Sunday, June 23, 2019

Montane ecosystems: Longevity (immortality even) & where are we now with reversing aging?, MIT Media Lab Direcctor Joi Ito's "THE RESPONSIBILITY OF IMMORTALITY: WELCOME TO THE NEW TRANSHUMANISM," and "The Future of Xapiens - Xapiens at MIT was live" with Pattie Maes, Max Tegmark, David Sinclair, George Church, Ed Boyden, and Joe Paradiso * * * Dartington Hall is so very beautiful! Wonderful that you'll be teaching there together, Victor and Angela (and Satya)! * * * Hippy Anjali Yoga Notations - http://www.scottmacleod.com/yoganotations.html ! you don't say! :) How best to explore both your Yoga and creativity in online group video Hangouts newly, I wonder?

June 23, 2019
Longevity & where are we now with reversing aging? 
* * * 
August 9, 2019 update
Hi M and Sandy, 

Here's what I'm tuning into re questions of longevity, reversing aging and even immortality (what a wild idea!) - https://scott-macleod.blogspot.com/2019/06/montane-ecosystems-longevity.html .

If I were to look at 3 items in this post, with an interest in learning more about DNA and reversing aging questions, I'd focus on

Joi Ito's "Wired" article

Harvard Professor David Sinclair's Tweets and Twitter stream

watch the FB video ... with Harvard's George Church, David Sinclair, MIT's Ed Boyden et al. ... 


L, Scott
* * *

June 23, 2019

 Just found ... 


Cell & molecular multiplexing. Well done team Ido.


https://twitter.com/geochurch/status/1141797394171908097


Ab-initio discovery of tumoricidal oligonucleotides in a DNA sequencing machine
https://www.biorxiv.org/content/10.1101/630830v2
https://twitter.com/IdoBachelet/status/1141722490814828545



*
reversing aging in dogs and mice evidence https://www.technologyreview.com/s/611018/a-stealthy-harvard-startup-wants-to-reverse-aging-in-dogs-and-humans-could-be-next/amp/
- https://time.com/5209427/aging-nicotinamide-mononucleotide-nmn/?amp=true
- https://www.leafscience.org/new-harvard-startup-wants-to-reverse-aging-in-dogs-and-then-humans/ - https://www.leafscience.org/dr-matt-kaeberlein-the-dog-aging-project/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411365/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936929/
- https://www.nextbigfuture.com/2018/09/george-church-talks-about-reversing-human-aging-and-claims-they-made-mice-live-twice-as-long.html?amp
- https://wiki.worlduniversityandschool.org/wiki/Longevity) ~ @WorldUnivAndSch @WUaSPress ~

https://twitter.com/scottmacleod/status/1154206724892635137
https://twitter.com/WorldUnivAndSch/status/1154206532197933056
https://twitter.com/WUaSPress/status/1154206646920523777



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David Sinclair, PhD AO

@davidasinclair

Study of 14.5K people shows even if you start exercising mid-life there are major benefits to longevity (24% reduction in death by all causes) and if you ramp up your existing program, even better (42%). #aging #fitness. https://tinyurl.com/y6lta5xz

https://twitter.com/davidasinclair/status/1148535407359025153


David Sinclair, PhD AO

@davidasinclair

Did you hear our last chat? Here it is:

#27 – David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging
“This is a lesson for anyone who's listening who thinks that getting to somewhere like this is easy. You have to be massively determined, you have to have grit, and I just wouldn't give up because there's nothing else I want to do in my life.” —David Sinclair

https://twitter.com/davidasinclair/status/1148675193990049792


A superb meeting on aging ⁦@harvardmed⁩ today & tomorrow. Raul Mostovslavsky is talking about the role of SIRT6 in metab & cancer. Also speaking: Nir Barzilai, Will Mair, Jan Vijg, Roz Anderson, Vamsi Mootha, Rich Miller, Brad Wilcox, Mark Mattson and Jay Olshansky #aging

https://twitter.com/davidasinclair/status/1149055346981216256



Congrats WeiWei on your paper showing that yeast with “chromatin stress” live longer. More evidence that DNA packaging is relevant to aging. Can’t wait for u to test if the protective genes we have isolated from space-resistant species extend lifespan too!




https://twitter.com/davidasinclair/status/1149159431646658560


300 fewer calories each day can make a tremendous difference in your life. But calorie restriction can be hard to maintain, even for motivated people.

https://twitter.com/davidasinclair/status/1149481009760493570



I love staying at the Harvard Club in NY for the photos in the rooms - this one from 1893. They remind me to make the most of every day before time runs out. And have a bit of fun along the way #longevity

https://twitter.com/davidasinclair/status/1149609934759219206


* * *
Friday, August 9, 2019

David Sinclair, PhD AO
@davidasinclair
Thanks Rhonda. Appreciate it.


Dr. Rhonda Patrick
@foundmyfitness
 · Aug 3
Genetic reprogramming in old mice can restore youthful gene activity patterns, reverse the DNA methylation aging clock, and restore the function and regenerative capacity of the aging retina.

Nice work by @davidasinclair and colleagues!  (link: https://www.biorxiv.org/content/biorxiv/early/2019/07/31/710210.full.pdf) biorxiv.org/content/biorxi…



https://twitter.com/davidasinclair/status/1157854819098517505


*
Dr. Rhonda Patrick
@foundmyfitness
Genetic reprogramming in old mice can restore youthful gene activity patterns, reverse the DNA methylation aging clock, and restore the function and regenerative capacity of the aging retina.

Nice work by
@davidasinclair
 and colleagues!  (link: https://www.biorxiv.org/content/biorxiv/early/2019/07/31/710210.full.pdf) biorxiv.org/content/biorxi…


https://twitter.com/foundmyfitness/status/1157712433672142848





* *
June 23, 2019 
See, too, especially,

Joi Ito's (June 4, 2018)
THE RESPONSIBILITY OF IMMORTALITY: WELCOME TO THE NEW TRANSHUMANISM


Here's the MIT Media Lab director Joi Ito's article on longevity I mentioned re the promise of gene editing research and longevity - https://web.archive.org/web/20180605002848/https://www.wired.com/story/the-responsibility-of-immortality/ - and while all the other versions of this article online that I looked for, including the main Wired version, seem to be no longer accessible, this Webarchive.org version contains the idea that Harvard researcher George Church is doing gene editing research now with dogs, having moved on from mice, as well as mentioning 9 main scientific appoaches to longevity: 

"He is currently experimenting with age reversal in dogs using gene therapy that has been successful in mice, a technique he believes is the most promising of nine broad approaches to mortality and aging—genome stability, telomere extension, epigenetics, proteostasis, caloric restriction, mitochondrial research, cell senescence, stem cell exhaustion, and intercellular communication."

I've also updated this blog entry - https://scott-macleod.blogspot.com/2018/06/koi-longevity-mit-media-lab-eternal.html - also in this tweet - https://twitter.com/scottmacleod/status/1004033825691717632 - with this article's new web site address. And I just added this article to the Longevity wiki subject - https://wiki.worlduniversityandschool.org/wiki/Longevity - at World Univ & Sch as well. 



*
And, also ...


The Future of  Xapiens -
Xapiens at MIT was live.
about 4 months ago ·

On March 7th, 2019 Xapiens, MIT's first initiative for human augmentation, brought together titans of science, innovation and engineering, intellectuals and industry leaders to imagine, envision and discuss the future of Homo Sapiens.

We were happy to welcome Pattie Maes, Max Tegmark, David Sinclair, George Church, Ed Boyden, and Joe Paradiso for a series of lectures and a panel discussion.

The future of our species will be majorly influenced by the technical advancements and ethical paradigm shifts over the next several decades. Artificial intelligence, neural enhancement, gene editing, solutions for aging and interplanetary travel, and other emerging technologies are bringing sci-fi’s greatest ideas to reality.

Sponsored by Media Lab and McGovern Institute for Brain Research.

- https://www.facebook.com/xapiensatMIT/videos/347012609252421/UzpfSTgyNDEzMDU2MToxMDE2MTM3ODMzNTI5MDU2Mg/ -




* *

Some Longevity blog posts re even reversing aging, and immortality, too  ... https://scott-macleod.blogspot.com/search/label/longevity ...




*

Koi: Longevity, MIT Media Lab - "eternal youth, eternal old age, or ...," You might enjoy this UPDATED article by MIT Media Lab director Joi Ito about "Transhumanism," Angela and Victor's Yoga over the decades, You'll also find both Gary Snyder and the former Reed President Colin Diver, and some Reed faculty - ie Carla Mann (Dance Prof.), with whom I stayed with (and who was a housemate for about 2.5 years in the early 1980s)

https://scott-macleod.blogspot.com/2018/06/koi-longevity-mit-media-lab-eternal.html


*

Peach blossom: World Univ & Sch - A University Internet Company, News, Hangout * * * Longevity ... Re questions about human longevity and gene editing * * * Some further interesting Brighde Chaimbeul Scottish small piping * * * Google + is closing consumer G+ tomorrow 4/2/19 - so I'm saving some years of G+ Profiles' posts to my blog (about 20 posts to a blog post page):

https://scott-macleod.blogspot.com/2019/04/peach-blossom-world-univ-sch-university.html


*

Lesser celandine: University on a smartphone? * * * 'A stealthy Harvard startup wants to reverse aging in dogs, & humans could be next: Biologist George Church says the idea is to live to 130 in body of a 22-year-old' - MIT Tech Review * * * @MIT @medialab Joi Ito's "THE RESPONSIBILITY OF IMMORTALITY: WELCOME TO THE NEW TRANSHUMANISM," * * * Wikidata-Workshop 2019 - Good presentations of Wikidata projects in English & German ... 'INSIDE THE ALEXA-FRIENDLY WORLD OF WIKIDATA,' * * * In the amazingly beautiful Stanford Memorial Church listening to yet another very beautiful concert - "Stanford Baroque Soloists: 17th Century German Masters - The Wild West of Western Music"

https://scott-macleod.blogspot.com/2019/03/lesser-celandine-university-on.html


*

Red-tailed hawk: MIT and Harvard professors are researching what appears to be immortality - or reversing aging - via gene editing * * * Grandpa, Sandy Brown, as a Scottish Unitarian? ... Planning on releasing my first recording - "Honey in the Bag" - Scottish small pipes' CD in 2020 ... (with some other projects before this: A) next book of poetry ahead this year, and maybe in 2019 beginning too, B) my Stanford-MIT STEM ethos comparison book since the 1960s in STS studies ... and hopefully, C) beginning my next actual-virtual Harbin book with realistic virtual earth in 2019) * * * Interesting post about 'consciousness' (how does it work? how to explain it?)



*

Blue poppy: Just heard Poet, Reedie, UC Davis Prof, Hippy Gary Snyder talk at Stanford * * * Thanks @RepAnnaEshoo and All for your great Stanford Law 'What the Loss of Net Neutrality Means for Democracy & Innovation' panel, WUaS seeks Network Neutral massive bandwidth for #RealisticVirtualEarth Telemedicine+ in all ~200 countries (eg for tele-robotic surgery, from multiple organizations, and in emergency situations - like the recent California wildfires) * * * In looking at the history of test results in my KP Profile (since 2014), am curious how such data could feed into Google's Stanford's Duke's Project Baseline ... and then even for genetic engineering and longevity questions eventually ... while I've blogged a fair amount about Project Baseline here's a description

https://scott-macleod.blogspot.com/2019/06/blue-poppy-just-heard-poet-reedie-uc.html





* * *

Dear Lynn, Angela, Victor and Satya! 

Dartington Hall is so very beautiful, Angela! Wonderful that you'll be teaching there together, Victor and Satya!

And you're teaching there on Bastille Day no less - http://www.angela-victor.com/content/schedule. Sounds like the opportunity for storming! :)

Jul 12, 2019 to Jul 14, 2019

Dartington Hall, Devon, UK

Angela Farmer and Victor van Kooten

Want to join us?

For information or registration please contact:
Satya Shepherd
satya@abcbronze.co.uk



And it hosts the Schumacher College - https://www.schumachercollege.org.uk - which I had thought was started before 1990, - https://en.wikipedia.org/wiki/Schumacher_College - although E.F. Schumacher wrote his (influential for hippies) "Small is Beautiful" book in 1973 - 


It looks too like its possible at the Schumacher College -  https://www.schumachercollege.org.uk/about - to do a very DEEP TIME WALK _ https://www.deeptimewalk.org - albeit in an App. Have you ever walked in Deep Time, Angela and Victor? 

Wish I could be there, but MIT OpenCourseWare-centric and wiki World University and School, which I'm developing, is still in the poor house ... one of these days, our fortunes will change ... and voila, further Yoga learning world-wide too. 

Happy teaching in Dartington Hall! (It would be nice to see you again, Satya!) And nice to see you Lynn last week in Yakima, Washington, on my way from Reed College to eastern Oregon to visit family. 3 Harbin-inspired books so far - https://amazon.com/author/scottmacleodworlduniversity - which also posts my quite active blog ... :)

Warm regards, Scotty 


*

Yes dear Scott,
We will teach there soon in Dartington Hall.
A pity you can’t make it, but it has been overbooked way back when.
Computing is beyond me.
I have iPads and that is as far as it will get for it is all secondhand creativity to me.
Lots of LOVE, victor


Sent from my iPad

*

Hi Victor and Angela, Lynn and Satya,

Thanks for you email, Victor.

Appreciating your creativity in many ways Angela and Victor - and re a kind of DEEP TIME WALKING which I experience in your courses - and re said your unfolding hippy artistic Yogic creativity ...

Have blogged about this, as well about reversing aging with genetic engineering, and even re living beyond Jeanne Calment's 122 years of age, and possibly re immortality - see MIT Media Lab's Joi Ito's Wired article in these regards, and George Church, Ed Boyden's, Patti Maes, David Sinclair and other MIT / Harvard professors here - https://scott-macleod.blogspot.com/2019/06/montane-ecosystems-longevity.html ...

Happy teaching (is this akin to storming the Dartington or the Bastille with meditation?:)

Scott

Hippy Anjali Yoga Notations - http://www.scottmacleod.com/yoganotations.html ! you don't say! :)

How best to explore both your Yoga and creativity in online group video Hangouts newly, I wonder? 



*





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at

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