivAndSch/status/2102121398168871236

https://x.com/Q_YogaMacFlower/status/2102122158210371695

https://x.com/WUaSPress/status/2102122759405089155

https://x.com/HarbinBook/status/2102122941832147359

https://x.com/sgkmacleod/status/2102123511775121665

https://x.com/scottmacleod/status/2102123999056785552

https://x.com/TheOpenBand/status/2102124083664363665

https://lnkd.in/p/dpXVsrrk = https://lnkd.in/p/dpXVsrrk

https://www.linkedin.com/posts/world-university-and-school_the-open-band-berkeley-theopenband-on-activity-7507890560322408449-Y_bJ ~


https://scott-macleod.blogspot.com/2026/09/anamudi-mountain-india.html




Agenda item 1 

Harvard ARDD Aging Research and Drug Development conference 10/1/26-10/3/26 in the TreeHouse in Allston, MA




Dear George, All, 

Greetings. Looking forward to meeting you in the Harvard TreeHouse. 

In thinking through some of my and World University and School's goals for the

Harvard ARDD 2026 
Aging Research and Drug Development conference 10/1/26-10/3/26 in Boston 

& re also 



these include 

1
Develop 3 WUaS aging reversal OSK pharmaceutical gene drug therapies initially with research, and then produce and manufacture them & with a realistic virtual earth for OSK, a digital-physical #RVEforGenetics on the digital or in-silico side - and in collaboration with possibly 3 different companies too (initially) ...that would all successfully become FDA approved ...

and then upload them to our body minds via the eRapid Fouling Resistant sensor or similar - 

#eRapidFoulingResistantSensor-https://wyss.harvard.edu/technology/erapid-multiplexed-electrochemical-sensors-for-fast-accurate-portable-diagnostics/ WITH #AgingReversal & #ExtremeLongevity #AvatarAgentElectronicHealthRecords?



(Interoperate with the Flywire Connectome Project re Drosophila fly brain, and newly develop this for aging reversal and longevity and for humans, and with 'citizen science' .... and in a #RVEforFlywireConnectome ?)


AND -

At #HarvardAgingResearch & #HarvardDrugDiscovery conf 10/1-10/3/26
https://agingpharma.org/program2026#virtual-cell-in-time & re  #VirtualAgingCell from #InsilicoMedicine https://youtu.be/vufvnB1R1xM #PetrinaKamya & #FedorGalkin Interoperate e.g. the years 2007, '12 & '24 #GStreetView w #GTimeSlider in https://goo.gl/maps/7gSsSTweRCBo9gf87 @ #GCellViewLevel @ #HarbinGateHouse WITH #AgingReversal & #ExtremeLongevity #AvatarAgentEHR from #GPegman?


AND





1 a
to reverse muscle wasting with an OSK drug - system wide for the whole body 

eg for muscle wasting aging reversal (eg for my 91 year old mother)


1 b
to help people become ~25 years old in a 150 year old (or a 1500 year old) bodymind  ... and with a realistic virtual earth too, so digitally create this pharmaceutical in something like a FORKED Google Street View with time slider AND adding the G cell and G molecule view etc levels and even possibly interoperating with Radical Numerics' General Biological Intelligence AI ... and with Insilico Medicine's 'virtual cell in time' potentially and Pharma AI - https://pharma.ai/ ... 


1 c
to reverse my right ear, what I'm calling "eustachian tube dysfunction" - possibly targeting the cells involved with an OSK gene drug therapy ... including for pressure and nerves in the area ..  and such that I could play the Scottish Highland Bagpipes' again, and put my head underwater etc and wouldn't have to sleep only on my right side (since pain occurs if I sleep on my left side)





2
Create a

realistic virtual earth & Harbin for aging reversal with Harbin gate house's 3 dates, & 3 years too to time slide cells And molecules back & with pegman as a avatar agent ehr by FORKING from Google Street View and adding the G Cell G Molecule, and even the G Qubit levels 


2 a
and even with the Google UCSB Quantum Computer and re - 


Super: #QuantumEchoes including running simulations FWD & in reverse #ReversingTheArrowOfTime

Reversing The Arrow Of Time 



2 b i
Could the ink drop become our "avatar agent electronic health records" as digital twins?

2 b ii 
or a digital cell interoperating with Insilico Medicine's virtual cell in time? 




3
Prove aging reversal - at Harvard ARDD 2026 itself 

per Anthonio Regalado's Tweet (scibrazil@gmail.com.- above) a few weeks ago 


Antonio Regalado
@antonioregalado

Age reversal remains unproven. Yet that is the goal of the healthspan XPRIZE pretty much. The purse is $81 million to the team able "restore" the cognitive & physical function of a person by 20 years, after 1 year of treatment. Finalists to be announced this summer
4:48 AM · Jun 9, 2026

https://x.com/antonioregalado/status/2064313678250332350




4
Create 

Courseware for aging reversal and extreme longevity and related research 

1-3 aging reversal genetics and or research courses for WUaS, with parallels to MIT OCW courses and to add here too -



5

Yoga ...

Develop a realistic virtual earth for Yoga (as in 8 limbs of Yoga) and Yoga asana perhaps interoperating with our avatar agent electronic health records or digital twins and for research too 

since 
Scientists discover why exercise reverses muscle aging | ScienceDaily



Incredible: A response to how #AgingReversal of #MuscleWasting works with movement at molecular level from #DukeUniversityNUS :
Scientists discover #WhyExerciseReversesMuscleAging | #ScienceDaily 

Researchers have uncovered a molecular “switch” that helps explain why exercise keeps aging muscles healthy. By reducing levels of a gene called DEAF1, physical activity allows older muscles to clear out damage, repair themselves, and maintain strength.

How to develop with #YogaAsana for 80 & 90 year olds esp in #RealisticVirtualEarthForMolecules etc and so as to live to 150 years of age and even 1500 years of age and well beyond?


Retweeting - 

#WUaSpharma 1st 2 #OSKGeneDrugTherapies w #EpigeneticReprogramming? 1) #AgingReversal of #MuscleWasting & #BoneDensityLoss before eg 70s, 2) #AgingReversalGenetics of #earENT #EustachianTubeDysfunction / sim w #OSKdrugs in #RealisticVirtualEarthForGenetics w #AvatarAgentEHR How?



Scientists discover why exercise reverses muscle aging | ScienceDaily 


Researchers have uncovered a molecular “switch” that helps explain why exercise keeps aging muscles healthy. By reducing levels of a gene called DEAF1, physical activity allows older muscles to clear out damage, repair themselves, and maintain strength.


5 A


As #aKindOfYoga, how @demishassabis to join or align (#YogaWUaS) #eRapidSensor https://wyss.harvard.edu/technology/erapid-multiplexed-electrochemical-sensors-for-fast-accurate-portable-diagnostics/ w #IF1ProteinControlsAgingRate = gene https://x.com/geochurch/status/1993414908600299747 - to our #AvatarAgentElectronicHealthRecords re Pegman in #GStreetView #GCellView w #GTimeSliders to #ReverseAging?

https://x.com/Q_YogaMacFlower/status/1998169594750754829?s=20

https://x.com/WorldUnivAndSch/status/1998167467076849702

https://x.com/HarbinBook/status/1998169340332671133?s=20

https://x.com/WUaSPress/status/1998169186212962672?s=20

https://x.com/scottmacleod/status/1998168989575635272?s=20

https://x.com/sgkmacleod/status/1998169416492830929?s=20

https://x.com/TheOpenBand/status/1998169517445529801?s=20



Retweeting -

Jay Jin
@JayJin_JJ
·
Dec 6
Replying to @Q_YogaMacFlower and @demishassabis

Oh wow, molecular health visualization in Street View?. ðŸ¤¯ That's absolutely wild - imagine zooming from your neighborhood straight into your DNA. This AI + biotech combo is exactly where breakthroughs happen. #HealthTech

https://x.com/JayJin_JJ/status/1997353871052509632?s=20




Expanded - 
Further as #aKindOfYoga, how @demishassabis to join or align (#YogaWUaS) #eRapidSensor https://wyss.harvard.edu/technology/erapid-multiplexed-electrochemical-sensors-for-fast-accurate-portable-diagnostics/ #IF1ProteinControlsAgingRate = gene https://x.com/geochurch/status/1993414908600299747 - to a #RealisticVirtualEarthForMolecules https://blog.google/technology/ai/google-deepmind-isomorphic-alphafold-3-ai-model/ to our #AvatarAgentElectronicHealthRecords re Pegman @ #GMoleculeLevel in #GStreetView w #GTimeSliders to #ReverseAging for #ExtremeLongevity?




Bring in Friends NtFs Quaker geneticists affiliated with the Friends Meeting at Cambridge, all over the world, and in Great Britain as well.


https://scott-macleod.blogspot.com/2026/09/deinandra-increscens.html





1 A

How best could a MIT Prof like Dr @GeoChurch develop a 1st #MITOCW #AgingReversalGenetics' course IN A #RealisticVirtualEarth ?


https://scott-macleod.blogspot.com/2026/09/sunda-pangolin-manis-javanica.html







Agenda item 2 

Thursday, September 24, 2026
Deinandra increscens: 

[Air-L] Open Position at UCSB Dept. of Communication * Thanks, Amy (Gonzales, Assistant Professor at UCSB), I may add this to the upcoming free-to-students' startup World University and School, building on CC-4 MIT OCW in 7 languages, and wiki, WUaS Weekly Business Meeting Agenda and News (loosely conducted in the manner of unprogrammed NtF Friends / Quakers) ... and as an UCSB alumnus, in Sociocultural Anthropology with a Master's degree focus on the Internet and virtual UNESCO World Heritage Sites, having taken Communication classes too, and worked as a TA in both departments * Working on writing "Society, Information Technology and the Global University" in the new Academic Press at WUaS (planned in all 7159 known living languages with machine and human translation) but am postponing publication of it until at least 2027. Friendly regards, Scott * * *


 

The UCSB Department of Communication is recruiting for a tenure-track/tenured open rank faculty position. We seek a scholar who conducts innovative, theoretically grounded, and empirically rigorous research using quantitative, qualitative, or mixed-method approaches that addresses the social consequences of AI from an organizational communication perspective. All courses are taught in-person on campus. A reasonable estimated full-time rate for this position is $95,000-$435,000 annually. The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

Link to Job Advertisement: https://recruit.ap.ucsb.edu/JPF03137


--
Amy Gonzales, Ph.D. (she/her)
Associate Professor, Department of Communication
Interim Co-Director, Chicano Studies Institute
UC Santa Barbara 

_______________________________________________
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Join the Association of Internet Researchers:
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Thanks, Amy (Gonzales, Assistant Professor at UCSB),
https://www.comm.ucsb.edu/people/amy-gonzales
https://www.linkedin.com/in/amylgonzales

I may add this to the upcoming free-to-students' startup World University and School, building on CC-4 MIT OCW in 7 languages, and wiki, WUaS Weekly Business Meeting Agenda and News (loosely conducted in the manner of unprogrammed NtF Friends / Quakers) ... and as an UCSB alumnus, in Sociocultural Anthropology with a Master's degree focus on the Internet and virtual UNESCO World Heritage Sites, having taken Communication classes too, and worked as a TA in both departments (I think there's a UCSB video of my teaching ... part of an UCSB program for learning to teach). (I was also active in the little Quaker Meeting in Santa Barbara. Do you know UCSB's Stephen Pope for example - also a Cornell alumnI think?) Juan-Vicente Palerm was my main professor at the end of my time at UCSB, before heading to Edinburgh, Scotland potentially to do a PhD ... with my MSc dissertation there about virtual St. Kilda as a nascent place. 

Thanks for this -

Profs at the Pub - Amy Gonzales

https://youtu.be/YNGNRMeytrc

Working on writing "Society, Information Technology and the Global University" in the new Academic Press at WUaS (planned in all 7159 known living languages with machine and human translation) but am postponing publication of it until at least 2027.  

Friendly regards,
Scott

https://scott-macleod.blogspot.com/search/label/society%20and%20information%20technology (in daily blog)


PS
Just TweetedX this, with many implications for reversing the digital divide -

Excited about #CFOs #QuakerCFOs for the #nonprofit #501c3 @WorldUnivAndSch wing - https://app.candid.org/profile/9121509/world-university-and-school-27-3105368 & https://worlduniversityandschool.org/ emerging (as #ForProfitinCA general stock company wing @WUaSPress http://worlduniversityandschool.org/AcademicPress.html waits) re coding for all 7.9B people https://wiki.worlduniversityandschool.org/wiki/You_at_World_University ~

https://x.com/Q_YogaMacFlower/status/2102964248964219382

https://x.com/WorldUnivAndSch/status/2102963894805463498

https://x.com/scottmacleod/status/2102964171700924788

https://x.com/sgkmacleod/status/2102964576723812735

https://x.com/HarbinBook/status/2102964478635876360

https://x.com/WUaSPress/status/2102964347551260731

https://x.com/TheOpenBand/status/1683154436514893825



https://scott-macleod.blogspot.com/2026/09/deinandra-increscens.html






Agenda item 3 

The Moonshot Podcast regarding the Moonshot Factory - Internet access for the remaining 2.6 billion people who don't have it yet! How could @WorldUnivAndSch facilitate #FreeUniversalEducation for all 7.9B in 7K langs & #EndPoverty w #Pi too? * * * 




Zoom conference call time newly ran out after the above - 

....






* 

 























https://en.wikipedia.org/wiki/Wuyi_Mountains

https://commons.wikimedia.org/wiki/Category:Wuyi_Mountains


....


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Sunday, October 4, 2026

Schisandra chinensis: How. best to develop a realistic virtual earth - eg think a forked Google Street View with time slider & with pegman becoming our avatar agent electronic medical records, digital health twins - for scientific hypothesis testing ?

 

How best to develop a #RealisticVirtualEarthFor, a #RVEforHypothesisTesting - eg think a forked #GoogleStreetView with #TimeSlider & with #Gpegman becoming our #AvatarAgentElectronicMedicalRecords or #DigitalHealthTwins ?
https://share.gemini.google/s004HVzzuoZj & see: https://scott-macleod.blogspot.com/2026/09/schisandra-chinensis.html ~


https://x.com/WorldUnivAndSch/status/2106361607706247241

and to publish papers too in a scientific press - 
https://x.com/WUaSPress/status/2106361894110126358


* 

How. best to develop a realistic virtual earth - eg think a forked Google Street View with time slider & with pegman becoming our avatar agent electronic medical records, digital health twins - for scientific hypothesis testing ? 




AND 

How. best to develop a realistic virtual earth - eg think a forked Google Street View with time slider & with pegman becoming our avatar agent electronic medical records, digital health twins - for scientific hypothesis testing, & with other Google AI And ML? How to test the hypothesis that a specific hormone affects the brain to extend life in this #RVEforHypothesisTesting, eg by doing an AI scientific literature review, by adding a picture or molecular model of this hormone to text-in-the-sidebar of G Street View, and regarding the part of the brain it affects, at the molecular and cellular levels etc. designing the experiment, and then doing the experiment virtually first, with implications output for doing the study in vivo?



To build a Realistic Virtual Earth (RVE) for Hypothesis Testing—combining spatial geospatial rendering, time-slider environmental contexts, and personal digital health twins—you can leverage Google Cloud’s geospatial stack, Google DeepMind’s biological AI tools, and medical language models.

Part 1: System Architecture for the RVE Platform

+-----------------------------------------------------------------------------------+
|                                 RVE UI LAYER                                      |
|  CesiumJS / Unreal Engine 5  <--->  Google Photorealistic 3D Tiles API            |
|  Sidebar UI: 3Dmol.js / NGL Viewer (Molecular) + FHIR EMR Dashboard (Avatar Agent)|
+-----------------------------------------------------------------------------------+
                                         |
                                         v
+-----------------------------------------------------------------------------------+
|                               RVE CORE PLATFORM                                   |
|  1. Geospatial Engine: Google Earth Engine (Historical Time-Slider & Climate)    |
|  2. Agent Framework: Avatar Pegman (Digital Twin / OMOP CDM / FHIR EMR)          |
|  3. Orchestration: Google Cloud Vertex AI Pipelines                               |
+-----------------------------------------------------------------------------------+
                                         |
                                         v
+-----------------------------------------------------------------------------------+
|                             GOOGLE AI / ML SUITE                                  |
|  * Gemini 1.5 Pro / MedLM: Literature Synthesis & Experimental Design            |
|  * AlphaFold 3 / AlphaProteo: Molecular Docking & Binding Affinity Predictions   |
|  * Differential Equation / Neural ODE Models: Cellular Pathways & Dynamics        |
+-----------------------------------------------------------------------------------+

1. Spatial Geospatial & Temporal Rendering Engine

  • Base Viewer: Fork an open-source 3D geospatial engine such as CesiumJS or Unreal Engine 5 (via the Cesium plugin) integrated with Google Photorealistic 3D Tiles API.

  • Temporal Layer (Time Slider): Connect the temporal slider to Google Earth Engine API and historical street-level imagery archives. This supplies time-series environmental data (e.g., air quality indices, temperature variations, UV index, urban greenspace density) mapped to specific geographic coordinates.

2. Avatar Pegman as an EMR-Linked Digital Health Twin

  • Data Standard: Map the avatar agent to standard HL7 FHIR resources or an OMOP Common Data Model (CDM) schema.

  • Spatial Agent Logic: Pegman acts as an autonomous agent representing a cohort or individual. As Pegman moves through space and time on the RVE, environmental exposures dynamically update the agent's physiological baseline parameters.

3. Google AI / ML Middleware Integration

  • Vertex AI Pipelines: Orchestrate workflows between spatial queries, biological modeling, and inference tasks.

  • Gemini / MedLM: Drive automated literature retrieval, hypothesis synthesis, and natural-language query interfaces in the sidebar.

  • AlphaFold 3 & AlphaProteo: Simulate 3D protein structures, ligand-receptor binding interactions, and custom biological agent modifications.

Part 2: Testing the Longevity Hormone Hypothesis

Here is a step-by-step workflow using Klotho (a well-established lifespan-extending hormone) targeting FGF21 / FGFR1c-Klotho receptor complexes in the brain’s choroid plexus and hippocampus.

[Phase 1: Lit Review] ---> [Phase 2: UI Context Integration] ---> [Phase 3: Multi-Scale Brain Mapping]
                                                                                  |
[Phase 6: In-Vivo Protocol] <--- [Phase 5: In-Silico Experiment] <----------------+

Step 1: AI Scientific Literature Review (Gemini / MedLM Agent)

The agent executes an automated pipeline querying PubMed, PMC, and bioRxiv to extract molecular pathways, target receptors, and dosage-response metrics.

Key Extracted Synthesis:

  • Hormone Target: Recombinant $\alpha$-Klotho ($\text{sKL}$).

  • Primary Brain Target: Hippocampal dentate gyrus (neural stem cell niche) and choroid plexus.

  • Receptor Mechanism: Forms a binary complex with FGFR1c, triggering the extracellular signal-regulated kinase ($\text{ERK1/2}$) and $\text{Akt}$ phosphorylation cascades, upregulating $\text{NMDAR}$ subunit GluN2B, and decreasing neuroinflammation ($\text{TNF-}\alpha$, $\text{IL-6}$).

Step 2: Sidebar UI Integration (Spatial & Biological Mapping)

When selecting Pegman or clicking a target brain region in the RVE interface:

  1. Left Main Window: RVE environment (e.g., Street View at a specific geographic location with environmental stress sliders like particulate matter $\text{PM}_{2.5}$).

  2. Right Sidebar:

    • Molecular View: Embedded 3Dmol.js or NGL Viewer showing the interactive 3D co-crystal structure of Klotho bound to FGFR1c (PDB ID derived via AlphaFold 3).

    • Spatial Health Panel: Real-time physiological telemetry of the Pegman avatar (e.g., baseline plasma Klotho concentration $c_0 = 500 \text{ pg/mL}$, biological age vs. chronological age).

Step 3: Multi-Scale Brain Mapping (Molecular to Cellular Levels)

ScaleBiological DomainMathematical / Machine Learning Representation
MolecularHormone-Receptor Binding KineticsRate equations: $\frac{d[RL]}{dt} = k_{\text{on}} [R][L] - k_{\text{off}} [RL]$ with $K_d = \frac{k_{\text{off}}}{k_{\text{on}}}$
CellularNeural Stem Cell Proliferation & Microglial ActivationSystems biology differential equations (ODE/SDE) predicting $\text{p16}^{\text{INK4a}}$ senescence reduction
Tissue / OrganHippocampal Long-Term Potentiation (LTP) & Synaptic DensityNeural network surrogate modeling synaptic transmission efficiency ($V_m$)
Organism / PopulationSurvival Function & Cox Proportional HazardSurvival model: $h(t \mid X) = h_0(t) \exp(\beta_1 X_{\text{Klotho}} + \beta_2 X_{\text{environment}})$

Step 4: Designing and Executing the Virtual (In-Silico) Experiment

A. Virtual Cohort & Experimental Groups

Define two avatar agent populations within the RVE across environmental conditions (e.g., low vs. high urban pollution exposure):

  • Control Group ($N=1,000$): Vehicle administration ($c_{\text{Klotho}} = \text{baseline}$).

  • Treatment Group ($N=1,000$): Systemic or central administration of elevated $\alpha$-Klotho ($c_{\text{Klotho}} = 2.5 \times \text{baseline}$).

B. Simulation Execution

  1. Molecular Dynamics (AlphaFold 3 / GROMACS): Calculate binding free energy ($\Delta G_{\text{bind}}$) of Klotho variants to brain FGFR1c receptors.

  2. Cellular Pathway Simulation: Integrate drug delivery kinetics across the Blood-Brain Barrier (BBB) into a differential kinetic solver:

    $$\frac{d[\text{p-ERK}]}{dt} = \frac{V_{\max} \cdot [RL]}{K_m + [RL]} - k_{\text{dephos}} [\text{p-ERK}]$$

  3. Lifespan Acceleration Simulation: Project survival curves using a Monte Carlo Markov Chain (MCMC) engine over a virtual 30-month rodent equivalent timeframe.

       100% |-------------\
            |              \=== Treatment (Klotho Boosted)
  Survival  |               \--- Control
     Rate   |                 \
         0% +---------------------------------->
            0        15        30  Months

Step 5: Translating Virtual Results into an In-Vivo Protocol

Based on the virtual experiment yielding a statistically significant hazard ratio reduction ($\text{HR} = 0.74, p < 0.001$), the RVE exports a laboratory-ready in vivo translation guide:

===================================================================================
                       IN-VIVO TRANSLATIONAL PROTOCOL OUTPUT
===================================================================================

1. ANIMAL MODEL & SAMPLE SIZE
   * Species: C57BL/6J Mice (Aged 18 months, human equivalent ~60 years).
   * Sample Size: N = 40 per arm (20 Male, 20 Female) powered for 80% beta at alpha=0.05.

2. DOSAGE & ADMINISTRATION ROUTE
   * Compound: Recombinant α-Klotho protein.
   * Route: Intranasal administration (to bypass BBB and target olfactory bulb / hippocampus).
   * Dose: 10 µg/kg body weight, administered twice weekly for 4 months.

3. PRIMARY & SECONDARY ENDPOINTS
   * Primary Endpoint: Median lifespan extension and Kaplan-Meier survival curves.
   * Secondary Biological Biomarkers:
     - Western blot / ELISA: Brain p-ERK1/2 to ERK ratio and GluN2B expression in hippocampus.
     - Immunohistochemistry: Ki-67+ and DCX+ neuroblasts in dentate gyrus (neurogenesis).
     - Single-cell RNA-seq: Reduction of senescent cell markers (p16INK4a, p21) in microglia.

4. BEHAVIORAL & COGNITIVE ASSAYS
   * Morris Water Maze & Novel Object Recognition at Months 1, 2, and 4 post-treatment.

5. SAFETY BOUNDS & TOXICOLOGY ALERTS
   * Monitor serum calcium and phosphate levels bi-weekly (to detect potential hyperphosphatemia).
===================================================================================


--

Society, Information Technology, and the Global University, (forthcoming, Academic Press at World University and School, 2026) 

Scottish Small Piping album #2 - Honey Piobaireachd (2022)
- Poetry! Order Book #5 Light, Float, Sit, Watsu ~ Virtually (2021, Academic Press at WUaS)

Scottish Small Piping album #1 Honey in the Bag ~ Out of the Air tune (2020)


Order Book #3 Winding Road Rainbow: Harbin, Wandering & the Poetry of Loving Bliss (2018,  Academic Press at WUaS)

Order Book #2 Haiku-ish and Other Loving Hippie Harbin Poetry (2017,  Academic Press at WUaS) 

Order Actual-Virtual Ethnographic Book #1: Naked Harbin Ethnography (2016, Academic Press at World University and School)



- Scott GK MacLeod  
Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki,
World University & School (WUaS)  
- USPS US Post Office, PO Box 132, General Delivery, Canyon, CA 94516

1) non-profit 501(c)(3) Public Charity
building on CC-4 licensed MIT OCW in 7 languages - 


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- wuas_ceo@worlduniversityandschool.org


https://wiki.worlduniversityandschool.org/wiki/Nation_States (planning ~200 countries' WUaS world class universities in their main languages, per the Olympics, for free-to-students' WUaS degrees from home)

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* * 

And how to do this building on developing a realistic virtual earth for aging reversal and extreme longevity genetic drug therapies beginning with the Harbin Hot Springs' gatehouse and its 3 dates presently - eg with AltosLabs in Palo Alto ? 


See: 



Dear George (Church - gchurch@genetics.med.harvard.edu), Akram (ABaharlouei@altoslabs.com) and Jesse (jpoganik@bwh.harvard.edu), 

Thanks for your great question, Akram, to George after your "Multiplex testing of de-aging polypharmacy & targeted delivery," something to the effect: if you had a magic machine, what would you target? 

George, Akram and Jesse, how best to revisit your reply to Akram, such that we could create this 'magic machine' beginning at the Harbin Hot Springs' gatehouse in Google street view with time slider ~ https://goo.gl/maps/7gSsSTweRCBo9gf87 ~ (https://twitter.com/HarbinBook ~ http://bit.ly/HarbinBook) - and with its 3 dates presently: 2007, 2012, and 2024? And at the #GCellView level and #GmoleculeView level, and with little GPegman becoming our #AvatarAgentElectonicHeatlhRecords as #DigitalHealthTwins? IN these regards, how to #TimeSlideGenes, too, virtually in each of our #AvatarAgentEHR back to 2007, 2012, and 2024, and also when we were 7, and 12, and 24 even, and possibly with Google DeepMind's AlphaFold 3 (which can predict a massive array of molecular compounds) too, focusing on coding first your reply at the close of your talk, George, to Akram's 'magic machine' question - and potentially with you Jesse and Brigham and Women's Hospital and Harvard Medical School in communication with Altos Lab with your machine learning expertise, Akram, and World University and School, building on MIT OCW in 7 languages, CODE little #GPegman as our #AvatarAgentElectonicHeatlhRecords as #DigitalHealthTwins?

How best could AltosLabs in Palo Alto with World University and School, in a #GrowWithGoogleWUaS program, further code this #RealisticVirtualHarbin 'magic machine' first for how George responded to Akram's question ... and in terms of aging reversal genetic, with extreme longevity genetic drugs emerging, FDA approved - by 2026? Brainstorming, could we even time slide our virtual genes out 1500 years, and in also reversing the direction of time (per Google Quantum Echoes' short video) such that we could become like 25 years of age in our avatar agent electronic health records, and then upload this to our bodies via drugs, wyss anti fouling sensor, vaccines, or smartwatches with a skin patch / similar (and even in a bidirectional digital-physical conversation), medicine - and see below. 

Thanks for your question, Akram (Baharlouei @ ABaharlouei@altoslabs.com - https://www.linkedin.com/in/akram-baharlouei-61784421 -& https://www.altoslabs.com/ in Palo Alto colleagues) and looking forward to building this out potentially.  

George, how best to listen to your response  to Akram's magic machine question again? Might a video recording emerge? 

Regards, more later, thanks, best wishes,
Scott



- Scott GK MacLeod  
Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki,
World University & School (WUaS)  
- USPS US Post Office, PO Box 132, General Delivery, Canyon, CA 94516





* 












https://www.harvardmagazine.com/2017/12/rare-plants-in-china



https://en.wikipedia.org/wiki/Schisandra

https://en.wikipedia.org/wiki/Schisandra_chinensis

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