On the digital or virtual side of #PhysicalDigital devs, how best to add these specific steps to #RealisticVirtualEarthForAgingReversal ...?
On digital or virtual side of #PhysicalDigital devs, how best to add these specific steps to #RealisticVirtualEarthForAgingReversal in a #RealisticVirtualEarthForGenetics in 1 #RealisticVirtualEarth eg #GStreetView w #TimeSlider & see #PeterNorvigs INCREDIBLE #ToolifyAIWUaS art.? https://t.co/E6lCQGjvmH
— WorldUnivandSch (@WorldUnivAndSch) February 1, 2025
https://x.com/WorldUnivAndSch/
https://x.com/sgkmacleod/
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https://x.com/WUaSPress/
https://x.com/Q_YogaMacFlower/
https://x.com/scottmacleod/
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Retweeting -
Can we reverse aging?
— Alex Plesa (@amplesa) December 21, 2023
7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, https://t.co/7ZXhqHYDAD we used 🧬 screens to find new rejuvenation factors🧵1/8 pic.twitter.com/4npP6FVDnc
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Can we reverse aging?
— Alex Plesa (@amplesa) December 21, 2023
7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, https://t.co/7ZXhqHYDAD we used 🧬 screens to find new rejuvenation factors🧵1/8 pic.twitter.com/4npP6FVDnc
https://x.com/amplesa/status/
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With 1000s of genes changing throughout aging, how do we know which ones to target? - Networks!
— Alex Plesa (@amplesa) December 21, 2023
To increase our odds of finding the right targets and comprehensively rejuvenating cells, we decided to focus on the central nodes in the aged gene regulatory networks. 2/8 pic.twitter.com/8YzYO7EdiN
https://x.com/amplesa/status/
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Next, to measure aging, we looked at gene expression changes in skin fibroblasts from donors aged 1-96yrs old. Assuming cells from young donors are healthier, we built transcriptomic functional indicators for 8 cellular processes and used them to measure overall cellular age. 3/8 pic.twitter.com/Z1oEuFaG7a
— Alex Plesa (@amplesa) December 21, 2023
https://x.com/amplesa/status/
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In search for new rejuvenation factors, we tested our top 90 genes by overexpressing them in human aged skin fibroblasts. Using the resulting gene expression profiles, we mapped out a landscape of fibroblast aging and rejuvenation, and identified SRSF1 as a promising target. 4/8 pic.twitter.com/TWYniYTNBO
— Alex Plesa (@amplesa) December 21, 2023
Ok, so from a gene expression standpoint, SRSF1 induction makes these cells younger. Does that mean they also function better? - Yes, in certain aspects.
— Alex Plesa (@amplesa) December 21, 2023
We observed a reduction in cellular senescence, proteasome load, and an increase in collagen production. 5/8 pic.twitter.com/QAPNNT6Hzw
https://x.com/amplesa/status/
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Ok, so from a gene expression standpoint, SRSF1 induction makes these cells younger. Does that mean they also function better? - Yes, in certain aspects.
— Alex Plesa (@amplesa) December 21, 2023
We observed a reduction in cellular senescence, proteasome load, and an increase in collagen production. 5/8 pic.twitter.com/QAPNNT6Hzw
https://x.com/amplesa/status/
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But does this work in living organisms? - It does, at least in the skin!
— Alex Plesa (@amplesa) December 21, 2023
We showed that SRSF1 gene therapy rejuvenates old skin and reverses its wound healing ability to youthful levels in 🐁 @justsaysinmice. Oh, and it’s also linked to longevity in worms 🪱 6/8 pic.twitter.com/16zY4EiYea
https://x.com/amplesa/status/
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Cool. What next? Testing SRSF1 in age-related disease models and for healthspan extension in old 🐁.
— Alex Plesa (@amplesa) December 21, 2023
Also, larger screens in other cell types🩸. We think this is a viable approach for discovering new rejuvenation factors to serve as basis for future age reversal therapies🧬! 7/8
https://x.com/amplesa/status/
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Thanks to @geochurch and all our amazing co-authors:
— Alex Plesa (@amplesa) December 21, 2023
Sascha Jung@wanghelenh
Fawad Omar@MichaelShadpour @Davetherobot
Maria Perez Matos
Naftali Horwitz
George Cai@NgianZhenKai @_Carol_Mag
Amy Wagers
@William_Mair
Antonio del Sol
8/8
https://x.com/WorldUnivAndSch/
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In what ways can a #RealisticVirtualEarthForGenetics think #GStreetView w #TimeSlider #GCellView #GMoleculeView help identify #WUaSPromisingTargets for #AgingReversal even w #FilmTo3DApps w #SkinFibroblastCells re #SRSF1 https://t.co/dOP0udzGmG in #WUaSLongevityGeneticsInstitute?
— WorldUnivandSch (@WorldUnivAndSch) December 24, 2023
https://x.com/LaurieGreen36/
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What does reverse aging mean exactly? Curious to know your take on it as it seems as if a lot of people have a different take on it
— Laurie Green (@LaurieGreen36) December 23, 2023
https://x.com/amplesa/status/
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Waymo #SelfDriving #AutonomousVehicle taxi cars are #robots & #AutonomousSystems (w 'way-more' in #ITrevolutionWUaS ahead) fr near #HIFishermansWharfSF
Ultimately, I think about it as converting a biological system (cell/tissue/organ/organism) to a more functional state, representative of a younger age.
— Alex Plesa (@amplesa) December 23, 2023
https://x.com/WorldUnivAndSch/
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https://x.com/WUaSPress/
https://x.com/sgkmacleod/
https://x.com/scottmacleod/
https://x.com/Q_YogaMacFlower/
https://x.com/TheOpenBand/
Waymo #SelfDriving #AutonomousVehicle taxi cars are #RobotsWUaS & #AutonomousSystems (w 'way-more' in #ITrevolution ahead) from near #HIFishermansWharfSF #HiYouthHostel They're driving in 4 US service areas - https://support.google.com/
How soon until Pittsburgh I wonder - and to help my mother with driving at night, thanks to these self-driving cars?
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Are Waymo taxi cars robots ?
- Waymo's robotaxis are equipped with cameras and sensors.
- The cars have a screen that displays what the car can see around it.
- Waymo's robotaxis have multiple layers of security to prevent unauthorized access.
- The cars' steering, braking, and controllers are isolated from outside communication.
- Waymo robotaxis operate in Phoenix, Arizona, San Francisco, California, and Los Angeles, California.
- Waymo plans to expand to Austin, Texas, Miami, Florida, and Tokyo, Japan.
- Waymo's goal is to make it easier and safer for people to get around.
- Waymo claims that its robotaxis are significantly safer than human-driven vehicles.
Searched -
next books - With "Naked Harbin Ethnography" book cover pic - May write new book after #SocInfoTechAndTheGlobalUniv @WUaSPress & 2nd #HarbinHotSpringsEthnography @HarbinBook '#TheWayOfTheGeneAndEthics: #AgingReversal, #ExtremeLongevity & Sex ' - #ScottGKMacLeod ~
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WUaS Educational Services' Stores' potentials & MIT OCW-centric wiki World Univ & Sch potentials - ? HI SF youth hostel Sun 2/4/25
Excited for #MITOCW-centric wiki #GrowWithGoogle @WorldUnivAndSch #ITplatforms where you can #WikiTeach & in ~200 countries & 7k+ languages w #AIandML -https://t.co/OedDI3heQu (https://t.co/YWks7t8iB2) https://t.co/uO5ySbzTGv & https://t.co/YGEXTuH9Ww & https://t.co/dLJc25SQOg ~
— WorldUnivandSch (@WorldUnivAndSch) January 19, 2025
https://x.com/WorldUnivAndSch/
https://x.com/scottmacleod/
https://x.com/Q_YogaMacFlower/
Excited for #MITOCW-centric wiki #GrowWithGoogle @WorldUnivAndSch #ITplatforms where you can #WikiTeach & in ~200 countries & 7k+ languages w #AIandML -https://t.co/VLazPJSQFk (https://t.co/rS8NNm0OlY) https://t.co/AaeFRSp997 & https://t.co/wOh8J7d3k4 & https://t.co/dqvjx1EvhC ~
— Languages-World Univ (@sgkmacleod) January 19, 2025
Glad @WorldUnivAndSch 1) to build on https://ocw.mit.edu/ in 5 languages & 2) w #GrowWithGoogleWUaS & re INCREDIBLE #PeterNorvig #ToolifyAIWUaS art. -"#RevolutionizingEducation w #MachineLearning & AI: #WorldUniversityInSchool" #WUaSUnivs dated 3/2/24 https://www.toolify.ai/
Glad @WorldUnivAndSch 1) to build on https://t.co/OEqcLjPOd8 in 5 languages & 2) w #GrowWithGoogleWUaS & re INCREDIBLE #PeterNorvig #ToolifyAIWUaS art. -"#RevolutionizingEducation w #MachineLearning & AI: #WorldUniversityInSchool" #WUaSUnivs dated 3/2/24 https://t.co/8Kx5cOWGm5 ~
— WorldUnivandSch (@WorldUnivAndSch) January 14, 2025
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https://x.com/HarbinBook/
https://x.com/WUaSPress/
https://x.com/sgkmacleod/
https://www.linkedin.com/
WUaS Educational Services' Stores planned in 5+ sizes (AND Physical-Digital in a #RealisticVirtualEarth) large: Ikeas (300,000 square feet)
! #WUaSEducationalServicesStores @WUaSPress planned in 5+ sizes in #PhysicalDigital #RealisticVirtualEarth lg: Ikea (300,000 sq ft), small #RobotVendingMachinesWUaS in ~200 countries & in main languages -https://wiki.
-https://scott-macleod.
! #WUaSEducationalServicesStores @WUaSPress planned in 5+ sizes in #PhysicalDigital #RealisticVirtualEarth lg: Ikea (300,000 sq ft), small #RobotVendingMachinesWUaS in ~200 countries & in main languages -https://t.co/LRKdU7umJc -https://t.co/YWks7t8iB2
— WorldUnivandSch (@WorldUnivAndSch) November 12, 2024
-https://t.co/2ZVx8jM36O ~
https://x.com/WorldUnivAndSch/
https://x.com/scottmacleod/
WUaS Educational Services' Stores planned in 5+ sizes (AND Physical-Digital in a #RealisticVirtualEarth) large: Ikeas (300,000 square feet)
! #WUaSEducationalServicesStores @WUaSPress planned in 5+ sizes in #PhysicalDigital #RealisticVirtualEarth lg: Ikea (300,000 sq ft), small #RobotVendingMachinesWUaS in ~200 countries & in main languages -https://wiki.
-https://scott-macleod.
https://x.com/WorldUnivAndSch/
https://x.com/scottmacleod/
! #WUaSEducationalServicesStores @WUaSPress planned in 5+ sizes in #PhysicalDigital #RealisticVirtualEarth lg: Ikea (300,000 sq ft), small #RobotVendingMachinesWUaS in ~200 countries & in main languages -https://
-https://scott-macleod.
https://x.com/WorldUnivAndSch/
https://x.com/WUaSPress/
AND
5+ sizes (AND Physical-Digital in a #RealisticVirtualEarth)
large: Ikeas (300,000 square feet)
med: Walmarts (180,000 square feet on avg)
small: SubwayRestaurants 2000 square feet (eg in the USA with 20,300 locations, & some ~300 square feet in India esp.) AND
very small: #ToyotaSiennas &
Robotic Vending machines -#RoboticBookshelvesOnWheels -https://youtu.be/FjQVf4EYurA
& in also Yachts or on ships
FOR #WUaSLegoRoboticsKits & #WUaSBooks -
AND as space for #PhysicalDigital #WUaSMeetUps for #WUaSstudents too (& as #QuakerMeetingHouses / #YogaHalls & #ConcertSpaces too)
Here's more regarding aging reversal genetic drug therapies emerging, from Harvard and MIT Professor of Genetics' George Church, in a 60 Minutes' 66 second's interview with Scott Pelley -
"How soon could humans reverse the aging process with genetic engineering?" (2019)
"Aging reversal is something that's been proven about eight different ways in animals," geneticist George Church says. So when will humans get to turn back the clock? Church tells 60 Minutes it's not that far away. See the full report, Sunday'
60 Minutes
A further related set of Tweets re aging reversal and extreme longevity genetic drug therapies in a #RealisticVirtualEarth -
An #AgingReversalMachine as #WUaSMultimediaHospitalRoom re view #GStreetViewRoom -https://youtu.be/q9FBhEAXRY4
An #AgingReversalMachine as #WUaSMultimediaHospitalRoom re view #GStreetViewRoom -https://t.co/8nAQqn71fs & #eRapid -https://t.co/xm76pcm4rZ for all ~200 countries' hospitals & online #WUaSAcademicMedicalCenter in online #WUaSHospitals too & w @geochurch https://t.co/NV5YQqtGEv ~
— WorldUnivandSch (@WorldUnivAndSch) April 1, 2024
Here's more regarding aging reversal genetic drug therapies emerging, from Harvard and MIT Professor of Genetics' George Church, in a 60 Minutes' 66 second's interview with Scott Pelley -
"How soon could humans reverse the aging process with genetic engineering?" (2019)
"Aging reversal is something that's been proven about eight different ways in animals," geneticist George Church says. So when will humans get to turn back the clock? Church tells 60 Minutes it's not that far away. See the full report, Sunday'
60 Minutes
https://youtu.be/bnCEIPQFNnk
AND more re MIT OCW-centric wiki World Univ & Sch and Aging_Reversal_Genetics too +
"Dr. Church predicted that human aging could be eradicated by the year 2030....The therapy that aims to reverse aging in people involves gene modification at cellular level" https://www.lifeextension.com/
https://x.com/WorldUnivAndSch/
https://x.com/scottmacleod/
https://x.com/Q_YogaMacFlower/
Waymo #SelfDriving #AutonomousVehicle taxi cars are #robots & #AutonomousSystems (w 'way-more' in #ITrevolutionWUaS ahead) fr near #HIFishermansWharfSF
Waymo #SelfDriving #AutonomousVehicle taxi cars are #robots & #AutonomousSystems (w 'way-more' in #ITrevolutionWUaS ahead) fr near #HIFishermansWharfSF #HiYouthHostel They're driving in 4 US service areas - https://t.co/68lEWjaP08 Impressive #GoogleAlphabet display of technology pic.twitter.com/d84XKxcYNA
— WorldUnivandSch (@WorldUnivAndSch) February 1, 2025
https://x.com/WorldUnivAndSch/
https://x.com/HarbinBook/
https://x.com/WUaSPress/
https://x.com/sgkmacleod/
https://x.com/scottmacleod/
https://x.com/Q_YogaMacFlower/
https://x.com/TheOpenBand/
Waymo #SelfDriving #AutonomousVehicle taxi cars are #RobotsWUaS & #AutonomousSystems (w 'way-more' in #ITrevolution ahead) from near #HIFishermansWharfSF #HiYouthHostel They're driving in 4 US service areas - https://support.google.com/
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https://en.wikipedia.org/wiki/Blue_pigeon
https://commons.wikimedia.org/wiki/Alectroenas
...
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