Yoga convo in exploring a #YogaAndLongevityGeneticsConvo conversation Yoga greetings (as in #8LimbsOfYoga) A #RestorativeYogaExplorations' class Sat 10/17 in #YogaAndLongevityGeneticsConvo & #AsWeMayLiveTo150andWellBeyond:)
Yoga greetings (as in #8LimbsOfYoga) A #RestorativeYogaExplorations' class Sat 10/17 in #YogaAndLongevityGeneticsConvo & #AsWeMayLiveTo150andWellBeyond:)
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How best to develop further #AlexZhavoronkov @biogerontology @geochurch a #RealisticVirtualEarthForCells #RVEforCells a #RVEforAgingReversal & to interoperate / #WikiAdd @InSilicoMeds' #VirtualCellInTime w / to a #ForkedGStreetView w #GTimeSlider @ #GCell #GAtom #GQubit levels?
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Alex Zhavoronkov PhD - Harvard ARDD 2026 #ARDD2026
Fascinating to see in the image at the top of Harvard ARDD' Alex Zhavoronkov PhD - TwitterX profile even the Yoga meditation, and the other imagas and pictures eg -
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)
@biogerontology
·
Harvard is where aging biology and drug discovery keep colliding in public. Steven Kozlowski at #ARDD2026. Photos:
https://agingpharma.org/photos2026
Alex Zhavoronkov PhD -
Alex Zhavoronkov PhD - Harvard ARDD 2026 #ARDD2026
Fascinating to see in the image at the top of Harvard ARDD' Alex Zhavoronkov PhD - TwitterX profile even the Yoga meditation, and the other imagas and pictures eg -
Alex Zhavoronkov PhD -
He's a Latvian born scientist having done his PhD in Moscow Russia.
LONGEVITY PLEDGE
My Dear Friends,
About 21 years ago, I decided to leave a successful career in IT to pursue a lifelong dream — to develop a set of technologies that would allow humans to age without losing and continuously improve. In my opinion, there is no cause more urgent, more altruistic, more impactful, more important, and more ambitious than enabling humans to improve continuously. Aging is restricting our freedom in more ways than any regime, religion, or exploitive corporation. Aging is the major barrier to individual freedom, hope, and prosperity. It inhibits economic growth as well as our collective ability to develop sustainably and responsibly.
After 21 years in the longevity field, while there was significant progress made in many areas of science and technology, I realize that the progress is much slower than I originally expected. Although there are many emerging business models and substantial progress in enabling technologies, including those developed by the companies I run or advise, we are still far from curing or preventing Parkinson's or Alzheimer's, not talking about substantially slowing down or reversing aging.
What frustrates me is that most people do not pay enough attention to the inevitable decline, frailty, loss of function, diseases, and death that are associated with aging and choose to be distracted and spend their time on attention-grabbing causes that only provide a temporary reward. And many very talented human beings choose to focus on inventing, making, and selling stuff and content that people can easily live without instead of contributing to fighting the one silent enemy that is certain to kill everyone eventually. This may be because the problem feels so grand and unachievable that it is easier to rely on others to solve it sometime in the future. But the problem is here, right now, and every individual contributor can make a difference. Like climate change or poverty, aging research requires everyone on the planet to become involved. But unlike climate change, aging is causing millions of casualties and suffering worldwide today and right now.
On the positive side, after two decades of hard work, my commercial ventures have started yielding financial returns. It would be logical to donate part of my wealth to charitable foundations focusing on aging research. However, my ventures are already focused on longevity or enabling technologies, and I do have a pretty good view of the recent trends. And I firmly believe that a company like Insilico Medicine will make much more impact in longevity biotechnology than any charity. That is why I continue to invest in the company personally.
Over the past two decades, I supported many projects in longevity, saw many failures, analyzed a massive number of grants, and learned how to evaluate the impact of the various longevity initiatives. In addition to capital, I can now bring years of experience, and multiple partner organizations to the most impactful projects.
Therefore, I would like to pledge everything I have now, and what I will get in the future, to only one cause — extending healthy productive longevity for all human beings. Instead of donating just a portion of my wealth and energy to this cause, I would like to do more.
Recently, I realized that while aging is at the core of most global problems, the generative AI I am working on can be applied to sustainability, environmentally friendly materials, new approaches to CO2 capture and utilization, and other areas related to keeping our planet clean. I will also dedicate a small part of my time and resources to the development of new technologies needed to ensure the long-term survival of humans and other essential species.
I pledge to spend 100% of my time and personal resources to accelerate research and clinical deployment of longevity technologies. At present, I am not married and do not have kids. I calculated that I could probably spend 6-7 hours a week on my personal life, and I didn't want to disappoint anyone by being a bad husband or a bad father. I will not marry until I meet someone as dedicated to the cause as I am. Also, if I ever reproduce, I pledge to train my kids to excel in biology, chemistry, computer science, and medicine and motivate them to prioritize extending healthy human longevity above all other values.
At present, I do not plan to leave an inheritance, and I will invest everything I have into projects and companies that extend healthy, productive life for everyone on the planet.
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With #RealisticVirtualEarthForOSK #RVEforProteins #RVEforAgingReversal #RVEforExtremeLongevity #RVEforClinicalTrials, how best to dev @WorldUnivAndSch @WUaSPress 1st #WUaSpharmaceutical ?
Retweeting -
How best to develop further #AlexZhavoronkov @biogerontology @geochurch a #RealisticVirtualEarthForCells #RVEforCells a #RVEforAgingReversal & to interoperate / #WikiAdd @InSilicoMeds' #VirtualCellInTime w / to a #ForkedGStreetView w #GTimeSlider @ #GCell #GAtom #GQubit levels?
https://x.com/WorldUnivAndSch/status/2111853584229036088
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Eustachian tube dysfunction (ETD) primarily targets the specialized lining, muscular framework, and structural support of the canal that links the middle ear to the back of the throat. [
1,
2]
When ETD occurs, it sets off a cascading cellular and tissue response across several key anatomical layers:
1. Cellular Layers Affected
- Ciliated Epithelial Cells: The lower half of the Eustachian tube is lined with respiratory epithelium featuring tiny, hair-like projections called cilia. In ETD—often triggered by smoking, infections, or toxins—these cilia are damaged or paralyzed. This halts mucociliary transport, preventing the mechanical sweeping of mucus away from the middle ear. [1, 2, 3]
- Goblet Cells and Submucosal Glands: These specialized cells secrete protective mucus. In obstructive ETD, inflammation prompts hypersecretion and hypertrophy (enlargement) of these cells, causing an overproduction of thick mucus that blocks the narrow tubal lumen. [1]
- Immune Cells: Inflammatory triggers recruit mast cells, eosinophils (especially in allergic rhinitis), and neutrophils to the tissue lining. They release histamines and cytokines that drive localized swelling. [1]
2. Tissue Layers Involved
- Mucosa and Submucosa (Lining): The soft tissue lining of the tube contains blood vessels, lymphatics, and fatty tissue. ETD causes profound mucosal edema (swelling) and vascular congestion. The expanded tissue physically closes off the airway, trapping air and building negative pressure in the middle ear. [1, 2, 3, 4]
- Peritubular Musculature: The opening and closing of the tube relies on the coordinates of key muscles, primarily the tensor veli palatini and the levator veli palatini. Functional ETD can involve weakness, inefficiency, or structural alterations (like cleft palate) in these muscle tissues, rendering them unable to dilate the tube properly. [1, 2, 3, 4]
- Cartilaginous and Bony Skeleton: The proximal two-thirds of the tube consists of a fibrocartilaginous skeleton. In young children, this cartilage tissue lacks natural structural stiffness, making the tube prone to functional collapse. In chronic conditions, surrounding fatty tissue deposits (such as from obesity) can also compress this structural framework. [1, 2, 3, 4, 5]
3. Secondary Secondary Damage ("Downstream Effect")
If the dysfunction persists, the vacuum created within the middle ear damages adjacent tissues:
- The Tympanic Membrane (Eardrum): Chronic negative pressure stretches and thins this fibrous tissue, causing retraction or collapse.
- Granulation Tissue: Unresolved fluid buildup triggers the formation of inflammatory granulation tissue and scar tissue, which can eventually stiffen the delicate middle ear bones (ossicles) and erode normal structural tissue. [1, 2, 3, 4]
To help tailor this breakdown, are you looking at this from an academic/biological perspective, or are you trying to understand the root cause of personal ear congestion or pressure symptoms?
--
Society, Information Technology, and the Global University, (forthcoming, Academic Press at World University and School, 2027)
Order Actual-Virtual Ethnographic Book #1:
Naked Harbin Ethnography (2016,
Academic Press at World University and School)
1) non-profit 501(c)(3) Public Charity
building on CC-4 licensed MIT OCW in 7 languages -
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Friendly informed WUaS in all 200 countries and in their main languages & re Friends House Moscow and aging reversal and extreme longevity genetics' drug therapies emerging -
I know a Quaker Russian woman from Pendle Hill Quaker Center for Study and Contemplation, where I lived and studied from about 1988-1991, from before 1996 ... (but when I asked Harvard Medical School's Vadim Gladyshev at Harvard ARDD 2026 about this Friends House Moscow he kind of walked away ...)
looked up Friends House Moscow ... and it seems to have a focus on nonharming (re pacificism, and conscientious objection, and see this blog's label for this)
Friends House Moscow (FHM) is an international Quaker organization established in 1996 to promote peace, support civil society, and assist underprivileged groups in Russia and former Soviet republics. [
1,
2,
3,
4,
5]
Key Activities & Focus Areas
- Pacifism & Conscientious Objection: Supports projects like Alternativshchik (an online platform and publication for conscientious objectors) and "For Our Sons" in Kazan, which provides legal help and guidance regarding alternative military service. [1, 2]
- Peace & Conflict Resolution: Funds and organizes Alternatives to Violence Project (AVP) workshops and community peace initiatives. [1, 2]
- Support for Underprivileged Groups: Assists orphan and disadvantaged child programs (such as Big Change), refugee and homeless aid, and migrant child school integration projects in cities like Kaluga and Novosibirsk. [1, 2]
- Quaker Outreach: Publishes and translates Quaker literature into Russian and supports local seekers, though FHM operates independently from local Russian Quaker worship groups. [1, 2]
- Official Website: Learn more at the Friends House Moscow Website. [1]
- USA Support Association: P.O. Box 60253, Palo Alto, CA 94306 (501(c)(3) tax-exempt). [1]
- UK Registered Charity: Friends House Moscow (Charity No. 1055965). [1, 2]
- Moscow Office Phone: +7 903 664 1075 (call ahead for visitor directions). [1]
If you are looking for specific information—such
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What's the history of #AustralianEucalyptuses being planted in California & creating much shade, but also being an invasive species? What are 2 or 3 books? ... & How to #WikiAdd > #RealisticVirtualEarthForEcology?
How to #WikiAdd > to #VirtualCellInTime in a #RVEforCells?
What's the history of #AustralianEucalyptuses being planted in CA & creating much shade, but also being an invasive species? What are 3 books?
Retweeting -
What's the history of #AustralianEucalyptuses being planted in California & creating much shade, but also being an invasive species? Are there 3 books?
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Yoga questions (as in 8 limbs of Yoga) -
becoming a Harvard Professor and in both the Harvard Divinity School, and in the Harvard Chan School of Public Health (or Harvard School of Anthropology) ... and live in Canyon 94516 too, and in developing free World University and School with its 250+ planned online WUaS Medical Schools & Law Schools, and the WUaS Yoga wiki schools in all 7159 known living languages?
And might I even become a Harvard Professor and in both the Harvard Divinity School, and in the Harvard Chan School of Public Health (or Harvard School of Anthropology) ... and live in Canyon 94516 too, and in developing free World University and School with its 250+ planned online WUaS Medical Schools & Law Schools ... and in WUaS seeking to code for all 7.9 billion people on the planet, and for avatar agent electronic medical records, and with aging reversal and extreme longevity genetics' drugs emerging, potentially FDA approved?
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https://thumb.wikimedia.org/wikipedia/commons/thumb/3/3f/Calidris_canutus_%28summer%29.jpg/1920px-Calidris_canutus_%28summer%29.jpg?utm_source=en.wikipedia.org&utm_campaign=index&utm_content=thumbnail
https://upload.wikimedia.org/wikipedia/commons/8/86/Red_knot_%28Calidris_canutus%29_juveniles_in_flight.jpg?utm_source=commons.wikimedia.org&utm_campaign=index&utm_content=original
https://en.wikipedia.org/wiki/Red_knot
https://commons.wikimedia.org/wiki/Category:Calidris_canutus
https://species.wikimedia.org/wiki/Calidris_canutus
....