Saturday, October 12, 2019

Chimera (genetics): Searched on "virtual lab genetic engineering" * * * the 'Vacanti Mouse' - and about genetic engineering which changes cell structure and function, for example, to add antennae to wings in flies (on this scale) * * * Am interested esp. in age reversal, and via genetic engineering reversal, in general, and for longevity especially too * * * 'Eustachian tube dysfunction' genetic therapy too * * * George Church's "Swiss army knife" metaphor for genetic engineering



Dear Dick, Erica, Byron, Cindy, Ed (all MDs), and All,
- https://eye.hms.harvard.edu/richardrobb
- https://connects.catalyst.harvard.edu/Profiles/display/Person/74233
- http://www.childrenshospital.org/centers-and-services/departments/ophthalmology/meet-the-team


How are you doing, Dick? I hope this finds you all well. 

A little further brainstorming about genetic engineering for 'eustachian tube dysfunction." I found this fascinating Vacanti mouse recently - 


https://upload.wikimedia.org/wikipedia/en/2/2e/Vacanti_mouse.jpg - here - https://en.wikipedia.org/wiki/Vacanti_mouse. Did you happen to know even Charles Vacanti, Dick or Erica, since he was at Harvard Medical School too? 

I'm wondering in what ways genetic engineering could 'restructure' my eustachian tube dysfunction (if this is an accurate diagnosis) eventually, and along the lines of learning from the above Vacanti mouse genetic engineering-wise. I have in mind also George Church's "Swiss army knife" metaphor for genetic engineering and on the scales of the Vacanti mouse, as well as my eustachian tube dysfunction - 

https://twitter.com/harvardmed/status/1163834701108396032 (https://scott-macleod.blogspot.com/2019/08/linnea-visit-virtual-harbin-hot-springs.html) - in these regards, and genetic engineering without limits too; will seek to blog soon about this in the 'genes' label.

Warm regards, Scott



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Dear Dick, Erica, Byron, Cindy, Ed, MDs all, (and Janie),

Blogged a bit about this - https://scott-macleod.blogspot.com/2019/10/chimera-genetics-searched-on-virtual.html.

Am interested esp. in age reversal, and via genetic engineering reversal, in general, and for longevity especially too.

And how would one reverse engineer the effects of a stroke in addition to "eustachian tube dysfunction," for example - and from this Vacant mouse photo https://upload.wikimedia.org/wikipedia/en/2/2e/Vacanti_mouse.jpg into a simulation - and especially in a realistic virtual earth for STEM? Am thinking here further Google Street View with time slider / Maps / Earth at the cellular and atomic levels, and with species and TensorFlow and especially integrated with CRISPR gene editing technologies) - and for further exploration of the actual-virtual, physical-digital for which I have some active #Hashtags in Twitter in these regards, eg see, -

Physical-Digital NEWLY, & into Actual-Virtual both re SCIENCE & #ClinicalTrials: https://wiki.worlduniversityandschool.org/wiki/Clinical_Trials_at_WUaS_(for_all_languages) … & #ActualVirtual #PhysicalDigital @HarbinBook Harbin Hot Springs' ethnographic project via https://scott-macleod.blogspot.com/search/label/ethno-wiki-virtual-world-graphy … & in 1 #RealisticVirtualEarth: THNX https://twitter.com/califf001/status/1182414666816991238 …~


https://twitter.com/WorldUnivAndSch/status/1182761798333652992
- where I'm glad Dr. Rob Califf at Duke recently posted this Lancet paper and a scientific paper with Digital-Physical in its title. I haven't seen this before and Rob is a former FDA commissioner.

Sincerely, Scott


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Dear Scott,
I'm no help on eustation tubes. I did know a J. Vacanti, not Charles. Sorry. Best wishes. Dick
Sent from my iPhone


*
Dear Dick, (and Erica))

Thanks for your email. How is your recovery proceeding, and are you up to talking on the phone, perhaps next weekend?

Am curious even how to explore 'reverse engineer' C & J Vacanti's? 'Vacanti mouse' (from late 1990s - https://en.wikipedia.org/wiki/Vacanti_mouse) in a realistic virtual earth - am thinking Google Street View with time slider / Maps / Earth at the cellular and atomic levels, and combined with CRISPR gene editing technologies - to understand and learn further principles about how that cow cartilage developed into an ear on the mouse, re further innovative thinking.

With very best wishes, Scott






* *
Hi Ed,

Nice to talk, and thnx for your call ... resending (since text messaging doesn't seem to be working) ... Hi Ed (and Val), I'm writing to send you a special invitation to party here in Canyon on 19/10/19 sometime after 5:50. It would be really nice to see you.

And pending FDA approval, re the Eustachian Tube Dysfunction genetic engineering brainstorming - which your KP colleague Dr. De Leon and my physician, might be interested in too.

Fond regards, Scott



* *

Congrats on your work anniversary, Gerd Moe-Behrens! 
- https://hackyourphd.org/2014/03/interview-gerd-moe-behrens-leukippos-synthetic-biology-lab-in-the-cloud/?lang=en
- http://www.leukippos.org/Leukippos_Institute/Leukippos_Institute_News.html

 While not quite your field of Synthetic Biology perhaps of - https://wiki.worlduniversityandschool.org/wiki/Synthetic_Biology - am curious what you think about genetic engineering re the 'Vacanti Mouse' - and about genetic engineering which changes cell structure and function, for example, to add antennae to wings in flies (on this scale) - https://scott-macleod.blogspot.com/2019/10/chimera-genetics-searched-on-virtual.html 

 Best regards, Scott (worlduniversityandschool.org)


*
See too re virtual laboratory for genetics:

Gerd Moe-Behrens'
Leukippos a Synthetic Biology Lab in the Cloud - Intro Coding Together



https://youtu.be/jDtxL7n148Y


*



Scott MacLeod  8:40 AM
Congrats on your work anniversary, Gerd! While not quite your field of Synthetic Biology perhaps - https://wiki.worlduniversityandschool.org/wiki/Synthetic_Biology - am curious what you think about genetic engineering re the 'Vacanti Mouse' - and about genetic engineering which changes cell structure and function, for example, to add antennae to wings in flies (on this scale) - https://scott-macleod.blogspot.com/2019/10/chimera-genetics-searched-on-virtual.html Best regards, Scott (worlduniversityandschool.org)


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TODAY 14 Oct 2019 (in LinkedIn)
Gerd Moe-Behrens, PhD sent the following messages at 4:34 AM

View Gerd’s profile
Gerd Moe-Behrens, PhD
Gerd Moe-Behrens, PhD  4:34 AM
Thanks

View Gerd’s profile
Gerd Moe-Behrens, PhD
Gerd Moe-Behrens, PhD  4:36 AM
Such experiment needs a careful ethical evaluation. We should not do everything what is technical possible. Chimeras and crossing the species barrier should be an ethical no no.


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Scott:
Am following too Stanford Law Professor Hank Greely in some of these ethical questions - https://twitter.com/HankGreelyLSJU - and there appears to be a new Stanford journal for ethics here. See too Greely's Tweet in blog post - https://scott-macleod.blogspot.com/2019/10/chimera-genetics-searched-on-virtual.html. Am curious too how such genetic engineering developments will emerge in a realistic virtual earth at the cellular and atomic levels - and for CRISPR. Appreciating your knowledge here, Gerd. Best regards, Scott (worlduniversityandschool.org)


*
Gerd:
Thanks for the great link. As I wrote in my biosafety paper:

Front. Microbiol., 25 January 2013 | https://doi.org/10.3389/fmicb.2013.00005

Preparing synthetic biology for the world

Gerd H. G. Moe-Behrens1, Rene Davis2 and Karmella A. Haynes2*

- https://www.frontiersin.org/articles/10.3389/fmicb.2013.00005/full -
is key for biosecurity. Thus we hopefully will never get a virtual earth.



*
Scott:
Thanks as well. I think how the realistic virtual earth / universe develops will be fascinating - and for ethics too - and Google Street View with time slider / Maps / Earth / Tensor Flow / Translate with avatar bots - with group-building Second Life but not cartoon-esque - is already its beginning ... along with 1000s of other digital virtual worlds and related STEM simulations. Cheers, Scott




* * *

Searched on "virtual lab genetic engineering"

https://amino.bio/pages/vbioengineer

*
https://learn.genetics.utah.edu/content/labs/


*
GREAT interactivity for LEARNING genetic engineering -


http://glencoe.mheducation.com/sites/dl/free/0078802849/383937/BL_22.html (try this in Safari where enabling Adobe Flash is possible)


*
https://www.labster.com/simulations/molecular-cloning/




* * *
Searched on
genetic engineering which changes cell structure and function eg "to add antennae to wings in flies" -

https://en.wikipedia.org/wiki/Genetic_engineering

https://en.wikipedia.org/wiki/Genetically_modified_mouse

https://en.wikipedia.org/wiki/Genetically_modified_insect

https://en.wikipedia.org/wiki/Genetically_modified_organism


https://ghr.nlm.nih.gov/primer/therapy/procedures

https://www.esgct.eu/useful-information/gene-and-cell-therapy-glossary.aspx


https://en.wikipedia.org/wiki/History_of_genetic_engineering

https://www.whatisbiotechnology.org/index.php/science/summary/transgenic/transgenic-animals-have-genes-from-other-species-inserted

https://www.teachengineering.org/lessons/view/uoh_genetic_lesson01

https://en.wikipedia.org/wiki/Chimera_(genetics)
https://en.wikipedia.org/wiki/Gene_targeting

https://en.wikipedia.org/wiki/Rudolf_Jaenisch

https://en.wikipedia.org/wiki/Transgene


Searched too on -
'Eustachian tube dysfunction' genetic therapy too



* * *

George Church's "Swiss army knife" metaphor for genetic engineering ...


And here's Harvard Genetics' Professor George Church on gene editing:


Harvard Medical School
✔
@harvardmed
HMS geneticist George Church is on a quest to read and write DNA without limits, to be able to address diagnostics and therapeutics for a range of diseases #ScienceMatters



https://twitter.com/harvardmed/status/1163834701108396032

(accessible too from this blog post - https://scott-macleod.blogspot.com/2019/08/linnea-visit-virtual-harbin-hot-springs.html - and see, too - https://scott-macleod.blogspot.com/2019/08/calluna-heather-where-to-find-virtual.html).



* *
Ethics and genetics:

Hank Greely
Germline editing

https://twitter.com/HankGreelyLSJU/status/1182855960202641409

*

In the opening article in the latest issue of @CRISPRjournal, SLS Professor @HankGreelyLSJU argues that germline editing is not inherently bad or unethical, but the technology is unlikely to be particularly useful: http://bit.ly/33lZVf8





*
See, too:

How best to add this CRISPR kit/lab tools https://twitter.com/ramymik/status/1181696994403897344 … >#RealisticVirtualEarth via #GooglePoly & #FilmTo3D App in #RealisticVirtualEarthForCRISPR for learning CRISPR lab techniques for working in real University labs #ActualVirtual #PhysicalDigital #biodesign #DIYbio?



https://twitter.com/WUaSPress/status/1182013264214937600







...


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