Dear @geochurch @DrCaliff_FDA @amplesa Frontier in #ExtremeLongevity questions: How to live for 123 years & what genes to add for this per https://youtu.be/bnCEIPQFNnk? I'd like to live to ~2085 & for my mother to live to 149 yo (~2111) How w a #
Dear @geochurch @DrCaliff_FDA @amplesa Frontier in #ExtremeLongevity questions: How to live for 123 years & what genes to add for this per https://youtu.be/bnCEIPQFNnk? I'd like to live to ~2085 & for my mother to live to 149 yo (~2111) How w a #
Dear @geochurch @DrCaliff_FDA @amplesa Frontier in #ExtremeLongevity questions: How to live for 123 years & what genes to add for this per https://t.co/nYJA6Umg4I? I'd like to live to ~2085 & for my mother to live to 149 yo (~2111) How w a #RealisticVirtualEarthForLongevity too? pic.twitter.com/otHAJYW5GI
— QuakerYogaMacFlower (@Q_YogaMacFlower) September 15, 2024
Dear @geochurch @DrCaliff_FDA @amplesa Frontier in #ExtremeLongevity questions: How to live for 123 years & what genes to add for this per https://t.co/TTMJ2oeFht? I'd like to live to ~2085 & for my mother to live to 149 yo (~2111) How w a #RealisticVirtualEarthForLongevity too? pic.twitter.com/qu3ZFNtT8J
— Scott_GK_MacLeod_WUaS_worlduniversityandschool.org (@scottmacleod) September 15, 2024
Dear @geochurch @DrCaliff_FDA @amplesa Frontier in #ExtremeLongevity questions: How to live for 123 years & what genes to add for this per https://t.co/NV5YQqtGEv? I'd like to live to ~2085 & for my mother to live to 149 yo (~2111) How w a #RealisticVirtualEarthForLongevity too?
— WorldUnivandSch (@WorldUnivAndSch) September 15, 2024
Dear @geochurch @DrCaliff_FDA @amplesa Frontier in #ExtremeLongevity questions: How to live for 123 years & what genes to add for this per https://t.co/GS7kjvSzzw? I'd like to live to ~2085 & for my mother to live to 149 yo (~2111) How w a #RealisticVirtualEarthForLongevity too? https://t.co/xm3LFgIS9r
— the Open Band (Berkeley) (@TheOpenBand) September 15, 2024
Dear @geochurch @DrCaliff_FDA @amplesa Frontier in #ExtremeLongevity questions: How to live for 123 years & what genes to add for this per https://t.co/Jd3DVmgjZf? I'd like to live to ~2085 & for my mother to live to 149 yo (~2111) How w a #RealisticVirtualEarthForLongevity too? https://t.co/xuOoPWsKpH
— HarbinBook (@HarbinBook) September 15, 2024
How to develop an #AgingReversalMachine in a #RealisticVirtualEarth #ForAgingReversal (& #ForExtremeLongevity) w #AlphaFold3Server for #MLprediction of ALL #LifesMolecules #GeneticDrugTherapies & re #GStreetView w #TimeSlider interoperable with #
How to dev an #AgingReversalMachine in a #RealisticVirtualEarth #ForAgingReversal (& #ForExtremeLongevity) w #AlphaFold3Server for #MLprediction of ALL #LifesMolecules #GeneticDrugTherapies & re #GStreetView w #TimeSlider interoperable with #AvatarAgentElectronicHealthRecords https://t.co/E6lCQGjvmH
— WorldUnivandSch (@WorldUnivAndSch) September 14, 2024
Can we reverse aging?
— Alex Plesa (@amplesa) December 21, 2023
7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, https://t.co/7ZXhqHYDAD we used 🧬 screens to find new rejuvenation factors🧵1/8 pic.twitter.com/4npP6FVDnc
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Can we reverse aging?
— Alex Plesa (@amplesa) December 21, 2023
7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, https://t.co/7ZXhqHYDAD we used 🧬 screens to find new rejuvenation factors🧵1/8 pic.twitter.com/4npP6FVDnc
https://x.com/amplesa/status/
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With 1000s of genes changing throughout aging, how do we know which ones to target? - Networks!
— Alex Plesa (@amplesa) December 21, 2023
To increase our odds of finding the right targets and comprehensively rejuvenating cells, we decided to focus on the central nodes in the aged gene regulatory networks. 2/8 pic.twitter.com/8YzYO7EdiN
https://x.com/amplesa/status/
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Next, to measure aging, we looked at gene expression changes in skin fibroblasts from donors aged 1-96yrs old. Assuming cells from young donors are healthier, we built transcriptomic functional indicators for 8 cellular processes and used them to measure overall cellular age. 3/8 pic.twitter.com/Z1oEuFaG7a
— Alex Plesa (@amplesa) December 21, 2023
https://x.com/amplesa/status/
4
In search for new rejuvenation factors, we tested our top 90 genes by overexpressing them in human aged skin fibroblasts. Using the resulting gene expression profiles, we mapped out a landscape of fibroblast aging and rejuvenation, and identified SRSF1 as a promising target. 4/8 pic.twitter.com/TWYniYTNBO
— Alex Plesa (@amplesa) December 21, 2023
https://x.com/amplesa/status/
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Ok, so from a gene expression standpoint, SRSF1 induction makes these cells younger. Does that mean they also function better? - Yes, in certain aspects.
— Alex Plesa (@amplesa) December 21, 2023
We observed a reduction in cellular senescence, proteasome load, and an increase in collagen production. 5/8 pic.twitter.com/QAPNNT6Hzw
https://x.com/amplesa/status/
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But does this work in living organisms? - It does, at least in the skin!
— Alex Plesa (@amplesa) December 21, 2023
We showed that SRSF1 gene therapy rejuvenates old skin and reverses its wound healing ability to youthful levels in 🐁 @justsaysinmice. Oh, and it’s also linked to longevity in worms 🪱 6/8 pic.twitter.com/16zY4EiYea
https://x.com/amplesa/status/
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Cool. What next? Testing SRSF1 in age-related disease models and for healthspan extension in old 🐁.
— Alex Plesa (@amplesa) December 21, 2023
Also, larger screens in other cell types🩸. We think this is a viable approach for discovering new rejuvenation factors to serve as basis for future age reversal therapies🧬! 7/8
https://x.com/amplesa/status/
8
Thanks to @geochurch and all our amazing co-authors:
— Alex Plesa (@amplesa) December 21, 2023
Sascha Jung@wanghelenh
Fawad Omar@MichaelShadpour @Davetherobot
Maria Perez Matos
Naftali Horwitz
George Cai@NgianZhenKai @_Carol_Mag
Amy Wagers@William_Mair
Antonio del Sol
8/8
https://x.com/amplesa/status/
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In what ways can a #RealisticVirtualEarthForGenetics think #GStreetView w #TimeSlider #GCellView #GMoleculeView help identify #WUaSPromisingTargets for #AgingReversal even w #FilmTo3DApps w #SkinFibroblastCells re #SRSF1 https://t.co/dOP0udzGmG in #WUaSLongevityGeneticsInstitute?
— WorldUnivandSch (@WorldUnivAndSch) December 24, 2023
https://x.com/WorldUnivAndSch/
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What does reverse aging mean exactly? Curious to know your take on it as it seems as if a lot of people have a different take on it
— Laurie Green (@LaurieGreen36) December 23, 2023
https://x.com/LaurieGreen36/
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Ultimately, I think about it as converting a biological system (cell/tissue/organ/organism) to a more functional state, representative of a younger age.
— Alex Plesa (@amplesa) December 23, 2023
https://x.com/amplesa/status/
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Sunday Plan
Hi Ma, (Pin, Ed),
How to dev an #AgingReversalMachine in a #RealisticVirtualEarth #ForAgingReversal (& #ForExtremeLongevity) w #AlphaFold3Server for #MLprediction of ALL #LifesMolecules #GeneticDrugTherapies & re #GStreetView w #TimeSlider interoperable with #AvatarAgentElectronicHealthRecords https://t.co/E6lCQGjvmH
— WorldUnivandSch (@WorldUnivAndSch) September 14, 2024
Can we reverse aging?
— Alex Plesa (@amplesa) December 21, 2023
7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, https://t.co/7ZXhqHYDAD we used 🧬 screens to find new rejuvenation factors🧵1/8 pic.twitter.com/4npP6FVDnc
How They Cloned a Sheep
1. Scientists took udder cells from Dolly’s DNA mother. They let the cells multiply and then they stopped the process when they had divided enough.
2. They took an egg cell from a different sheep and removed the nucleus.
3. They put one udder cell next to the egg cell without a nucleus and joined them using electricity. The egg cell now contained all the udder cell’s DNA.
4. The egg cell divided until it developed into an embryo. An embryo is the early stage of an animal before it has been born or hatched. This embryo was placed inside a third sheep. Five months later, this sheep gave birth to Dolly .
And how to do this in a realistic virtual earth for genetics ?
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https://en.wikipedia.org/wiki/Mountain_goat
https://commons.wikimedia.org/wiki/Oreamnos_americanus
...
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