#GoogleAI-NIH #Connectome project 'genes neurons #WUaSAgingReversal' How to #WikiAdd "Transcriptomic reprogramming for neuronal age reversal" #APlesa, #MShadpour, @EBoyden3 & @GeoChurch >#GoogleStreetView w #TimeSlider #GoogleCellView #GoogleMoleculeView ?
#GoogleAI-NIH #Connectome project
— WorldUnivandSch (@WorldUnivAndSch) September 28, 2023
'genes neurons #WUaSAgingReversal' How to #WikiAdd
"Transcriptomic reprogramming for neuronal age reversal" #APlesa, #MShadpour, @EBoyden3 & @GeoChurch https://t.co/c9AEyDn5Y8 >#GoogleStreetView w #TimeSlider #GoogleCellView #GoogleMoleculeView ? https://t.co/33eobGfbbJ
Today we discuss our partnership with the National Institutes of Health (@NIH) and several other collaborators to expand the frontiers of connectomics by mapping a small fraction (2-3%) of the mouse brain over the next five years. Learn more at: https://t.co/W3s9TcoTqk pic.twitter.com/cb9Lhf4TTo
— Google AI (@GoogleAI) September 26, 2023
Great: when will #CitizenScientists & #WUaSstudents @WorldUnivAndSch drag&drop #CElegans or #DrosophilaFly or #Mouse #Connectomes #FiringNeurons >#GoogleStreetView w #TimeSlider #GoogleCellView #GoogleMoleculeView eg for #AgingReversalResearch in a place http://tinyurl.com/yc7c5ecm?
Great: when will #CitizenScientists & #WUaSstudents @WorldUnivAndSch drag&drop #CElegans or #DrosophilaFly or #Mouse #Connectomes #FiringNeurons >#GoogleStreetView w #TimeSlider #GoogleCellView #GoogleMoleculeView eg for #AgingReversalResearch in a place https://t.co/rwcH9IsYw7? https://t.co/33eobGfbbJ
— WorldUnivandSch (@WorldUnivAndSch) September 27, 2023
https://x.com/WorldUnivAndSch/
https://twitter.com/WUaSPress/
Retweeting -
Today we discuss our partnership with the National Institutes of Health (@NIH) and several other collaborators to expand the frontiers of connectomics by mapping a small fraction (2-3%) of the mouse brain over the next five years. Learn more at: https://goo.gle/3PSWAPM
Today we discuss our partnership with the National Institutes of Health (@NIH) and several other collaborators to expand the frontiers of connectomics by mapping a small fraction (2-3%) of the mouse brain over the next five years. Learn more at: https://t.co/W3s9TcoTqk pic.twitter.com/cb9Lhf4TTo
— Google AI (@GoogleAI) September 26, 2023
https://x.com/GoogleAI/status/
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excited to work with many amazing collaborators on this project
@harvardbrainsci
@PrincetonNeuro
@gsxej
@AllenInstitute
@FieteGroup
@JHUAPL
excited to work with many amazing collaborators on this project @harvardbrainsci @PrincetonNeuro @gsxej @AllenInstitute @FieteGroup @JHUAPL https://t.co/cyqZjYd62Z
— Viren Jain (@stardazed0) September 26, 2023
https://x.com/stardazed0/
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searched on 'genes and neurons,'
and then on 'aging reversal'
Transcriptomic reprogramming for neuronal age reversal
Abstract
Aging is a progressive multifaceted functional decline of a biological system. Chronic age-related conditions such as neurodegenerative diseases are leading causes of death worldwide, and they are becoming a pressing problem for our society. To address this global challenge, there is a need for novel, safe, and effective rejuvenation therapies aimed at reversing age-related phenotypes and improving human health. With gene expression being a key determinant of cell identity and function, and in light of recent studies reporting rejuvenation effects through genetic perturbations, we propose an age reversal strategy focused on reprogramming the cell transcriptome to a youthful state. To this end, we suggest using transcriptomic data from primary human cells to predict rejuvenation targets and develop high-throughput aging assays, which can be used in large perturbation screens. We propose neural cells as particularly relevant targets for rejuvenation due to substantial impact of neurodegeneration on human frailty. Of all cell types in the brain, we argue that glutamatergic neurons, neuronal stem cells, and oligodendrocytes represent the most impactful and tractable targets. Lastly, we provide experimental designs for anti-aging reprogramming screens that will likely enable the development of neuronal age reversal therapies, which hold promise for dramatically improving human health.
Abstract
Genes encode proteins that are critical for the development and regulation of neural circuits involved in various aspects of brain function such as emotion, thought, learning, and neurological disease. We would like to understand the manner in which proteins responsible for neuronal activities are related to mental processes or brain diseases. Molecular genetics provides the means to determine the genes involved in a particular function of the brain. The human genome project has revealed that a human cell has approximately 30,000–60,000 genes. Neurons differ from other types of cells because they express a set of genes that is specific to them. Neurons are estimated to express ∼ 40% of their total genes, some of which are also expressed in other types of cells. Neuron-specific genes encode neuropeptides, enzymes involved in the synthesis of neurotransmitters (NT), ion channels and receptors, synaptic proteins, and neurotrophic receptors. However, genes expressed in other cell types, such as those encoding protein kinases, cytoskeletal proteins, growth factors, etc., collaborate with neuron-specific genes and are thus involved in neuron-specific behavior such as axon guidance, synaptic plasticity, and neuronal cell death. In this chapter, we examine the basic structure of neurons and discuss genes and proteins that play a key role in neuronal functions. Although complex functions of the brain are determined by the pattern of neuronal connectivity and probably by the number of neurons, it is important to understand the molecular machinery of neurons and synapses given that genetic defects are known to cause many neurological disorders. In addition, remarkable progress has been made to develop drugs that target specific molecules or genes involved in neuronal functions.
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#Stanford #Canyon94516 #CanyonUSPostOffice #670RidgecrestRd #SemesterAtSea2005 #Sailboatshttps://t.co/1R4xzyGzz9 '#undoctoredPhotos'? >#RealisticVirtualEarthForTraveling in 1 #RealisticVirtualEarth for #WhereIsThatML? #WUaSphotography #HarbinHotSprings @HarbinBook #IndiaWUaS ~
— the Open Band (Berkeley) (@TheOpenBand) September 28, 2023
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Here's a synopsis of the Oedipus complex in my daily blog in my July 7, 2023 "Yellow Elder ... " post - http://scott-macleod.blogspot.
I'm interested in "who came before" questions, genealogically - and in particular, for example, how to go from my mother's father, Sandy Brown (aka Alexander Chadbourne Brown - https://www.wikitree.com/
Humphrey Chadbourne (1653-1695)
https://www.wikitree.com/wiki/
Sarah (Bolles) Chadbourne (1656 - 1694)
https://www.wikitree.com/wiki/
Bacon, Elaine. c1994. The Chadbourne Family in America: A Family Genealogy. Penobscot, Maine: Penobscot Press.
"Sarah Bolles
Wells 20 Jan 1656/7, living in Kittery 16 May 1695, dau of Joseph and Mary (Howell?) Bolles. Sarah Bolles has a well-established royal descent, being descended from Edward I, King of England (1272-1307 ) and many earlier Kings of England, Scotland and France, as authenticated in Ancestral Roots of Sixty Colonists, by Frederick Lewis Weis, 6th Edition [1988]"
https://chadbourne.org/
"Sarah Bolles (20 Jan 1656 - 1694), who married Humphrey Chadbourne (10 generations back from this author), reportedly comes from a long, documented line of kings and queens in Scotland, England and France (see Bacon's "The Chadbourne Family in America: A Family Genealogy" and, also - https://www.wikitree.com/
Bacon, Elaine. c1994. The Chadbourne Family in America: A Family Genealogy. Penobscot, Maine: Penobscot Press.
http://scottmacleod.com/
Humphrey Chadbourne (1653 - 1695)
https://www.wikitree.com/wiki/
William Chadbourne (1683 - 1759)
https://www.wikitree.com/wiki/
Benjamin Chadbourne (1718 - 1799)
https://www.wikitree.com/wiki/
Jonathan Chesley Chadbourne (1752 - 1855)
https://www.wikitree.com/wiki/
Ichabod Rollins Chadbourne (1787 - 1855)
https://www.wikitree.com/wiki/
Alexander Scammell Chadbourne (1831 - 1900)
https://www.wikitree.com/wiki/
Martha Holway (Chadbourne) Brown (1871 - 1909)
https://www.wikitree.com/wiki/
Alexander Chadbourne "Sandy" Brown (18 Apr 1903 in Boulder, Colorado - Died AROUND 1987 at about age 83 in Cincinnati, Ohio)
https://www.wikitree.com/wiki/
Janet "Janie" Kirkbride (Brown) MacLeod (born 2 April 1935 - )
https://www.wikitree.com/wiki/
Scott GK MacLeod MacLeod III (born 31 Dec 1960 - )
https://www.wikitree.com/wiki/
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Bolivian Quaker Education Friends, World University and School Universitians, Dear Nancy Marshall (BQEF Clerk of the Board), All, ~ Here is a donation to the BQEF in the form of Stanford Mine Pi cryptocurrency coins' free money daily, and potentially for all 12 million Bolivians ~
WUaS - World University and School <worlduniversityandschool@gmail.com>
Wed, Sep 27, 2:41 PM (1 day ago)
to Nancy, office, nanmar4009
I am sending you 1Ï€! Pi is a new digital currency developed by Stanford PhDs, with over 47 million members worldwide. To claim your Pi, follow this link https://minepi.com/sgkmac
Un plan de estudios que facilita la enseñanza de la programación y la hace divertida de aprender.
Un plan de estudios que facilita la enseñanza de la programación y la hace divertida de aprender.
https://youtu.be/NWR6O_Xme8k
https://www.youtube.com/@
https://scott-macleod.
https://
PSa
Stanford [codex_group_meetings] TODAY! CodeX Mtg (9/21 @1.30p PT): Fence; verifying citations with OpenAI * * * Thanks Vivek Natarajan (@vivnat) for your excellent @StanfordBMIR & re also 'Med-PaLM: A #LargeLanguageModel from Google Research'- https://sites.
https://
https://scott-macleod.
Topic: M 10/2/23 World Univ & Sch - WUaS News and Q&A
Time: Oct 2, 2023 10:00 AM Pacific Time (US and Canada), 1:00 PM Eastern Time,
Join Zoom Meeting
https://us04web.zoom.us/j/
Meeting ID: 724 0689 2652
Passcode: 5FtVpp
CS FIRST: Un plan de estudios que facilita la enseñanza de la programación y la hace divertida de aprender
https://csfirst.withgoogle.
MIT OCW Courses in Spanish
http://ocw.abu.edu.ng/courses/
new #BOLIVIA https://wiki.
#MITOCWSpanish
http://ocw.abu.edu.ng/courses/
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https://en.wikipedia.org/wiki/Vernonia_djalonensis
https://commons.wikimedia.org/wiki/Category:Vernonia
https://www.wikidata.org/wiki/Q15566586
https://fr.wikipedia.org/wiki/Vernonia
https://commons.wikimedia.org/wiki/Category:Vernonia_djalonensis
https://symbolhunt.com/national-flowers/
...
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