Saturday, August 8, 2026

Pine Hill Flannelbush: Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:)?

 


Dear Yoga friends, family in their 80s and 90s' ~ Ma/Janie, and Alden (Briscoe - who went to Quaker George School in Philadelphia before Harvard college), & Quakertarian & Veterinarian & cousin Annie (Brown in NE Oregon) in her 60s, Dick (Robb MD, possibly posthumously, also an ophthalmology professor in Harvard Medical School - and might you Dick have helped develop the ongoing clinical trials for ER-100, epigenetic reprogramming for open-angle Glaucoma, and one other Glaucoma condition?, and see - https://share.google/aimode/uWGl5Ms0ZBrwk3sx6), and George (Church) and Maitreyi (Mazumdar MD - both professors in Harvard Medical School too), Peter (Norvig, Stanford AI), Doortje (Van Kooten, and Angela and your father Victor, and please forward), Valerie & Ed Smyth MDs, & Marlynn Wei MD JD (co-author of "The Harvard Medical School Guide to Yoga: 8 Weeks to Strength, Awareness, and Flexibility," 2017, Harvard Press), Pin/Sid Mazumdar HHS, David Chalmers, Philosopher of Consciousness at NYU (professor of philosophy and neural science at New York University (NYU), as well as co-director of NYU's Center for Mind, Brain and Consciousness), all, 


Yoga greetings for the Restorative Yoga explorations on Saturday August 8, 2026  (and as we may live to 150 and well beyond:)  ... around 8 am your time (until again I can start streaming some Yoga explorations from the shop, and in an iterating realistic virtual earth for Yoga, at 670 Ridgecrest Rd Canyon 94516) & Happy restorative Yoga explorations ... & potentially re independence or liberation or freedom due to extreme longevity and aging reversal genetic drug therapies emerging, FDA approved - and the divine?? willing too??? - and with a physical-digital #RealisticVirtualEarth a #RealisticVirtualEarthForYogaAsana, a #RealisticVirtualEarthForGenetics, a #RealisticVirtualEarthForQuantum, and a #RealisticVirtualEarthForAgingReversal (accessible in the US and around the world too, potentially from home too) ... and interoperating with our #AvataraAgentElectronicHealthRecords  (emerging from #GPegman in #GStreetView) in one physical~digital #RealisticVirtualEarth and (and think Google Street View with time slider) at the #GCell, #GMolecule, #GAtom, AND #GQubit - #Hashtags on #TwitterX and some on #Linkedin (and with the Google Quantum Computer at UCSB) view levels ...

Restorative Chair Yoga explorations to begin ... 


A
Urdhva Hastasana (Upward Raised Hands) in a Chair ... 



B
and then Urdhva Hastasana in Tadasana (Mountain pose) standing pose  ...


Can you ease your inner arms up into the sky above you, as they stream up out of your outer arms, palms facing each other ... Find the spaces in your shoulders, in your elbow joints, in your wrists, hands and fingers ... and as you also root down through your feet and legs ... Upper inner body and arms stream up from the roots of your legs ...


C
and then lying on one's back, height under head (like a folded blanket) ... so prone on the floor, as if in savasana, but big toes touching slightly pigeon toes - or knees bent (per image below) - extend your arms straight up toward the sky, and then extend them, describing an arc with your fingertips, over your head toward the floor .. 




D
My mother Janie, at 91, above, seeks to walk 2 miles per day, and with walking sticks, thinking these help her stand upright and less hunched over, and for the walking exercises benefits ... (I wonder if this actually contracts the muscles of the shoulder girdle and thus might make her more hunched upper body muscular-wise ... but also think the walking sticks are good for adding more movement while walking 2 miles ... ) ... And I also explore the 8 limbs of Yoga while walking with poles ... eg pratyahara (withdrawal of the senses, e.g. dharana - concentration, dhyana - meditation, as I find a rhythm walking with poles almost like tele-marking in skiing ... and release inwardly re both dharana and dhyana ...)


D 1

I wrote her this email this morning ... 

"Upward 

Hi Ma, 

To keep from hunching over, explore doing

Upward Raised Hands Yoga pose restoratively and even meditatively, & daily ... 



More later about this in today's 8/8/26 (for Saturday too) restorative Yoga explorations' email. 

Love, Scott



D 2
Also asked Google AI Mode - 

What are 10 benefits of walking 3 miles a day in terms of eg calorie burning etc? "Walking 3 miles a day burns roughly 300 calories, strengthens your heart, and builds muscle" - https://share.google/aimode/ioAnJpq5Clnk7naHl ... Also asked - "what are 10 benefits of doing 10 Yoga Sun salutations per day in terms of eg calorie burning etc?" ... so taking possibly 5 or so minutes rather than 40 minutes for walking 2 miles - "Doing 10 Sun Salutations (Surya Namaskar) every day burns roughly 70 to 140 calories, strengthens muscles, boosts flexibility, and improves heart health." ... https://share.google/aimode/Mgv1oRn8kZfQ7UaKJ ... Thoughts?



E
General Biological Intelligence AI - #GeneralBiologicalIntelligence 

Further re last week re Yoga Sat 8/1/26 - and regarding Stanford PhD in machine learning Eric Nguyen -


This amazing interview of Eric Nguyen - https://x.com/mariogabriele/status/2084610303673934104 -  combines both potentially the language of DNA and re #TextInTheSideBar (think GStreetView with Time Slider) ... with images for an emerging General Biological Intelligence AI, so both modalities, and so much more ... re World University and Schools' seeking to develop further a #RealisticVirtualEarthForAgingReversal,a #RealisticVirtualEarthForExtremeLongevity, a #RealisticVirtualEarthForDNA #RealisticVirtualEarthForYogaAsana  ... but it doesn't mention either Aging Reversal or consciousness emerging from biology (and see PS)

Eric Nguyen @exnx · I sat down with @mariogabriele  on the Generalist podcast to talk about why DNA is the most complicated and important language ever - https://x.com/mariogabriele/status/2084610303673934104 ...


So I asked ... 



https://x.com/TheOpenBand/status/2084705096332718096 



Retweeting -

Mario Gabriele
@mariogabriele
What happens when AI can write the genetic code for life itself?

Eric Nguyen (@exnx) is the co-founder of
@RadicalNumerics, the lab behind the models that generated the first genome ever created entirely by AI, a bacteriophage that had never existed in nature until it wrote one. He believes DNA should be treated the way language is treated: something a model can read, then write.

With more DNA sitting in public databases than there is text on the entire internet, he sees an almost unmined field, one where the models built to make sense of it remain, by his own admission, no more sophisticated than linear regression.

Thank you to the partners who make this possible
@ahrefs
 Brand Radar: Find your brand in AI results: https://ahrefs.com/generalist
@brexHQ
: The intelligent finance platform: https://brex.com/mario
@Guru_HQ
: The AI source of truth for work:

(3:35) An overview of Radical Numerics
(11:08) Why they started with DNA
(26:24) The limits of language models in biology
(31:15) Eric’s free-range upbringing and path to his PhD program
(41:20) Applying long-context models to DNA and meeting his co-founders
(55:30) How better general LLMs benefit Radical Numerics
(1:02:05) Making biology more concrete
(1:18:09) Final meditations

https://x.com/mariogabriele/status/2084610303673934104



F
Also, asked today re Yoga asana too, and potentially for aging reversal in the future and in a realistic virtual earth for genetics as well - 

What genes or complex of genes control movement in human & mammal bodies & particularly that might inform or control #YogaAsana movements, for ex & re #AgingReversal? 


Regarding genes, gene expression & genomics, what genes or complex of genes control movement in human & mammal bodies & particularly that might inform or control #YogaAsana movements, for ex & re #AgingReversal?



Have any questions, thoughts, or similar you'd like to share? Please email yogamacflower@gmail.com ... and 

in exploring a #YogaAndLongevityGeneticsConvo


exploring an 8/1/26 #YogaAndLongevityGeneticsConvo -https://scott-macleod.blogspot.com/2026/07/twin-flower-linnaea-borealis.html?
How with #GeneralBiologicalIntelligenceAI to #GTimeSlide to years 2007, 2012 & 2024 AND when we were 7, 12 & 24 in #GStreetView w #GTimeSlider @  https://goo.gl/maps/7gSsSTweRCBo9gf87 ~ #AgingReversal #AvatarAgentEHR?



Yogically (as in 8 limbs of Yoga) re uniting seeing with seer envisioning - wise, Desiderata prose poem greetings (https://www.desiderata.com/desiderata.html), Namaste (the light within salutes the light within you), warm regards, 
Scott



PS
A related Yoga consciousness question ... Philosopher of Consciousness David Chalmers (above)? 




PPS









* * 

AI Mode - 


How best could we engage these gene complexes with Yoga asana to reverse aging NOW in these genes & their networks eg in the way exercise builds muscle in aging people this reversing muscle wasting due to aging - and with calorie restriction as well as eventual aging reversal vaccines FDA approved ?



Engaging these target gene complexes to slow or partially reverse age-related muscle wasting (sarcopenia) and tissue degradation relies on epigenetic remodeling—changing how accessible and active these genes are without altering the underlying DNA sequence. Combining dynamic physical loading (yoga asana) with biochemical stressors (nutrient sensing) creates a synergistic effect across these networks.

Strategy 1: Targeted Yoga Asana Loading (Mechanotransduction)

Physical movement forces cells to deform, triggering mechanotransduction—a process where mechanical stress on cell membranes gets converted into biochemical signals that remodel chromatin and alter nuclear architecture.

  • Sustained Isometric Holds (e.g., Utkatasana / Chair Pose, Virabhadrasana / Warrior Holds):
    • Gene Targets: ACTN3, MSTN, mTORC1 signaling.
    • Mechanism: Isometric tension under load downregulates Myostatin (MSTN—the muscle-suppressing gene), while activating mTOR pathways. This mimics traditional resistance exercise to stimulate protein synthesis and halt sarcopenic atrophy.
  • Active End-Range Stretching (e.g., Paschimottanasana / Forward Bends, Hanumanasana):
    • Gene Targets: COL1A1, COL5A1, PIEZO2.
    • Mechanism: Tensile strain on muscle fascia triggers PIEZO2 ion channels, signaling structural remodeling in tendon and extracellular matrix (ECM) genes. Over time, this decreases pathological cross-linking of collagen, restoring tissue compliance without damaging matrix integrity.
  • Vinyasa & Dynamic Transitions:
    • Gene Targets: PGC-1α, SIRT1.
    • Mechanism: Rhythmic, flow-based movement drives calcium influx in skeletal muscle, activating the CAMK/PGC-1α axis. This stimulates mitochondrial biogenesis, clearing damaged mitochondria (mitophagy) and boosting cellular energy production.

Strategy 2: Integration with Calorie Restriction (CR)

Calorie restriction (or intermittent fasting windowing) creates a nutrient-scarce state that alters histone modifications and DNA methylation profiles.

Pathway / ComplexAction under Calorie RestrictionInteracting Yoga Synergy
Sirtuins (SIRT1, SIRT3, SIRT6)Upregulated due to elevated NAD^+ levels; deacetylates histones to protect genomic stability.Practice during fasted states to amplify SIRT-driven mitochondrial repair and lipid oxidation.
Autophagy / mTOR SuppressionLow amino acid availability turns off mTORC1, initiating cellular self-cleaning.Post-practice refeeding resets mTOR sharply, maximizing muscle protein recovery while minimizing chronic inflammation.
DNA Methylation Drift BufferAttenuates age-associated epigenetic drift across tissue types.Combined long-term CR and structured exercise yield compound reductions in biological age metrics.

Strategy 3: The Role of Novel Age-Reversal Vaccines

While traditional vaccines train the immune system against external pathogens, emerging biogerontology therapies focus on therapeutic senolytic vaccines and epigenetic reprogramming.

  • Senolytic Vaccines (Targeting Senescent Cells):
    • Current Reality: As of mid-2026, no senolytic "aging reversal vaccine" has received full FDA approval for general anti-aging or sarcopenia.
    • Mechanism in Trials: Experimental senolytic vaccines target surface antigens on Senescence-Associated Secretory Phenotype (SASP) cells—such as glycoprotein nonmetastatic melanoma protein B (GPNMB). By training the immune system's T-cells to remove these "zombie cells," tissue inflammation drops, allowing healthy muscle stem cells (satellite cells) to repair damaged muscle fibers.
  • Partial Epigenetic Reprogramming (Yamanaka Factors):
    • Vector-delivered transient expression of OCT4, SOX2, and KLF4 (OSK) can reset the epigenetic age clock of damaged tissues without causing dedifferentiation (tumorigenesis). These therapies remain in human clinical trials for localized conditions (such as optic neuropathies and muscle regeneration) and are not yet FDA-approved for systemic age reversal.

The Integrated "NOW" Protocol

Combining these modalities yields a non-pharmacological framework to optimize neuromuscular epigenetics:

  1. Fasted Movement Windows: Perform active, posture-focused yoga asana during an intermittent fasting window to maximize SIRT1 and PGC-1α expression.
  2. Targeted Resistance: Incorporate isometric holds at challenging joints/angles to suppress MSTN and stimulate local growth signaling.
  3. Nutrient Timing: Break calorie-restricted windows with essential amino acids to stimulate precise, episodic mTOR activity, preserving lean muscle mass while gaining the epigenetic maintenance benefits of restriction.




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https://calscape.org/plant/1690/Fremontodendron-decumbens-(Pine-Hill-Flannelbush)







https://www.ccgproject.org/species/fremontodendron-decumbens-pine-hill-flannelbush


https://saveplants.org/plant-profile/?CPCNum=1952



https://en.wikipedia.org/wiki/Fremontodendron_californicum

https://en.wikipedia.org/wiki/Fremontodendron


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Friday, August 7, 2026

Boundary Waters Canoe Area Wilderness, Minnesota: take still a while longer to build out the 501 c 3 @WorldUnivAndSch legal entity https://app.candid.org/profile/9121509/world-university-and-school-27-3105368 for #FreeToStudents #freeWUaSdegrees building on https://ocw.mit.edu/ in 7 languages WITH the for profit general stock company in CA the #WUaScorp @WUaSPress ~ * * * #ContinualAILearning: Right now, there are greater than 5 prominent AI minds, & they are all quite similar to each other on account of being trained on roughly.same data - Dwarkesh Patel - How might developing multiple AIs in all 7159 #WUaSlanguages https://wiki.worlduniversityandschool.org/wiki/Languages affect AIs? * * * What is ?#GenZsocialism per 6/6/26 #EconomistMagazine article? "described as a novel, "#MeFirst" #LeftistIdeology focused on ... personal financial relief & #TargetedWealthRedistribution, driven by affordability crisis, high rent, & #FreeMarketSystemsSkepticism ...

 

It will take still a while longer to build out the 501 c 3  @WorldUnivAndSch legal entity  https://app.candid.org/profile/9121509/world-university-and-school-27-3105368 for #FreeToStudents #freeWUaSdegrees building on https://ocw.mit.edu/ in 7 languages  WITH the for profit general stock company in CA the #WUaScorp @WUaSPress ~






* 

1
World University and School, a 501 c 3 tax exempt legal entity 


2
Academic Press at WUaS and WUaS Educational Services' Stores, a for profit general stock company in the state of California legal entity 







Society, Information Technology, and the Global University, (forthcoming, Academic Press at World University and School, 2026) 

Scottish Small Piping album #2 - Honey Piobaireachd (2022)
- Poetry! Order Book #5 Light, Float, Sit, Watsu ~ Virtually (2021, Academic Press at WUaS)

Scottish Small Piping album #1 Honey in the Bag ~ Out of the Air tune (2020)


Order Book #3 Winding Road Rainbow: Harbin, Wandering & the Poetry of Loving Bliss (2018,  Academic Press at WUaS)

Order Book #2 Haiku-ish and Other Loving Hippie Harbin Poetry (2017,  Academic Press at WUaS) 

Order Actual-Virtual Ethnographic Book #1: Naked Harbin Ethnography (2016, Academic Press at World University and School)


https://wiki.worlduniversityandschool.org/wiki/Nation_States (planning ~200 countries' WUaS world class universities in their main languages, per the Olympics, for free-to-students' WUaS degrees from home)

https://wiki.worlduniversityandschool.org/wiki/Languages (planning to be in all 7159 living languages, each as or with wiki schools for open people-to-people wiki-teaching and wiki-learning, e.g. from here - https://wiki.worlduniversityandschool.org/wiki/Subjects)

- Scott GK MacLeod  
Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki,
World University & School (WUaS)  
- USPS US Post Office, PO Box 132, General Delivery, Canyon, CA 94516

1) non-profit 501(c)(3) Public Charity
building on CC-4 licensed MIT OCW in 7 languages - 


2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html
- wuas_ceo@worlduniversityandschool.org





* * * 


#ContinualAILearning:
Right now, there are greater than 5 prominent AI minds, & they are all quite similar to each other on account of being trained on roughly.same data - Dwarkesh Patel - How might developing multiple AIs in all 7159 #WUaSlanguages https://wiki.worlduniversityandschool.org/wiki/Languages affect AIs?


#ContinualAILearning:
Right now, there are <5 prominent AI minds, & they are all quite similar to each other on account of being trained on roughly.same data. 
How might developing multiple AIs in all 7159 #WUaSlanguages https://wiki.worlduniversityandschool.org/wiki/Languages affect AIs?






Society, Information Technology, and the Global University, (forthcoming, Academic Press at World University and School, 2026) 

Scottish Small Piping album #2 - Honey Piobaireachd (2022)
- Poetry! Order Book #5 Light, Float, Sit, Watsu ~ Virtually (2021, Academic Press at WUaS)

Scottish Small Piping album #1 Honey in the Bag ~ Out of the Air tune (2020)


Order Book #3 Winding Road Rainbow: Harbin, Wandering & the Poetry of Loving Bliss (2018,  Academic Press at WUaS)

Order Book #2 Haiku-ish and Other Loving Hippie Harbin Poetry (2017,  Academic Press at WUaS) 

Order Actual-Virtual Ethnographic Book #1: Naked Harbin Ethnography (2016, Academic Press at World University and School)


https://wiki.worlduniversityandschool.org/wiki/Nation_States (planning ~200 countries' WUaS world class universities in their main languages, per the Olympics, for free-to-students' WUaS degrees from home)

https://wiki.worlduniversityandschool.org/wiki/Languages (planning to be in all 7159 living languages, each as or with wiki schools for open people-to-people wiki-teaching and wiki-learning, e.g. from here - https://wiki.worlduniversityandschool.org/wiki/Subjects)

- Scott GK MacLeod  
Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki,
World University & School (WUaS)  
- USPS US Post Office, PO Box 132, General Delivery, Canyon, CA 94516

1) non-profit 501(c)(3) Public Charity
building on CC-4 licensed MIT OCW in 7 languages - 


2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html
- wuas_ceo@worlduniversityandschool.org







* * * 


What is ?#GenZsocialism per 6/6/26 #EconomistMagazine article? "described as a novel, "#MeFirst" #LeftistIdeology focused on ... personal financial relief & #TargetedWealthRedistribution, driven by affordability crisis, high rent, & #FreeMarketSystemsSkepticism ... 


?#GenZsocialism per 6/6/26 #EconomistMagazine article? "described as a novel, "#MeFirst" #LeftistIdeology focused on...personal financial relief & #TargetedWealthRedistribution, driven by affordability crisis, high rent, & #FreeMarketSystemsSkepticism .. https://share.google/aimode/22QiXNOZEEtKa4N1m ~

https://x.com/WorldUnivAndSch/status/2085859034129977394

https://x.com/HarbinBook/status/2085857712819384631

https://x.com/Q_YogaMacFlower/status/2085857958018388339

https://x.com/WUaSPress/status/2085858683846803771

https://x.com/sgkmacleod/status/2085858938973831430





The rise of Gen-Z socialism | June 6th 2026 | The Economist

The Economist
https://www.economist.com

economist.com/weeklyedition/2026-06-06



According to The Economist, "Gen-Z socialism" is described as a novel, "me-first" leftist ideology focused on immediate personal financial relief and targeted wealth redistribution, driven by an affordability crisis, high rent, and skepticism of free-market systems. This movement prioritizes policies such as strict price controls, rent freezes, and high taxes on the wealthy to address economic inequality. Read the full story at The Economist. [1, 2, 3, 4]



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https://www.savetheboundarywaters.org/updates/boundary-waters-day-history-protecting-wilderness





https://en.wikipedia.org/wiki/Boundary_Waters_Canoe_Area_Wilderness

https://commons.wikimedia.org/wiki/Category:Boundary_Waters_Canoe_Area_Wilderness

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