AAAB
https://x.com/Q_YogaMacFlower/
https://x.com/sgkmacleod/
https://x.com/scottmacleod/
https://x.com/TheOpenBand/
https://x.com/HarbinBook/
https://x.com/WUaSPress/
https://x.com/WorldUnivAndSch/
Retweeting
BBBC
https://x.com/Q_YogaMacFlower/
https://x.com/Q_YogaMacFlower/
https://x.com/HarbinBook/
https://x.com/scottmacleod/
https://x.com/sgkmacleod/
https://x.com/TheOpenBand/
https://x.com/WUaSPress/
@Forrest_PhD
Drug (predicted) to Slow Aging
DDDE
https://x.com/Forrest_PhD/
@Forrest_PhD
Drug (predicted) to Slow Aging
https://x.com/Forrest_PhD/
The molecular compound depicted in the post by Michael Forrest, PhD (@Forrest_PhD) is Bedaquiline (also known by its brand name Sirturo).
Dr. Forrest’s research and his company, Biophysical Therapeutics, focus on a specific mechanism of aging involving the F1F0 ATP synthase enzyme. In the post you mentioned, he identifies Bedaquiline as a "predicted" drug to slow aging because of its ability to selectively inhibit the reverse mode (ATP hydrolysis) of this enzyme.
Key Details about the Drug and Post:
The Compound: Bedaquiline is a diarylquinoline antibiotic that was originally FDA-approved to treat multi-drug-resistant tuberculosis.
The Mechanism: Dr. Forrest’s hypothesis (published in bioRxiv and elsewhere) suggests that IF1 protein is a natural "master switch" of aging. This protein blocks the reverse mode of ATP synthase, which normally generates metabolic heat and harmful Reactive Oxygen Species (ROS).
The Prediction: He posits that drugs like Bedaquiline, which can mimic the action of the IF1 protein by inhibiting ATP hydrolysis without stopping ATP synthesis (the forward mode that provides energy), could reduce the rate of biological aging, decrease metabolic heat, and potentially be used in anti-aging cosmetic creams or medical treatments.
In his Twitter/X feed, he frequently shares the skeletal molecular structure of Bedaquiline—recognizable by its central quinoline ring with bromine, hydroxyl, and amine substitutions—as the lead candidate for this "metabolic slowing" approach to longevity
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As part of 1 holistic #RealisticVirtualEarth #ForEverything, how to grow wtih a #
As part of 1 holistic #RealisticVirtualEarth #ForEverything - https://www.toolify.ai/ai-
https://x.com/WorldUnivAndSch/
https://x.com/Q_YogaMacFlower/
https://x.com/sgkmacleod/
https://x.com/WUaSPress/
https://x.com/HarbinBook/
https://x.com/scottmacleod/
https://x.com/TheOpenBand/
Retweeting -
Iyengar Yoga (UK)
@UKIYENGARYOGA
"Don't practice for cosmetic beauty, practice for cosmic beauty. Practice for inner beauty and inner light." ~ B.K.S. Iyengar
#bksiyengar #iyengaryoga #beauty
https://x.com/UKIYENGARYOGA/
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#PeterNorvig: "Creating a #RealisticVirtualEarth:
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https://en.wikipedia.org/wiki/Hibiscus_insularis
https://commons.wikimedia.org/wiki/Hibiscus_insularis
...


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