Friday, February 18, 2022

Steller sea lion: 4 main Tweets today about this gene editing Debate yesterday: Vote, comment & watch: "Use Gene Editing to Make Better Babies" * 4 Re #GermlineEditing & #WUaSGreatDebate check out #ForTheMotion & #AgainstTheMotion here https://intelligencesquaredus.org/debates/use-gene-editing-make-better-babies & Video will be up for 7 days > 1 #PhysicalDigital #RealisticVirtualEarthForGenetics @WorldUnivAndSch Connect w/ #StanfordMinePi cryptocurrency https://minepi.com/sgkmac? * * Surfing in February in Santa Cruz, California, not too far from the University, (with UCSC's former banana slug mascot, now sea lion , 8 yrs ago today. With an invitation to @WorldUnivAndSch'S open Monthly Business Meeting Sa 9a PT http://scott-macleod.blogspot.com/2022/02/otter-sea-enhydra-lutris.html?m=0 ~

 

4 main Tweets today about this gene editing Debate yesterday: Vote, comment & watch: "Use Gene Editing to Make Better Babies" . . . 




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Germline editing for heritable genetic diseases, eg Cystic Fibrosis & Muscular Dystrophy?, FDA approved, equitable - https://www.ncbi.nlm.nih.gov/books/NBK447263/ in 1 #RealisticVirtualEarth #RealisticVirtualEarthForCRISPR ForGenetics w 7.9 billion #AvatarBotElectronicMedicalRecords @WorldUnivAndSch ?











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?#GermlineEditing in 200 countries for heritable genetic diseases: https://www.medicinenet.com/genetic_disease/article.htm (FDA approved, equitable)
https://www.statnews.com/2020/09/04/heritable-genome-editing-will-require-heavy-lifting-us-policy/ in 1 #PhysicalDigital #RealisticVirtualEarth #RealisticVirtualEarthForGenetics w 7.9B #AvatarBotElectronicMedicalRecords @WorldUnivAndSch?













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Re #GermlineEditing & #WUaSGreatDebate check out #ForTheMotion & #AgainstTheMotion here https://intelligencesquaredus.org/debates/use-gene-editing-make-better-babies & Video will be up for 7 days > 1 #PhysicalDigital #RealisticVirtualEarthForGenetics @WorldUnivAndSch Connect w/ #StanfordMinePi cryptocurrency https://minepi.com/sgkmac?











Claim Pi ...




Claim Pi image ?...






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"Use Gene Editing to Make Better Babies" . . . 
 
Main Points

For the Motion -

  • The use of gene editing allows for couples to have children when they might otherwise have that option unavailable for them. It also allows for less to be left to chance during the pregnancy.
  • Gene editing will allow for babies to be born with reduced or eliminated chances of inheriting and passing on genes linked to diseases. We have a moral imperative to use technology that will improve the quality of life.
  • It is only a matter of time before gene editing becomes a widespread technology, potentially used by competitors and rivals on the international stage. If we have the technology, we should use it to our advantage to remain competitive.


Against the Motion - 


  • The use of gene editing to create "better" outcomes in children will inherently create social stratification based on any gene editing, likely reflecting existing socioeconomic status. Additionally, the term 'better' is arbitrary and potentially short-sighted and dangerous.
  • Currently, there exist reasonable alternatives to gene editing for every condition for which gene editing can be used. 
  • The technology is still developing, and the long-term effects of any gene-editing could be potentially dangerous with consequences echoing throughout the gene environment. 


https://intelligencesquaredus.org/debates/use-gene-editing-make-better-babies



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A Realistic Virtual Earth for Genetics with TensorFlowAI Translate ... for regulating in all 200 countries ... Researchers could get access to best emerging genetics' IT ...?


gchurch@genetics.med.harvard.edu





Propose topic 


Nicole Comfort Ph.D. - 
In our polarized and politicized society, it’s so refreshing to listen to civilized scientific debate. I encourage you to listen to the debate on germline gene editing here: https://t.co/if9UPjHHLw Thank you @geochurch @amywebb @FrancoiseBaylis @JohnDonvan 








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From Yesterday's blog post - 





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Check out this debate this afternoon with Harvard Medical School's George Church & 3 others at 2 PT on gene editing - "For what diseases? ... FDA approvable, and equitably accessible ..." -

https://twitter.com/geochurch/status/1494080415895896066 with relevance @WorldUnivAndSch & a #RealisticVirtualEarthForGenetics for molecular engineering 

https://twitter.com/WorldUnivAndSch/status/1494341090001883136

https://twitter.com/scottmacleod/status/1494342662635220995?s=20&t=9wUZE2I_rZ2o9N52I6Zyqw

https://twitter.com/HarbinBook/status/1494343166744432650?s=20&t=9wUZE2I_rZ2o9N52I6Zyqw

https://twitter.com/TheOpenBand/status/1494342913022566412?s=20&t=9wUZE2I_rZ2o9N52I6Zyqw

https://twitter.com/sgkmacleod/status/1494342778393743368?s=20&t=9wUZE2I_rZ2o9N52I6Zyqw

https://twitter.com/WUaSPress/status/1494342456036376579?s=20&t=9wUZE2I_rZ2o9N52I6Zyqw



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What Is Gene Therapy? How Does It Work?

https://www.fda.gov/consumers/consumer-updates/what-gene-therapy-how-does-it-work


FDA allows marketing of first direct-to-consumer tests that provide genetic risk information for certain conditions

https://www.fda.gov/news-events/press-announcements/fda-allows-marketing-first-direct-consumer-tests-provide-genetic-risk-information-certain-conditions



WARNING LETTER

Haloderm, Inc.

MARCS-CMS 608852 — OCTOBER 06, 2020

https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/warning-letters/haloderm-inc-608852-10062020



Human Gene Therapy for Rare Diseases

Guidance for Industry

https://www.fda.gov/media/113807/download



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What Is Gene Therapy? How Does It Work? https://www.fda.gov/consumers/consumer-updates/what-gene-therapy-how-does-it-work FDA allows marketing of first direct-to-consumer tests ... https://www.fda.gov/news-events/press-announcements/fda-allows-marketing-first-direct-consumer-tests-provide-genetic-risk-information-certain-conditions Haloderm, Inc. WARNING LETTER https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/warning-letters/haloderm-inc-608852-10062020 Human Gene Therapy for Rare DiseasesGuidance for Industry ~

https://twitter.com/scottmacleod/status/1494350489059676160





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Hi Ed, there's a debate this afternoon with HMS's George Church & 3 others at 2 PT on gene editing - "You can vote & comment.   For what diseases (present & future) is genetic medicine a good option, FDA approvable, and equitably accessible" - https://twitter.com/geochurch/status/1494080415895896066 with relevance @WorldUnivAndSch & #RealisticVirtualEarthForGenetics for molecular engineering (https://twitter.com/WorldUnivAndSch/status/1494341090001883136) Any interest? I'm attending (go to an academic debate together? We haven't done this much :)




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Will genetic engineering drugs be different, in an unique category, from say new antibiotics? I selected the 'undecided' option when registering - https://intelligencesquaredus.org/debates/use-gene-editing-make-better-babies - about this 'motion' "Use Gene Editing to Make Better Babies" ... you? You'd register with this link ... 






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Hi Ma, 

Lots of contested views in this 'gene editing' debate I just heard ... Did you hear it ? ...  But fascinating and good to air the issues at a high level (germ line vs somatic, equitability, covert nation states' governments' experiments, eugenics' questions, with this MIT Tech Review cover being mentioned - "Marcy Darnovsky just called out MIT Technology Review for having a blue eye blonde baby on our designer babies cover from 2015."
https://twitter.com/antonioregalado/status/1494444483987058690, re-Tweeted by Stanford Law Prof and Bioethicist, Hank Greely etc.) ... appreciating George Church's gene editing thinking ... And the progressive debate (since all 5 were progressive) ... am still undecided about the motion ... Interesting to get into a formal contested ideas' space ... Which the west does well ...

I think they're going to keep debate open for 7 days ... To allow further voting ... Was impressed too with John Donvan the moderator ... 

... Ed didn't attend gene editing debate, and is visiting his aunt instead  ... in Concord? he wrote ... 

Genetic engineering revolution drug therapies emerging ... Which aren't just adding substances, but importantly editing genes, and adding and subtracting them too ... Whole new world of medicine ...for all 200 countries ... 


Debate on gene editing ... Yields some engaged tweets from Stanford Law prof Hank Greely


In this debate, George Church just called mRNA vaccines gene therapy.  This is sufficient to be banned from further speech.

Interesting to see that George Church is saying mRNA vaccines are gene editing in a way ... 

Am wondering how such a panel will inform Longevity Genetics' engineering thinking (and potentially re WUaS Longevity Genetics' Institute too)...


How's your day going? 

Love, Scott





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Some after this 'gene editing' debate knowledge sharing - 


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MIT Tech Review: "In this debate, George Church just called mRNA vaccines gene therapy.  This is sufficient to be banned from further speech"

 

Antonio Regalado

@antonioregalado

Feb 17

In this debate, George Church just called mRNA vaccines gene therapy.  This is sufficient to be banned from further speech.

https://twitter.com/antonioregalado/status/1494438954904530947


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george church

@geochurch

Feb 19

Replying to 

@antonioregalado

I said "AstraZeneca & Sputnik Covid19 vaccines are Adenoviral capsid delivery of DNA"  (& yes, btw, synthetic mRNA in LNPs can also be a form of gene therapy)

https://twitter.com/geochurch/status/1495002233045405699



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george church

@geochurch

Feb 19

Replying to 

@antonioregalado

"these mRNA vaccines, which have been developed and approved within a few months, signify a breakthrough in the field of gene therapy"

https://twitter.com/geochurch/status/1495006382092951555




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Antonio Regalado

@antonioregalado

Feb 18

Replying to 

@dshahh

good example. if gene therapy refers to the ends (change in nuclear DNA), not the means, could we say radiation therapy qualifies?

https://twitter.com/antonioregalado/status/1494766715456167941



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george church @geochurch Feb 19

Replying to 

@antonioregalado and @dshahh

Gene therapies consist of genes (just as mAb Tx consists of antibodies, & protein Tx consist of proteins). Genes can be RNA or DNA (e.g. in viral delivery of Tx & can interconvert via RT & RNAP).

https://twitter.com/geochurch/status/1495027566817812483?s=20&t=1Ag-3plY-O4lAu_Cx6yt1w








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Ma, 

How are you? 

Since C (H. MD) in Moraga suggested that I call the Moraga police in around September 2020 after illegal break INS with brown goo evidence on my floor one night ... which calling was wise re State of California law and law enforcement issues (but possibly a risk for Cindy and Byron at the time - due to the unbridled criminality in Canyon hypothetically) ... And C. went to Stanford as an undergrad and her younger daughter may still be in the Seattle area .... 

Could C. (and B.) thinking-wise arrange for me to meet possibly a 20-something yo MD SEEKING a partner ... ? 

Calling the police in Moraga may open a way to getting a house in Canyon and for a song possibly ... Which could lead too to an Academic Medical Center with Warm Water Cure up on the ridge in Canyon and East Bay MUD ... Cindy's originally from San Diego so is a native California as is Byron ... And the culture is different from the East Coast ... And which could be interesting to study Ethnographically at Harbin Hot Springs for centuries to come - with a WuAS Longevity Genetics'Institute and in the Canyon Pinehurst road creek & EB MUD watershed. 

Am not sure if N.P. MD would be a good fit or if we would connect naturally ... but it might be interesting to meet (A.C, MD and emergency room medicine comes to mind here, and that Celtic Craig Cuttyhunk connection re Massachusetts too:)

Love, Scott


Some Tweets related to yesterday's gene editing debate ...


2

Germline editing for heritable genetic diseases, eg Cystic Fibrosis & Muscular Dystrophy?, FDA approved, equitable - https://www.ncbi.nlm.nih.gov/books/NBK447263/ in 1 #RealisticVirtualEarth #RealisticVirtualEarthForCRISPR ForGenetics w 7.9 billion #AvatarBotElectronicMedicalRecords @WorldUnivAndSch ?

https://twitter.com/scottmacleod/status/1494707231559876609

https://twitter.com/WorldUnivAndSch/status/1494707507368923148

https://twitter.com/sgkmacleod/status/1494707443263180801

https://twitter.com/HarbinBook/status/1494707583101247489

https://twitter.com/TheOpenBand/status/1494707643251761152

https://twitter.com/WUaSPress/status/1494707703834238978



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3

?#GermlineEditing in 200 countries for heritable genetic diseases: https://www.medicinenet.com/genetic_disease/article.htm (FDA approved, equitable)

https://www.statnews.com/2020/09/04/heritable-genome-editing-will-require-heavy-lifting-us-policy/ in 1 #PhysicalDigital #RealisticVirtualEarth #RealisticVirtualEarthForGenetics w 7.9B #AvatarBotElectronicMedicalRecords @WorldUnivAndSch?

https://twitter.com/n_comfort/status/1494447310721400840

https://twitter.com/sgkmacleod/status/1494710574604697604

https://twitter.com/scottmacleod/status/1494710366986596357

https://twitter.com/WUaSPress/status/1494711728101224449

https://twitter.com/TheOpenBand/status/1494711505970884609

https://twitter.com/HarbinBook/status/1494711073403899905

https://twitter.com/WorldUnivAndSch/status/1494710897532563458



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4



Re #GermlineEditing & #WUaSGreatDebate check out #ForTheMotion & #AgainstTheMotion here https://intelligencesquaredus.org/debates/use-gene-editing-make-better-babies & Video will be up for 7 days > 1 #PhysicalDigital #RealisticVirtualEarthForGenetics @WorldUnivAndSch Connect w/ #StanfordMinePi cryptocurrency https://minepi.com/sgkmac?










Claim Pi ...

https://twitter.com/scottmacleod/status/1494716755016437760



And related ideas ...


Realistic Virtual Earth for Genetics with TensorFlowAI Translate ... For regulating in all 200 countries ... Researchers could get access to best emerging genetics IT ...


francoise.baylis@dal.ca

hello@futuretodayinstitute.com

darnovsky@geneticsandsociety.org

gchurch@genetics.med.harvard.edu

nicole.comfort@columbia.edu (re her Tweet below)

Propose topic 

John Donvan? - iq2usinfo@iq2us.org 


In our polarized and politicized society, it’s so refreshing to listen to civilized scientific debate. I encourage you to listen to the debate on germline gene editing here: https://t.co/if9UPjHHLw Thank you @geochurch @amywebb @FrancoiseBaylis @JohnDonvan 

https://twitter.com/n_comfort/status/1494447310721400840



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Appreciating this sentence re the following UCSC banana slug mascot and the other 2 species, the Sea lion and the Sea Otter re upcoming WUaS Monthly Business Meeting


"The students' embrace of such a lowly creature was their response to the fierce athletic competition fostered at most American universities."

https://www.ucsc.edu/about/mascot.html

(Ed is an alum of UC Santa Cruz California :)


Surfing in February in Santa Cruz, California, not too far from the University, (with UCSC's former banana slug mascot, now sea lion

https://www.ucsc.edu/about/mascot.html), 8 yrs ago today. With an invitation to @WorldUnivAndSch'S open Monthly Business Meeting Sa 9a PT

http://scott-macleod.blogspot.com/2022/02/otter-sea-enhydra-lutris.html?m=0

https://twitter.com/scottmacleod/status/1494688606841016321



More about this gene editing debate here too in yesterday's blog post 

http://scott-macleod.blogspot.com/2022/02/eastern-newt.html?m=0



-- 

- Scott GK MacLeod  

Founder, President, CEO & Professor

World Univ & Sch (WUaS) - PO Box 442, Canyon, CA 94516 

1) non-profit World University and School - http://worlduniversityandschool.org  

2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html


(o) 415 480 4577 - sgkmacleod@worlduniversiryandschool.org 

(m) 412 478 0116 - sgkmacleod@gmail.com 


World Univ & Sch Innovation Research -  scottmacleod.com 






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Ma,

This book review of 'Klara and the Sun' Robot Store cafes just popped up from The Guardian paper in Great Britain -


Klara and the Sun by Kazuo Ishiguro audiobook review – a ghost in the machine: 
Narrator Sura Siu brings a childike innocence to Ishiguro’s exploration of what it means to be human


More about Ishiguro's life here from the Nobel prize committee - https://www.nobelprize.org/prizes/literature/2017/ishiguro/biographical/ ...

More about 'Klara and the Sun' Robot Person book here -
 https://the-bibliofile.com/klara-and-the-sun-analysis-chapter-summary/

Love, Scott

- Scott GK MacLeod  
Founder, President, CEO & Professor
World Univ & Sch (WUaS) - PO Box 442, Canyon, CA 94516 
1) non-profit World University and School - http://worlduniversityandschool.org  
2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html

(m) 412 478 0116 - sgkmacleod@gmail.com 

World Univ & Sch Innovation Research -  scottmacleod.com 







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https://en.wikipedia.org/wiki/Steller_sea_lion

https://commons.wikimedia.org/wiki/Eumetopias_jubatus

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