"Impact of Yoga and Meditation on Cellular Aging in Apparently Healthy Individuals: A Prospective, Open-Label Single-Arm Exploratory Study"
moving forward ? Stanford Law CodeX Fellowship & 670 Ridgecrest Road Canyon 94516?
Scott MacLeod <sgkmacleod@worlduniversityandschool.org> |
| | | |
to Sid, Marti, Peter, Janie, Dick, Nick, Shawn, Erica, Lydia, David, Hugh, John, Joan, Dennis, Joichi, Edward, John |
|
Dear Ed, John, Pin, (All),
Good morning! How are you?
Ed, you've mentioned telomerase or telomere endings and aging reversal when we've talked about this (on a walk) ... (- and of about 10 approaches to aging reversal, per George Church).
Found an interesting NIH 2017 science paper from India - and about Yoga - in these regards:
Impact of Yoga and Meditation on Cellular Aging in Apparently Healthy Individuals: A Prospective, Open-Label Single-Arm Exploratory Study
What do you think? Could Kaiser Permanente NorCal - WUaS Academic Medical Center with WUaS Longevity Genetics' (Institute in Canyon 94516) be a possibility for further related research and with a realistic virtual earth for aging reversal at the cell, molecule and street view all with time sliders' levels?
Some related sets of Tweets this morning below.
How to develop this research in a #GCellView #RealisticVirtualEarthForGenomics (in Google Street View with time slider conceptually) environment - and what's an open-label study? and what's a single-arm exploratory study?
Abstract
This study was designed to explore the impact of Yoga and Meditation based lifestyle intervention (YMLI) on cellular aging in apparently healthy individuals. During this 12-week prospective, open-label, single arm exploratory study, 96 apparently healthy individuals were enrolled to receive YMLI. The primary endpoints were assessment of the change in levels of cardinal biomarkers of cellular aging in blood from baseline to week 12, which included DNA damage marker 8-hydroxy-2′-deoxyguanosine (8-OH2dG), oxidative stress markers reactive oxygen species (ROS), and total antioxidant capacity (TAC), and telomere attrition markers telomere length and telomerase activity. The secondary endpoints were assessment of metabotrophic blood biomarkers associated with cellular aging, which included cortisol, β-endorphin, IL-6, BDNF, and sirtuin-1. After 12 weeks of YMLI, there were significant improvements in both the cardinal biomarkers of cellular aging and the metabotrophic biomarkers influencing cellular aging compared to baseline values. The mean levels of 8-OH2dG, ROS, cortisol, and IL-6 were significantly lower and mean levels of TAC, telomerase activity, β-endorphin, BDNF, and sirtuin-1 were significantly increased (all values p < 0.05) post-YMLI. The mean level of telomere length was increased but the finding was not significant (p = 0.069). YMLI significantly reduced the rate of cellular aging in apparently healthy population.
Take blood samples at the beginning of 12 weeks and at the end with an N of 100, with 50 people doing Yoga regularly, and 50 not - ... and look at the cardinal biomarkers mentioned in the article?
What do you think?
Fond regards, best wishes, Yogic-ally,
Scott
PS
Next steps #AgingReversalGenetics #ExtremeLongevity w #YogaScience?
Def: Yoga & Meditation based lifestyle intervention (#YMLI): health strategy incorp. classic compon. of #WorldUnivYoga incl. #Asanas postures, #Pranayama breathing, #Dhyana #meditation #Tolahunase2017 #GCellView?
Retweeted -
searched '#AgeReversal #GeneDrugs before 2030s @geochurch'+?
*
AND
searched '#AgeReversal #GeneDrugs before 2030s @geochurch'+?
AND
Yoga Notations
(which have a genetic yoga focus and inquiries too)
*
Ed and John,
Greetings ! How are you? I hope this email finds you well. Pittsburgh is 43 F presently
... and am wondering about moving forward into a newly safe open 670 Ridgecrest Road Canyon 94516 - possibly together with a Stanford Law CodeX Fellowship position this year.
Want to meet for a coffee in a video call this weekend? Saturday or Sunday at 9 ET (12 noon PT) OR another time (possibly the following weekend a little later)?
Friendly greetings, abolitionally, best regards,
Scott
PS
pretty cool developments (for your kids or grandkids too?) -
A
Begin free #MITOCW+centric #WUaSdegrees - 4yr Bach, 2yr AS, 4yr high sch, 7yr PhD, 3yr Law, MD - ANYTIME fr home re 1st #WUaSBookstore #WUaSBusinessPlan #WalnutStreetPghPA w #WUaSstudents matric. in w #WUaSLegoRobotics '#CSFirst #wGoogle @ #WUaSunivs +
https://csfirst.withgoogle.com/s/en/home ~
Retweeting -
Begin free #MITOCW+centric #WUaSdegrees - 4yr Bach, 2yr AS, 4yr high sch, 7yr PhD, 3yr Law, MD - ANYTIME fr home re 1st #WUaSBookstore #WUaSBusinessPlan #WalnutStreetPghPA w #WUaSstudents matric. in w #WUaSLegoRobotics '#CSFirst #wGoogle @ #WUaSunivs +
https://csfirst.withgoogle.com/s/en/home ~
*
B
*
C
-#RealisticVirtualEarthForLegoRobotics ~
Retweeting
Toyota THR3 #Robot #ToyotaTHR3 #Artificialintelligence #englishhome #WholeNewGame
*
Scott MacLeod <sgkmacleod@worlduniversityandschool.org> |
| Feb 3, 2024, 8:49 PM (14 hours ago)
| | |
|
Ed, John,
Good evening.
Thanks for your encouragement to move forward into a newly safe open Canyon 94516 - when the WUaS Academic Medical Center can know it's safe.
How are you doing? Hoping this message finds you well.
Glad too for the opportunity to apply for the Stanford Law CodeX Fellowship program ... with housing potentially, and that Roland Vogl, its executive director, is thinking both about MIT OCW-centric wiki World Univ & Sch and potentially safe Canyon 94516 too.
Am curious to meet ..... .... .. in some of these regards as well - and wonder if Roland (with Byron and Cindy Hann MDs who live close to Canyon) have this in mind too.
Thoughts, ideas, questions, suggestions?
Best regards,
Scott
--
Society, Information Technology, and the Global University (2024, forthcoming)
- Scott GK MacLeod
Founder, President, CEO & Professor
CC-4 licensed MIT OCW-centric, Wiki,
World University & School (WUaS)
- PO Box 442, Canyon, CA 94516
- 5816 Callowhill St., Pittsburgh, PA 15206
1) non-profit 501(c)(3) Public Charity
MIT OCW-centric,
* * *
searched '#AgeReversal #GeneDrugs before 2030s @geochurch'+? WUaSYoga
Operationalizable #AgingReversal #TelomereDNA #YogaScience #HarbinHotSprings' #WarmPoolMeditation #RelaxationResponse & #WUaSYoga & #WUaSMeditation based lifestyle interventions (#YMLI) #WUaSResearch
https://pubmed.ncbi.nlm.nih.gov/28191278/ in #RealisticVirtualHarbin w #WUaSBrainwaveHeadbands?
*
Further operationalizable #AgingReversal #TelomereDNA #YogaScience parallels are there between #HarbinHotSprings #WarmPoolMeditation #RelaxationResponse & #Yoga & #Meditation based lifestyle intervention (#YMLI) for #WUaSResearch -
https://pubmed.ncbi.nlm.nih.gov/28191278/ - in #RealisticVirtualHarbin w #WUaSBrainwaveHeadbands ?
* *
"
An interesting operationalizable definition of Yoga for genetic aging reversal science? -
yoga and meditation based lifestyle intervention (ymli)
*
Next steps #AgingReversalGenetics #ExtremeLongevity w #YogaScience?
Def: Yoga & Meditation based lifestyle intervention (#YMLI): health strategy incorporating classic components of #WorldUnivYoga incl. #Asanas postures, #Pranayama breathing, #Dhyana #meditation #Tolahunase2017 #GCellView?
Retweeted -
searched '#AgeReversal #GeneDrugs before 2030s @geochurch'+?
*
AND
searched '#AgeReversal #GeneDrugs before 2030s @geochurch'+?
AND
Yoga Notations
(which have a genetic yoga focus and inquiries too)
*
*
Yoga Notations
(which have an Olympics' higher, faster, stronger genetic and with yoga focus and inquiries too)
* *
Scott MacLeod <sgkmacleod@worlduniversityandschool.org> | Sun, Feb 4, 2024 at 8:48 PM |
To: Edward Smyth <esmythmd@gmail.com>, John Sargent MD <jsargent@tuftsmedicalcenter.org>, Sid Mazumdar <sid.mazumdar@gmail.com>, Marti - Maitreyi Mazumdar <maitreyi.mazumdar@childrens.harvard.edu>, Peter Norvig <pnorvig@google.com>, Janie MacLeod <jkbmacleod@icloud.com>, Dick Robb <rrobbmd@verizon.net>, Nick Thompson <npt134@gmail.com>, Shawn Flaherty <stf@pghfirm.com>, Erica Robb Thaler <erica.thaler@uphs.upenn.edu>, Lydia Pintscher <lydia.pintscher@wikimedia.de>, "Demoise, David C" <demoisedc@upmc.edu>, "Hugh M. Thomas" <h.thomas@miami.edu>, John Kidder <jkidder@vtc.edu>, Joan Kidder <kidderjoan@gmail.com>, Dennis Epple <epple@andrew.cmu.edu>, Joichi Ito <Joiito@gmail.com>, Scott MacLeod <yogamacflower@gmail.com> |
Dear Ed, John, Pin, (All),
#WUaSResearch ahead? ...
This is how Aging Reversal works ... and as Harvard Researcher Alex Plesa, working with George Church, proceeds on Twitter, with much potentially for a Realistic Virtual Earth For Aging Reversal at WUaS -
* 1/8 Can we reverse aging? 7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, https://biorxiv.org/content/10.1101/2023.11.13.566787v1… we used screens to find new rejuvenation factors1/8
* 2/8 With 1000s of genes changing throughout aging, how do we know which ones to target? - Networks! To increase our odds of finding the right targets and comprehensively rejuvenating cells, we decided to focus on the central nodes in the aged gene regulatory networks. 2/8 https://twitter.com/amplesa/status/1737852956572266885
* 3/8 Next, to measure aging, we looked at gene expression changes in skin fibroblasts from donors aged 1-96yrs old. Assuming cells from young donors are healthier, we built transcriptomic functional indicators for 8 cellular processes and used them to measure overall cellular age. 3/8
* 4/8 In search for new rejuvenation factors, we tested our top 90 genes by overexpressing them in human aged skin fibroblasts. Using the resulting gene expression profiles, we mapped out a landscape of fibroblast aging and rejuvenation, and identified SRSF1 as a promising target. 4/8
* 5/8 Ok, so from a gene expression standpoint, SRSF1 induction makes these cells younger. Does that mean they also function better? - Yes, in certain aspects. We observed a reduction in cellular senescence, proteasome load, and an increase in collagen production. 5/8
* 6/8
But does this work in living organisms? - It does, at least in the skin! We showed that SRSF1 gene therapy rejuvenates old skin and reverses its wound healing ability to youthful levels in . Oh, and it’s also linked to longevity in worms 6/8
* 7/8
Cool. What next? Testing SRSF1 in age-related disease models and for healthspan extension in old . Also, larger screens in other cell types. We think this is a viable approach for discovering new rejuvenation factors to serve as basis for future age reversal therapies! 7/8
* 8/8
Thanks to and all our amazing co-authors: Sascha Jung Fawad Omar Maria Perez Matos Naftali Horwitz George Cai Amy Wagers Antonio del Sol 8/8
* Also, continuing -
What does reverse aging mean exactly? Curious to know your take on it as it seems as if a lot of people have a different take on it
*
*
AND - Also, from this email thread earlier too - Turks And Caicos Heather (TC - National flower of Turks and Caicos Islands): "Impact of Yoga and Meditation on Cellular Aging in Apparently Healthy Individuals: A Prospective, Open-Label Single-Arm Exploratory Study" * * * searched '#AgeReversal #GeneDrugs before 2030s @geochurch'+? WUaSYoga Operationalizable #AgingReversal #TelomereDNA #YogaScience #HarbinHotSprings' #WarmPoolMeditation #RelaxationResponse & #WUaSYoga & #WUaSMeditation based lifestyle interventions (#YMLI) #WUaSResearch https://pubmed.ncbi.nlm.nih.gov/28191278/ in #RealisticVirtualHarbin w #WUaSBrainwaveHeadbands?
Am curious how to bring in meditation as the relaxation response and regarding this genetics too ... and in the Harbin Hot Springs warm pool, potentially from home too in our bathtubs ... and for scientific research with new wearable research technologies. :)
Thoughts, ideas, questions, suggestions?
Scott Will seek to add here further too -
Dear Ed, John, Pin, (All),
Good morning! How are you?
Ed, you've mentioned telomerase endings and aging reversal when we've talked about this (on a walk) ... (- and of about 10 approaches to aging reversal, per George Church).
Found an interesting NIH 2017 science paper from India - and about Yoga - in these regards:
Impact of Yoga and Meditation on Cellular Aging in Apparently Healthy Individuals: A Prospective, Open-Label Single-Arm Exploratory Study
What do you think? Could Kaiser Permanente NorCal - WUaS Academic Medical Center with WUaS Longevity Genetics' (Institute in Canyon 94516) be a possibility for further related research and with a realistic virtual earth for aging reversal at the cell, molecule and street view all with time sliders' levels?
Some related sets of Tweets this morning below.
How to develop this research in a GCellView #RealisticVirtualEarthForGenomics (in Google Street View with time slider conceptually) environment - and what's an open-label study? and what's a single-arm exploratory study?
AbstractThis study was designed to explore the impact of Yoga and Meditation based lifestyle intervention (YMLI) on cellular aging in apparently healthy individuals. During this 12-week prospective, open-label, single arm exploratory study, 96 apparently healthy individuals were enrolled to receive YMLI. The primary endpoints were assessment of the change in levels of cardinal biomarkers of cellular aging in blood from baseline to week 12, which included DNA damage marker 8-hydroxy-2′-deoxyguanosine (8-OH2dG), oxidative stress markers reactive oxygen species (ROS), and total antioxidant capacity (TAC), and telomere attrition markers telomere length and telomerase activity. The secondary endpoints were assessment of metabotrophic blood biomarkers associated with cellular aging, which included cortisol, β-endorphin, IL-6, BDNF, and sirtuin-1. After 12 weeks of YMLI, there were significant improvements in both the cardinal biomarkers of cellular aging and the metabotrophic biomarkers influencing cellular aging compared to baseline values. The mean levels of 8-OH2dG, ROS, cortisol, and IL-6 were significantly lower and mean levels of TAC, telomerase activity, β-endorphin, BDNF, and sirtuin-1 were significantly increased (all values p < 0.05) post-YMLI. The mean level of telomere length was increased but the finding was not significant (p = 0.069). YMLI significantly reduced the rate of cellular aging in apparently healthy population.
Take blood samples at the beginning of 12 weeks and at the end with an N of 100, with 50 people doing Yoga regularly, and 50 not - ... and look at the cardinal biomarkers mentioned in the article?
What do you think?
Fond regards, best wishes, Yogic-ally, Scott
PS Next steps #AgingReversalGenetics #ExtremeLongevity w #YogaScience? Def: Yoga & Meditation based lifestyle intervention (#YMLI): health strategy incorp. classic compon. of #WorldUnivYoga incl. #Asanas postures, #Pranayama breathing, #Dhyana #meditation #Tolahunase2017 #GCellView?
Retweeted -
searched '#AgeReversal #GeneDrugs before 2030s @geochurch'+?
* AND
searched '#AgeReversal #GeneDrugs before 2030s @geochurch'+?
AND Yoga Notations (which have a genetic yoga focus and inquiries too)
Ed, John,
Good evening.
Thanks for your encouragement to move forward into a newly safe open Canyon 94516 - when the WUaS Academic Medical Center can know it's safe.
How are you doing? Hoping this message finds you well.
Glad too for the opportunity to apply for the Stanford Law CodeX Fellowship program ... with housing potentially, and that Roland Vogl, its executive director, is thinking both about MIT OCW-centric wiki World Univ & Sch and potentially safe Canyon 94516 too.
Am curious to meet ..... .... .. in some of these regards as well - and wonder if Roland (with Byron and Cindy Hann MDs who live close to Canyon) have this in mind too.
Thoughts, ideas, questions, suggestions?
Best regards, Scott
Ed and John,
Greetings ! How are you? I hope this email finds you well. Pittsburgh is 43 F presently
... and am wondering about moving forward into a newly safe open 670 Ridgecrest Road Canyon 94516 - possibly together with a Stanford Law CodeX Fellowship position this year.
Want to meet for a coffee in a video call this weekend? Saturday or Sunday at 9 ET (12 noon PT) OR another time (possibly the following weekend a little later)?
Friendly greetings, abolitionally, best regards, Scott
PS pretty cool developments (for your kids or grandkids too?) -
A Begin free #MITOCW+centric #WUaSdegrees - 4yr Bach, 2yr AS, 4yr high sch, 7yr PhD, 3yr Law, MD - ANYTIME fr home re 1st #WUaSBookstore #WUaSBusinessPlan #WalnutStreetPghPA w #WUaSstudents matric. in w #WUaSLegoRobotics '#CSFirst #wGoogle @ #WUaSunivs + https://csfirst.withgoogle.com/s/en/home ~
Retweeting -
Begin free #MITOCW+centric #WUaSdegrees - 4yr Bach, 2yr AS, 4yr high sch, 7yr PhD, 3yr Law, MD - ANYTIME fr home re 1st #WUaSBookstore #WUaSBusinessPlan #WalnutStreetPghPA w #WUaSstudents matric. in w #WUaSLegoRobotics '#CSFirst #wGoogle @ #WUaSunivs + https://csfirst.withgoogle.com/s/en/home ~
* B
* C -#RealisticVirtualEarthForLegoRobotics ~
Retweeting
Toyota THR3 #Robot #ToyotaTHR3 #Artificialintelligence #englishhome #WholeNewGame
--
Society, Information Technology, and the Global University (2024, forthcoming)
- Scott GK MacLeod Founder, President, CEO & Professor CC-4 licensed MIT OCW-centric, Wiki,
World University & School (WUaS) - PO Box 442, Canyon, CA 94516 - 5816 Callowhill St., Pittsburgh, PA 15206
1) non-profit 501(c)(3) Public Charity MIT OCW-centric,
|
|
*
https://www.timespub.tc/2010/02/the-elusive-heather/
Turks & Caicos | The Heather Plant (Limonium bahamense)
https://blog.detailsflowers.com/blog/caribbean-flowers-and-fun-facts
https://symbolhunt.com/wp-content/uploads/2021/07/Turks-Caicos-heather.jpg
https://en.wikipedia.org/wiki/Limonium
https://species.wikimedia.org/wiki/Limonium
https://symbolhunt.com/national-flowers/
...
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