Thursday, September 10, 2026

Godwits: MIT Alumni Startups' NorCal Co-working space at Goodwin's in SF Th Sep 10, 2026 * * * How best for #GrowWithGoogleWUaS @WorldUnivAndSch to possibly interoperate our #AvatarAgentElectronicHealthRecords the Pharma.AI platform re #PandaOmics #Chemistry42 #InSilicoMeds - in a #RealisticVirtualEarth ? * * * How to create a #RealisticVirtualEarthForHistory & add eg 9/11 too re & from #InternetArchive - to create history anew & w #HistoryWikiVirtualWorldGraphy as new theory & method @WorldUnivAndSch & think #GoogleStreetView w #GTimeSlider to which we can add?

 


MIT Alumni Startups' NorCal Co-working space at Goodwin's in SF Th Sep 10, 2026



from:Scott MacLeod sgkmacleod@worlduniversityandschool.org
to:
date:Sep 10, 2026, 4:50 PM
subject:MIT Alumni Startups NorCal Co-working space at Goodwin's Th Sep 10, 2026
mailed-by:worlduniversityandschool.org



Dear Dane, Shuja, (Roland), All, 

Thanks so much for the 

MIT Alumni Startups NorCal 9-5 Co-working space at Goodwin's in SF Th Sep 10, 2026.


Here in Agenda item 2 are the WUaS questions I and World Univ & School, building on CC4 MIT Open Course Ware in 7 languages, would like to explore further with you in these 3 9-5 MITAS coworking spaces at Goodwin's this autumn , perhaps better initially in writing -



Thanks so much, and perhaps we can talk further about these in October as free-to-students' WUaS develops further.


Best regards, 
Scott
Scott GK MacLeod 





Thursday, September 10, 2026 in SF - 

New for MITAS Founders: Co-working & Office Hours at Goodwin

Building a startup doesn't have to be a solo journey. This fall, MITAS is launching a new Founder Co-Working Program in partnership with Goodwin, giving selected founders a dedicated workspace alongside access to experienced startup attorneys.


Participants will have the opportunity to work from Goodwin's San Francisco office, connect with fellow MIT founders, and take advantage of office hours covering topics such as company formation, fundraising, intellectual property, commercial agreements, compliance, and M&A.

The first co-working sessions will be held at Goodwin's San Francisco office (525 Market Street) on:

The program is complimentary for selected MITAS members, but space is limited, and participation is by application.


2 A
WUaS initial questions & items for attorneys potentially ... 



2 A i

intellectual property - 

a
between both WUaS wings - and re CC-4 licensed World University and School being Creative Commons' licensed building on CC-4 MIT OCW in 7 languages 


b


and in developing WUaS in all 200 countries and in their main languages, and in all 7,159 living languages 

and in seeking to develop further Creative Commons licensing ... but also develop WUaS intellectual property 



2 A ii
commercial agreements - 

c
between both WUaS wings 


d
with Abstract-Technology.de + open 3dX Europe platform 

e
with Gushwork for building WUaS web pages ahead +



f
Walmart-WUaS partnership for store in a store model 


g
and leading to a WUaS Corporation IPO potentially ...


h
re Stanford Mine Pi cryptocurrency-WUaS partnering communications ? 



h i 
and the Mainnet Blockchain ?

h ii 
and re a WUaS Corporation IPO too ...


2 A iii
compliance 

i 
for listing a WUaS Corporation IPO on say a stock market, or multi listing on all 200 countries' main stock markets even - and re Pi Cryptocurrency and re our physical-digital WUaS Educational Services' Stores, and the Academic Press at WUaS planned in 7159 living languages, publish to 1) paper, and 2) from Text in the Sidebar of Google Street View with time slider  ? 



2 A iii 
investment agreements - 

re Agenda item B below re Ittihad in the United Arab Emirates, for example 




2 A iv

j
fundraising 

grant write for this with https://simpler.grants.gov/ for coding for both of these WUaS wings?



from - 

Rwenzori Mountains, Uganda: Recording of Tu 9/8/26 @WorldUnivAndSch @WUaSPress #WUaSNewsAndQA #WUaSWeeklyBusinessMeeting #RealisticVirtualEarth ~ * (was- Tu 9/8/26 & M 9/14/26 open best STEAM Creative Commons' licensed OpenCourseWare wiki World Univ & Sch WUaS News and Q&A, with Zoom URL)







--

Society, Information Technology, and the Global University, (forthcoming, Academic Press at World University and School, 2026) 

Scottish Small Piping album #2 - Honey Piobaireachd (2022)
- Poetry! Order Book #5 Light, Float, Sit, Watsu ~ Virtually (2021, Academic Press at WUaS)

Scottish Small Piping album #1 Honey in the Bag ~ Out of the Air tune (2020)


Order Book #3 Winding Road Rainbow: Harbin, Wandering & the Poetry of Loving Bliss (2018,  Academic Press at WUaS)

Order Book #2 Haiku-ish and Other Loving Hippie Harbin Poetry (2017,  Academic Press at WUaS) 

Order Actual-Virtual Ethnographic Book #1: Naked Harbin Ethnography (2016, Academic Press at World University and School)



- Scott GK MacLeod  
Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki,
World University & School (WUaS)  
- USPS US Post Office, PO Box 132, General Delivery, Canyon, CA 94516

1) non-profit 501(c)(3) Public Charity
building on CC-4 licensed MIT OCW in 7 languages - 


2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html
- wuas_ceo@worlduniversityandschool.org


https://wiki.worlduniversityandschool.org/wiki/Nation_States (planning ~200 countries' WUaS world class universities in their main languages, per the Olympics, for free-to-students' WUaS degrees from home)

https://wiki.worlduniversityandschool.org/wiki/Languages (planning to be in all 7159 living languages, each as or with wiki schools for open people-to-people wiki-teaching and wiki-learning, e.g. from here - https://wiki.worlduniversityandschool.org/wiki/Subjects)







* 


Hi Akhilan,  Hillary, Jingyun, Zack, Shuja, 

Very nice to meet and talk with you at the MIT Alumni Startups NorCal Co-working space Th Sep 10, 2026 in SF. 


More about  World University and School / WUaS below in the PS, and also what I shared with Akhilan, below that, and re Aging Reversal Genetics -  https://wiki.worlduniversityandschool.org/wiki/Aging_Reversal_Genetics - for example.
  
How to interoperate aspects of what we're working in a #RealisticVirtualEarthFor everything - and here's #PeterNorvig's INCREDIBLE #ToolifyAIWUaS article Revolutionizing Education with Machine Learning and AI" - https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306 mentioning a #RealisticVirtualEarth for the first time that I know of other than by WUaS.

Best regards, 
Scott









PPS 

What is #ReversingTheArrowOfTime in these #GQuantumEchoes ? & & #RealisticVirtualHarbin Hot Springs below re How to #GTimeSlide to years 2007, '12 & '24 


Hi Akhilan, 

Great to meet you and thanks. 


#ReversingTheArrowOfTime  & #RealisticVirtualHarbin Hot Springs below re 

How with #GeneralBiologicalIntelligenceAI to #GTimeSlide to years 2007, '12 & '24  https://goo.gl/maps/7gSsSTweRCBo9gf87 AND when we were 7, 12 & 24 in #GStreetView w #GTimeSlider @HarbinBook re WITH #AgingReversal & #ExtremeLongevity #AvatarAgentEHR?


Thank you, Namaste, Yogically (as in 8 limbs of Yoga), best regards, 
Scott









How best can @WorldUnivAndSch in #GrowWithGoogleWUaS program w the #GQuantumComputer in these #GQuantumEchoes - https://youtube.com/shorts/AFhuNsebOpA INTEROPERATE this FWD & REWIND of ink drop @ 5 secs w #OSK & #AvatarAgentEHR 
#ReversingTheArrowOfTime in a #RealisticVirtualEarthForGenetics ?



AND 

How best can @WorldUnivAndSch in a #GrowWithGoogleWUaS program w the #GQuantumComputer @ #UCSB in these #GQuantumEchoes - https://youtube.com/shorts/AFhuNsebOpA INTEROPERATE this FWD & REWIND of ink drop @ 5 secs with #OSK & #AvatarAgentEHR 
#ReversingTheArrowOfTime in a #RealisticVirtualEarthForQuantum #ForAgingReversal #ForGenetics ?






*

Google Quantum Echoes' Youtube video - 
and re 'reversing the arrow of time' ? 






What is Reversing The Arrow Of Time here in these Quantum Super Echoes - https://youtube.com/shorts/AFhuNsebOpA and how could this be developed to determine complex molecular structures for aging reversal and extreme longevity genetic drUg therapies emerging FDA approved and with the Google Quantum computer at UCSB for ex?


What is "Reversing the Arrow of Time" in Quantum Super Echoes?

In classical physics, entropy dictates that once a system scrambles—like a drop of ink dissolving in the ocean—it is practically impossible to perfectly undo [00:08]. However, in the quantum realm, Google Quantum AI's "Quantum Echoes" algorithm utilizes a time-reversal protocol that mimics rewinding the clock [00:15].

The mechanism works through Out-of-Time-Order Correlators (OTOCs) run on Google's 105-qubit Willow chip:

  1. Forward Evolution: A carefully crafted quantum signal is sent forward through the quantum processor, allowing qubits to interact and scramble information [00:34].
  2. Perturbation (The Tweak): A slight perturbation or "tweak" is applied to one of the qubits [00:34].
  3. Backward Evolution (The Rewind): The quantum system's evolution is precisely reversed [00:34].
  4. Constructive Interference: Because the quantum state is reversed, the signal "unscrambles" itself and constructive interference amplifies a return signal—the "Quantum Echo" [00:41].

This allows scientists to rescue complex, weak quantum signals that would normally be lost to noise or classical decay, acting essentially as a quantum microscope [01:45].

Developing This for Aging Reversal & Extreme Longevity Genetic Drug Therapies

To advance extreme longevity research and develop genetic drug therapies that can successfully clear FDA-approval pipelines, we must understand exactly how molecules interact at the atomic scale. Historically, Google Quantum AI's hardware research has been closely integrated with the University of California, Santa Barbara (UCSB).

Using the Willow chip's verifiable quantum advantage—which completes in 2 hours what would take a classical supercomputer roughly 13,000 times longer [00:48]—this technology can be developed to accelerate drug discovery in several key ways:

1. A High-Precision "Molecular Ruler" for NMR

In proof-of-principle work with UC Berkeley, Google applied this algorithm to perform NMR (Nuclear Magnetic Resonance) spectroscopy on organic molecules [01:12]. NMR is the standard tool used by biochemists to determine molecular geometry. Quantum echoes allow NMR to act as a much "longer" molecular ruler, resolving atomic distances and 3D structures that conventional methods simply cannot reach.

2. Resolving Protein Folding in Aging Pathways

Many aging-related diseases and longevity targets involve complex, misfolded proteins or intricate epigenetic regulators. Quantum computing can simulate protein folding in their natural medium [01:31], bypassing classical computational bottlenecks. Scaling this technique to molecules with 50 to 60 spins will allow researchers to accurately model how longevity therapies fold and bind [01:26].

3. Mapping Exact Drug-Target Binding

Before an extreme-longevity genetic therapy or small molecule can win FDA approval, researchers must prove exactly how and where it binds to its target receptors to minimize off-target side effects. A quantum microscope powered by Willow can map these drug-target interfaces at unprecedented resolutions, dramatically shortening the pre-clinical trial design phase and optimizing drug efficacy.

To learn more about how Google is scaling this technology from theory to physical biochemistry, you can watch the full video on the Google Research YouTube Channel.







*

What is Reversing The Arrow Of Time here in these Quantum Super Echoes - https://youtube.com/shorts/AFhuNsebOpA and how could this be developed to determine complex molecular structures for aging reversal and extreme longevity genetic drUg therapies emerging FDA approved and with the Google Quantum computer at UCSB for ex?







PPS

8/15/26 #YogaAndLongevityGeneticsConvo - https://scott-macleod.blogspot.com/2026/08/american-lotus-nelumbo-lutea.html Combine #LanguageOfDNA #TextInTheSideBarForDNA w #DNApictures w #GeneralBiologicalIntelligenceAI to help #AgingReversal w #AvatarAgentEHR & #GTimeSlide in #GStreetView > 2007 '12 & '24 @ https://goo.gl/maps/7gSsSTweRCBo9gf87 ~

https://x.com/WorldUnivAndSch/status/2088739316390617502

https://x.com/Q_YogaMacFlower/status/2088739420929409429




PPSa


exploring an 8/1/26 #YogaAndLongevityGeneticsConvo -https://scott-macleod.blogspot.com/2026/07/twin-flower-linnaea-borealis.html?
How with #GeneralBiologicalIntelligenceAI to #GTimeSlide to years 2007, 2012 & 2024 AND when we were 7, 12 & 24 in #GStreetView w #GTimeSlider @  https://goo.gl/maps/7gSsSTweRCBo9gf87 ~ #AgingReversal #AvatarAgentEHR?






EXPANDED -
exploring an 8/1/26 #YogaAndLongevityGeneticsConvo -
How with #GeneralBiologicalIntelligenceAI to #GTimeSlide to years 2007, 2012 & 2024 AND when we were 7, 12 & 24 in #GStreetView w #GTimeSlider @ #HarbinGateHouse re ~ https://goo.gl/maps/7gSsSTweRCBo9gf87 ~ WITH #AgingReversal & #ExtremeLongevity #AvatarAgentEHR?



AND 
George Church. 

Centers For Age Control Inc Developer of AgeMeter®
@agemeter
Acclaimed Scientist Dr. George Church Describes Your Need For AgeMeter®️ Functional Age Test
Info and Shipping for Medical Practices https://bit.ly/3WMqPdz
Info and Download for Consumer iPad App https://bit.ly/3WSrni4
#AgeMeter #Longevity #Health #Wellness #FunctionalAgeTest

https://x.com/agemeter/status/1824963816007835788





* 


red everlasting (#ElichrysumSanguineum): #Qubits, Yoga, & #AgingReversal w #GQubit, AND #FilmToAvatarAgentYogaTeachers such as #YoginiAngelaFarmer AND.. EXPERIMENTING? - Restorative Yoga class on Saturdays (and #AsWeMayLiveTo150andWellBeyond:)?
https://scott-macleod.blogspot.com/2026/07/red-everlasting-elichrysum-sanguineum.html #WUaSyoga ~

https://x.com/WorldUnivAndSch/status/2080837177362268342

https://x.com/Q_YogaMacFlower/status/2080838174461559280

https://x.com/scottmacleod/status/2080868318035267652

https://x.com/scottmacleod/status/2080837314209894510

https://x.com/HarbinBook/status/2080837942285840690

https://x.com/WUaSPress/status/2080838048259227831

https://x.com/sgkmacleod/status/2080837736664383997

https://x.com/TheOpenBand/status/2080814649491202281



retweeting -

Helichrysum sanguineum 😁

#Flowers #RedEverlasting #HelichrysumSanguineum

https://x.com/gontanokoneroku/status/1922079352000545013


no retweet - 

https://x.com/HarbinBook/status/2080814333945409651

https://x.com/sgkmacleod/status/2080814410805960818





PPPS

Open WUaS Weekly Business Meeting generally on Mondays at 10 am PT, FYI - 

Rwenzori Mountains, Uganda: Recording of Tu 9/8/26 @WorldUnivAndSch @WUaSPress #WUaSNewsAndQA #WUaSWeeklyBusinessMeeting #RealisticVirtualEarth ~ * (was- Tu 9/8/26 & M 9/14/26 open best STEAM Creative Commons' licensed OpenCourseWare wiki World Univ & Sch WUaS News and Q&A, with Zoom URL)








*

from:Scott MacLeod sgkmacleod@worlduniversityandschool.org
to:
date:Sep 10, 2026, 3:41 PM
subject:Re: MIT Alumni Startups NorCal Co-working space Th Sep 10, 2026
mailed-by:worlduniversityandschool.org

 


Hi Johnny, Dan, and Akhilan, Hillary, Jingyun, Zack, Shuja, 

Very nice to meet you!

A question for you and MIT Alumni Startups in ~28 countries ... and potentially in all 200 countries, if WUaS can help with this - 



best regards, 
Scott 



- Scott GK MacLeod  
Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki,
World University & School (WUaS)  
- USPS US Post Office, PO Box 132, General Delivery, Canyon, CA 94516

1) non-profit 501(c)(3) Public Charity
building on CC-4 licensed MIT OCW in 7 languages - 


2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html
- wuas_ceo@worlduniversityandschool.org


https://wiki.worlduniversityandschool.org/wiki/Nation_States (planning ~200 countries' WUaS world class universities in their main languages, per the Olympics, for free-to-students' WUaS degrees from home)

https://wiki.worlduniversityandschool.org/wiki/Languages (planning to be in all 7159 living languages, each as or with wiki schools for open people-to-people wiki-teaching and wiki-learning, e.g. from here - https://wiki.worlduniversityandschool.org/wiki/Subjects)







Jingyun MIT
https://www.linkedin.com/in/jyfan/

jingyun@budailabs.org
budailabs.org



Hilary mit alum 6.2
drkelf@alum.mit.edu
LinkedIn ?



Akhilan Boopathy - 
https://www.linkedin.com/in/akhilanb/ 
Kuai
We provide algorithms to train foundation models faster and cheaper.


Dan Rahill 




* * 


Stanford [codex_group_meetings] Looking for AI Safety Expert

External
Inbox

Roland Vogl

12:51 PM (8 hours ago)
to codex_group_meetings
Hi Everyone,

A prominent litigation law firm is looking for an expert with technical depth in how modern language models are built, trained, evaluated, and deployed, ideally with a background in AI safety or alignment. The expert must also be able to explain these issues clearly in expert reports, depositions, and live testimony. If you're interested, email me and I will connect you. 

Best,
Roland


************************************
Co-founder and Executive Director
Executive Director and Lecturer 
_______________________________________________
codex_group_meetings mailing list
codex_group_meetings@lists.stanford.edu
https://mailman.stanford.edu/mailman/listinfo/codex_group_meetings


* 


from:Scott MacLeod sgkmacleod@worlduniversityandschool.org
to:
date:Sep 10, 2026, 3:09 PM
subject:Re: [codex_group_meetings] Looking for AI Safety Expert
mailed-by:worlduniversityandschool.org


Hi Roland, and Johnny, 

We're at a MIT Alumni Startups NorCal 1st co-working session in SF, and MIT alum Johnny Choi is an AI safety expert - https://www.linkedin.com/in/johnny-choi-b4154038/ more on the physical side than languages models side ... 

All the best, 
Scott




--



--

Society, Information Technology, and the Global University, (forthcoming, Academic Press at World University and School, 2026) 

Scottish Small Piping album #2 - Honey Piobaireachd (2022)
- Poetry! Order Book #5 Light, Float, Sit, Watsu ~ Virtually (2021, Academic Press at WUaS)

Scottish Small Piping album #1 Honey in the Bag ~ Out of the Air tune (2020)


Order Book #3 Winding Road Rainbow: Harbin, Wandering & the Poetry of Loving Bliss (2018,  Academic Press at WUaS)

Order Book #2 Haiku-ish and Other Loving Hippie Harbin Poetry (2017,  Academic Press at WUaS) 

Order Actual-Virtual Ethnographic Book #1: Naked Harbin Ethnography (2016, Academic Press at World University and School)



- Scott GK MacLeod  
Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki,
World University & School (WUaS)  
- USPS US Post Office, PO Box 132, General Delivery, Canyon, CA 94516

1) non-profit 501(c)(3) Public Charity
building on CC-4 licensed MIT OCW in 7 languages - 


2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html
- wuas_ceo@worlduniversityandschool.org


https://wiki.worlduniversityandschool.org/wiki/Nation_States (planning ~200 countries' WUaS world class universities in their main languages, per the Olympics, for free-to-students' WUaS degrees from home)

https://wiki.worlduniversityandschool.org/wiki/Languages (planning to be in all 7159 living languages, each as or with wiki schools for open people-to-people wiki-teaching and wiki-learning, e.g. from here - https://wiki.worlduniversityandschool.org/wiki/Subjects)









* * * 


How best for #GrowWithGoogleWUaS @WorldUnivAndSch to possibly interoperate our #AvatarAgentElectronicHealthRecords  the Pharma.AI platform re #PandaOmics  #Chemistry42  #InSilicoMeds - in a #RealisticVirtualEarth ?


How best for #GrowWithGoogleWUaS @WorldUnivAndSch to possibly interoperate our #AvatarAgentElectronicHealthRecords  the Pharma.AI platform re #PandaOmics 
#Chemistry42 
#InSilicoMeds -
https://share.google/aimode/ppSgyiyFUf7hHkeYA in a #RealisticVirtualEarth ?







* * 
And again from - 



. . . 


The Pharma.AI Platform

PandaOmics (The Target Finder)

Chemistry42 (The Molecule Designer)

InSilicoMeds (The Trial Predictor)



What are the details of the rentosertib trial that reversed biological aging markers?







* * 

insilico medicine ai drug discovery and google's founders re sergey brin and larry page



Insilico Medicine, a prominent pioneer in generative AI-driven drug discovery, and Google’s co-founders, Sergey Brin and Larry Page, are major forces driving a shared frontier: leveraging advanced computation and artificial intelligence to combat human aging and disease. [1, 2]
While Brin and Page do not directly run Insilico Medicine (which was founded and is led by CEO Dr. Alex Zhavoronkov), their ideological missions, investment circles, and corporate ecosystems are deeply intertwined in the multibillion-dollar "longevity biotech" movement. [1, 2, 3]
1. The Core Intersection: Curing Aging Through AI
Both Insilico Medicine and Google's founders view aging not as an inevitable natural law, but as a complex biological program that can be reverse-engineered using data science. [1]
  • Insilico Medicine's Approach: Founded in 2014, the company pioneered using Generative Adversarial Networks (GANs) to conceptualize new molecules from scratch. It specializes in discovering treatments for age-related illnesses, such as fibrosis and oncology. Its lead AI-designed drug candidate, rentosertib (for idiopathic pulmonary fibrosis), is a primary example of how AI can shrink preclinical timelines from six years down to just a fraction of that time. [1, 2, 3, 4]
  • Brin and Page's Approach: In 2013, Larry Page and Sergey Brin famously leveraged Google's capital to launch Calico Life Sciences (California Immortality Labs), an Alphabet subsidiary explicitly tasked with understanding the biology of aging and extending the human lifespan. [1, 2]
2. Overlapping Investment Ecosystems
Though Brin and Page’s direct personal wealth is heavily concentrated in Alphabet's internal ventures like Calico, Insilico Medicine is backed by the exact same tight-knit circle of tech-billionaire venture capitalists who collaborate with Google's founders: [1, 2, 3]
Entity / InvestorConnection to Insilico MedicineConnection to Google's Founders
Peter ThielHis network and major biotech co-investors heavily back Insilico.Co-invests alongside Brin in anti-aging research and biotech platforms.
Vinod KhoslaKhosla Ventures funds heavily overlap in the AI/longevity space supporting Insilico.Maintained long-term strategic dialogues with Brin and Page regarding healthcare regulations.
Google Cloud & GeminiInsilico integrated Google's Gemini models and Enterprise Agent Platform into its own "PandaClaw" system to accelerate target discovery.Brin and Page remain the controlling shareholders of Google's parent company, Alphabet, which owns these AI architectures.
3. Competitors or Collaborators?
While Insilico Medicine operates as an independent, publicly traded biotech firm (listed on the Hong Kong Stock Exchange), Google has simultaneously built internal rivals to Insilico's business model. [1]
  • Alphabet operates Isomorphic Labs (born out of Google DeepMind).
  • Led by Demis Hassabis, Isomorphic Labs uses AI architectures like AlphaFold to map proteins and design drugs.
  • Both Insilico and Isomorphic Labs are so formidable that global pharmaceutical giant Eli Lilly has signed massive multi-billion-dollar drug discovery partnerships with both entities. [1, 2, 3]
As Insilico's founder Alex Zhavoronkov notes on the challenge ahead, “Regardless of how rich you are…you cannot buy one year of life with a drug.” Rather, the realistic goal of these AI systems is to radically dial back a person's biological age and prevent the degradation of human health span [The Wall Street Journal].
If you are exploring the crossover between tech giants and biotech, tell me:
  • Are you looking for a deep dive into Insilico's specific drug pipeline (like rentosertib)?
  • Do you want to compare Google's Isomorphic Labs vs. Insilico Medicine's AI platform?
  • Are you researching how to invest in the longevity biotech market?





Alex (Aleksandrs Zavoronkovs) Zhavoronkov

https://www.linkedin.com/in/zhavoronkov/








* 

Insilico Medicine ai drug discovery 


Insilico Medicine is a leading biotechnology company that uses generative artificial intelligence (AI) to discover and develop new medicines. Traditionally, finding a new drug takes up to six years and costs millions of dollars. Insilico uses its AI systems to shrink that early-stage timeframe down to 12 to 18 months. [1, 2, 3]
The company is famous for creating the first entirely AI-discovered and AI-designed drug to reach human clinical trials. [1, 2]
🧠 The Pharma.AI Platform
Insilico operates an "end-to-end" software suite called Pharma.AI, which manages the drug creation process from A to Z. Think of it as a three-step assembly line: [1, 2]
  • PandaOmics (The Target Finder): This tool acts like a biological detective. It analyzes massive amounts of data from patients to find the exact root cause of a disease—like a specific protein or "target" that needs to be blocked. [1, 2]
  • Chemistry42 (The Molecule Designer): Once the target is found, this system imagines and designs brand-new chemical structures to attack it. It works like a 3D printer for molecules, inventing formulas that have never existed before. [1, 2]
  • InSilicoMeds (The Trial Predictor): This tool helps predict how a drug will behave in human clinical trials, saving time and lowering the risk of failure. [1, 2]
💊 Major Milestones & Breakthroughs
  • Rentosertib (ISM001-055): This is Insilico's flagship drug candidate designed to treat Idiopathic Pulmonary Fibrosis (IPF), a severe lung disease. In recent trials, the drug met its safety goals and even showed potential to reverse biological aging indicators in patients.
  • Massive Pipeline: Insilico has nominated over 30 preclinical candidates for diseases ranging from cancer to immune disorders, with multiple drugs actively advancing through human clinical trials.
  • Mega Partnerships: Major pharmaceutical giants, including Eli Lilly and SK Biopharmaceuticals, partner with Insilico or pay billions to license their AI-discovered molecules.
  • Robotic Labs: To test its AI concepts in the real world, Insilico pairs its software with fully automated, robotic smart labs that mix and test chemicals without human error. [1, 2, 3, 4, 5, 6, 7]
Would you like to know more about how their specific drug for lung disease works, or are you more interested in the software platforms they license to other scientists?





* 

What are the details of the rentosertib trial that reversed biological aging markers?

#RentosertibTrialDetails that #ReversedBiologicalAgingMarkers -


Rentosertib (formerly known as ISM001-055) is an oral small-molecule drug developed by Insilico Medicine using generative AI. While popular media sometimes frames it as a "reverse-aging" pill, scientists clarify that rentosertib has not been established as an anti-aging therapy for general rejuvenation. Instead, it is an investigational drug designed to treat idiopathic pulmonary fibrosis (IPF), a severe, age-related lung disease. [1, 2, 3, 4]
The connection to biological aging comes from its unique mechanism and exploratory biomarker data collected during its clinical trials. [1, 2]
🧬 The "Aging" Connection: How it Works
Rentosertib targets TNIK (Traf2- and Nck-interacting kinase). Insilico's AI platform prioritized TNIK by evaluating biological pathways where cellular senescence, chronic inflammation, and fibrosis intersect. [1, 2, 3, 4]
  • Senomorphic Activity: In laboratory models, rentosertib acts as a senomorphic agent. It doesn't necessarily kill old cells (like a senolytic), but it modifies them so they stop releasing harmful, pro-inflammatory chemicals. [1, 2, 3]
  • Reduction in Markers: The drug has demonstrated the ability to significantly reduce the senescence-associated secretory phenotype (SASP) and halt extracellular matrix remodeling, which are two core drivers of biological aging and organ scarring. [1, 2]
📊 Clinical Trial Details & Findings
The human data pointing toward these biological aging adjustments came from its Phase IIa clinical trial (GENESIS-IPF), the results of which were published in Nature Medicine. [1, 2]
  • The Cohort: The trial involved 71 adult patients diagnosed with IPF. [1]
  • The Design: A 12-week, randomized, double-blind, placebo-controlled study evaluating multiple dosing arms (30 mg once daily, 30 mg twice daily, 60 mg once daily, and a placebo). [1]
  • Proteomic Profiling (The Aging Markers): Researchers performed deep proteomic profiling on patient serum samples, mapping 2,841 proteins using the Olink Explore panel. They observed:
    • Significant reductions in pro-fibrotic and age-associated proteins (such as COL1A1, MMP10, and FAP).
    • A clear increase in the anti-inflammatory marker IL-10. [1, 2]
  • Primary Outcomes: The 60 mg once-daily dose was safe, well-tolerated, and demonstrated a significant clinical response, showing a mean improvement in lung function (Forced Vital Capacity) of +98.4 mL over 12 weeks, compared to a -20.3 mL decline in the placebo group. [1, 2]
🚀 Current Status (2026)
Insilico Medicine officially initiated a global Phase III clinical trial for Rentosertib. This larger study is a randomized, double-blind, placebo-controlled trial evaluating roughly 320 patients over 52 weeks. It will use advanced AI algorithms to track whether rentosertib can safely achieve a true clinical reversal of fibrotic lung damage over a longer term. [1, 2, 3]
If you are looking into the clinical side of longevity, would you like to explore other actual cellular reprogramming trials focused purely on age-reversal, or do you want more details on the AI design process behind rentosertib?

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