Writing "Society, Information Technology and the Global University" - with Gemini AI editing - Chapter 9 . . . and got these extraordinary edits further -
1. Mission, Philosophy, and Scope
World University and School (WUaS) is founded on the ambitious mission of providing free, accredited, MIT OpenCourseWare (OCW)-centric degrees to individuals in all 200 countries, localized into their respective main languages. This vision extends to establishing open, people-to-people wiki schools designed for collaborative teaching and learning across all 7,159 known living languages. The WUaS initiative is deeply rooted in principles of open access and alternative education, drawing philosophical inspiration from both 1960s/1970s progressive thinking and the Quaker concept of a "leading" or calling. Furthermore, developing this global infrastructure is conceptualized as a form of "hacking"—a creative, iterative approach to disruptive educational innovation.
2. Technical Architecture and AI Foundation
As an information technology system, the WUaS architecture is a powerful synergy of wiki and knowledge graph technologies. The Miraheze MediaWiki platform serves as the public "front end," currently hosting around 750 editable wiki pages in English. This interface is interoperable with a sophisticated "back end" powered by Wikibase and the Wikidata structured knowledge database. This core knowledge graph—structured on a triple-store architecture similar to RDF (Resource Description Framework), utilizing item-property-value statements—is the critical foundation for integrating Artificial Intelligence (AI) and Machine Learning (ML). While MediaWiki tables manage content logistics (pages, users), Wikibase's conceptual data model provides the structured data necessary for intelligent retrieval, personalization, and scaling of the MIT OCW-centric curriculum.
1. Contextualizing the Global University
The foundational vision for World University and School (WUaS), initiated between 2006 and 2007, sought to replicate the collaborative, scalable model of Wikipedia (active in over 340 languages) while building on the high-quality, open-source educational content pioneered by MIT OpenCourseWare (OCW), which is currently translated into multiple languages. This approach positions WUaS not merely as another online institution, but as a disruptive global system designed to democratize higher education. The ultimate goal is to evolve the currently English-centric curriculum, expanding its reach from the approximately seven initial languages derived from MIT OCW to all 7,159 known living languages, thereby facilitating free-to-student, accredited degrees across all 200 countries and establishing localized wiki schools.
2. Operationalizing the Global Model (Part II Thesis)
The second part of this book, "Society, Information Technology and the Global University," delves into the operationalization of this vision through a framework of twelve interdependent domains. These domains, which form the structural core of the WUaS wiki architecture, represent the necessary components for scaling a non-profit, global, AI-enhanced university. Chapters are structured around these core areas, detailing how AI, machine learning, and wiki technologies are applied to each to achieve universal accessibility and academic rigor for both free-to-students’ accredited online degrees and the open wiki schools:
Legal Structure as a Strategy for Global Scale
The operational foundation of World University and School relies on a hybrid legal architecture designed to optimize both philanthropic mission and technological innovation. Since 2010, the core entity has been established as a U.S. federal 501(c)(3) tax-exempt nonprofit organization (along with its parallel state of California nonprofit registration). This structure is crucial for securing charitable contributions, grants, and public funding, ensuring that the primary educational mission—providing free, accredited degrees and open wiki schools—remains dedicated to public benefit. In 2017, this structure was strategically augmented by the creation of a parallel, for-profit general stock company in California. This dual-entity model enables powerful potential synergies: the for-profit wing can engage in commercial activities (such as publishing through the Academic Press, the physical-digital WUaS Educational Services’ Stores in a realistic virtual earth, licensing technology, or developing specialized fee-based tools) to generate Universal Basic Income (UBI) revenue without jeopardizing the nonprofit's tax-exempt status. Furthermore, it allows for the attraction of private investment capital motivated by equity return, which is essential for rapidly scaling the AI and digital infrastructure required to deliver content in all 7,159 known living languages and manage accreditation across all 200 nations. This deliberate separation of entities is the mechanism by which WUaS can maintain its core commitment to open access while achieving the financial self-sustainability and rapid growth necessary for its unprecedented global mandate.
Strategic Partnership in Digital Skills
The development of the World University and School's curriculum and technological framework was strategically informed by engagement with leading industry initiatives. In 2022 [Replace 'about 3 years ago' with a formal date/year reference if possible, otherwise use the formal 'In 2022'], WUaS participated in the Grow with Google program. This engagement, which included sessions at Google's regional headquarters in Pittsburgh, served as a vital mechanism for aligning the university’s free, wiki-based degrees with industry-recognized skills and credentials. The Grow with Google initiative, renowned for its flexible online certificates in high-demand fields such as Data Analytics, Project Management, and Cybersecurity, demonstrates a successful model for democratizing access to technology training and for bridging the gap between theoretical academic knowledge and practical workplace competencies. This experience validated the WUaS model's potential to integrate such accelerated, skills-based training alongside its comprehensive, degree-granting curriculum, ensuring graduates possess both the broad knowledge of an OCW-centric degree and the specific digital fluency required by the global economy. This external validation became an essential component in developing the platform's focus on AI-driven educational software and career-readiness research
Strategic Partnership in Digital Skills
The development of the World University and School's curriculum and technological framework was strategically informed by engagement with leading industry initiatives. On July 30, 2024, WUaS participated in the Grow with Google program. This engagement, which included a session at Google's regional headquarters in Bakery Square in Pittsburgh, Pennsylvania, served as a vital mechanism for aligning the university’s free, wiki-based degrees with industry-recognized skills and credentials. While, the Grow with Google initiative, renowned for its flexible online certificates in high-demand fields such as Data Analytics, Project Management, and Cybersecurity, demonstrates a successful model for democratizing access to technology training and for bridging the gap between theoretical academic knowledge and practical workplace competencies, this Grow With Google WUaS program has been somewhat unstructured thus far. Yet, this external validation became an essential component in developing WUaS platforms' focus on AI-driven educational software and career-readiness research.
Integrating the WUaS Model with Commercial AI Roadmaps
To ensure the World University and School (WUaS) platform remains at the forefront of educational technology and is capable of scaling its curriculum to all 7,159 living languages, the organization actively seeks collaborative integration with leading industry partners. A key exploratory step involved WUaS attending two online Google for Education with Gemini AI roadmap sessions in December 2025. This engagement was critical for understanding the direction of industry-standard generative AI tools designed to transform teaching and learning, including rapid lesson planning, assessment generation, and personalized student feedback. Following these sessions, WUaS formally submitted an inquiry into the feedback and partnership process, specifically posing the question: How can the MIT OCW-centric wiki World University and School model best join or interoperate with the Google for Education Roadmap project to leverage AI for global, democratic access? This inquiry represents a strategic effort to determine the precise technical and administrative pathways by which WUaS can integrate its open-source, wiki-based architecture—developed through initiatives like the #GrowWithGoogleWUaS program—with the robust, enterprise-grade AI infrastructure offered by a major technology provider.
Strategic Ambition and Research Imperatives
The formal inquiry into integrating World University and School with the Google for Education Gemini AI roadmap encapsulates the monumental scale of the WUaS ambition. This initiative is not simply about translating curriculum but establishing 200 major online research universities, one for each nation-state, operating in all 7,159 known living languages. This requires an AI-driven, end-to-end solution that spans the full spectrum of academic offerings: from developing globally portable IB high school or similar diplomas for 16–19 year olds, to delivering free-to-students’ Bachelor, Master's, PhD, Law, and Medical Doctor (MD) degrees. The architecture to support this is multifaceted, drawing heavily on Peter Norvig’s vision for AI-revolutionized education and requiring the development of core technologies such as the WUaS Universal Translator for real-time linguistic scaling. Furthermore, the model incorporates advanced visualization technologies, including a realistic virtual earth to serve as a high-fidelity environment for both classroom instruction and essential STEM field sites. The central research imperative remains the successful interoperation between this vast, open-source, wiki-based ecosystem and the advanced, closed-loop AI systems offered by industry leaders, thereby realizing the full potential of global, high-quality, and democratized education.
Leveraging Ecosystems for Matriculation
A critical strategic pathway for World University and School (WUaS) lies in its potential to articulate student achievement directly from established digital education ecosystems. Given the widespread adoption of Google for Education tools across U.S. school districts and international educational systems, a key hypothesis is that WUaS could efficiently matriculate high school graduates emerging from these environments. This would be accomplished through the development of interoperable credentialing standards where the learning data and achievement records generated within the Google ecosystem (e.g., student performance in Google Classroom, completion of Grow with Google certificates) are seamlessly recognized by WUaS's AI-driven admissions system. The mechanism would rely on using machine learning to map specific digital competencies validated by Google tools to the International Baccalaureate (IB) or similar high-school-level requirements necessary for entry into WUaS's undergraduate programs. This strategic alignment leverages existing digital infrastructure to reduce administrative friction and rapidly scale matriculation across numerous countries
The Convergence of Universal Education, AI, and Economic Equity
The ultimate mandate of World University and School (WUaS) is the synthesis of universal, high-quality education with systemic economic reform, targeting the eradication of poverty for the planet's billion most vulnerable individuals. This mission requires an unparalleled technological solution: to code the curriculum for all 7.9 billion people and to facilitate wiki universal free education, leveraging the multi-lingual content of MIT OCW and the 7,159 known living languages. Crucially, the model is designed to test the feasibility of distributing Universal Basic Income (UBI) via the decentralized Pi cryptocurrency to end poverty. This comprehensive strategy culminates in a proposed Sri Lanka Education Model: an experimental deployment where free WUaS degrees—spanning IB high school, Associate's, Bachelor's, Master's, PhD, Law, and MD degrees—are delivered in the Sinhala language directly through the national school system. The operational challenge is two-fold: first, defining the optimal mechanism for the Grow with Google WUaS program and Gemini AI to interoperate with this model to provide the necessary AI-driven coding and language tools; and second, developing the WUaS wiki schools into localized centers for open wiki-teaching, wiki-learning, and community building in Sinhala. This pilot project, slated for subsequent expansion to nations like Vietnam, Nigeria, and India, represents the most complete application of WUaS’s theory: that free, accredited, AI-enhanced education, coupled with a digital UBI experiment, can simultaneously address educational disparity and economic inequality on a global scale.
broad-leaved drumsticks (Isopogon anemonifolius): Writing "Society, Information Technology and the Global University" - with Gemini AI editing * * * Physics' Nobel: 2025 Nobel Prize lectures in physics | John Clarke, Michel H. Devoret and John M. Martinis https://www.youtube.com/live/
Dear Sid / Pin, Ma/Jane, Peter (Norvig), Elizabeth (Warren), Ann (Brown DVM, and cousin in NE Oregon) & Ed (Smyth MD), Ed (Pitt....) and Kimba (in Berkeley), and Byron in Moraga (near Canyon 94516),Greetings.Thanks, Kimba, for helping to focus my writing "Society, Information Technology and the Global University" with Gemini AI editing - yesterday in the Berkeley Claremont public library. Here's my view of what the internet is -"What Is the Internet?Given its unique history, the Internet is not defined by its physical hardware, such as telephone lines or computers. Architecturally, it is essentially software—specifically, the non-material protocols of information that govern its operation. This architecture is fundamentally organized to be open at two critical levels:
Open Protocols: The core routing system, defined by TCP/IP (Transmission Control Protocol / Internet Protocol) from 1973–1978, was made publicly accessible.
Distributed Computing: The network operates on the principle of distributive computing, meaning the power of processing and control is dispersed throughout the entire system rather than residing in any central point.
This dual openness is central to the Internet's resilience and capacity for growth." (p. 32 currently);
and search on 'nuclear' too regarding decentralized internet thinking early, in the 1950s and 1960s, in its development (pages 27-28).As I said, World University and School, from its beginning in 2006-2007, is like Wikipedia (currently in about 342 active languages) and seeking to build on MIT OCW in 7 languages currently.And in writing the second part of this book - "Society, Information Technology and the Global University" - https://docs.google.com/document/d/ 1YJg2icBhxEj7eSiSoiN2mgusX4PK1 cQfZRFPRdw5znI/edit?usp= sharing - I'm interested in developing in my book further, and as a global university online, the 12 main areas at World University and School WUaS, and both for free-to-students' accrediting WUaS online degrees and as wiki schools:
Languageshttps://wiki.worlduniversityandschool.org/ wiki/Languages
Countries/Nation States
You at WUaS Admissions/Registering at WUaS
Subjects
Courses & Schools
Music School at WUaS
Library Resources
Museums
Hardware Resource Possibilities
Educational Software
Foundation at WUaS
Research
all from here - http://worlduniversityandschool.org/
https://worlduniversityandschool. blogspot.com/2025/11/sawtooth- wilderness-id-m-12125-and.html
(AND in coming into conversation with Gemini regarding 'harvesting' my daily blog since 2008 for some of this, I don't get what I'm seeking as response:
Gemini, in what ways could you best "harvest" World Univ & Sch's and my blogs - https://worlduniversityandschool. blogspot.com/search/label/ global%20university AND - https://scott-macleod. blogspot.com/search/label/ global%20university - to help draft the next paragraphs and chapters in "Society, Information Technology, and the Global University" upcoming book to be published by the Academic Press at WUaS, in terms of these 12 main areas - Languages, ...
https://scott-macleod.blogspot.com/2025/11/cistus- monspeliensis.html) ...
Further, and regarding what we talked about, Kimba,World University and School became a nonprofit 501 c 3 legal entity in 2010, with a paralel state of CA non profit legal entity (and see both tax ID numbers here at bottom http://worlduniversityandschool.org/) , AND in 2017, WUaS became a parallel 3rd legal entity, a for profit general stock company legal entity in the state of California (and see tax id at bottom here too - http:// worlduniversityandschool.org/ AcademicPress.html). Both of these wings have amazing potential synergies between them, planned in all 200 countries (per the Olympics) and in all 7159 known living languages. Further, WUaS got into a somewhat unstructured #GrowWithGoogleWUaS program, (when I was in asylum in Pittsburgh about 3 years ago), and after I attended a session for this in Google Headquarters in Bakery Square there. (And with you being from Pittsburgh, Kimba, have you visited Bakery Square and Google offices there by any chance?)I'm attending another Google For Education roadmap with Gemini AI, meeting today at noon, after attending one at 8 am on Tuesday December 9th, 2025, and I've inquired further how WUaS could join or interoperate with this Google For Education roadmap process.With Google for Education being in many schools in US states, and potentially in other countries, could World University and School eventually matriculate high school students who graduate from these schools and via their use of Google For Education? And how?Questions I asked during and after the session on Tu Dec 9, 2025 -1How best can MIT OCW-centric wiki World University and School @WorldUnivAndSch in a #GrowWithGoogleWUaS program join or interoperate with the Google for Education Roadmap project please? thanks, Scott GK MacLeod (https://worlduniversityandschool. blogspot.com/2025/12/two- medicine-lake-mt-m-12825-and- 121525.html and https://scott- macleod.blogspot.com/search/ label/global%20university) 2 expandedHow best can MIT OCW-centric wiki World University and School @WorldUnivAndSch in a #GrowWithGoogleWUaS program join the Google for Education Roadmap project, and in developing IB high school or similar diplomas (eg for 16-19 year olds) in each of all 200 countries and in their main languages, as well as for WUaS to develop 200 major online research universities in all 200 countries (https://wiki.worlduniversityandschool.org/ wiki/Nation_States - each a major world class online WUaS university, with Gemini AI) and in all 7159 living languages (and regarding a WUaS Universal Translator - https://wiki. worlduniversityandschool.org/ wiki/WUaS_Universal_Translator ), and for free-to-students' online-from-home Bachelor, PhD, Law, MD, IB high school / sim, AA/AS and Master's WUaS degrees, and potentially in a realistic virtual earth for STEM field sites, and a realistic virtual earth for classrooms? And please see Peter Norvig's INCREDIBLE #ToolifyAIWUaS article "Revolutionizing Education with Machine Learning and AI: #WorldUniversityINSchool (updated March 2, 2024) - https://www.toolify.ai/ai- news/revolutionizing- education-with-machine- learning-and-ai-2574306 (And see also these related World Univ & Sch TwitterX feeds and re Gemini AI too - What does intelligent mean in 'real time intelligence systems' ? Gemini AI response -
Fascinating: What does intelligent mean in #RealTimeIntelligenceSystems regarding #IT? #GeminiAIreIntelligentIT -
https://g.co/gemini/share/3d0ba9073bc1
In real-time intelligence systems, "intelligent" refers to ability of system to perceive, process, reason, learn:
https://www.toolify.ai/ai-news/revolutionizing- education-with-machine- learning-and-ai-2574306 ~
https://x.com/WorldUnivAndSch/status/1948050028708446713
https://x.com/WUaSPress/status/1948050241489699162
https://x.com/sgkmacleod/status/1948050528375857488
https://x.com/scottmacleod/status/1948050661872128405
https://x.com/Q_YogaMacFlower/status/1948050399333900794
https://x.com/HarbinBook/status/1948050595795152945
https://x.com/TheOpenBand/status/1948050349803331654
"what does intelligent mean in real time intelligence systems regarding information Technologies
https://g.co/gemini/share/3d0ba9073bc1) Thanks, Scott GK MacLeod Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki,
World University & School (WUaS)
- USPS US Post Office, General Delivery, Canyon, CA 94516
1) non-profit 501(c)(3) Public Charity
best STEAM CC licensed OCW, Wiki,
wiki https://wiki.worlduniversityandschool.org/ wiki/Subjects,
https://wiki.worlduniversityandschool.org/ wiki/The_College_at_World_ University_and_School
World University and School - http://worlduniversityandschool.org
- https://twitter.com/WorldUnivAndSch
2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/ AcademicPress.html
- https://twitter.com/WUaSPress
(o) 415 480 4577 - sgkmacleod@worlduniversityandschool.org
(m) 412 478 0116 - sgkmacleod@gmail.com
World Univ & Sch Innovation Research -
- scottmacleod.com
- https://twitter.com/scottmacleod
- https://x.com/Q_YogaMacFlower/status/ 1815700381474689273
- http://www.linkedin.com/in/scottgkmacleod
- https://twitter.com/sgkmacleod (all 7,159 known living languages at WUaS)
- https://scott-macleod.blogspot.com/search/label/ global%20university
- https://worlduniversityandschool. blogspot.com/search/label/ global%20university" As we talked about further, Kimba,In WUaS was seeking to code for all 7.9 billion people on the planet (from https://wiki.worlduniversityandschool.org/ wiki/You_at_World_University) and to facilitate wiki universal free education, and free WUaS degrees, building on MIT OCW course in 7 languages, in all 200 countries, and possibly in all 7159 known living languages, and to end poverty via distributing Stanford Mine Pi cryptocurrency free money daily - https://minepi.com/sgkmac - what are the next best steps ? And how best to interoperate with the Grow With Google WUaS program and Google For Education with Gemini AI? A Sri Lanka WUaS education model with Pi cryptocurrency UBI experiments to end poverty there, and facilitated free MIT OCW_centric WUaS degrees - Bachelor, PhD, Law, MD, IB high school / similar, AA / AS, and Master's degrees in the Sinhala language, and out of high schools there? And see Agenda Item 6 here - https:// worlduniversityandschool. blogspot.com/2025/11/sawtooth- wilderness-id-m-12125-and.html . How best to develop the WUaS wiki schools for open wiki-teaching and wiki-learning, and community building in the Sinhala language there? And then develop this WUaS education model with Pi cryptocurrency in Vietnam, Nigeria and India (and see agenda item 1a here - https:// worlduniversityandschool. blogspot.com/2025/12/two- medicine-lake-mt-m-12825-and- 121525.html)? Who are the target audiences of this book?Academic professionals, undergraduates, and graduate students (particularly in other countries and languages, too) and potentially in all 200 countries' main languages, translated into their languages ... eg Tamil and Telugu speakers and young people and students in south India and in all countries?Could the writing of this part 2 of my book also inform a kind of road map with Google For Education with WUaS with Gemini AI ? ... and in conjunction with the Google for Education Roadmap, which seems both hardware and platform focused? The 2nd meeting of this at noon today 12/11/25.As an unprogrammed Friendly NtF Quaker leading or calling or inspiration, since the beginning in 2006, WUaS continues to grow and develop with a loosely WUaS Monthly Business Meeting process, now. become a Weekly Business Meeting process ... and see the Agenda items / Minutes here - https://worlduniversityandschool. blogspot.com/search/label/ Business%20Meeting and https://scott-macleod. blogspot.com/search/label/ Business%20Meeting Stanford Law CodeX and Stanford Law Rock Center directors?And how best to develop a realistic virtual earth further as STEM field sites and classrooms, and even at teh G Cell View, G Molecule View + levels and in thinking in terms of Google Street View with time slider, Google Maps, and TensorFlow AI ... and even for a #RealsiticVirtualEarthForHistor y, and a # RealsiticVirtualEarthForArchae ology, # RealsiticVirtualEarthForGeneti cs, and even a #RealsiticVirtualEarthForAging reversal? More later, but I invite you to read the first 8 chapters and the beginning of Chapter 9 here - "Society, Information Technology and the Global University" - https://docs.google.com/document/d/ 1YJg2icBhxEj7eSiSoiN2mgusX4PK1 cQfZRFPRdw5znI/edit?usp= sharing - and I look forward to hearing what you think further. And how best to weave in the above with the beginning of Chapter 9 above too? Add the above to Gemini AI and seek its editing further?Best wishes, abolition, regards,ScottScott GK MacLeod----Society, Information Technology, and the Global University (2026, forthcoming)Scottish Small Piping album #2 - Honey Piobaireachd (2022)- https://twitter.com/TheOpenBand (Berkeley) Scottish Small Piping album #1 Honey in the Bag ~ Out of the Air tune (2020)Order Book #4 To the Dance or the Pools? ~ Virtually! How different it is to soak at Harbin Hot Springs, than to realize it in virtual reality (2019)Order Book #3 Winding Road Rainbow: Harbin, Wandering & the Poetry of Loving Bliss (2018)Order Book #2 Haiku-ish and Other Loving Hippie Harbin Poetry (2017)Order Actual-Virtual Ethnographic Book #1: Naked Harbin Ethnography (2016)- Scott GK MacLeodFounder, President, CEO & Professorat / of best STEAM CC licensed OCW, Wiki,World University & School (WUaS)- USPS US Post Office, General Delivery, Canyon, CA 945161) non-profit 501(c)(3) Public Charitybest STEAM CC licensed OCW, Wiki,World University and School - http://worlduniversityandschool.org 2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/ AcademicPress.html (o) 415 480 4577 - sgkmacleod@worlduniversityandschool.org (m) 412 478 0116 - sgkmacleod@gmail.comWorld Univ & Sch Innovation Research -
* * *
Proposed Reedie+ book group beginning in late December 2024 or early 2026?
Under Stars
Under splendid stars,
the smells of oaks
and northern
California tilth,
coming over
the hill from
Napa Valley
to Middletown,
suffuse all air with
earthy fragrance,
welcoming me
back to Harbin land, ~
into the waters soon.
How different it is to soak at Harbin Hot Springs, than to realize it in virtual Reality" (2019)
Novel by J. L. Carr
Is there a limit to human longevity? [Theoretically no]
https://youtu.be/2oT1LUeCME0
Could humans live forever?
[Statistically yes]
In a #
https://x.com/Q_YogaMacFlower/
https://share.google/aimode/
* * *
Might we live to 150 years old+ w #FDAapproved #AgingReversal & #ExtremeLongevity #GeneDrugs emerging? How to lessen side effects: https://t.co/Y2UjbE1yqO? Yoga #YogaMeditation #YogaAsana can help. How to stop #DrugSideEffects wi #RealisticVirtualEarthForPharma @WorldUnivAndSch?
— WorldUnivandSch (@WorldUnivAndSch) December 12, 2025
https://x.com/WorldUnivAndSch/
https://x.com/Q_YogaMacFlower/
https://x.com/WUaSPress/
https://x.com/sgkmacleod/
https://x.com/scottmacleod/
https://x.com/TheOpenBand/
https://share.google/aimode/
A "realistic virtual Earth for molecules" concept points toward advanced computational simulations—such as high-fidelity Molecular Dynamics (MD) simulations, machine learning, and virtual reality (VR) visualization—to model the complex environment where drugs operate.
These approaches can lessen or eliminate side effects in brand new ways by providing unprecedented insight into the full dynamic behavior of drug molecules, moving beyond static, simplified models.
Advanced Insight into Drug Behavior
A virtual Earth for molecules would offer several new avenues for reducing side effects:
Predicting "Off-Target" Binding: Side effects often occur because a drug molecule binds to a biological target (like a different protein or receptor) that it wasn't intended for. This is known as "promiscuity" or off-target binding.
The virtual environment can screen vast libraries of virtual compounds—potentially hundreds of millions—to predict how a molecule will interact with all relevant targets in the human body, including those that cause adverse effects.
Modeling True Dynamic Interaction: A drug and its targets are not static; they are constantly moving, changing shape, and interacting with their environment (water, cell membranes, other molecules).
Molecular Dynamics (MD) simulations track these rapid atomic and molecular movements over time with high precision. This allows researchers to:
Analyze how the drug binds to its intended target and how long it stays there (residence time). A short residence time might mean low efficacy, while an unpredictable binding/unbinding pattern could relate to side effects.
Observe conformational changes—how the drug or its target protein changes shape upon binding—which can reveal unexpected activity or toxicity.
Integrating ADMET Properties: A drug's behavior in the body is governed by its Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) properties.
Virtual models can predict these properties early in the discovery phase, allowing scientists to filter out molecules with poor metabolic pathways or high toxicity potential before they even enter a lab.
Virtual Toxicity and Safety Panels: Computer models can be used to predict undesirable targets—those known to cause side effects—and screen potential drugs against a virtual safety panel to prioritize the safest compounds for development.
Accelerating and De-risking Discovery
Ultimately, this "Virtual Earth" allows pharmaceutical companies to perform virtual screening on a massive scale, optimizing drug candidates for both efficacy and safety simultaneously. This drastically reduces the number of problematic compounds that enter expensive and risky clinical trials, thereby accelerating the entire drug discovery pipeline and improving patient safety from the outset.
The video below discusses how virtual reality is being used in the drug discovery process.
A "realistic virtual Earth for molecules" concept points toward advanced computational simulations—such as high-fidelity Molecular Dynamics (MD) simulations, machine learning, and virtual reality (VR) visualization—to model the complex environment where drugs operate.
These approaches can lessen or eliminate side effects in brand new ways by providing unprecedented insight into the full dynamic behavior of drug molecules, moving beyond static, simplified models.
Advanced Insight into Drug Behavior
A virtual Earth for molecules would offer several new avenues for reducing side effects:
Predicting "Off-Target" Binding: Side effects often occur because a drug molecule binds to a biological target (like a different protein or receptor) that it wasn't intended for.1 This is known as "promiscuity" or off-target binding.
The virtual environment can screen vast libraries of virtual compounds—potentially hundreds of millions—to predict how a molecule will interact with all relevant targets in the human body, including those that cause adverse effects.
Modeling True Dynamic Interaction: A drug and its targets are not static; they are constantly moving, changing shape, and interacting with their environment (water, cell membranes, other molecules).2
Molecular Dynamics (MD) simulations track these rapid atomic and molecular movements over time with high precision.3 This allows researchers to:
Analyze how the drug binds to its intended target and how long it stays there (residence time).4 A short residence time might mean low efficacy, while an unpredictable binding/unbinding pattern could relate to side effects.
Observe conformational changes—how the drug or its target protein changes shape upon binding—which can reveal unexpected activity or toxicity.5
Integrating ADMET Properties: A drug's behavior in the body is governed by its Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) properties.6
Virtual models can predict these properties early in the discovery phase, allowing scientists to filter out molecules with poor metabolic pathways or high toxicity potential before they even enter a lab.7
Virtual Toxicity and Safety Panels: Computer models can be used to predict undesirable targets—those known to cause side effects—and screen potential drugs against a virtual safety panel to prioritize the safest compounds for development.
Accelerating and De-risking Discovery
Ultimately, this "Virtual Earth" allows pharmaceutical companies to perform virtual screening on a massive scale, optimizing drug candidates for both efficacy and safety simultaneously. This drastically reduces the number of problematic compounds that enter expensive and risky clinical trials, thereby accelerating the entire drug discovery pipeline and improving patient safety from the outset.
The video below discusses how virtual reality is being used in the drug discovery process.
* * *
https://youtu.be/3Dey3wzYvXw
#ToyotaConfigurator or?
A #ToyotaSiennaShower? Appreciating #TinyCampersDesignInnovation 21 min mark in "I Made #AnOrigamiShower With 4 Ways to Bathe. #SiennaMicroRV V2 ep.10" with electric kettle in pic too. I blogged abt this: https://t.co/8LFZN1iC6I https://t.co/WWDpYgLs2F #ToyotaConfigurator or?
— QuakerYogaMacFlower (@Q_YogaMacFlower) December 12, 2025
https://x.com/Q_YogaMacFlower/
https://x.com/WorldUnivAndSch/
https://x.com/sgkmacleod/
https://x.com/WUaSPress/
https://x.com/HarbinBook/
https://x.com/scottmacleod/
https://x.com/TheOpenBand/
*
https://en.wikipedia.org/wiki/Mimulus
https://commons.wikimedia.org/wiki/Category:Mimulus
...
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