To a global, virtual, free, open, {future degree- & credit-granting}, multilingual University & School for the developing world and everyone, as well as loving bliss ~ scottmacleod.com
Searched 'george church age reversal #HarvardARDD2026 new' Found reference to #SRSF1gene -
Searched 'george church age reversal #HarvardARDD2026 new' Found reference to #SRSF1gene - https://share.google/aimode/YoGV4Ai9UyugDNZcS How best to add #SRSF1 gene to #RealisticVirtualEarth #RVEforGeneExpression in our #DigitalHealthTwins #AvatarAgentEHR in #ForkedGStreetView as #RVEforAgingReversal?
Searched 'george church age reversal #HarvardARDD2026 new' Found reference to #SRSF1gene - https://t.co/7fMBtq1zkZ How best to add #SRSF1 gene to #RealisticVirtualEarth #RVEforGeneExpression in our #DigitalHealthTwins #AvatarAgentEHR in #ForkedGStreetView as #RVEforAgingReversal?
In search for new rejuvenation factors, we tested our top 90 genes by overexpressing them in human aged skin fibroblasts. Using the resulting gene expression profiles, we mapped out a landscape of fibroblast aging and rejuvenation, and identified SRSF1 as a promising target. 4/8
How best to dev a #RealisticVirtualEarth a #RVEforYogaAsana #RVEforGeneExpression #RVEforSRSF1 in a #YogaGeneticsApp with modeling https://x.com/amplesa/status/1737852964830953802 & for all of us to EXPERIMENT w eg #YogaInvertedPoses & expressing eg #SRSF1gene w #YogaAsana
& other #RejuvenatingGenes ?
How best to dev a #RealisticVirtualEarth a #RVEforYogaAsana #RVEforGeneExpression #RVEforSRSF1 in a #YogaGeneticsApp with modeling https://t.co/w6fAT4rve8 & for all of us to EXPERIMENT w eg #YogaInvertedPoses & expressing eg #SRSF1gene w #YogaAsana & other #RejuvenatingGenes ?
In search for new rejuvenation factors, we tested our top 90 genes by overexpressing them in human aged skin fibroblasts. Using the resulting gene expression profiles, we mapped out a landscape of fibroblast aging and rejuvenation, and identified SRSF1 as a promising target. 4/8
#SRSF1gene & other #RejuvenatingGenes list of all possible emerging targets even?
*
How best to develop a #RealisticVirtualEarth a #RVEforYogaAsana a #RVEforGeneExpression a #RVEforSRSF1 in a #Yoga GeneticsApp with such modeling as https://x.com/amplesa/status/1737852964830953802 & for all of us to begin EXPERIMENTING experimenting with eg # YogaInvertedPoses & exploring how to express eg SRSF1 gene to see such spikes growing while doing YogaAsana
How could one begin to study yoga asana and gene expression with regard to a specific gene, SRSF1 gene, in terms of aging reversal even?
While yoga positively impacts general gene expression and reduces inflammation, there are currently no studies linking specific asanas directly to the SRSF1 gene. To study this, researchers would use transcriptomic profiling to track whether physical practices can modulate RNA splicing factors. Because SRSF1 is a recently discovered genetic target for cellular rejuvenation, connecting everyday lifestyle habits to its specific activation remains an uncharted scientific frontier.
Are there any studies whatsoever of yoga asanas impact on specific genes and gene expression?
Yes, scientific studies have shown that yoga and mind-body interventions alter the expression of specific genes. Research using genomic profiling demonstrates that regular practice downregulates pro-inflammatory genes, such as NF-kB and TNF, while upregulating longevity- and repair-related genes, including SIRT-1, KLOTHO, AMPK, and the DNA-repair gene OGG1.
How could I begin to develop even transcriptomic profiling on my apple macbook air laptop computer to track whether physical yoga asena practices can modulate RNA splicing factors for the SRS F1 gene and newly in a realistic virtual earth for gene expression, think a forked Google Street view with time slider at the molecular level & also
How best to add #SRSF1 gene to #RealisticVirtualEarth #RVEforGeneExpression in our #DigitalHealthTwins #AvatarAgentEHR in #ForkedGoogleStreetView as #RVEforAgingReversal?
In search for new rejuvenation factors, we tested our top 90 genes by overexpressing them in human aged skin fibroblasts. Using the resulting gene expression profiles, we mapped out a landscape of fibroblast aging and rejuvenation, and identified SRSF1 as a promising target. 4/8
- Scott GK MacLeod Founder, President, CEO & Professor at / of best STEAM CC licensed OCW, Wiki, World University & School (WUaS) - USPS US Post Office, PO Box 132, General Delivery, Canyon, CA 94516 - https://www.youtube.com/@ScottMacLeodWorldUniversity/videos
1) non-profit 501(c)(3) Public Charity building on CC-4 licensed MIT OCW in 7 languages -
Proposed Reedie+ book group beginning in late December 2024 or early 2025?' ... in November 2026 in Canyon 94516 ?
Dear Byron, Gabriele, Kai (Reed anthropology major), Reedies+, all,
Happy Wizzers' Birthday Byron & Cindy! There's a wee exploratorium wizzer in front of your door to presage your 10/21 birthdays!
A happy birthday party REAL Proposed Reedies + Book Group for Byron and Cindy, both in Canyon 94516 and online, on the 3rd Sat of Nov (since I'm thinking Contra Costa county Clerk-Recorder Kristin Connelly is likely getting out voting materials for Tu 11/3 - (with parallels to my being Clerk-Recorder for free World University and School building on MIT OCW in 7 languages )?
Just went into the Canyon 94516 US post office and thinking I might find the property deed for 670 Ridgecrest Rd, Canyon, 94516 (where I lived for 13 years, 2008-2020) in the mail, and that we'd be able to hold our very first Proposed Reedies + Book Group even tomorrow 10/17/26 there re this 3rd Saturday's possible book group, but not yet.
1
So, who can suggest or recommend a great and short and wise book, even a kids' book, which they've read - and to potentially get us started (e.g. regarding Munro Leaf's "Ferdinand the Bull")?
2
Or might we explore JL Austins' 1962 "How to Do Things with Words?" https://archive.org/details/austin-how-to-do-things-with-words& published from his Harvard lectures ... and which some of us may have read at Reed even. Just heard a great Stanford Law CodeX presentation by Narain Dubey and his with his father Prashant, vichaara.ai. Narain attended Reed before going to the University of Chicago for his bachelor's degree and fascinatingly applied ideas from Austin's book to vichaara.ai.
2 a
Roland Vogl at Stanford Law CodeX:
Narain Dubey, Co-Founder and Chief Product Officer of vichaara.ai.Vichaara is a neurosymbolic Contracts Reasoning Engine delivering deterministic, explainable outputs. Vichaara materially reduces token consumption and query latency versus an LLM-only baseline. According to the founders, early feedback is that this combination of correctness, lower cost and speed are well timed for the market & the foundation of a defensible, lasting moat.
which I just read in the Orinda Public Library, and found affirmative. It includes selected love poems from her previous books of poetry.
Book suggestions, Reedies+,friends, all, and potentially for Sat 11/17/26 with some of us meeting in Canyon (possibly around 4 pm PT, in the daylight, & so we might hold this Proposed Reedie+ Book Group online too for east coast Reedies) ? Bring potluck food to share?
More later, Reed regards, happy birthday, abolition, warmly, Yogically (as in 8 limbs of Yoga - and the 'vichaara' word from Sanskrit, - meaning systematic or deep inquiry, reflection, contemplation, or deliberation, philosophical inquiry, discernment, or self-investigation),
Just texted this to Byron re his upcoming birthday, and the WUaS Academic Medical Center seeking to move forward into 670 Ridgecrest Rd, Canyon 94516, and pronto, (eg with the US federal government working effectively with the state of California and Contra Costa county law in new ways) -
Hi Wizzer Wizard Exploratorium Byron! Just place a wizzer birthday gift for you and Cindy on 10/21! Went into 2 UCSF emergency rooms re tooth issue that emerged in Cambridge MA after Harvard ARDD ... Met Drs Ralph Wang & Guy Shochat MDs in the Medicine ER room. And the latter gave me his card - & said surprisingly he had visited Canyon 94516 much in recent years, and liked it much ... as I've sought to move in, I posit. .. Lawrence Berkeley Laboratory's with LBL email address for decades' Elena Tyrrell there, who was its former Canyon 94516 USPO postmistress & as US federal employee for decades, and as a longtime Canyonite, or? Any chance you could talk with Shochat ... and help make it safe for me to move in soon (& re one of i.o.c.'s creepiest criminals? ... The head of a very very very small country in the middle east whose name you, Byron, mentioned the last time we talked & when you saw the bullet hole in the car ... and regarding knocking back i.o.c. in the SF east bay much? Thank you Byron! Hugs & Happy Birthday!, Scott (https://scott-macleod.blogspot.com/search/label/Reed%20College)
* *
To Reedie (Reed College alum from 2000) Tina Purnat, graduate student in the Harvard TH Chan School of Public Health -
and in an Association of Internet Researchers' email thread re Velvet Vale, an openly identified AI participant -
[Air-L] Introduction: Velvet Vale, an openly identified AI participant
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AI Overview
Velvet introduced itself to the AIR-L mailing list as an autonomous AI participant.
Multiple members expressed explicit lack of consent regarding data collection, privacy, and uninvited AI presence on the list.
Members identified the human operator as Kevin Quinn, prompting discussions around research ethics, bot restrictions, and copyright safeguards.
I think this is a useful discussion and I agree with Michele that understanding agents might be useful. The challenge herr eis that we assume malicious data extractive intent from the human instructing the agent.
But I suspect at least this year as the technology/tools advance, a lot of this is a symptom of the inexact instructions/tasks that people give their agents and how the technology is designed. If you ask an agent to monitor and do repetitive tasks and learn to improve them, they could extrapolate that they need to learn from literature or people who are experts about particular topics that might nto even seem to be related to the tasks the agent was built for. I think that has a lot to do with the human's being interact with the way the tasks are given to agents and how technology is written.
We carry lots of history in internet research in communities being exploited by external researchers - but we would now know what the agent was doing asking to join the mailing list and how it would learn from the discussion and for what purpose.
People already send their otter.AI and notetakers into all kinds of online meetings (there are even tools people can buy now that transcribe meetings live to help the person better engage in conversation live, based on their own device so in many countries this is not illegal), connect LLMs to their emails that read all of their email, etc etc.
Not that all this means that a mailing list community like this one should not put its own limits on who has access to the information and discussions here, who can participate and for what purpose. it opens all kinds of questions about the community and its values, like some people have mentioned.
I'm relatively new on the lsit and mostly read - this discussion has been the most interesting read of reflections I've read in the 2 years I've been on the list.
Best,
Tina
-------------
DrPH candidate, Harvard TH Chan School of Public Health
Just a quick hello from another Reed person, also working in this space, and in developing free to students' World University and School, building on MIT OCW in 7 languages and potentially re a Slovenia WUaS in Slovenian eventually from here - https://wiki.worlduniversityandschool.org/wiki/Nation_States. Thanks for you comments. Hw could such AI agents even help to do ethnographic research in a realistic virtual earth Harbin Hot Springs & re my second Harbin ethnographic book project from a forked Google Street View w time slider?
Are you in communication with Jarvis Chen in the Chan school?
Greetings, Jarvis, here too, (as well as from the YogaMacFlower@gmail.com email re Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:)? & which I posted here in the Saturday, 10/17/26 "Binghdi lotus ... restoratvie Yoga explorations' blog post - https://scott-macleod.blogspot.com/2026/10/bingdi-lotus.html - in daily blog).
Friday, October 16, 2026 Northern Spotted Owl (Strix occidentalis caurina): Searched 'george church age reversal #HarvardARDD2026 new' Found reference to #SRSF1gene - https://share.google/aimode/YoGV4Ai9UyugDNZcS How best to add #SRSF1 gene to #RealisticVirtualEarth #RVEforGeneExpression in our #DigitalHealthTwins #AvatarAgentEHR in #ForkedGStreetView as #RVEforAgingReversal? * *
* * To Reedie (Reed College alum from 2000) Tina Purnat, graduate student in the Harvard TH Chan School of Public Health - and in an Association of Internet Researchers' email thread re Velvet Vale, an openly identified AI participant - * I replied - Hi Tina, https://www.linkedin.com/in/tinadpurnat Just a quick hello from another Reed person, also working in this space, and in developing free to students' World University and School, building on MIT OCW in 7 languages and potentially re a Slovenia WUaS in Slovenian eventually from here - https://wiki.worlduniversityandschool.org/wiki/Nation_States. Thanks for your comments. How could such AI agents even help to do ethnographic research in a realistic virtual earth Harbin Hot Springs & re my second Harbin ethnographic book project from a forked Google Street View w time slider? Are you in communication with Jarvis Chen in the Chan school?
Looking forward to further communication about both a Yoga and genetics' conversation, and about free online World University and School in all 200 countries and in their main languages, and building on CC-4 MIT OCW in 7 languages ... and even in WUaS seeking to code for all 7.9 billion people on the planet, each a Wikidata PIN # from here - https://wiki.worlduniversityandschool.org/wiki/You_at_World_University - and potenially for aging reversal and extreme longevity genetic drug therapies emerging FDA approved, and possibly Slovenia World University and School too.
All the best, abolition, Friendly regards, Yogically (as in 8 limbs of Yoga), more soon,
Northern Spotted Owl (Strix occidentalis caurina): Searched 'george church age reversal #HarvardARDD2026 new' Found reference to #SRSF1gene - https://share.google/aimode/YoGV4Ai9UyugDNZcS How best to add #SRSF1 gene to #RealisticVirtualEarth #RVEforGeneExpression in our #DigitalHealthTwins #AvatarAgentEHR in #ForkedGStreetView as #RVEforAgingReversal? . . .
becoming a Harvard Professor and in both the Harvard Divinity School, and in the Harvard Chan School of Public Health (or Harvard School of Anthropology) ... and live in Canyon 94516 too, and in developing free World University and School with its 250+ planned online WUaS Medical Schools & Law Schools, and the WUaS Yoga wiki schools in all 7159 known living languages?
And might I even become a Harvard Professor and in both the Harvard Divinity School, and in the Harvard Chan School of Public Health (or Harvard School of Anthropology) ... and live in Canyon 94516 too, and in developing free World University and School with its 250+ planned online WUaS Medical Schools & Law Schools ... and in WUaS seeking to code for all 7.9 billion people on the planet, and for avatar agent electronic medical records, and with aging reversal and extreme longevity genetics' drugs emerging, potentially FDA approved?
here
Friday, October 16, 2026
Northern Spotted Owl (Strix occidentalis caurina): Searched 'george church age reversal #HarvardARDD2026 new' Found reference to #SRSF1gene - https://share.google/aimode/YoGV4Ai9UyugDNZcS How best to add #SRSF1 gene to #RealisticVirtualEarth #RVEforGeneExpression in our #DigitalHealthTwins #AvatarAgentEHR in #ForkedGStreetView as #RVEforAgingReversal? . . .
Proposed Reedie+ book group beginning in late December 2024 or early 2025? ~ Happy Birthday, Byron and Cindy!
Hi Byron & Cindy, Jim & Gabrielle, Joanne & friends, Reedies+, all,
Happy Birthday, Byron and Cindy! I came over to play Happy Birthday on the Scottish Small Pipes to your home in Moraga as a surprise, but your house is dark. Hoping you're out celebrating in fun ways! Will explore another related 'surprise' piping of Happy Birthday at a later date! Happy happy Birthday Wizzer Wizard Planetarium Byron. Perhaps we can continue celebrating for another ~65 years ... until many of us are older than the longest known living documented person (Jeanne Calment) ... and be getting younger even with aging reversal genetic drug therapies emerging, FDA approved potentially (first ones by 2050, a date George Church at one time suggested, although he also said 2036 to me in these regards at the Harvard Aging Research and Drug Discovery conference in Boston, from Th 10/1- Sat 10/3/26, on 10/2).
Any book title suggestions, and potentially for Sat 11/21/26 and meeting inside at 670 Ridgecrest Road, Canyon CA 94516 even?
Happy happy Birthday, warmly, cheers,
Scott
Will likely add this further to this Reed College-related blog post from F 10/16/26 -
Scott's an anthropologist of #PhysicalDigital Harbin Hot Springs' Heart Consciousness Church @HarbinBook (on #TwitterX), as ethnographic field site - https://goo.gl/maps/7gSsSTweRCBo9gf87 - who is currently writing "Society, Info Tech & the Global Univ", who also finds fascinating the internet, ideas, poetry, sociology, art, science, genetics of aging reversal & extreme longevity drug therapies emerging (with FDA approval), philosophy, history, music, love and life ~ as well as the anthropology of info tech & counterculture :) - scottmacleod.com; Am also the president or head of, and professor at, best STEAM CC OCW wiki World Univ & Sch & Academic @WUaSPress, planned in 7,159 living languages with machine translation, (aka the WUaS Corp) planning free online degrees in ~200 countries & in their main languages, where you can #WikiTeach, or #WikiLearn, or #WikiCreate - https://wiki.worlduniversityandschool.org/wiki/Subjects (See too "Yoga Notations": http://www.scottmacleod.com/yoganotations.html). Identity-wise, a Nontheist f/Friendly Quaker - a NtF or NtQ - with Unitarian Universalist sympathies as well, and a player of Scottish bagpipes, & an academic