Saturday, November 1, 2025

Loch Mealt, Isle of Skye, Scotland: Was visiting #RealHarbinHotSprings last Monday. How best in #HomeBathtub in #RealisticVirtualHarbin to create contrast between Harbin warm pool & Harbin hot pool #HWarmPool & #JustRightTooHot #HHotPool above it with this Onsen Youtube #ONSENyt- https://youtu.be/X6YBetANDUI (regarding also sit on #HWarmPool's front bench near #HarbinWPFrontStairs w view toward #HotPoolRm)? * * * * Moraga public library 10/31/25 - Regarding our conversation about eliciting loving bliss neurophysiology or neural cascades of pleasure ... (and regarding your focus on promotion too) * * * For real real time music making eventually, in a #RealisticVirtualEarthForMusicMaking even? * * * In terms of adding copies of genes back into human body minds, rather than engineering cells, and per George Church in this 60 Minutes 67 second-long interview excerpt - How soon could humans reverse the aging process with genetic engineering? https://youtu.be/bnCEIPQFNnk ... please watch / access the video Gemini AI ... What genes to potentially add back into human bodies to reverse muscle wasting genetically and epigenetically?

 


Was visiting #RealHarbinHotSprings last Mon. How best in #HomeBathtub in #RealisticVirtualHarbin to create contr btw #HWarmPool & #JustRightTooHot #HHotPool ...


I visited #RealHarbinHotSprings last Monday. How best in #HomeBathtub in #RealisticVirtualHarbin to create contrast between Harbin warm pool & Harbin hot pool #HWarmPool & #JustRightTooHot #HHotPool above it with this Onsen Youtube #ONSENyt- https://youtu.be/X6YBetANDUI
(regarding also sit on #HWarmPool's front bench near #HarbinWPFrontStairs w view toward #HotPoolRm)?


Was visiting #RealHarbinHotSprings last Mon. How best in #HomeBathtub in #RealisticVirtualHarbin to create contr betw #HWarmPool & #JustRightTooHot #HHotPool abv it w #ONSENyt- https://youtu.be/X6YBetANDUI
(re sit on #HWarmPool's fr bench near #HarbinWPFrontStairs w view> #HotPoolRm)?










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Was just visiting #ActualHarbinHotSprings last Monday - how best in emerging #PhysicalDigital #RealisticVirtualHarbin for #EthnographicResearch #STEMresearchWUaS to create contrast betw #HWarmPool & #JustRightTooHot #HarbinHotPool above it in #ONSEN video - https://youtu.be/X6YBetANDUI
(re sitting on #HWarmPool's front bench near #HarbinWPFrontStairs looking toward the #HarbinHotPoolRoom) re #HomeBathtub ?



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Asked #GoogleAIStudio -
aistudio.google.com How best to create the beginning of #RealisticVirtualHarbin #HotSpringsWarmPool with #ONSEN video - youtu.be/X6YBetANDUI sitting on #HWarmPool's front bench near #HarbinWPFrontStairs looking toward the #HarbinHotPoolRoom doorway?



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https://youtu.be/X6YBetANDUI





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Moraga public library 10/31/25 - 

Regarding our conversation about eliciting loving bliss neurophysiology or neural cascades of pleasure ... (and regarding your focus on promotion too)

(wrote accidentally 'Morag apublic library 10/31/25' ... where morag in Scotland means 'great' and moraga in Spanish means a countryside or beach picnic)


John, 

Again, nice to meet and talk with you.

Regarding our conversation about eliciting loving bliss neurophysiology or neural cascades of pleasure ... (and regarding your focus on promotion too) ... and in one conceiving as if playing one's bodymind as a musical instrument, or re a related on off switch ...

1
here are the Guidelines for practicing a musical instrument I mentioned, (which I've found useful in playing now the Scottish small pipes for example)

Guidelines for practicing a musical instrument

2
And here is a riff with the above, brainstorming - 

Guidelines for practicing loving bliss vis-à-vis practicing a musical instrument


3
And here's a related letter in these regards - 

Loving bliss and practices to elicit this 

I wrote these some years ago, and only sometimes explore eliciting loving bliss neurophysiology, e.g. by turning on specirc music as an input or on off switch for example, and may explore updating these further in the future.

Am not sure how one would promote these ... and I think teaching or 'education' about them might be a similar focus and per this wiki subject or school too - https://wiki.worlduniversityandschool.org/wiki/Loving_Bliss_(eliciting_this_neurophysiology)  (from https://wiki.worlduniversityandschool.org/wiki/Subjects) ...

thoughts? 

Regards, best wishes, more later, thanks, cheers, 
Scott
'loving bliss' label -


PS
After talking with you re the Cromarty dialect in Scotland, and WUAS seeking to create wiki schools in all 7159 known living languages (mutual intelligibility is one definition of language) per the Ethnologue, and extinct languages too ... I wanted to learn a little further about the Cromarty dialect and what makes it distinct 


Found -

The Cromarty dialect, a dialect of North Northern Scots spoken in Cromarty, Scotland, is now extinct after the death of its last native speaker, Bobby Hogg, in 2012. The dialect was unique for its specialized nautical vocabulary, the use of archaic "thee" and "thou," and an aspirate "h" that could be added or dropped in certain words. 
  • Extinction: The last native speaker, Bobby Hogg, died on October 2, 2012, leading to the dialect's extinction.
  • Linguistic classification: It was a dialect of Modern Scots, specifically belonging to the North Northern Scots branch.
  • Origin: It is thought to have developed from the language of fishing families who moved north in the 15th and 16th centuries, possibly with influences from a fusion with English from visiting soldiers.
  • Key features:
    • Nautical terminology: The dialect was heavily specialized for talking about fishing techniques and equipment.
    • Archaic forms: It used archaic pronouns like "thee" and "thou," which were still in common use in the first half of the 20th century.
    • Aspirate "h": It featured an "h" being either added or subtracted from words. For example, "ear" could become "hear" and "herring" could become "erring".
  • Preservation efforts: Efforts were made to record the dialect before it disappeared, with the help of the Hogg brothers and projects like Am Baile, a Scottish Highland Council initiative

AND
And here's a wiki school or subject in these regards - 





PPS
Seeking for avatar agents (online digital bots as large language models and with ChatGPT Gemini AI etc) will help people who might be interested (linguists, scholars, Scots, etc.) learn to speak Cromarty dialect in the future)




The Cromarty Fisherfolk Dialect 

(in northeast Scotland, now extinct)


https://www.ambaile.org.uk/coo/user/assets/3/621.pdf



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On Fri, Oct 31, 2025 at 4:08 PM Scott MacLeod <sgkmacleod@worlduniversityandschool.org> wrote:
Hi John,

Great to hear from you and to meet you.

Want to explore finding great Walking Bass lines on Web video in one way or the other re 


and say in Barber Shop Quartet Singing - 
? 

Cheers, 
Scott
And here is a recent open free Mondays at 10 am PT WUaS News and Q&A to see the process that is in some ways guiding best STEAM CC OpenCourseWare World Univ & Sch - 
https://worlduniversityandschool.blogspot.com/2025/10/mt-hood-clackamas-wilderness-or-m.html



PS
While I added these here years ago, they aren't quite the inspiring Singing_Walking_Bass_Lines I'm looking for - 
(to see how WUaS can work too, wiki-wise) .

Select Video and Audio

[edit]


Bitte Bass. 2010. Sing Sing Sing Walking Bass. Youtube.com.

FairField Four - Children Go Where I Send Thee. 1992. FairField Four - Children Go Where I Send Thee. (From the album "Standing in the Safety Zone" - Hear, too - https://www.youtube.com/watch?v=ZoEgxT_SmCo and https://www.youtube.com/watch?v=wxT56WIAOtA). Vinicius Lima Youtube channel.

Kingway88. 2010. Chris Tomlin - Sing Sing Sing Own Bass Line. Youtube.com.

Davemuscato. 2010. Walking Bass. Youtube.com.




PPS


On Fri, Oct 31, 2025 at 1:42 PM John Seifert <fv5live@icloud.com> wrote:
Nice Experience… Enjoy your day!

Sent from my iPhone

On Oct 31, 2025, at 1:11 PM, Scott MacLeod <sgkmacleod@worlduniversityandschool.org> wrote:


John, 

Happy Halloween. 



Scott




--
--

Society, Information Technology, and the Global University (2025, forthcoming) 

- Scott GK MacLeod  
Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki, 
World University & School (WUaS) 
- USPS US Post Office, General Delivery, Canyon, CA 94516 


1) non-profit 501(c)(3) Public Charity 
best STEAM CC licensed OCW, Wiki, 
World University and School - http://worlduniversityandschool.org 

2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html

(m) 412 478 0116 - sgkmacleod@gmail.com 


World Univ & Sch Innovation Research - 






* * * 


For real real time music making eventually, in a #RealisticVirtualEarthForMusicMaking even?

Reposting Kent Walker's LinkedIn post - 

For #RealRealTime music-making eventually? Best STEAM Creative Commons' licensed #OpenCourseWare wiki #WorldUniversityAndSchool's Music School for all musical instruments, ever, each a wiki Subject page or School, & in all languages, ever, and for #OnlineMusicMakingWUaS, would be very interested in this, & for our WUaS free-to-students' online #WUaSMusicDegrees - https://wiki.worlduniversityandschool.org/wiki/World_University_Music_School and in a

#RealisticVirtualEarthForMusicMaking (and re a

#RealisticVirtualEarth & WUaS, - please see Peter Norvig's INCREDIBLE

#ToolifyAIWUaS article - https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306). Thanks!


https://www.linkedin.com/posts/scott-macleod-4691a011a_love-this-one-well-be-piloting-google-beam-activity-7390448329018507264-GDXR




* 
slightly differently - 
 
For real real time music making eventually even? Best STEAM Creative Commons' licensed OpenCourseWare wiki World University and School's Music School for all musical instruments, each a wiki Subject page or School, & in all languages, ever, and for online music-making, would be very interested in this, & for our WUaS free-to-students' online music degrees - https://wiki.worlduniversityandschool.org/wiki/World_University_Music_School
 and in a #RealisticVirtualEarthForMusicMaking (and re a #RealisticVirtualEarth & WUaS please see Peter Norvig's INCREDIBLE #ToolifyAIWUaS article - https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306) Thanks!



Reposting - 

Love this one: We’ll be piloting Google Beam in select USO centers globally.

This 3D video communication platform is AI-powered to transform video streams into conversations that make you feel like you're in the same room.

Find out more → http://goo.gle/3Laextc






* * * 


What are leading universities studying higher, faster, stronger, more supple (Yoga) genetics and epigenetics around the world (e.g. for athletes, possibly re Olympic athletes, and even for Yoga asana too)? 





Research into the genetics and epigenetics of physical performance, often connected to the phrase "higher, faster, stronger" (the Olympic motto "Citius, Altius, Fortius"), is a growing field. Leading universities and research initiatives are studying elite athletes, though the specific application to yoga asana within this genetic context is less prominent and more focused on the general health benefits and their epigenetic impacts. 
Leading Universities and Research Initiatives
The primary effort in the genetics of elite athletic performance is led by the Wu Tsai Human Performance Alliance, a collaborative research initiative involving several top institutions: 
  • Stanford University (USA): Stanford is a central hub of the Alliance and spearheads the ELITE (Exercise at the Limit—Inherited Traits of Endurance) Study. This international study aims to identify the genetic factors that contribute to elite endurance performance by recruiting 10,000 top athletes with high VO2 max scores. Researchers like Dr. Euan Ashley co-lead projects such as the Molecular Athlete project here.
  • Boston Children's Hospital (USA): Another core hub of the Wu Tsai Human Performance Alliance, contributing to research on peak human performance and its medical applications.
  • The University of Kansas (USA): Also part of the Alliance, involved in the interdisciplinary study of human performance.
  • University of Oregon (USA): A hub within the Alliance, focusing on different aspects of human performance research.
  • Salk Institute for Biological Studies (USA): Contributes to the fundamental biological research within the Alliance.
  • University of California San Diego (USA): The sixth primary hub involved in this major research effort. 
Research on Yoga and Epigenetics
While the above institutions focus on general athletic performance, other research focuses specifically on the epigenetic effects of practices like yoga. This research tends to concentrate on the health and wellness impacts, rather than high-performance athletics or Olympic potential: 
  • Various Institutions in Collaboration (e.g., NIH, University of Patras, Erasmus University Medical Center): Research reviews published in journals associated with the National Institutes of Health (NIH) explore the potential clinical benefits of yoga on epigenetics and gene expression. These studies indicate that yoga interventions can influence gene expression profiles, likely mediated by epigenetic pathways, particularly in areas related to stress reduction and overall health. 
Summary
The most prominent universities studying the genetics of elite athletic performance are those within the Wu Tsai Human Performance Alliance, with Stanford University leading the large-scale ELITE Study. Research on the epigenetics of yoga is conducted across various institutions globally and highlights its potential health benefits, but is largely a separate field from the high-performance athletic genetics research




* * 
In brief, how would higher, faster, stronger, more supple (Yoga) genetics and epigenetics work genetically (e.g. for athletes, possibly for Olympic athletes, and even for Yoga asana too) - and how could even a realistic virtual earth for genetics and think alpha fold 3 server, and google Street view with a google time slider, google maps connected through our avatar agent electronic health records via possibly the e-Rapid sensor - and with little Pegman in street view becoming our  electronic health records,  brainstorming-wise? 



Genetics and Epigenetics of Elite Performance
Genetics provides the baseline potential for traits like strength, speed, and flexibility through variations in specific genes. Epigenetics, in brief, explains how environmental factors like training, nutrition, and lifestyle can modulate this genetic expression, optimizing the inherited potential. 
  • Genetics: Specific gene variants are consistently associated with different types of performance. The ACTN3 gene (R/R genotype) is linked to power and sprint activities (higher, faster, stronger), while the ACE gene (I/I genotype) is associated with endurance (more supple in terms of sustained effort and efficiency). These genes influence muscle fiber type composition, oxygen transport, and injury susceptibility.
  • Epigenetics: Training and lifestyle factors induce reversible chemical changes (e.g., DNA methylation) that turn genes "on" or "off" without altering the underlying DNA sequence. For athletes, this can mean:
    • Optimized adaptation: Intense training triggers epigenetic changes that promote muscle growth, enhance recovery, and improve cardiovascular efficiency.
    • Injury resistance: Certain epigenetic patterns can influence collagen production and inflammatory responses, potentially reducing injury risk.
    • Yoga asana: Yoga practice itself has been shown to influence stress-related gene targets and downregulate pro-inflammatory cytokines, promoting mind-body well-being and cellular integrity. 
Brainstorming: Virtual Earth and Health Tech Integration 
A realistic virtual earth platform integrating advanced AI and health data could revolutionize personalized health and athletic development: 
  • AlphaFold 3 Server Integration: AI models could predict how specific genetic variations and epigenetic changes impact protein structure and function (e.g., muscle proteins, collagen), offering a molecular-level understanding of physical traits. This could inform personalized training and nutrition plans based on an individual's unique molecular profile.
  • Google Street View & Time Slider for Environmental Context: Public health researchers currently use Street View to assess the local environment's impact on health (e.g., green spaces, sidewalks). The integration of a time slider could track environmental changes over an individual's lifetime, correlating environmental exposures with their health records and epigenetic profiles.
  • Avatar Agent Electronic Health Records (EHRs): The "little pegman" could act as a user's avatar, representing their longitudinal EHR data within the virtual earth environment.
    • Geospatial Health Analysis: Clinicians and researchers could use the avatar's location history (via GPS data from connected devices like an eRapid sensor) to visually map health outcomes against environmental factors, identifying localized health risks or benefits.
    • Predictive Modeling: By combining genetic data, real-world environmental exposure data (Street View), and physiological sensor data (eRapid sensor), AI could create highly accurate predictive models for disease susceptibility, athletic potential, and optimal training responses.
    • Interactive Health Planning: The avatar could navigate potential training routes or locations, with the system providing feedback on environmental factors (e.g., air quality, terrain, access to facilities) and how they might interact with their genetic/epigenetic profile to achieve "higher, faster, stronger, more supple" goals.



* * 

For reversing muscle wasting too, and as we age from age 40 on, in brief, how would higher, faster, stronger, more supple (Yoga) genetics and epigenetics work genetically (e.g. for athletes, possibly for Olympic athletes, and even for Yoga asana too) - and how could even a realistic virtual earth for genetics epigenetics genomics and think alpha fold 3 server, and google Street view with a google time slider, google maps connected through our avatar agent electronic health records via possibly the erapid sensor - and with little pegman in street view becoming our electronic health records, brainstorming-wise?


Genetics and epigenetics influence muscle traits by setting a baseline potential and regulating how genes respond to environmental factors like exercise and diet. A virtual earth system could integrate genomic, environmental, and health data to enable personalized health strategies for reversing muscle wasting and promoting healthy aging. 
Genetics and Epigenetics of Muscle Health and Performance
  • Genetics (The Blueprint): Genes establish an individual's potential for traits like muscle fiber type (fast-twitch for power/strength, slow-twitch for endurance), bone structure, and hormone levels (e.g., testosterone, IGF1). Variants in genes like ACTN3 and ACE are associated with power and endurance performance, respectively. However, genetics provide a baseline, not a fixed outcome; training and environment are crucial for maximizing this potential.
  • Epigenetics (The Regulator): Epigenetic modifications (e.g., DNA methylation, histone modification) don't change the DNA sequence but control which genes are turned on or off. These are dynamically influenced by lifestyle choices like exercise, nutrition, and stress.
    • Reversing Muscle Wasting/Aging: Regular exercise can slow or even reverse aspects of epigenetic aging in skeletal muscle, making muscle tissue appear biologically younger. It helps maintain a "youthful" gene expression profile by modulating pathways involved in muscle growth, repair, and inflammation.
    • Performance (Strength, Speed, Suppleness): Exercise triggers a cascade of events that alter the epigenome, selectively activating genes for muscle adaptation, growth (hypertrophy), and recovery. This allows muscles to respond to training stimuli (e.g., higher intensity, resistance) by increasing strength and size. 
Brainstorming a Virtual Earth Integration for Health
A realistic virtual earth system could serve as a powerful interface for integrating vast amounts of health data and optimizing personalized health interventions: 
  • Data Integration: The system would link personal genomic, epigenomic, and health records (via an avatar agent) with real-world environmental data (e.g., local air quality, temperature, food environment) from satellite imagery, Google Maps, and potentially ERAPID sensors.
  • Personalized Insights (Pegman as EHR): Little Pegman in Street View could transform into a visual representation of an individual's electronic health record (EHR). Clicking on Pegman could display a "time slider" revealing health changes over time, influenced by location-specific environmental factors or past lifestyle choices.
  • Predictive Modeling (AlphaFold 3): Data could be fed into advanced AI models like AlphaFold 3 to predict how specific genetic variations and epigenetic patterns might influence protein function, disease susceptibility (like sarcopenia), and response to specific interventions (e.g., a particular yoga pose or diet).
  • Simulations and Interventions: The virtual environment could simulate the impact of different lifestyle changes. For example, the avatar agent could "walk" past a virtual gym, and the system could project the potential positive epigenetic and muscle health outcomes of joining that gym, providing data-driven motivation for specific actions.
  • Proactive Health Management: This system could facilitate personalized medicine by identifying those at genetic risk for age-related muscle loss and recommending preventative measures (e.g., specific resistance training and protein intake recommendations) before significant decline occurs.





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In terms of adding copies of genes back into human body minds, rather than engineering cells, and per George Church in this 60 Minutes 67 second-long interview excerpt - How soon could humans reverse the aging process with genetic engineering? https://youtu.be/bnCEIPQFNnk ... please watch / access the video Gemini AI ... What genes to potentially add back into human bodies to reverse muscle wasting genetically and epigenetically?


Based on the 60 Minutes interview excerpt with George Church and supporting information regarding his research, here is the answer to your questions about reversing the aging process.

Timeline for Age Reversal in Humans

George Church estimated that a veterinary product for age reversal, currently in clinical trials on dogs, might be a couple years away [01:00]. After that, he projected it would take another ten years to get through the human clinical trials [01:00]-[01:04], placing the potential availability of such a therapy for humans about a decade or more from the time of the interview.

Church clarified that his lab's approach is not gene editing but rather adding extra copies of genes to boost function that has declined with age [00:52]-[01:00].

Genes to Potentially Add to Reverse Muscle Wasting

While the video does not name the specific genes, George Church's related research focuses on using a multiplex gene therapy approach to add copies of genes to reverse age-related decline, including muscle wasting.

Genetic Factors for Muscle Wasting

The primary gene identified in research connected to George Church that addresses muscle wasting is:

  • Follistatin (FST): This protein promotes muscle growth and repair. In studies on mice, the gene therapy delivering Follistatin significantly improved physical performance and helped prevent body mass loss. It is strongly implicated in treating muscular dystrophy and muscle loss caused by aging.

Another key gene used in this anti-aging approach is:

  • Telomerase Reverse Transcriptase (TERT): TERT is a gene that helps lengthen telomeres, which are protective caps on the ends of chromosomes that shorten with age.

Epigenetic Factors

The work also encompasses the epigenetic reversal of aging, which involves restoring youthful patterns of gene expression. Church believes a surprising amount of rejuvenation can be achieved this way. An approach to epigenetic reprogramming involves the use of Yamanaka factors, which are specific genes that can reset the cell's age. These factors include:

  • Oct4, Sox2, and Klf4 (OSK): Ectopic expression of these genes has been shown to restore youthful DNA methylation patterns and improve tissue function and regeneration in aging central nervous system tissue. Since the gene therapy approach uses the addition of genes to achieve this reprogramming, it addresses the epigenetic component of aging.

The therapy delivers these factors into the bloodstream, which means they do not require efficient delivery to every single cell to have a body-wide effect.



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* 

In terms of adding copies of genes back into human body minds, rather than engineering cells, and per George Church in this 60 Minutes 67 second-long interview excerpt - How soon could humans reverse the aging process with genetic engineering?

https://youtu.be/bnCEIPQFNnk - and For reversing muscle wasting too, and as we age from age 40 on, in brief, how would higher, faster, stronger, more supple (Yoga) genetics and epigenetics work genetically (e.g. for athletes, possibly for Olympic athletes, and even for Yoga asana too) - and how could even a realistic virtual earth for genetics epigenetics genomics and think alpha fold 3 server, and google Street view with a google time slider, google maps connected through our avatar agent electronic health records via possibly the erapid sensor - and with little pegman in street view becoming our electronic health records, brainstorming-wise?




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Mealt waterfall with Kilt Rock behind














https://en.wikipedia.org/wiki/Loch_Mealt

https://commons.wikimedia.org/wiki/Category:Loch_Mealt


...


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