Wednesday, June 26, 2024

Saussurea alpina: Where is a #RealisticVirtualEarth emerging? #PeterNorvig: https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306 #GStreetView w #GTimeSlider #GMaps - https://youtu.be/q9FBhEAXRY4 '#GCellView' #DrosophilaConnectome #GMoleculeView? https://wyss.harvard.edu/news/the-wyss-institutes-2023-2024-validation-projects/ #GAtomView A Better Way To Picture Atoms https://youtu.be/W2Xb2GFK2yc ? * * And how best to integrate this with AlphaFold3 server ? - An iterating #RealisticVirtualEarth?


Where is a #RealisticVirtualEarth emerging we can see or 'wiki' with or code too? Thnx #PeterNorvig: 







. . . with many implications for genetic aging reversal and extreme longevity too 





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Where is a #RealisticVirtualEarth emerging we can see or 'wiki' with or code too? Thnx #PeterNorvig: 
& search on - 
"Creating a Realistic Virtual Earth"
#GStreetView w #GTimeSlider #GMaps - https://youtu.be/q9FBhEAXRY4
'#GCellView'? @FlywireNews #DrosophilaConnectome
#GMoleculeView?
#GAtomView
A Better Way To Picture Atoms
https://youtu.be/W2Xb2GFK2yc ?







. . . with many implications for genetic aging reversal and extreme longevity too 




*

N-Dimensionally esp ?

Here's the idea -

You can actually experience this data as part of the amazing Invisible Worlds exhibit at the American Museum of Natural History in NYC:




* 

The fly has a full #connectome, basically a directed + weighted graph. But what are its connection ‘signs’, excitatory/inhibitory?  

We move towards this answer, predicting transmitters from EM! w/
@BobQubit, vid
@amyneurons, Published
@CellCellPress
: http://cell.com/cell/fulltext/S0092-8674(24)00307-6

https://x.com/as_bates/status/1791915932341719379



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* 

FlyWire is a connectome, or wiring diagram, of the brain of a female fruit fly, Drosophila melanogaster, created by researchers at Princeton University with the help of AI. The project is funded by the US Brain Initiative and has been collaborated with the Cambridge Drosophila Connectomics Group. 
FlyWire Connectome
FlyWire
80 Level
FlyWire: A Whole-Brain Connectome of a Drosophila Brain
Jul 3, 2023
Nature
Gigantic map of fly brain is a first for a complex animal - Nature
Mar 10, 2023 — The research, published on 9 March in Science1, provides a brain-wiring diagra...
The connectome includes over 120,000 neurons and more than 30 million synapses, as well as annotations for cell classes and types, nerves, hemilineages, and predictions of neurotransmitter identities. The FlyWire data is available online via Codex (Connectome Data Explorer) at codex.flywire.ai. 
The FlyWire connectome has been used to produce a consensus cell type atlas for the Drosophila brain, which includes 4,552 cell types. This atlas includes 3,094 cell types that validate those previously proposed in the hemibrain connectome, and 1,458 new cell types that are the result of the FlyWire connectome spanning the entire brain. 

* 



FlyWire is a connectome, or wiring diagram, of the brain of a female fruit fly, Drosophila melanogaster, created by researchers at Princeton University with the help of AI. The project is funded by the US Brain Initiative and has been collaborated with the Cambridge Drosophila Connectomics Group.

FlyWire Connectome
FlyWire

80 Level
FlyWire: A Whole-Brain Connectome of a Drosophila Brain
Jul 3, 2023

Nature
Gigantic map of fly brain is a first for a complex animal - Nature
Mar 10, 2023 — The research, published on 9 March in Science1, provides a brain-wiring diagram...
The connectome includes over 120,000 neurons and more than 30 million synapses, as well as annotations for cell classes and types, nerves, hemilineages, and predictions of neurotransmitter identities. The FlyWire data is available online via Codex (Connectome Data Explorer) at codex.flywire.ai.
The FlyWire connectome has been used to produce a consensus cell type atlas for the Drosophila brain, which includes 4,552 cell types. This atlas includes 3,094 cell types that validate those previously proposed in the hemibrain connectome, and 1,458 new cell types that are the result of the FlyWire connectome spanning the entire brain.



* 


The fly has a full #connectome, basically a directed + weighted graph. But what are its connection ‘signs’, excitatory/inhibitory?  

We move towards this answer, predicting transmitters from EM! w/
@BobQubit, vid
@amyneurons, Published
@CellCellPress
: http://cell.com/cell/fulltext/S0092-8674(24)00307-6

https://x.com/as_bates/status/1791915932341719379




--


Society, Information Technology, and the Global University (2024, forthcoming)

- Scott GK MacLeod  
Founder, President, CEO & Professor
CC-4 licensed MIT OCW-centric, Wiki, 
World University & School (WUaS) 
- PO Box 442, Canyon, CA 94516 
- 5816 Callowhill St., Pittsburgh, PA 15206

1) non-profit 501(c)(3) Public Charity 
MIT OCW-centric, 
 World University and School - http://worlduniversityandschool.org  

2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html

(m) 412 478 0116 - sgkmacleod@gmail.com 


World Univ & Sch Innovation Research -  scottmacleod.com 




* * 

And how best to integrate this with AlphaFold3 server ? - An iterating #RealisticVirtualEarth?  


AlphaFold 3 predicts the structure and interactions of all of life’s molecules 




How best to interoperate "impact of modifying genes and proteins? 🧬" w a #RealisticVirtualEarthForGenes #RealisticVirtualEarthForProteins
@WorldUnivAndSch #WUaSunivs 
https://www.toolify. ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306 
-#ToolifyAIWUaS w https://blog. google/technology/ai/google-deepmind-isomorphic-alphafold-3-ai-model/#future-cell-biology think #GstreetView w #TimeSlider #GAtomView ?
https://twitter. com/scottmacleod/status/1796502507575025975 

https://twitter. com/WorldUnivAndSch/status/1796502696910012679 

https://twitter. com/TheOpenBand/status/1796503322985460072 

https://twitter. com/sgkmacleod/status/1796503237778141566 

https://twitter. com/HarbinBook/status/1796503144375230473 

https://twitter. com/WUaSPress/status/1796502812538650981 



Retweeting - 

What is the impact of modifying genes and proteins? 🧬

We're developing the #opensource Perturbation Catalogue to answer this, integrating harmonised and curated gene, variant, and expression data

Are you a postdoc or full stack dev? Help us build this!

https://twitter. com/OpenTargets/status/1796148051146313846. ... to https://wiki.worlduniversityandschool. org/wiki/Virtual_Worlds and https://wiki.worlduniversityandschool. org/wiki/Aging_Reversal_Genetics and https://wiki.worlduniversityandschool. org/wiki/Open_Access_Resources (from https://wiki.worlduniversityandschool. org/wiki/Subjects)





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How best to interoperate "impact of modifying genes and proteins? 🧬" w a #RealisticVirtualEarthForGenes #RealisticVirtualEarthForProteins
@WorldUnivAndSch #WUaSunivs 







Retweeting - 

What is the impact of modifying genes and proteins? 🧬

We're developing the #opensource Perturbation Catalogue to answer this, integrating harmonised and curated gene, variant, and expression data

Are you a postdoc or full stack dev? Help us build this!







A #RealisticVirtualEarthFor #AgingReversalMachine too? Thnx #PeterNorvig for #ToolifyAI WOW! article: 
"#RevolutionizingEducation w #MachineLearning & AI" : @WorldUnivAndSch #WUaSunivs 



*

A #RealisticVirtualEarthFor #AgingReversalMachine too? Thnx #PeterNorvig for #ToolifyAI WOW! article: 
"#RevolutionizingEducation w #MachineLearning & AI" : @WorldUnivAndSch #WUaSunivs 
AAAB










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WOW: "#AlphaFold3 takes us beyond proteins to a broad spectrum of biomolecules. This leap could unlock more transformative science" - to accelerate #WUaSDrugDesign & #WUaSgenomics research"-Steps to #RealisticVirtualEarthFor #ForProteins #ForPharmaceuticals #AgingReversalMachine?







Retweeting - 

1.8M+ researchers have used @GoogleDeepMind’s AlphaFold protein predictions in their work on vaccine development, cancer treatment + more. AlphaFold 3 is the latest breakthrough, predicting the structures + interactions of all of life’s molecules with unprecedented accuracy. We’re sharing access to these capabilities through AlphaFold Server to enable other scientific discoveries. blog.google/technology/ai/…




*
AlphaFold 3 predicts the structure and interactions of all of life’s molecules
May 08, 2024


Introducing AlphaFold 3, a new AI model developed by Google DeepMind and Isomorphic Labs. By accurately predicting the structure of proteins, DNA, RNA, ligands and more, and how they interact, we hope it will transform our understanding of the biological world and drug discovery.



G
Google DeepMind AlphaFold team
I
Isomorphic Labs


AND 

In what ways @HankGreelyLSJU @johncumbers All could #AlphaFold3 be emerging #CSvocabulary to also predict #GeneExpression  -https://blog.google/technology/ai/google-deepmind-isomorphic-alphafold-3-ai-model/#future-cell-biology & in building a #RealisticVirtualEarthForGenetics >https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306 eg in #GStreetView w #TimeSlider #GCellView #GAtomView ?








Retweeting - 

Another indication of the complexity of gene expression, in this case in regard to splicing. My sense in this (very interesting) paper is that we still lack the vocabulary to talk about the organizational and spatiotemporal processes here. #HowLifeWorks 





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https://en.wikipedia.org/wiki/Saussurea_alpina

https://commons.wikimedia.org/wiki/Saussurea_alpina

https://commons.wikimedia.org/wiki/Category:Saussurea_alpina

https://species.wikimedia.org/wiki/Saussurea_alpina

https://www.wikidata.org/wiki/Q1421617























https://en.wikipedia.org/wiki/Saussurea_esthonica

https://species.wikimedia.org/wiki/Saussurea_esthonica



https://en.wikipedia.org/wiki/Saussurea


...


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