Dear All, Byron & Cindy, Donna, Ed, (ABCDE), Drs., (Byron & Cindy (Hann MDs), Ed (Smyth MD, Kaiser Permanente NorCal, I think)), Pin/Sid (Mazumdar HHS), Peter (Norvig, Google AI), George (Church, Harvard Med Sch), US Senator Alex Padilla from CA, Lt. John (Tadler, Allegheny County Police in Pgh, and re FBI workshop in 2013), US Senator from MA and former Harvard Law Professor Elizabeth Warren),
Happy Independence Day!
All the best, abolition-ally, Friendly regards,
Scott
And see today's blog post F 7/4/25 -
PS
Am supposed to have an ancestor who accepted the sword of surrender from the British in the American Revolution, and fought in Shays' Rebellion, and see - https://scott-macleod.
AI Overview
"Benjamin Lincoln accepted the sword of surrender from the British on October 19, 1781, at Yorktown, Virginia, during the surrender ceremony that formally ended the Siege of Yorktown and the American Revolutionary War's major land battles. While General Cornwallis did not personally surrender, he sent his second-in-command, General Charles O'Hara, to surrender to Lincoln, who represented General Washington"
His name is on a plaque in front of the Unitarian Universalist Church in Concord MA ... and he lived in Hingham MA which home I visited October 11, 2024 (and here are 3 photos - https://photos.app.goo.gl/
Here's his WikiTree wiki genealogical tree entry - https://www.wikitree.com/
Happy American Independence Day!
Society, Information Technology, and the Global University (2025, forthcoming)
Scottish Small Piping album #2 - Honey Piobaireachd (2022)
- https://twitter.com/
Scottish Small Piping album #1 Honey in the Bag ~ Out of the Air tune (2020)
Order Book #4 To the Dance or the Pools? ~ Virtually! How different it is to soak at Harbin Hot Springs, than to realize it in virtual reality (2019)
Order Book #3 Winding Road Rainbow: Harbin, Wandering & the Poetry of Loving Bliss (2018)
Order Book #2 Haiku-ish and Other Loving Hippie Harbin Poetry (2017)
Order Actual-Virtual Ethnographic Book #1: Naked Harbin Ethnography (2016)
- Scott GK MacLeod
Founder, President, CEO & Professor
CC-4 licensed MIT OCW-centric, Wiki,
World University & School (WUaS)
- USPS US Post Office, General Delivery, Canyon, CA 94516
1) non-profit 501(c)(3) Public Charity
MIT OCW-centric,
World University and School - http://
2) for profit general stock company WUaS Corporation in CA - http://
(o) 415 480 4577 - sgkmacleod@
(m) 412 478 0116 - sgkmacleod@gmail.com
World Univ & Sch Innovation Research - scottmacleod.com
* * *
Are #WholeGenomeSequencing #WGS & -#GeneticGenealogy AND -#ExtremeLongevity & #AgingReversal #GeneticDrugTherapies ahead -in a #
Are #WholeGenomeSequencing #WGS & -#GeneticGenealogy AND -#ExtremeLongevity & #AgingReversal #GeneticDrugTherapies ahead -in a #
https://x.com/WUaSPress/
https://x.com/Q_YogaMacFlower/
https://x.com/HarbinBook/
https://x.com/sgkmacleod/
https://x.com/scottmacleod/
https://x.com/TheOpenBand/
Are #WholeGenomeSequencing #WGS & -#GeneticGenealogy AND -#ExtremeLongevity & #AgingReversal #GeneticDrugTherapies ahead -in a #RealisticVirtualEarthForGenomics #GenomesWUaS https://t.co/3XZzYEaWHM? How could a #RealisticVirtualEarthForGenetics help? - https://t.co/y0k4qqNwyF ~
— WorldUnivandSch (@WorldUnivAndSch) July 4, 2025
https://x.com/Q_YogaMacFlower/
https://x.com/HarbinBook/
https://x.com/sgkmacleod/
https://x.com/scottmacleod/
https://x.com/TheOpenBand/
*
04 June 2021
A complete human genome sequence is close: how scientists filled in the gaps
Researchers added 200 million DNA base pairs and 115 protein-coding genes — but they’ve yet to entirely sequence the Y chromosome.
By Sara Reardon
https://www.nature.com/
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whole genome sequencing and extreme longevity & aging reversal genetic drug therapies - is this ahead?
Yes, whole-genome sequencing (WGS) and genetic drug therapies related to aging reversal and extreme longevity are promising areas of research that are actively advancing, with the potential for significant future breakthroughs.
Here's why and what that entails:
1. Whole-Genome Sequencing (WGS) & Longevity Research:
- WGS provides insights into rare genetic variants associated with healthy aging and extreme longevity (EL).
- Studying individuals with extreme longevity, such as centenarians and semi-supercentenarians, allows researchers to assess the impact of genetic variability on this trait.
- WGS can lead to the identification of key genes and pathways that contribute to human longevity and healthy aging.
- Advances in sequencing technologies have made WGS more accessible and affordable, enabling widespread adoption in research and potentially in clinical settings for rare genetic disorders.
2. Aging Reversal and Genetic Drug Therapies:
- Genetic therapies have been shown to extend lifespan and reduce age-related deficits in model organisms like mice, for example, by utilizing genetic reprogramming.
- Studies have demonstrated the potential to reverse cellular aging without causing cells to become cancerous, opening avenues for therapeutic interventions.
- Chemical approaches to reprogramming cells to a younger state are being explored, offering a potential alternative to gene therapy.
- Partial cellular reprogramming has shown promise in extending lifespan in mice, potentially paving the way for clinical applications.
- Numerous companies are actively developing gene therapies and other aging therapeutics.
3. Specific Examples of Progress:
- Researchers using WGS data identified a longevity-associated variant in the SLC9A2 gene, which was linked to reduced hypertension risk and potentially increased cancer risk.
- A promising gene therapy intervention involving Yamanaka factors extended the remaining lifespan of very old mice.
- Harvard scientists have identified a chemical drug cocktail that may reverse aging.
- Researchers have identified more than 100 genes associated with rejuvenation mechanisms.
4. Looking Ahead:
- Continued research utilizing WGS and advanced genetic technologies is crucial for understanding the complex mechanisms of aging.
- Developing therapies based on these findings holds potential for treating age-related diseases, improving healthspan, and potentially extending lifespan.
- However, it's important to acknowledge that the field is still in its early stages, and there are significant challenges to overcome before these therapies are widely available to humans.
In summary, while aging reversal and extreme longevity through genetic drug therapies are not yet a widespread reality, the rapid advancements in WGS technology and the encouraging results from research in model organisms and initial human studies suggest that these approaches hold tremendous potential and are on the horizon. Ethical considerations, safety concerns, and the need for further research and clinical trials are vital aspects to address in the development and implementation of these groundbreaking therapies
*
whole genome sequencing and genetic genealogy - is this ahead?
Whole-genome sequencing (WGS) is advancing rapidly and holds significant promise for genetic genealogy, particularly in providing a much more comprehensive view of an individual's ancestry compared to current standard methods.
Here's why WGS is considered to be "ahead" or the future of genetic genealogy:
- Comprehensive Data: WGS analyzes the entire genome, including both coding and noncoding regions, offering a complete picture of an individual's genetic makeup. This provides a higher resolution and allows for the identification of a wider range of genetic variations relevant to tracing ancestry and understanding population history.
- Overcoming Limitations of Current Methods: Current ancestry tests, primarily based on single nucleotide polymorphisms (SNPs), analyze only a fraction of the genome. WGS overcomes this limitation by capturing all genetic information, including larger structural variations and regions that are difficult to analyze with SNP-based tests, leading to more detailed and accurate genealogical insights.
- Cost Reduction: The cost of WGS has decreased dramatically, making it more accessible for genealogical research. Some technologies are even approaching the $100 mark when performed at scale.
- Improved Accuracy: WGS offers a higher resolution and more accurate identification of genetic variants compared to traditional methods. This allows for the tracing of ancestral lineages with greater precision.
- Potential for Integration: WGS data can be combined with traditional genealogical research and other "omics" data (like transcriptomics and epigenomics) to create a more comprehensive understanding of family history.
However, it's important to acknowledge that there are still some challenges to address:
- Data Interpretation: WGS generates a large amount of complex data that requires extensive analysis and interpretation by specialists.
- Privacy Concerns: The comprehensive nature of WGS raises concerns about data privacy and the potential for misuse of genetic information.
- Lack of Understanding: General public understanding of genetics and the ethical issues involved in WGS is still developing.
Despite these challenges, the continued advancements in technology and decreasing costs suggest that WGS is becoming increasingly important and is likely to become the standard for genetic genealogy in the future
--
Society, Information Technology, and the Global University (2025, forthcoming)
Scottish Small Piping album #2 - Honey Piobaireachd (2022)
- https://twitter.com/
Scottish Small Piping album #1 Honey in the Bag ~ Out of the Air tune (2020)
Order Book #4 To the Dance or the Pools? ~ Virtually! How different it is to soak at Harbin Hot Springs, than to realize it in virtual reality (2019)
Order Book #3 Winding Road Rainbow: Harbin, Wandering & the Poetry of Loving Bliss (2018)
Order Book #2 Haiku-ish and Other Loving Hippie Harbin Poetry (2017)
Order Actual-Virtual Ethnographic Book #1: Naked Harbin Ethnography (2016)
- Scott GK MacLeod
Founder, President, CEO & Professor
CC-4 licensed MIT OCW-centric, Wiki,
World University & School (WUaS)
- USPS US Post Office, General Delivery, Canyon, CA 94516
1) non-profit 501(c)(3) Public Charity
MIT OCW-centric,
World University and School - http://
2) for profit general stock company WUaS Corporation in CA - http://
(o) 415 480 4577 - sgkmacleod@
(m) 412 478 0116 - sgkmacleod@gmail.com
World Univ & Sch Innovation Research - scottmacleod.com
* * *
When will Toyota humanoid robots enter daily use in Japan?
Toyota to open world’s first robot city later this year, and other technology news you need to know
Jun 18, 2025
Jun 18, 2025
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When will #ToyotaHumanoidRobots enter daily use in Japan? "Toyota to open world’s first #RobotCity later this year" 6/18/25 https://www.weforum.org/
When will #ToyotaHumanoidRobots enter daily use in Japan? "Toyota to open world’s first #RobotCity later this year" 6/18/25 https://t.co/ILWCb14dMp & How could @WorldUnivAndSch #WUaSstudents w #WUaSHomeRobotics help in a #RealisticVirtualEarthForRobotics https://t.co/8Kx5cOWGm5 ?
— WorldUnivandSch (@WorldUnivAndSch) July 4, 2025
https://x.com/WorldUnivAndSch/
https://x.com/Q_YogaMacFlower/
https://x.com/HarbinBook/
https://x.com/TheOpenBand/
https://x.com/sgkmacleod/
https://x.com/scottmacleod/
https://x.com/WUaSPress/
* *
How could @WorldUnivAndSch bring virtual #HumanoidRobots into daily life both virtually w this world’s 1st #ToyotaRobotCity later this year 6/18/25 https://www.weforum.org/
How could @WorldUnivAndSch bring virtual #HumanoidRobots into daily life both virtually w this world’s 1st #ToyotaRobotCity later this year 6/18/25 https://t.co/ILWCb14dMp AND in peoples' homes w #WUaSHomeRobotics in all 200 countries /main langs with #WUaSLegoRobotics to start?
— WorldUnivandSch (@WorldUnivAndSch) July 6, 2025
https://x.com/WorldUnivAndSch/
https://x.com/Q_YogaMacFlower/
https://x.com/scottmacleod/
https://x.com/WUaSPress/
https://x.com/sgkmacleod/
https://x.com/HarbinBook/
https://x.com/TheOpenBand/
*
.webp)
https://en.wikipedia.org/wiki/Allium_giganteum
https://commons.wikimedia.org/wiki/Allium_giganteum
https://commons.wikimedia.org/wiki/Category:Allium_giganteum
https://www.theguardian.com/lifeandstyle/2017/sep/17/ornamental-bulbs-alliums-you-can-eat-james-wong
https://en.wikipedia.org/wiki/Allium
...
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