Dear George (Church, in Harvard Med Sch, and thanks for this recent article - https://wyss.harvard.edu/news/
Can we reverse aging? 7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, https://t.co/7ZXhqHYDAD we used 🧬 screens to find new rejuvenation factors🧵1/8 https://t.co/4npP6FVDnc
— Alex Plesa (@amplesa) December 21, 2023
https://x.com/
and
Dear Yoga friends & family in their 80s and 90s ~ Ma/Janie, and Alden (Briscoe - who went to Quaker George School in Philadelphia before Harvard college), & QuakerunitarianYogini & veterinarian & cousin Annie (Brown in NE Oregon) in her 60s, Dick (Robb MD, possibly posthumously, also an ophthalmology professor in Harvard Medical School), and Maitreyi (Mazumdar MD - a professor in Harvard Medical School too), Vivek (Buch MD, professor of surgery in the Stanford Medical School), MacLeod kin or family, Doortje (Van Kooten, and Angela, and your father Victor, and please forward), Valerie & Ed Smyth MDs, & Marlynn Wei MD JD (co-author of "The Harvard Medical School Guide to Yoga: 8 Weeks to Strength, Awareness, and Flexibility," 2017, Harvard Press), Pin/Sid Mazumdar, HHS, all,
Yoga greetings (as in 8 limbs of Yoga) from the SF East Bay MUD greenwood, for these email restorative Yoga explorations' on Saturday November 7, 2026 (and as we may live to 150 and well beyond:) ... around 8 am Your Time ...
1
Siddhasana
Inspired and exploring, I took the opportunity last week to record this Yoga meditation, and let's explore it this Saturday in Siddhasana or on a chair -
Some Yoga meditations to explore inner releasing actions with one's nostril skin to touch of breath ~
https://youtu.be/tGgeyHJKkfU
(and see - https://scott-macleod.
https://youtu.be/tGgeyHJKkfU
(and see - https://scott-macleod.
2
Surya Namaskar ~ Sun Salutation
Then let's explore further and restoratively doing Sun Salutation, once on each side, with as you know it, or possibly with
(and see again, and for a written doing of this Yoga asana too - https://scott-macleod.
3
Savasana
And then let's explore this again on our backs releasing, and further restoratively -
Some Yoga meditations to explore inner releasing actions with one's nostril skin to touch of breath ~
https://youtu.be/tGgeyHJKkfU
4
And as we may live to 150 and well beyond :) ... and in this Yoga and Longevity Genetics' conversation - am curious how this scientific envisioning
Reversing age by reprogramming gene expression networks: Aging-specific screening platform identifies gene with multifaceted rejuvenation potential that extends health- and lifespan in mice
https://wyss.harvard.edu/news/
October 14, 2026
https://wyss.harvard.edu/news/
October 14, 2026
e.g. regarding the SRSF1 gene expression ... might help with living to 150 and well beyond ... and as we begin to explore this article for example in a realistic virtual earth for OSK, a rve for genetics, a rve for Yoga asana too, and regarding -
Envisioning rejuvenating gene therapy
Taking full advantage of their transcriptomic age predictor, the researchers then designed a focused library of genes that were predicted to impact aging and could be over-expressed in aged fibroblast cell lines. “We were working on the premise that over-expressing a single gene with validated rejuvenation outcomes could eventually be advanced into an organ- or tissue-specific gene therapy if combined with the right delivery system,” said Plesa.
AND
Importantly, when delivered to aged mice, where it primarily accumulated in the liver, SRSF1 reduced the animals’ rate of aging and extended their lifespan by 14%, highlighting SRSF1 as a “geroprotective” target. The findings are published in Nature Aging.
“It has been a long-standing goal of my lab to devise clinically useful de-aging strategies by identifying genes that, when engineered in the genome for under- or over-expression in aging target tissues, extend human healthspan. Our platform and findings on SRSF1 are an important step on that quest,” said Church, who is also Professor of Genetics at Harvard Medical School. “Aging research is transiting an inflection point where the exponential progress of biotech is impacting the core aging processes which would otherwise kill 90% of us.”
4 A
So I searched on
realistic virtual earth building at the google cell & g molecule levels for srsf1 rejuvenating gene and aging reversal
and found -
To construct a realistic virtual simulation of aging reversal—mapping from a macro "Virtual Earth" view down to the precise Google-scale cellular networks and G-molecule architectural grids—we can deploy a unified, multi-scale digital twin framework. This visualization maps the recent breakthroughs surrounding the SRSF1 (Serine/arginine-rich splicing factor 1) rejuvenating gene, which has been shown to extend mammalian median lifespan by 14% and reduce tissue frailty. [1, 2, 3]
This architectural blueprint outlines how a nested digital twin translates real-time clinical, cellular, and molecular variables into an immersive, interactive global health map.
1. Macro Level: The Virtual Earth Sandbox
At the global layer, the engine visualizes population-wide epidemiological datasets, clinical trials, and environmental factors impacting biological age.
- Global Longevity Grids: Immersive geospatial mapping overlays real-time biological clocks (e.g., Horvath-style transcriptomic and epigenetic age predictors) across different demographics.
- Vector Propagation Fields: Displays the macro-delivery of geroprotective interventions, such as mapping the systemic distribution efficiency of liver-tropic Adeno-Associated Viruses (AAVs) engineered with SRSF1 payloads across target populations.
2. Meso Level: The Google Cell Network
Zooming into an individual digital twin from the macro globe opens the Google Cell Layer, which treats a tissue or organ system similarly to a hyper-detailed urban navigation map.
[Organ / Tissue Micro-Map] ➔ [Cell-Type Nodes (Fibroblasts / Hepatocytes)]
│
┌─────────────────────────────- Cellular Navigation & Telemetry: Users can search and "street-view" micro-environments (e.g., human dermal fibroblasts or hepatic tissue). Cells are logged as discrete spatial nodes displaying structural data like membrane integrity, morphology, and transcriptomic age scores. [1, 2]
- Dynamic State Colorization:
- Aged/Senescent Cells: Rendered as static, muted nodes emanating an inflammatory cloud of Senescence-Associated Secretory Phenotypes (SASP) or "inflammaging" biomarkers.
- SRSF1-Rejuvenated Cells: Activating an SRSF1 expression prompt transitions these nodes into vibrant, fluid pathways. Unlike high-risk Yamanaka factor reprogramming (which can cause cells to lose their identity and form tumors), the SRSF1 protocol updates the transcriptome while perfectly preserving the cell's specialized identity and spindle-shaped morphology. [1, 2, 3, 4]
- Systemic Telemetry Hub: Displays real-time cell readouts showing a ~25% increase in collagen production and a ~30% decrease in damaging Reactive Oxygen Species (ROS) post-intervention. [1]
3. Micro Level: The G-Molecule Architectural Grid
Zooming deep into the nucleus of a cell node exposes the G-Molecule Grid, a physics-bound molecular simulation executing alternative pre-mRNA splicing networks.
- The Spliceosome Assembly Line: Renders the physical DNA/RNA transcription loops. SRSF1 is visualized as a specialized mechanical regulator that binds to pre-mRNA strands.
- Alternative Exon Routing: The simulation maps how SRSF1 precisely edits the raw transcript, selecting and combining specific alternative exons while bypassing corrupted, aged instructions.
| Molecular Grid Target | Aged State Mechanism | SRSF1-Rejuvenated State Mechanism |
|---|---|---|
| Translation Module | Ribosomal accumulation of defective, misfolded proteins (Proteostatic Stress). | Resetting of alternative splicing for translation initiation factors, clearing protein congestion. |
| Histone Methylation | Epigenetic "noise" causing genome instability and loss of gene regulation. | Restructuring chromatin-modifying complexes to re-lock youthful gene expression profiles. |
| DNA Repair Subsystem | Unrepaired double-strand breaks triggering permanent cell cycle arrest (senescence). | Splicing-mediated activation of core DNA repair enzymes, patching structural genomic breaks. |
The Integrated De-Aging Vector
By connecting these three tiers, an engineer can watch an intervention cascade in real-time. For example: increasing the SRSF1 regulatory slider at the G-Molecule level alters alternative splicing -> which clears proteostatic stress and cuts inflammation at the Google Cell level -> which slows frailty progression by 44% and extends overall median lifespan by 14% on the Virtual Earth macro-scale. [1]
If you are developing or designing a specific element of this system, tell me:
- Which software stack or engine are you planning to use? (e.g., Unreal Engine 5, WebGL/Three.js, Omniverse, or pure Python modeling?)
- Are you focusing on the front-end UI navigation or the underlying biochemical/machine learning data models?
I can provide custom data schema templates or script logic tailored to that layer.
5
Until such extreme longevity and aging reversal genetic drug therapies emerge, and FDA approved, happy restorative Yoga explorations ...
Yogically (as in 8 limbs of Yoga) as we may live to 150 and well beyond:) and in exploring this Yoga-wise, Desiderata prose poem greetings (https://www.desiderata.com/
Scott
Added the following "Reversing age by reprogramming gene expression networks" article to
https://wiki.
https://wiki.
https://wiki.
https://wiki.
https://wiki.
Boettner, Benjamin. 2026. [https://wyss.harvard.edu/
with this summary in the WUaS wiki pages -
added Harvard Wyss Institute aging reversal article - Reversing age by reprogramming gene expression networks: Aging-specific screening platform identifies gene with multifaceted rejuvenation potential that extends health- and lifespan in mice
Some quotes therefrom -
"The top-scoring gene, encoding an RNA processing factor known as SRSF1, was indeed able to reduce features that corresponded to several hallmarks of aging, such as a biological process where damaged cells stop dividing but do not die (cellular senescence), disruptions in the normal balance and turnover of proteins (proteostatic stress), and chronic low-grade inflammation (also dubbed “inflammaging”)."
"“Aging research is transiting an inflection point where the exponential progress of biotech is impacting the core aging processes which would otherwise kill 90% of us.” "
"Very intriguingly, when they packaged the SRSF1 gene in a liver-tropic adeno-associated virus (AAV) and used it to treat mice, they observed liver rejuvenation and systemic benefits: SRSF1-treated animals grew frail more slowly and lived longer, with median lifespan extended by 14% compared to controls. "
Article again
Reversing age by reprogramming gene expression networks: Aging-specific screening platform identifies gene with multifaceted rejuvenation potential that extends health- and lifespan in mice
https://wyss.harvard.edu/news/
GGS
Saturday, October 17, 2026 "Bingdi lotus: ..." https://scott-macleod.
Bingdi lotus: Sat Oct 17, 2026 ~ Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:)? * How to explore with a #YogaGeneticsApp even Yoga-promising #RejuvenatingGenes such as SRSF1 and with YOGA asana INVERSIONS, in ways we can experiment with doing Yoga, and in our avatar agent electronic health records emerging from little G Pegman in a FORKED Google.Street View with time slider on the digital side ... and with a digital-physical #RealisticVirtualEarthForYoga?
https://scott-macleod.
https://scott-macleod.
GGGS
Thursday, August 13, 2026
*
https://apps.lucidcentral.org/plants_se_nsw/text/entities/lotus_australis.htm
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