Thursday, July 3, 2025

Halcyon smyrnensis: Karen Brennan's 4 principles of learning as a constructivist Harvard professor of education * * * Mark K. MacLeod. 2023. The DNA of Clan MacLeod: Is Leòd our common ancestor? ~ and some genetic genealogy questions re identity too? * MacLeod Y-DNA - How are people all with the last name MacLeod in my and your genetic lines related genetically, and how can we see this with current genealogy genetic tests and on current genealogy platforms - not yet whole genome sequencing - and how do we navigate and represent on online genealogy tree platforms the ancestors we have no biographical data for, but for whom we do have extrapolatable genetic data? ... * * * Are #WholeGenomeSequencing #WGS & -#GeneticGenealogy AND -#ExtremeLongevity & #AgingReversal #GeneticDrugTherapies ahead -in a #RealisticVirtualEarthForGenomics ...?

 


Karen Brennan's 4 principles of learning as a constructivist Harvard professor of education


Great Thinking: Karen Brennan's
"4 PRINCIPLES OF #LearningDesign ...(#HGSE LDIT)"
https://youtu.be/yKGvocaiH98
as #constructivist (& #HarvardProfessorOfEducation)
personalizing
creating
sharing
reflecting
To https://wiki.worlduniversityandschool.org/wiki/Theories_of_Learning ~


https://x.com/WorldUnivAndSch/status/1940832949358022744

https://x.com/scottmacleod/status/1940835863237451883

https://x.com/sgkmacleod/status/1940835213875335181

https://x.com/WUaSPress/status/1940835436311859593

https://x.com/HarbinBook/status/1940835639404200425

https://x.com/TheOpenBand/status/1940835943889752555

https://x.com/Q_YogaMacFlower/status/1940835021281222754

in contrast to #behaviorism and see -
https://wiki.worlduniversityandschool.org/wiki/Animal_Behavior






* * 

Brennan, Karen, with Maria Bernal, 2024. [https://youtu.be/yKGvocaiH98  4 PRINCIPLES OF LEARNING DESIGN - KAREN BRENNAN (HGSE LDIT)]. Cambridge, MA: https://www.youtube.com/@mariabernal6003.



* 
Karen Brennan
4 principles of learning design as a constructivist (and Harvard Professor of Education)

4 PRINCIPLES OF LEARNING DESIGN - KAREN BRENNAN (HGSE LDIT)


personalizing

creating

sharing

reflecting







* 

what's the competing theory of learning to Constructivism?



behaviorism 









Society, Information Technology, and the Global University (2025, forthcoming) 

- Scott GK MacLeod  
Founder, President, CEO & Professor
CC-4 licensed MIT OCW-centric, Wiki, 
World University & School (WUaS) 
- USPS US Post Office, General Delivery, Canyon, CA 94516 


1) non-profit 501(c)(3) Public Charity 
MIT OCW-centric, 
 World University and School - http://worlduniversityandschool.org  

2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html

(m) 412 478 0116 - sgkmacleod@gmail.com 


World Univ & Sch Innovation Research -  scottmacleod.com 





* * * 


MacLeod, Mark K. The DNA of Clan MacLeod: Is Leòd our common ancestor? ~ and some genetic genealogy questions re identity too?


Dear Mark, 

Thanks for this excellent video ... And can you say this in Scottish Gaelic or the Scots' language (with and without Google Translate for Youtube?:) - 

MacLeod, Mark K. 2023.
The DNA of Clan MacLeod: Is Leòd our common ancestor?
https://youtu.be/-5ZGWndVWNI
Isle of Skye, Scotland: https://www.youtube.com/@markkmacleod

- and this time I took some notes and am asking some questions that come to mind ... and in learning the language of genetics (from a practical family identity biology perspective) - genealogy genetics - and in seeking to understand your thinking especially. (And how could we eventually represent the data and questions you cover in new ways in a realistic virtual earth for genealogy and genetics?). (Am recalling that all people share ~50% of their genetic material with each of their parents, about 25% with their grandparents, and see PS ... And as I've mentioned to you before, I enjoy seeing 'who came before' in genealogy platforms online ...  and learning about them with genealogy software / platforms / trees ... and regarding construing your questions possibly in a different way. And could I see your Ancestry .com family tree to go back from our great great great grandfather Norman John MacLeod, for whom there's some documentary evidence, to Leod in one way or another, and add some of this to https://www.wikitree.com/wiki/MacLeod-2524 ? ... And with Ancestry .com's new updated genetics' email (Your AncestryDNA Results have been updated 

"You have 1 new journey.
Ancestral journeys reveal where your ancestors may have lived over the past 300 years and why they may have moved— 
 
View my journey" - 
https://www.ancestry.com/account/signin?rtype=77&returnUrl=https%3A%2F%2Fwww.ancestry.com%2Fdna%2Forigins%2FFBC34825-6562-46E4-95F8-8A6FF7864CF7%2Fjourneys%3Fo_sch%3DEmail%2BCampaigns), do I have to be a member again to access this? And am curious further to learn how you're approaching analyzing MacLeod DNA data here too - "MacLeod Y-DNA

The MacLeod surname project is open to males with the surname MacLeod in any of its various spellings. A Y-DNA test is required for participation" 
https://www.familytreedna.com/groups/acms-mac-leod/dna-results - and for the extreme longevity genetics' long term too ie if we live to a possible 1500 years old ... with lots of MacLeod offspring further:) 


at the 1:45 minute marker - 
"Is Leòd really our common ancestor?" 

Are you asking can we extrapolate every MacLeod's genetics in the first group you identify - and I'd be interested to see the genetic data for this in another possible great MacLeod DNA video you make (i.e. with the last name MacLeod, and the genetics for those we don't have names, documents, or otherwise biographical or genealogy evidence for) - to trace them back to Leòd, as in he's the ~20th (or 25th or whatever the number) great grandfather of each and everyone with the last name MacLeod in the first group or similar? And I wonder too if you're engaging in a form of scientism or social constructionism regarding 'here are the Clan Macleod family history narratives, construed by you as The DNA of Clan MacLeod, and here's a scientistic window into reading the genetics from a genealogy genetics' perspective'. What do you think? I found your talk very compelling and fascinating. Thank you.

(My initial related question genetically somehow is - How are people all with the last name MacLeod in my and your genetic lines related genetically, and how can we see this with current genealogy genetic tests and on current genealogy platforms - not yet whole genome sequencing - and how do we navigate and represent on online genealogy tree platforms the ancestors we have no biographical data for, but for whom we do have extrapolatable genetic data? 


2:00 
"All of MacLeod men today can be placed into 1 of 5 distinct genetic groups ..."  

I'd be interested further in seeing some of this actual data perhaps at some point ... appreciating your broad introduction into genetics (with the practical lens of family genealogy and a quite coherent MacLeod DNA identify genetic narrative) ... 

How to make all the data you draw on accessible in an open source manner such that scientists and geneticists - and genetic genealogists - could further develop your great thinking - AND in a #RealisticVirtualEarthForGenealogy (https://x.com/scottmacleod/status/1407796864662003716)?


I'll have a look again at 

The DNA of Clan MacLeod (2025)
By Mark K. MacLeod1, Colin Macleod and Roderick A. F. MacLeod
WWW: Journal of Genetic Genealogy

in some of the above regards too.


Mark - appreciating much your abstracting to MacLeod DNA family history in creative and chiefly ways ... as a great MacLeod historian as well ...

Hold fast, warm regards, Happy birthday again,
Scott
blog post to come further and in this label too - 




PS

Asked Gemini AI - 

If 
all people share 

~50% of their genetic material with each of their parents

25% with their grandparents 

12.5 % with great grandparents 

6.25 % with great great grandparents

3.125 % with great great great grandparents 


how much does an individual share with each of the next 10 generations?


Asked Gemini AI and found out - 

Here's how much genetic material is shared with each of the next 10 generations, continuing the halving pattern:

Great-great-great-great grandparents (1st next generation): 3.125%/2=1.5625%

Great-great-great-great-great grandparents (2nd next generation): 1.5625%/2=0.78125%

Great-great-great-great-great-great grandparents (3rd next generation): 0.78125%/2=0.390625%

Great-great-great-great-great-great-great grandparents (4th next generation): 0.390625%/2=0.1953125%

Great-great-great-great-great-great-great-great grandparents (5th next generation): 0.1953125%/2=0.09765625%

Great-great-great-great-great-great-great-great-great grandparents (6th next generation): 0.09765625%/2=0.048828125%

Great-great-great-great-great-great-great-great-great-great grandparents (7th next generation): 0.048828125%/2=0.0244140625%

Great-great-great-great-great-great-great-great-great-great-great grandparents (8th next generation): 0.0244140625%/2=0.01220703125%

Great-great-great-great-great-great-great-great-great-great-great-great grandparents (9th next generation): 0.01220703125%/2=0.006103515625%

Great-great-great-great-great-great-great-great-great-great-great-great-great grandparents (10th next generation): 0.006103515625%/2=0.0030517578125%

It's important to note that these percentages represent theoretical averages. Due to the random nature of genetic recombination, the actual amount of shared DNA with any specific ancestor can vary slightly.


https://g.co/gemini/share/f1a33fd1789c




PPS

Since all people share the above, MARK can you fill in the names or genetic data proxies for those MacLeods prior to Norman James MacLeod ? ... 

~50% of their genetic material with each of their parents - (Gordon K MacLeod MD - https://www.wikitree.com/wiki/MacLeod-2525 - for me - https://www.wikitree.com/wiki/MacLeod-2524, or Bruce Vincent MacLeod - https://www.wikitree.com/wiki/MacLeod-2527 -for you - https://www.wikitree.com/wiki/MacLeod-2532 )

25% with their grandparents (Gordon K MacLeod Sr - https://www.wikitree.com/wiki/MacLeod-2528 )

12.5 % with great grandparents (Ernest James MacLeod - https://www.wikitree.com/wiki/MacLeod-2924 )

6.25 % with great great grandparents - James McLeod / MacLeod - https://www.wikitree.com/index.php?title=MacLeod-2925 (and just removed the 'Edward' per your research) - who emigrated from Scotland

3.125 %  with great great great grandparents (Norman John MacLeod - https://www.wikitree.com/wiki/MacLeod-2926)

1.5625% with great-great-great-great grandparents (who is?)

0.78125% with great-great-great-great-great grandparents 

0.390625% with great-great-great-great-great-great grandparents 

0.1953125% with great-great-great-great-great-great-great grandparents 

0.09765625% with Great-great-great-great-great-great-great-great grandparents 

0.048828125% with Great-great-great-great-great-great-great-great-great grandparents 

0.01220703125% with Great-great-great-great-great-great-great-great-great-great-great grandparents 

0.006103515625% with Great-great-great-great-great-great-great-great-great-great-great-great grandparents 







PPPS


How best to develop #GenealogyResearchWU in a new direction in a #RealisticVirtualEarth, #RealisticVirtualEarthForGenealogy, #RealisticVirtualEarthForHistory, a #RealisticVirtualEarthForGenetics & re #AgingReversalGenetics & #ExtremeLongevityGenetics, w related #GeneTherapies coming?

https://x.com/scottmacleod/status/1924253472939258284

https://x.com/WorldUnivAndSch/status/1924253052036682162

https://x.com/Q_YogaMacFlower/status/1924253576752517185

https://x.com/HarbinBook/status/1924254393630888430

https://x.com/sgkmacleod/status/1924253883142156636

https://x.com/WUaSPress/status/1924254076398875123



Retweeting -

Roots in #VintonIA #DesMoinesIA How could I #ScottGKMacLeod talk virtually with my mother's Pa #SandyBrown #AlexanderChadbourneBrown & #ChadbourneAncestors #wuAsVR #WUaSAR? #REALISTICVIRTUALEARTHFORHISTORY in #GoogleStreetView w #TimeSlider & for #REALISTICVIRTUALEARTHForGenealogy?

https://x.com/scottmacleod/status/1407796864662003716


AND

https://x.com/TheOpenBand/status/1924254804462928365

retweeting Clan MacLeod parliament

#ClanMacLeod Parliament is in full swing now with over 300 delegates attending the week's full programme of events. The pic shows the first Clan Parliament in 1956. The gathering of MacLeods from all over the globe was an idea of Dame Flora MacLeod, the 28th Chief of the Clan.

https://x.com/Dunvegan_Castle/status/1021747928598306816



PPPPS
How is whole genome sequencing of ancestors in genealogy done, if at all?


Whole genome sequencing (WGS) in genealogy involves analyzing an individual's entire DNA sequence to understand their ancestry and potentially identify relatives, though it's not the primary tool used in most consumer-grade genealogy testing. While traditional genealogy relies on autosomal DNA, WGS offers a more comprehensive view of the genome, including non-coding regions and rare variants, which can be valuable for tracing deep ancestry and identifying distant relatives. 
Here's how it works and its role in genealogy:
1. DNA Extraction and Sequencing:
  • A DNA sample (usually blood or saliva) is taken from an individual. 
  • The DNA is extracted, purified, and then sequenced using specialized machines that read the order of all base pairs (A, T, C, and G) in the genome. 
  • This process, known as whole genome shotgun sequencing, breaks the DNA into smaller fragments, sequences them, and then reassembles them to create a complete DNA sequence. 
2. Data Analysis and Interpretation:
  • The raw DNA data is then analyzed using bioinformatics pipelines to identify genetic variants and compare them to reference genomes. 
  • This analysis can reveal information about ancestry, including ethnic origins and potential connections to other individuals who have also been sequenced. 
  • While WGS can be used for traditional genealogical research, it's more commonly used in genetic genealogy to identify distant relatives, uncover deeper ancestral lineages, and solve cold cases where traditional methods have failed. 
3. WGS vs. Other DNA Tests:
  • .Opens in new tab
    (like those offered by 23andMe, AncestryDNA, and MyHeritage) typically analyze specific regions of the genome (like SNPs) to estimate ethnicity and identify close relatives. 
  • .Opens in new tab
    focuses on the protein-coding regions of the genome, which are more relevant for health-related information. 
  • .Opens in new tab
    provides the most comprehensive view of the genome, including non-coding regions and rare variants, which can be particularly useful for tracing deep ancestry and identifying distant relatives. 
4. WGS in Genetic Genealogy: 
  • WGS can be valuable for identifying distant relatives by analyzing shared DNA segments, even those that are small and rare.
  • It can be used to break through "brick walls" in family trees by identifying previously unknown connections and tracing lineages back further in time.
  • WGS data can be used in conjunction with traditional genealogy methods to build more complete and accurate family trees.
5. Challenges and Considerations:
  • Cost: WGS is significantly more expensive than other DNA tests. 
  • Data Storage and Interpretation: WGS generates a large amount of data that requires specialized expertise for analysis and interpretation. 
  • Privacy: WGS data can reveal sensitive information about health and ancestry, so it's crucial to consider privacy and data security. 
In conclusion, while WGS is not the primary tool used in most genealogy testing, it offers a powerful approach for understanding deep ancestry and identifying distant relatives due to its comprehensive analysis of the genome




PPPPS
Julia Abernethy ucl macleod genetic study linkedin
12:30 in video 








* * 
Saturday, July 5, 2025 



Mark MacLeod

10:34 AM (22 minutes ago)
to me
Thanks Scott. 

I sense that you understand that the reduction of the autosomal DNA contribution with each generation, for example from the MacLeod line, is different than the Y-DNA analysis that looks at SNPs that have been inherited since modern human existed. The MacLeods in our immediate family who have taken the Big Y DNA test all have essentially the same SNPs, including R-BY3210 which first appeared in Leòd, or someone close to him in his paternal line. 

All the best, 

Mark


On Thu, May 22, 2025 at 5:53 PM Scott MacLeod <sgkmacleod@worlduniversityandschool.org> wrote:
Mark, 

In a related vein, I just shared this with you and my mother, Jane, Sid/Pin (Mazumdar in HHS in the US federal govt & best friend from high school), and best friend in the SF Bay Area Ed (Smyth MD) - 


"Hi Ed, Ma, Pin, ... How are you? Greetings! Thanks Ed for precipitating my moving into a newly safe 670 Ridgecrest Road, and with WUaS PO Box 442, Canyon 94516 mail too ... and I can hypothesize that the investigation into the culture of criminality and international organized crime in the greater SF Bay Area, and individuals too, back decades even ... may be unfolding further since I first drove west from asylum in Pgh on 12/10/24   ... Just emailed my cousin Mark Macleod in Portland Maine further (and as a Stanford alum, and possibly a US general re the Oil industry per LinkedIn, and having lived in Scotland too and being deeply interested in genealogy genetic) ... re my ongoing seeking to move into a newly safe Canyon 94516 ... and beginning a family - 

"Scott MacLeod <sgkmacleod@worlduniversityandschool.org>
4:08 PM (39 minutes ago)
to MacLeod

Hi Mark,

Appreciating the genetic genealogy language in your paper ...


The DNA of Clan MacLeod (2025)
By Mark K. MacLeod, Colin Macleod and Roderick A. F. MacLeod
WWW: Journal of Genetic Genealogy
https://archive.org/details/jo-gg-issue-131-mac-leod  

and the name Dave Vance also came up in its regard (with a Brown University degree in CS from 1984) ...

https://blog.familytreedna.com/dave-vance-named-familytreedna-general-manager/

https://www.linkedin.com/in/jdavidvance

Will read your paper further ... and re #TextInTheSidebar of a #RealisticVirtualEarthForGenealogy  #RealisticVirtualEarthForGenetics ... and could Dave Vance and Rob Spencer even help with this, potentially with Peter Norvig and Google too?

And how to connect potentially with Donna Leet MD I wonder? (And might we move in together to a newly safe open 670 Ridgecrest Rd, Canyon 94516, where I lived for about 13 years until calling the local police twice at Stanford alum too Cindy, and Byron, Hann MDs encouragement {who lived together in Scotland for 3 years, and where Byron's step-brother may be stationed in Scotland as part of the US federal government even} from nearby Moraga CA)?

Regards, Hold Fast MacLeod, best wishes,
Scott
https://scott-macleod.blogspot.com/2025/05/hawaiian-monk-seal.html


PS

WUaS is just making contact with Rippling in SF and the US federal government and state of CA too ... regarding next steps forward -
https://scott-macleod.blogspot.com/2025/05/butte-county-meadowfoam.html ...

Scott" Thoughts?
 Fond regards, abolition-ally, Harbin ethnographically, Yogically, 
Scott (

Thoughts, Mark?

Hold Fast MacLeod, best wishes, Happy birthday further!, 
Scott







Society, Information Technology, and the Global University (2025, forthcoming) 

- Scott GK MacLeod  
Founder, President, CEO & Professor
CC-4 licensed MIT OCW-centric, Wiki, 
World University & School (WUaS) 
- USPS US Post Office, General Delivery, Canyon, CA 94516 


1) non-profit 501(c)(3) Public Charity 
MIT OCW-centric, 
 World University and School - http://worlduniversityandschool.org  

2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html

(m) 412 478 0116 - sgkmacleod@gmail.com 


World Univ & Sch Innovation Research -  scottmacleod.com 

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On Thu, May 22, 2025, 16:08 Scott MacLeod <sgkmacleod@worlduniversityandschool.org> wrote:
Hi Mark, 

Appreciating the genetic genealogy language in your paper ... 


The DNA of Clan MacLeod (2025)
By Mark K. MacLeod, Colin Macleod and Roderick A. F. MacLeod
WWW: Journal of Genetic Genealogy

and the name Dave Vance also came up in its regard (with a Brown University degree in CS from 1984) ...



Will read your paper further ... and re #TextInTheSidebar of a #RealisticVirtualEarthForGenealogy  #RealisticVirtualEarthForGenetics ... and could Dave Vance and Rob Spencer even help with this, potentially with Peter Norvig and Google too?

And how to connect potentially with Donna Leet MD I wonder? (And might we move in together to a newly safe open 670 Ridgecrest Rd, Canyon 94516, where I lived for about 13 years until calling the local police twice at Stanford alum too Cindy, and Byron, Hann MDs encouragement, from nearby Moraga CA)?

Regards, Hold Fast MacLeod, best wishes, 
Scott


PS

WUaS is just making contact with Rippling in SF and the US federal government and state of CA too ... regarding next steps forward - 

Scott
On Tue, May 20, 2025 at 9:48 AM Scott MacLeod <sgkmacleod@worlduniversityandschool.org> wrote:
Mark, 

Are you suggesting or proposing or hypothesizing a north of Scotland Leod MacLeod gene (since ~1300) - eg SNP BY3210 and related ones - (and if so, a further question comes to mind ... how prevalent are the SNP BY3210 and related genes in your paper ... in the rest of the 7.9 billion people in the planet ) ?

A further sociological social science anthropological thought comes to mind regarding social constructionism.

Social constructionism is a theory suggesting that many aspects of our world, including knowledge and reality, are not objective truths but are created and shaped by social interactions and cultural contexts. It argues that shared understandings, language, and cultural practices play a crucial role in defining and maintaining these constructs.

... and regarding the terms, language, names, concepts you're operatioinalizing regarding genetics. 

More later, all the best,
Scott 


On Mon, May 19, 2025 at 8:50 AM Scott MacLeod <sgkmacleod@worlduniversityandschool.org> wrote:
Mark

Fascinating and thank you for sharing your excellent paper - 

The DNA of Clan MacLeod (2025)
By Mark K. MacLeod1, Colin Macleod and Roderick A. F. MacLeod
WWW: Journal of Genetic Genealogy
 
And happy birthday further! Sounds like you had a good birthday celebration. 

Identity (anthropology and sociology-wise) and troopbondage (http://scottmacleod.com/JohnMoneyConceptsOfDeterminism.html) come to mind in reading your paper and regarding connecting a name to genes through time (big-picture-wise) ... And I'd like to iteratively make it possible to examine such (your) terms, categories, concepts and names in your paper ... in an unfolding genetic science conversation ... and in a #RealisticVirtualEarthForGenealogy (and in thinking Google Street View with time slider +). Thanks for all the great maps with genetic trajectories in your paper too, #TextInTheSidebar.

Appreciating the genetic-knowledge-look into as an affirmation of MacLeod identity. Thanks so much for publishing this in the Journal of Genetic Genealogy, and interesting to learn of - https://www.familytreedna.com/groups/acms-mac-leod/dna-results ... Am wondering if I can add teh genetic saliva test I took with Ancestry .com years ago to this ... as I did to WikiTree - https://www.wikitree.com/wiki/MacLeod-2524 some years ago. (I don't currently have an active credit card, for example, and in growing a worldwide WUaS abolition movement). I've added some of this thread here - https://scott-macleod.blogspot.com/2025/05/hawaiian-monk-seal.html - for the record.

After emailing you yesterday, I created this set of Tweets and 2 related LinkedIN posts (with useful #Hashtags, but not yet cross-platform that I know of) too in some of these regards - 

How best to dev #GenealogyResearchWU in a new direction in a #RealisticVirtualEarth, #RealisticVirtualEarthForGenealogy, #RealisticVirtualEarthForHistory, a #RealisticVirtualEarthForGenetics & re #AgingReversalGenetics & #ExtremeLongevityGenetics, w related #GeneTherapies coming?

https://x.com/scottmacleod/status/1924253472939258284

AND 
https://x.com/TheOpenBand/status/1924254804462928365

retweeting Clan MacLeod parliament picture

#ClanMacLeod Parliament is in full swing now with over 300 delegates attending the week's full programme of events. The pic shows the first Clan Parliament in 1956. The gathering of MacLeods from all over the globe was an idea of Dame Flora MacLeod, the 28th Chief of the Clan.

https://x.com/Dunvegan_Castle/status/1021747928598306816


retweeting both where my Grandfather "Sandy" Alexander Chadbourne Brown had some roots in Vinton Iowa, briefly, between being born in Boulder, CO, and going to Exeter and then MIT for school, as well as retweeting a picture of the MacLeod parliament.


Time to check out further - 

Mark K. MacLeod. 2023

The DNA of Clan MacLeod: Is Leòd our common ancestor?

https://youtu.be/-5ZGWndVWNI

Isle of Skye, Scotland: https://www.youtube.com/@markkmacleod 
(and the other 2 videos here - thanks :)
 
(May begin the 'MacLeod Society Worldwide' wiki subject / school here - https://wiki.worlduniversityandschool.org/wiki/Subjects - thanks to and with your greeat research, Mark!)  

Thanks so much, happy birthday, Friendly Quaker regards (remembering your father, Bruce), all the best, 
Scott 

Will add some of this further here too (as a form of publishing as well) - 
https://scott-macleod.blogspot.com/2025/05/hawaiian-monk-seal.html 



PS

How best to develop #GenealogyResearchWU @ #MITOCW-centric wiki #WorldUniversityAndSchool in a new direction in a #RealisticVirtualEarth, #RealisticVirtualEarthForGenealogy, #RealisticVirtualEarthForHistory, a #RealisticVirtualEarthForGenetics ? ...


How best to dev #GenealogyResearchWU in a new direction in a #RealisticVirtualEarth, #RealisticVirtualEarthForGenealogy, #RealisticVirtualEarthForHistory, a #RealisticVirtualEarthForGenetics & re #AgingReversalGenetics & #ExtremeLongevityGenetics, w related #GeneTherapies coming?

https://x.com/scottmacleod/status/1924253472939258284

https://x.com/WorldUnivAndSch/status/1924253052036682162

https://x.com/Q_YogaMacFlower/status/1924253576752517185

https://x.com/HarbinBook/status/1924254393630888430

https://x.com/sgkmacleod/status/1924253883142156636

https://x.com/WUaSPress/status/1924254076398875123



Retweeting -

Roots in #VintonIA #DesMoinesIA How could I #ScottGKMacLeod talk virtually with my mother's Pa #SandyBrown #AlexanderChadbourneBrown & #ChadbourneAncestors #wuAsVR #WUaSAR? #REALISTICVIRTUALEARTHFORHISTORY in #GoogleStreetView w #TimeSlider & for #REALISTICVIRTUALEARTHForGenealogy?

https://x.com/scottmacleod/status/1407796864662003716


AND

https://x.com/TheOpenBand/status/1924254804462928365

retweeting Clan MacLeod parliament

#ClanMacLeod Parliament is in full swing now with over 300 delegates attending the week's full programme of events. The pic shows the first Clan Parliament in 1956. The gathering of MacLeods from all over the globe was an idea of Dame Flora MacLeod, the 28th Chief of the Clan.

https://x.com/Dunvegan_Castle/status/1021747928598306816


AND similar Tweet -

How best to dev #GenealogyResearchWU in a new direction in a #RealisticVirtualEarth, #RealisticVirtualEarthForGenealogy, #RealisticVirtualEarthForHistory, a #RealisticVirtualEarthForGenetics & re #AgingReversalGenetics & #ExtremeLongevityGenetics, w related gene therapies coming?

https://x.com/Q_YogaMacFlower/status/1924252178010820761

https://x.com/scottmacleod/status/1924251904064069635

https://x.com/WorldUnivAndSch/status/1924252060876448016



https://www.linkedin.com/posts/scottgkmacleod_genealogyresearchwu-mitocw-worlduniversityandschool-activity-7330250046275256320-ioNL

https://www.linkedin.com/posts/scott-macleod-4691a011a_genealogyresearchwu-mitocw-worlduniversityandschool-activity-7330250149203509250-P_Yr


http://scottmacleod.com/family.htm

http://scottmacleod.com/ScottMacLeodFamilyHistory.htm

https://wiki.worlduniversityandschool.org/wiki/Genetics

(@ https://www.linkedin.com/in/mark-macleod-7a048916?originalSubdomain=ca)




PPS
How much are you in communication with Rob Spencer in CT, whose MIT and Pfizer background seem potentially very helpful re developments in genetic genealogy (and especially regarding a #RealisticVirtualEarthForGenealogy)?






On Sun, May 18, 2025 at 4:48 PM Scott MacLeod <sgkmacleod@worlduniversityandschool.org> wrote:
Mark, 

Happy Birthday from your 1st cousin in Middletown, CA not that far away from "Harbin Hot Springs - Heart Consciousness Church!" How are you doing? And how are you celebrating? How is your genealogy research going? (And how best to develop genealogy research in a brand new direction in a #RealisticVirtualEarth a #RealisticVirtualEarthForGeneaology, a #RealisticVirtualEarthForHistory, and a #RealisticVirtualEarthForGenetics ... and even regarding emerging aging reversal genetics and extreme longevity genetics, with related drug therapies potentially emerging ?)

Are you still 'mining' Ancestry .com for its genealogy treasures - and even sharing the following Ancestry emails occasionally (in the pS, that just came into my sgkmacleod@gmail.com email box :)?

Warm regards, 
Scott(y)






PS

Your May Update: A 50-year reunion, plus new trivia

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A reunion 50 years in the making.
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What is the name of the US Naval vessel that mysteriously vanished from the Atlantic Ocean in 1918?

1. USS Utah
2. USS Rochester
3. USS Cyclops
4. USS Aroostook

Get the full story and discover the answer at the bottom of this email.
Celebrate mom with a good read.
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Join Ancestry expert Crista Cowan as she shares how to strengthen your family tree and make new connections through the power of DNA.

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Read on for this month’s answer.
Which US vessel vanished from the sea in 1918? Here’s a hint: It’s named after a myth. Now learn more about the mystery.
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--

Society, Information Technology, and the Global University (2025, forthcoming) 

- Scott GK MacLeod  
Founder, President, CEO & Professor
CC-4 licensed MIT OCW-centric, Wiki, 
World University & School (WUaS) 
- USPS US Post Office, General Delivery, Canyon, CA 94516 


1) non-profit 501(c)(3) Public Charity 
MIT OCW-centric, 
 World University and School - http://worlduniversityandschool.org  

2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html

(m) 412 478 0116 - sgkmacleod@gmail.com 


World Univ & Sch Innovation Research -  scottmacleod.com 





* * * 

Are #WholeGenomeSequencing #WGS & -#GeneticGenealogy AND -#ExtremeLongevity & #AgingReversal #GeneticDrugTherapies ahead -in a  #RealisticVirtualEarthForGenomics ...?

Are #WholeGenomeSequencing #WGS & -#GeneticGenealogy AND -#ExtremeLongevity & #AgingReversal #GeneticDrugTherapies ahead -in a  #RealisticVirtualEarthForGenomics #GenomesWUaS https://www.nature.com/articles/d41586-021-01506-w? How could a #RealisticVirtualEarthForGenetics help? - https://scott-macleod.blogspot.com/2025/06/white-throated-kingfisher-halcyon.html ~

https://x.com/WorldUnivAndSch/status/1941159710973219226

https://x.com/WUaSPress/status/1941160452131856601

https://x.com/Q_YogaMacFlower/status/1941159960358048224

https://x.com/HarbinBook/status/1941160541399212326

https://x.com/sgkmacleod/status/1941160351757901898

https://x.com/scottmacleod/status/1941161114102059038

https://x.com/TheOpenBand/status/1941161861862572221





* 

04 June 2021
A complete human genome sequence is close: how scientists filled in the gaps
Researchers added 200 million DNA base pairs and 115 protein-coding genes — but they’ve yet to entirely sequence the Y chromosome.
By Sara Reardon

https://www.nature.com/articles/d41586-021-01506-w





* 

whole genome sequencing and extreme longevity & aging reversal genetic drug therapies -  is this ahead?

Yes, whole-genome sequencing (WGS) and genetic drug therapies related to aging reversal and extreme longevity are promising areas of research that are actively advancing, with the potential for significant future breakthroughs. 
Here's why and what that entails:
1. Whole-Genome Sequencing (WGS) & Longevity Research:
  • WGS provides insights into rare genetic variants associated with healthy aging and extreme longevity (EL).
  • Studying individuals with extreme longevity, such as centenarians and semi-supercentenarians, allows researchers to assess the impact of genetic variability on this trait.
  • WGS can lead to the identification of key genes and pathways that contribute to human longevity and healthy aging.
  • Advances in sequencing technologies have made WGS more accessible and affordable, enabling widespread adoption in research and potentially in clinical settings for rare genetic disorders. 
2. Aging Reversal and Genetic Drug Therapies:
  • Genetic therapies have been shown to extend lifespan and reduce age-related deficits in model organisms like mice, for example, by utilizing genetic reprogramming.
  • Studies have demonstrated the potential to reverse cellular aging without causing cells to become cancerous, opening avenues for therapeutic interventions.
  • Chemical approaches to reprogramming cells to a younger state are being explored, offering a potential alternative to gene therapy.
  • Partial cellular reprogramming has shown promise in extending lifespan in mice, potentially paving the way for clinical applications.
  • Numerous companies are actively developing gene therapies and other aging therapeutics. 
3. Specific Examples of Progress:
  • Researchers using WGS data identified a longevity-associated variant in the SLC9A2 gene, which was linked to reduced hypertension risk and potentially increased cancer risk.
  • A promising gene therapy intervention involving Yamanaka factors extended the remaining lifespan of very old mice.
  • Harvard scientists have identified a chemical drug cocktail that may reverse aging.
  • Researchers have identified more than 100 genes associated with rejuvenation mechanisms. 
4. Looking Ahead:
  • Continued research utilizing WGS and advanced genetic technologies is crucial for understanding the complex mechanisms of aging.
  • Developing therapies based on these findings holds potential for treating age-related diseases, improving healthspan, and potentially extending lifespan.
  • However, it's important to acknowledge that the field is still in its early stages, and there are significant challenges to overcome before these therapies are widely available to humans. 
In summary, while aging reversal and extreme longevity through genetic drug therapies are not yet a widespread reality, the rapid advancements in WGS technology and the encouraging results from research in model organisms and initial human studies suggest that these approaches hold tremendous potential and are on the horizon. Ethical considerations, safety concerns, and the need for further research and clinical trials are vital aspects to address in the development and implementation of these groundbreaking therapies



* 
whole genome sequencing and genetic genealogy - is this ahead?

Whole-genome sequencing (WGS) is advancing rapidly and holds significant promise for genetic genealogy, particularly in providing a much more comprehensive view of an individual's ancestry compared to current standard methods. 
Here's why WGS is considered to be "ahead" or the future of genetic genealogy:
  • Comprehensive Data: WGS analyzes the entire genome, including both coding and noncoding regions, offering a complete picture of an individual's genetic makeup. This provides a higher resolution and allows for the identification of a wider range of genetic variations relevant to tracing ancestry and understanding population history.
  • Overcoming Limitations of Current Methods: Current ancestry tests, primarily based on single nucleotide polymorphisms (SNPs), analyze only a fraction of the genome. WGS overcomes this limitation by capturing all genetic information, including larger structural variations and regions that are difficult to analyze with SNP-based tests, leading to more detailed and accurate genealogical insights.
  • Cost Reduction: The cost of WGS has decreased dramatically, making it more accessible for genealogical research. Some technologies are even approaching the $100 mark when performed at scale.
  • Improved Accuracy: WGS offers a higher resolution and more accurate identification of genetic variants compared to traditional methods. This allows for the tracing of ancestral lineages with greater precision.
  • Potential for Integration: WGS data can be combined with traditional genealogical research and other "omics" data (like transcriptomics and epigenomics) to create a more comprehensive understanding of family history. 
However, it's important to acknowledge that there are still some challenges to address:
  • Data Interpretation: WGS generates a large amount of complex data that requires extensive analysis and interpretation by specialists.
  • Privacy Concerns: The comprehensive nature of WGS raises concerns about data privacy and the potential for misuse of genetic information.
  • Lack of Understanding: General public understanding of genetics and the ethical issues involved in WGS is still developing. 
Despite these challenges, the continued advancements in technology and decreasing costs suggest that WGS is becoming increasingly important and is likely to become the standard for genetic genealogy in the future

--


Society, Information Technology, and the Global University (2025, forthcoming) 

- Scott GK MacLeod  
Founder, President, CEO & Professor
CC-4 licensed MIT OCW-centric, Wiki, 
World University & School (WUaS) 
- USPS US Post Office, General Delivery, Canyon, CA 94516 


1) non-profit 501(c)(3) Public Charity 
MIT OCW-centric, 
 World University and School - http://worlduniversityandschool.org  

2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html

(m) 412 478 0116 - sgkmacleod@gmail.com 


World Univ & Sch Innovation Research -  scottmacleod.com 







* 









https://www.shanghaibirding.com/birds-of-china/white-throated-kingfisher/



https://static.wikia.nocookie.net/animals/images/5/58/White-throated_kingfisher.jpg/revision/latest?cb=20191117222853


https://upload.wikimedia.org/wikipedia/commons/thumb/c/c8/White-throated_kingfisher_%28Halcyon_smyrnensis%29_Galle.jpg/1200px-White-throated_kingfisher_%28Halcyon_smyrnensis%29_Galle.jpg













https://en.wikipedia.org/wiki/White-throated_kingfisher


https://commons.wikimedia.org/wiki/Category:Halcyon_smyrnensis

https://species.wikimedia.org/wiki/Halcyon_smyrnensis

...



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