To a global, virtual, free, open, {future degree- & credit-granting}, multilingual University & School for the developing world and everyone, as well as loving bliss ~ scottmacleod.com
We are so excited for you to join us for class #1 of HTGAA 2026, to be held Tuesday Feb 3 from 2-5p ET!
(1) For registered MIT, Harvard, and Wellesley students: please come in person to E15-359 at the MIT Media Lab! We will begin class promptly at 2:05p ET.
(2) For all global listeners, including prospective Committed Listeners (who plan to do the homework and final projects alongside MIT/Harvard/Wellesley students), please join via zoom:
>>> <<<
Please do not share the zoom link!
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For global listeners you can also join HTGAA as a Committed Listener, where you will do the homework alongside our registered MIT, Harvard, and Wellesley students, complete a final project, and join a learning cohort as a part of one of our fifteen global nodes.
All prospective Committed Listeners must complete Homework #1, which will be assigned in class tomorrow, and will be due on Feb 10 at 2p ET prior to the start of class. You will submit your homework via a google form we will provide, where you can also rank your preferences for which node you would like to join.
After evaluating the Week #1 Homework, we will reach out to you and let you know about your node placement. Please note that there may be capacity challenges, and while we hope to accept every Committed Listener, we may have restrictions.
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Bio Bootcamp
Thank you all again for being part of the HTGAA 2026 Bio-Bootcamp! We loved having you with us and were excited to see so much engagement throughout the week.
As many of you requested, we’ve now collected all of the presentation slides for you to revisit at your own pace. You can find the Bio-Bootcamp slides here. Feel free to treat these as a learning resource you can return to anytime during the HTGAA course.
As we continue improving the Bio-Bootcamp experience, we’d really appreciate your feedback. If you have a few minutes, please consider filling out the Bio-Bootcamp 2026 survey.
The survey is 100% anonymous and voluntary, so we encourage you to be honest! Let us know what you enjoyed, what could be improved, and what you’d love to see more of in the future.
Good luck on your further HTGAA journey!
////
See you all for class #1 tomorrow!!!!
Best,
David
-------------- David Sun Kong, Ph.D. Director Community Biotechnology Initiative MIT Media Lab
Thanks so much for sending me the email with the HTGAA Zoom link in the PS last night below.
I just tried to join the class ... but got a Zoom message saying "The host has removed me from the meeting" ... when I tried to join again a second time, Zoom said "Unable to join the meeting".
subject:Re: HTGAA Class #1 ||| Tues Feb 3, 2-5p ET ||
mailed-by:worlduniversityandschool.org
Dear Professors David (Sun Kong), George (Church), Chris (Mason) of HTGAA 2026, Peter (Norvig), and All,
I'm continuing to try to gain access to today's HTGAA 2026 presentations and talks from the Berkeley Claremont public library, but not yet successfully.
In reading through the Bio-bootcamp slides, I am inquiring how best to add these biological processes to a Realistic Virtual Earth, and please see the PS.
Seeking to develop a realistic virtual earth for aging reversal genetics, as well as a related course for this - https://wiki.worlduniversityandschool.org/wiki/Aging_Reversal_Genetics - and potentially out of a newly safe, vacant, with deed 670 Ridgecrest, Canyon, CA 94516, and its shop, and in a #WUaSHospitalMultimediaRoom a #WUaSSTEMLaboratoryMultimediaRoom.
Looking forward to joining today's class as the way opens.
here is the World University and School (Building on MIT OCW IN 7 LANGUAGES) WUaS Agenda for M 2/9/26, to season for a week and to invite your thinking and feedback too -
How best to add the processes depicted in these MIT Harvard Wellesley How to grow (almost) Anything synthetic biology course slides - https://drive.google.com/drive/folders/1utVFn2i0tBfRth_B5U9shNvpYvNf1FZh - to an iterating #RealisticVirtualEarth & with a #Realistic Virtual Earth For Synthetic Biology ... and in Google Street View with Times Slider GCell View GMolecule View with TensorFlow AI and animate them interactively to allow for subsequent scientific experiments and research?
ⓘ Informational: External Sender This sender is external to Weill Cornell Medicine. Be careful when clicking links or opening attachments.
*
Dear Drs David (Sun Kong), George (Church), Chris (Mason) of HTGAA 2026, Peter (Norvig), and All,
Thanks so much, Chris, for your email to all of us ! At noon PT? now? I still can't get in ...
>>> <<<
Will keep trying ... and wait for the way to open.
Further Gemini AI responses regarding building a realistic virtual earth for synthetic biology and genetics and in 1 iterating realistic virtual earth below.
- USPS US Post Office, PO Box 132, General Delivery, Canyon, CA 94516
PS
In Google Street View with time slider right now, and here at the Harbin Hot Springs' gate house - ~ https://goo.gl/maps/7gSsSTweRCBo9gf87 ~ for example, or in Pegman becoming our avatar agent electronic health records at the bottom left, how best to add the processes depicted in these MIT Harvard Wellesley How to grow (almost) Anything synthetic biology course slides -https://drive.google.com/drive/folders/1utVFn2i0tBfRth_B5U9shNvpYvNf1FZh- to an iterating #RealisticVirtualEarth & with a #Realistic Virtual Earth For Synthetic Biology ... and in Google Street View with Times Slider GCell View GMolecule View with TensorFlow AI and animate them interactively to allow for subsequent scientific experiments and research?
To develop an iterating#RealisticVirtualEarththat integrates synthetic biology processes—specifically those from the MIT/Harvard/Wellesley "How to Grow (Almost) Anything" course—into an interactive, scientific environment like Google Street View, you can leverage several advanced computational and biological modeling strategies:
1. Integration of Molecular and Cellular Modeling
To move from a macro view (Street View) to the microscopic (GCellandGMoleculeviews), you can integrate high-fidelity biological models into the virtual environment:
Input-Output Functions (IOFs):Utilize IOFs to characterize all causal interactions between neurons or biological components, which is essential for predicting physiology from molecularly annotated connectomes.
Animate Interactively:Use TensorFlow AI to model population dynamics and the interactions of countless molecules that shape these functions.This allows for the integration of sensors to effectors, effectively describing behavior within the simulation.
Multi-layer Neural Networks:Fit IOFs using multi-layer artificial neural networks constrained by physiological knowledge, which can make the simulations more meaningful for scientific research.
2. Utilizing Virtual World Platforms for Research
The conceptual framework of "Real Virtuality" allows for the combining of artistic forms and technology into hybrid expressions.
Avatar-Agent Integration:Pegman can evolve into an avatar agent that integrates electronic health records using theblockchain ledgerfor health data, facilitating an "Anonymized Health Token" system.
Platform Synergy:Use platforms like Second Life or OpenSimulator, which are designed for integrating new media elements.For example, scripts can be written to bring together theScratchprogramming language (from MIT Media Lab) with virtual world environments to create interactive scientific field sites and classrooms.
3. Application of Synthetic Biology Processes
Specific processes from the "How to Grow (Almost) Anything" course, such as CRISPR gene editing, can be modeled for experimental purposes:
CRISPR Modeling:Simulate the use of CRISPR to edit specific loci on genes, such as creating high-yield algae for biofuels.
Robotic and Automation Simulation:Incorporate "robots hiding in plain sight" by using avatar bots to inhabit and control virtual environments, which could redefine virtual structures as active "computers".
4. Supporting Subsequent Scientific Experiments
To ensure the #RealisticVirtualEarth serves as a robust research tool:
Open Science Commitment:Ensure all data and code are shared openly to encourage community collaboration in experimental design and theoretical analysis.
High-Throughput Handling:Use simulated microfluidics and modern microscopy hardware to allow for high-throughput handling and imaging of biological models (likeC. elegans) within the virtual earth.
Educational Foundation:Leverage resources from theWorld University and School (WUaS), which plans for subjects like Genetics, Bioengineering, and Artificial Intelligence, to provide a structured academic context for these simulations
Integrating the biological processes from the "How to grow (almost) Anything" course into a realistic, interactive virtual environment involves a multi-layered approach that bridges molecular biology with spatial intelligence and AI.
Based on the course materials, you can structure your #RealisticVirtualEarthfor Synthetic Biology by following these steps:
1. Model the Biological "Ground Truth"
The core of your virtual earth must be built on the fundamental processes identified in the course:
The Central Dogma: Animate the flow of information from DNA to mRNA to protein. Use the course's detail on transcription (DNA to mRNA) and translation (mRNA to protein) as the logic for your "GMolecule View".
Genetic Circuits: Implement functional components like Input Modules (sensors/receptors) and Logic Modules (transcriptional regulators like the lac operon). These can be animated to show how cells "compute" environmental signals into outputs like green fluorescent protein (GFP).
Physical Scale: Use the course's scale data for accuracy. For example, a base pair is approximately 2 nm in length, and an animal cell is between 10 μm and 100 μm.
2. Implementation in Google Street View with GCell & GMolecule Views
To transition from a macroscopic "Street View" to a microscopic "GCell/GMolecule View," you can utilize several frameworks:
Temporal Scaling (Times Slider): Use the concept of the synthetic biology design cycle (Design → Build → Test → Learn) to show how a modified organism evolves over time within a specific geographic location.
Interactive Animation: Animate molecular tools like CRISPR-Cas9, ZFNs, and TALENs. Your virtual environment can allow users to "drop in" these tools to see them create double-stranded breaks and trigger cellular repair mechanisms like NHEJ or HDR in real-time.
Phage Therapy Simulations: Model the "arms race" between bacteriophages and bacteria. You can simulate how a point mutation in a bacterial protein (like DnaJ) prevents phage propagation and how researchers engineer phages to overcome this resistance.
3. TensorFlow AI and Scientific Research Integration
To make the environment a tool for subsequent research:
AI-Driven Prediction: Use TensorFlow to predict the outcomes of codon optimization. The course notes that different organisms use different sets of degenerate codons; your AI can simulate how these choices affect protein expression levels.
Protein Evolution: Animate directed molecular evolution to design advanced proteins, such as red fluorescent proteins with better photostability and reduced toxicity.
Digital Biocolorants: Model how different combinations of genes (like crtEB for carotenoids) result in specific visible "biocolors" in organisms like E. coli, which can be visually represented in your virtual earth.
4. Interactive Collaboration
To allow for subsequent research:
Simulation Sandbox: Allow users to select a chassis (e.g., E. coli, yeast, or mammalian cells) and introduce custom DNA designs into that virtual host to observe the metabolic or therapeutic output.
Data Analysis Layers: Layer in virtual "next-gen sequencing" or "mass spectrometry" readouts that appear as the user interacts with the animated biological processes
*
Scott MacLeod <sgkmacleod@worlduniversityandschool.org>
to:"David S. Kong" <dkong@mit.edu>,
George Church <gchurch@genetics.med.harvard.edu>,
Christopher E Mason <chm2042@med.cornell.edu>,
Alden Briscoe <abriscoe@brakeleybriscoe.com>,
Byron Hann <byronhann1@gmail.com>,
Peter Norvig <pnorvig@google.com>,
Donna Leet MD <donna.leet@ucsf.edu>,
Robin Appleberry <robinappleberry@yahoo.com>,
Edward Smyth <esmythmd@gmail.com>,
Janie MacLeod <jkbmacleod@icloud.com>,
Sid Mazumdar <sid.mazumdar@gmail.com>,
Scott Gordon MacLeod <president@worlduniversityandschool.org>,
president@harvard.edu,
president@mit.edu,
Shawn Flaherty <stf@pghfirm.com>,
Elizabeth Warren <warren@law.harvard.edu>,
Elizabeth Warren <Elizabeth_Warren@warren.senate.gov>,
Joichi Ito <Joiito@gmail.com>
date:Feb 4, 2026, 5:18 PM
subject:Re: HTGAA Class #1 ||| Tues Feb 3, 2-5p ET ||
mailed-by:worlduniversityandschool.org
Dear Drs. David (Sun Kong), George (Church), Chris (Mason) of HTGAA 2026, Peter (Norvig), Presidents at MIT and Harvard, US Senator and former Harvard Law Professor Elizabeth Warren, AI readers, All,
Might a videorecording of HTGAA 2/3/26 and a new Zoom URL be forthcoming soonish, please, and such that I can join the live HTGAA 2026 class next week - and with some knowledge of what happened in the first class? (And are you receiving these emails, David (Sun Kong), my having received a message to the effect that perhaps you aren't?)
Thanks for your email to almost all of us in some of these regards, Chris -
Christopher E Mason
Tue, Feb 3, 11:45 AM (1 day ago)
Reply
More
to George, Alden, Byron, Peter, Donna, Robin, Edward, Janie,Sid, me, David
Thanks - Dr. Kong should be able to help with access.
Cheers,
Chris
----------------------------------------------
Christopher E. Mason, Ph.D.
WorldQuant Professor of Genomics and Computational Biomedicine
Department of Systems and Computational Biomedicine
Weill Cornell Medicine
Are you referring to access to yesterday's videorecording and HTGAA 2026 class next week for me as a global listener - with a Zoom URL, or something else?
Might one of the reasons I couldn't join the class yesterday be due to ICE, either the Thai graduate student TA, I think, who in HtGAA 2025 was acting very strangely (aggressively, arbitrarily, ... almost as if he could be seeing prostitutes as sex slaves I posit and wonder ... sometimes appearing with a rooster on his head, and even in the HTGAA 2025 class photo ... and could this even be suggesting that he was a cock?) ... OR could it be due also possibly to ICE immigration and customs enforcement - and their involvement entanglement in MIT too, with all the defense department monies MIT gets, and with their recent murders on the streets of US states ... ? And could even the MIT Media Lab be involved in international organized crime in new ways post epstein and lewin?
David (Sun Kong), having received an HTGAA 2026 with Zoom URL welcome email the night before the first HTGAA 2026 class, - which was blocked - how please to get a Zoom URL for next week's HTGAA 2026 that works please, and as a global listener.
I write as President of World University and School, building on CC-4 MIT OCW in 7 languages, and on Wikipedia / Wikidata in ~342 languages, and in growing an abolition movement worldwide to protect people and in seeking to code for all 7.9 billion people on the planet each a Wikidata PIN # from here - https://wiki.worlduniversityandschool.org/wiki/You_at_World_University- and to abolish the wrongful buying and selling of people in the illegal sex, drugs, violence, car theft, military targeting industries etc. internationally and their latent networks of violence ... as you may have been reading in the WUaS Weekly Business Meeting WUaS News and Q&As, most recently on M 2/2/26 - https://worlduniversityandschool.blogspot.com/2026/02/mount-shasta-wilderness-m-2226-2926.html.
I also write regarding HTGAA 2026 in GROWING a #RealisticVirtualEarth For Synthetic Biology, For Biomedical Engineering, a #RealisticVirtualEarthForGenetics, and a #RealisticVirtualEarthForExtremeLongevity #RealisticVirtualEarthForAgingReversal in collaboration with HTGAA (and see Peter Norvig's INCREDIBLE ToolifyAIWUaS article regarding a Realistic Virtual Earth -https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306which is the first time someone has mentioned a RVE that I know of other than WUaS) and at the GCellular and GMolecular levels etc too (think GStreetView with GTimeSlider) ... and also regarding an Aging Reversal Genetics' course, with parallels to a MIT OCW course, to be listed potentially here - https://wiki.worlduniversityandschool.org/wiki/Aging_Reversal_Genetics.. and so that MIT and Harvard and Wellesley etc students can all begin to work on Aging_Reversal_Genetics' gene therapies and similar with time.
Adn with George (Church above) having recently retweeted some Michael Forrest's Tweets regarding potentially longevity molecules -
Great #NewZealandpatentGranted #NewCancerDrugs - How will a #RVEforPatenting integrate all 200 #WUaSNationStates' #PatentLawOffices eg #RealisticVirtualEarthForPatenting #RealisticVirtualEarthForPatents w #RealisticVirtualEarthForMolecules in #GStreetView &@ #GMoleculeView level?
And where ICE, the MIT graduate student, could also be very useful in developing a #RealisticVirtualEarthForSyntheticBiology - and in the Thai language especially and for Thai WUaS students in their homes in Thailand ...
As a conscientious objector (as a Friend / Quaker), I'm also growing a worldwide World Univ & Sch WUaS abolition movement - building on CC-4 licensed MIT OCW in 7 languages +again - to knock back international organized crime and to protect people ... even regarding the tragic epstein and lewin catastrophes out of MIT ... and potentially re international organized crime operating at MIT and the Ivy league Universities, the Stanford and the University of California s for example too. (MIT alums in chemistry/ physics' Larry Viehland and his wife kim viehland, where Larry was involved in World University and School for a few years, but after his wife pastor kim viehland asked 'where are we going to get the prostitutes from? - in their house at Pittsburgh, PA, where I was in asylum, in 2 different asylum house, after death threats in the sf bay area, for 2 1/2 years ... and could they continue to be involved in international organized crime out of Pittsburgh, even, and tragically?) ... My grandfather Sandy Brown (Alexander Chadbourne Brown), with 2 MIT degrees, I think, in chemical engineering from the 1920s, and something like 9 patents, was found hung in my grandparents' basement in Cincinnati Ohio in 1985 ... and with my grandfather being a birthright Unitarian, and involved in the Unitarian Church in Cincinnati for something like 50 years ...and inquiry-wise could MIT organized crime (or MIT international organized crime) have hung him ... and regarding even tragically sex trafficking prostitution with kids in the Unitarian Church of Cincinnati, I've wondered a number of times? And could Larry and 'pastor' kim viehland both have learned about the reasons for why my grandfather Sandy Brown was hanged - while I was in asylum in Pittsburgh from the SF Bay Area ... - and regarding MIT organized crime in the midwest ? Larry is from Missouri and Kim is from West Virginia prior to MIT; Larry dropped out of WUaS very suddenly when I was in asylum in Pittsburgh from Aug 2022 to Dec 2024. My father, too, Gordon K MacLeod MD, a professor of Public Health at the University of Pittsburgh for many decades came back from a 4 day semester at sea voyage, UPitt managed at the time, with a subdural hematoma, - and was he whacked in Belize on 12/30/04, the day before my birthday, by international organized crime in cahoots with us uniformed armed services (since ret major general douglas fraser of the southern command in the us air force would likely have signed off on my father's head injury which lead to his death almost 3 years later I posit) - and as I seek to stay alive with some death threats both in the SF Bay Area and sadly a murderous run through attempt of me in Pittsburgh in asylum, as well as the 'murder 'word spoken to me in Chase bank Shadyside Pgh by Shauna McNally with jp morgan Chase bank operating in about 100 out of 200 countries ... and possibly involved in the wrongful buying and selling of people - modern slavery I posit - in the illegal sex and violence industries etc too.
David (Sun Kong), Chris (Mason), George (Church), how best please to join the HTGAA 2026 as a global listener ... where joining this network again this year could keep me alive from elite universities' international organized crime for example?
Tuesday, February 3, 2026 Dactylorhiza hatagirea (Himalayan Marsh Orchid): consciousness > reality re #Yoga - Asked #GeminiAIrePhilosophy where has #YogaPhilosophy as in #8LimbYogaPhilosophy gone regarding #WesternPhilosophy ...
From a related email thread on Monday, February 2, 2026 -
HTGAA 2026 - beginning Tu, February 3 from 2-5p ET!
Scott MacLeod <sgkmacleod@worlduniversityandschool.org>
to:"David S. Kong" <dkong@mit.edu>,
George Church <gchurch@genetics.med.harvard.edu>,
Peter Norvig <pnorvig@google.com>,
htgaa2025-TAs@media.mit.edu,
htgaa2025-globalTAs@media.mit.edu,
Alden Briscoe <abriscoe@brakeleybriscoe.com>,
Byron Hann <byronhann1@gmail.com>,
Donna Leet MD <donna.leet@ucsf.edu>,
Robin Appleberry <robinappleberry@yahoo.com>,
Christopher E Mason <chm2042@med.cornell.edu>,
Jim Spohrer <spohrer@gmail.com>,
Edward Smyth <esmythmd@gmail.com>,
Sid Mazumdar <sid.mazumdar@gmail.com>,
Janie MacLeod <jkbmacleod@icloud.com>,
charrison@pfizer.co.uk,
"Joseph C Wu (CVI)" <stanfordcvi@stanford.edu>,
suvinsun@mit.edu
date:Feb 2, 2026, 4:09 PM
subject:HTGAA 2026 - beginning Tu, February 3 from 2-5p ET!
mailed-by:worlduniversityandschool.org
Dear Professors David (Sun Kong), George (Church), Chris (Mason) of HTGAA 2026, Peter (Norvig), and All,
Hi @davidsunkong @geochurch: I've applied 2X to be a global listener for #HTGAA2026, registering on Sun, 1/11/26 & F 1/30/26, & I also I submitted a @WorldUnivAndSch #PhysicalDigital #HTGAAVirtualNode Lab proposal but haven't heard back whatsoever. Will you post the URL to #TwitterX?
M 2/2/26 open WUaS Weekly Business Meeting World Univ & Sch News and Q&A (where WUaS is building on MIT OCW in its 7 languages to facilitate free online-from-home WUaS Degrees, and as we accredit further - and potentially in a #RealisticVirtualEarth & see Peter Norvig's INCREDIBLE #ToolifyAIWUaS article here - https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306)
The deadline to apply for How To Grow (Almost) Anything has been extended to February 1 at 11:59p PT
Apply today via the link below!
Class begins on Tuesday, February 3? from 2-5p ET!
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