Friday, March 20, 2026

Lotus (Hosackia) formosissimus (gracilis): Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:)? ~ and even with eventually Youth Vaccines (e.g. vaccines that could reverse organs in an 80 year old to a 30 year old) ... and read on ...


Dear Dick (Robb MD, possibly posthumously, also a professor in Harvard Medical School), UU Chris Michaels, Annie, Alden, Donna, George and Maitreyi (both professors in Harvard Medical School too), Ma/Janie, Peter (Norvig Stanford AI, and your pnorvig@google hasn't been working for about a week, so I'm sending this in a different way), Marlynn Wei (author of "The Harvard Medical School Guide to Yoga" - which I just returned to the public library, and might a second edition be possible ... and Yoga-brainstorming with Yogi's Victor and Angela helping write this, - albeit unlikely I posit), Doortje (Van Kooten, in the Netherlands, and how would you say your father Victor, and Angela teach consciousness or awareness - or the inner body - and regarding the 8 Limbs of Yoga?), Yogis & Yoginis, All,  


A
Yoga greetings! How are you all? And how are your Regenerative Yoga explorations going - and especially on Saturdays at around 8 am Pacific Time ? We may all be able to get together in a Zoom call Yoga hall in the not too distant future - and for Yoga exploration conversations  ... and as we may live to 150+ and well beyond with genetic drug therapies emerging, and even with eventually Youth Vaccines (e.g. vaccines that could reverse organs in an 80 year old to a 30 year old) ... and read on ... 


B
Added last week's Restorative Yoga explorations here with Yoga and longevity genetics' conversation - https://scott-macleod.blogspot.com/2026/03/sacred-lotus-nelumbo-nucifera.html on Thursday, 3/12/26 ... for your Yoga adventuring


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Would you like to explore these Angela Farmer Yoga asana explorations (in the videos to the left) on Saturday, March 21, 2026, say the 2nd 4 in this group of 8  on Angela's web page here~

https://angela-victor.com/who/angela/

https://angela-victor.com/who/victor/ (Victor doesn't have any Yoga movement teachings on his page yet, it appears)

and check out their Yoga teaching 'self-studies' (svadhyaya s, I'll call this, the Sanskrit word for study of the Self, as Victor & Angela translate Yoga from the East to the West emerging out of the 1960s and 1970s in their Yoga teachings) on these pages

from - https://angela-victor.com/who/ ?



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Or with the first four of these videos from Angela also accessible here  

(which I found helpful ... and especially possibly for you Unitarian Universalist Chris Michaels regarding building "strength, awareness, and flexibility" - and per this book - 
"The Harvard Medical School guide to yoga : 8 weeks to strength, awareness, and flexibility"
https://archive.org/details/harvardmedicalsc0000grov/mode/2up - not full text)-


C 2 
  - I've been having trouble accessing a whole range of web sites and URLs while in the Berkeley Public Library Claremont recently, and surprisingly in this city of the Free Speech movement, and just now I couldn't even access Yogini Angela Farmer's Yoga videos' web page -https://angela-victor.com/who/ - in the free Tor Browser tool for privacy and freedom - https://www.torproject.org/download/ - which has been been working for other website her in the public library recently) ... Peter, other computer scientists here?


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And if Angela's 8 videos are not accessible on Saturday, March 21, 2026, please explore further for example - 

open free Restorative Yoga class on Saturdays & in the mornings (and as we may live to 150 and well beyond:)? - Sat 2/7/26 https://scott-macleod.blogspot.com/2026/02/kadamba-flower.html
12/25/25

AAAB

https://youtu.be/F61foSTThsY
12/27/25 

BBBC
https://youtu.be/AIKPYP939q8 
https://youtube.com/@ScottMacLeodWorldUniversity/videos 
#YogaAndLongevityGeneticsConvo #WUaSYoga ~


https://x.com/TheOpenBand/status/2020543732777635955




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and possibly with the Kaiser Permanente Yoga poses  in this email thread below too.




D
3-4 yoga movement explorations / poses in about 15 minutes on Saturdays at around 8am your time ... ?



E

What will 'youth vaccines' be made up of initially ... e.g. vaccines that could reverse organs in an 80 year old to a 30 year old, & in #AvatarAgentElectronicHealthRecords & as #DigitalTwinOrganisms, esp with #RealisticVirtualEarthForYogaAsana & #RealisticVirtualEarthForYoga, in one iterating #RealisticVirtualEarth and a #RealisticVirtualEarthForVaccines?

Some incredle Gemini and AI responses below and here - 

... and please see the PS ... Further thoughts?

Namaste, Yogically, (abolition), warm regards, 
Scott

Saturday, March 14, 2026
Yellow Water-lily (Nuphar lutea): Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:)? ~ Want to explore these Angela Farmer Yoga asana explorations (in the videos to the left) on Saturday, March 14, 2026 ~ https://angela-victor.com/who/angela/








PS

What will youth vaccines be made up of initially ... e.g. vaccines that could reverse organs in an 80 year old to a 30 year old, & in #AvatarAgentElectronicHealthRecords & as #DigitalTwinOrganisms, esp with #RealisticVirtualEarthForYogaAsana in one iterating #RealisticVirtualEarth and a #RealisticVirtualEarthForVaccines?



What will youth vaccines be made up of initially e.g. vaccines that could reverse organs in an 80 year old to a 30 yo? How to begin to develop these in #AvatarAgentElectronicHealthRecords & as #DigitalTwinOrganisms, esp with #RealisticVirtualEarthForYogaAsana a #RealisticVirtualEarthForYogaPoses #RealisticVirtualEarthForVaccines in one iterating #RealisticVirtualEarth?

https://gemini.google.com/share/6b6df75619e9





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What will #YouthVaccinesWUaS be made up of initially e.g. vaccines that could #reverseOrgans in an 80 yo to a 30 yo? How to dev w #AvatarAgentElectronicHealthRecords & as #DigitalTwinOrganisms, esp with #RealisticVirtualEarthForYogaAsana & #RVEforVaccines?
https://gemini.google.com/share/6b6df75619e9 ~

https://x.com/Q_YogaMacFlower/status/2034708113010684294

https://x.com/WorldUnivAndSch/status/2034708275833520310





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What will youth vaccines be made up of initially e.g. vaccines that could reverse organs in an 80 year old to a 30 yo? How to begin to develop these in #AvatarAgentElectronicHealthRecords & as #DigitalTwinOrganisms, esp with #RealisticVirtualEarthForYogaAsana a #RealisticVirtualEarthForYogaPoses #RealisticVirtualEarthForVaccines in one iterating #RealisticVirtualEarth?




The concept of "youth vaccines"—more scientifically known as epigenetic reprogramming or senolytic therapy—is one of the most ambitious frontiers in longevity science. We aren't just talking about a flu shot for aging; we are talking about biological "software" updates.

Here is a breakdown of what these vaccines might contain and how your vision of Digital Twins and Virtual Earths could facilitate their development.

1. The Composition of a "Youth Vaccine"

To reverse an 80-year-old’s organs to a 30-year-old state, the vaccine wouldn't use dead viruses. Instead, it would likely consist of:

  • Yamanaka Factors (OSKM): These are four specific genes ($Oct4, Sox2, Klf4, c-Myc$) that can "reprogram" an adult cell back into a pluripotent stem cell state. Modern research focuses on "partial reprogramming" to reset the cellular clock without losing the cell's identity (e.g., keeping a heart cell a heart cell).

  • mRNA Delivery Systems: Similar to COVID-19 vaccines, mRNA would provide the instructions for cells to temporary produce reprogramming proteins or repair telomeres.

  • Senolytics: Compounds designed to seek out and destroy "zombie cells" (senescent cells) that have stopped dividing and secrete inflammatory signals that age surrounding tissue.

2. Developing via #AvatarAgentElectronicHealthRecords

To build these safely, we move from "one size fits all" medicine to Precision Longevity.

  • The Avatar Agent: Your Electronic Health Record (EHR) becomes a living agent. It doesn't just store past data; it uses AI to predict how your specific genome will react to a reprogramming stimulus.

  • Continuous Feedback: By integrating wearable data and epigenetic clocks (like the Horvath Clock) into the EHR, the "Avatar" can simulate the rate of organ rejuvenation before a single drop is injected.

3. The Role of #DigitalTwinOrganisms

A Digital Twin is a virtual model of a physical object—in this case, you.

  • Organ-Specific Simulation: You can't test a youth vaccine on a human liver without risk. A Digital Twin allows researchers to run "What If" scenarios: “If we apply mRNA-12 for 14 days, does the liver return to 30-year-old metabolic function, or does it risk oncogenesis (cancer)?”

  • Iterative Testing: We can run 10,000 versions of the vaccine on the Digital Twin to find the exact dosage that maximizes rejuvenation while minimizing side effects.

4. #RealisticVirtualEarth for Yoga and Vaccines

Your idea of a "Realistic Virtual Earth" (RVE) creates a holistic environment where biological and physical data merge.

  • Yoga Asana & Biomechanics: In the RVE, we can track how rejuvenated tissues (simulated via the vaccine) improve range of motion and respiratory efficiency during Yoga Asanas.

  • The Feedback Loop: 1. Yoga/Physical Input: The RVE records the physical stressors and benefits of specific poses.

    2. Vaccine/Biological Input: The RVE simulates how the "youth vaccine" repairs the micro-tears and inflammation caused by physical activity.

    3. The Result: A perfectly balanced protocol where the vaccine provides the "hardware" (younger cells) and Yoga provides the "software" (optimized movement and nervous system regulation).

The Next Step

This is a massive, multi-disciplinary vision. Would you like me to dive deeper into the specific AI architectures needed to link an Electronic Health Record to a real-time Digital Twin for longevity testing?








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What will youth vaccines be made up of initially e.g. vaccines that could reverse organs in an 80 year old to a 30 yo? How to begin to develop these in a #RealisticVirtualEarthForYogaAsana a #RealisticVirtualEarthForYogaPoses #RealisticVirtualEarthForVaccines in one iterating #RealisticVirtualEarth?




"Youth vaccines" aimed at reversing organ aging from 80 to 30 years old will initially be designed as senolytic vaccines and mRNA-based reprogramming therapies. These therapeutic approaches are intended to remove "zombie" (senescent) cells that accumulate with age or to reprogram cells back to a younger state.
Here is an overview of what these vaccines will likely consist of and how to develop them in a #RealisticVirtualEarth.
1. Composition of Initial Youth Vaccines
  • Senolytic Vaccines (Clearance): These target proteins expressed on the surface of senescent cells. A prime candidate is human cytomegalovirus-derived glycoprotein B (HCMV-gB), which, when targeted, helps the immune system eliminate aging fibroblasts, rejuvenating tissues.
  • mRNA Reprogramming (Rejuvenation): Similar to COVID-19 mRNA vaccines, these deliver genetic instructions to cells. Instead of antigens, they deliver transcription factors—such as OCT4, SOX2, KLF4, and c-MYC (OSKM)—packed into lipid nanoparticles to reprogram somatic cells into a younger, pluripotent-like state.
  • NAD+ Boosters (Metabolic): Vaccines targeting the enzyme CD38, which breaks down NAD+ (nicotinamide adenine dinucleotide). Reducing CD38 activity increases NAD+ levels, restoring metabolic function in organs like the liver, heart, and kidneys.
  • Protein-Based Subunits: Synthetic vaccines using specific proteins that, when combined with adjuvants, boost the immune system’s ability to clear damaged cells.
2. Developing in a #RealisticVirtualEarth (Iterating Platform)
To develop these vaccines efficiently, a #RealisticVirtualEarth can merge biological simulation with AI-driven design (#RealisticVirtualEarthForVaccines), creating a digital twin of human biology.
  • Virtual Cellular Environments: Use AI to simulate the epigenetic landscape of an 80-year-old cell vs. a 30-year-old cell. The #RealisticVirtualEarth will model how different OSKM factor combinations change gene expression.
  • In-Silico Clinical Trials: Simulate vaccine delivery (using lipid nanoparticles) in the virtual body to predict organ-specific effects, reducing the need for live animal models.
  • Yoga and Physical Simulation (#RealisticVirtualEarthForYogaAsana): Simulate how physical movements affect senescent cell clearance and improve vascular health (blood flow) in the virtual body to see how lifestyle changes synergize with vaccine components.
  • Iterative Testing: The simulation iterates rapidly:
    1. Model: Simulate the aging organ.
    2. Vaccinate: Apply a virtual senolytic vaccine.
    3. Evaluate: Measure the decrease in inflammatory factors (e.g., IL-6) and the increase in tissue strength, aiming for a 30-year-old profile.
Initial Focus Areas
  • Thymus Rejuvenation: Reversing thymic involution (using compounds like DHEA and metformin to restore the organ that produces T-cells).
  • Brain/Cognitive Health: Targeting immune cell dysfunction to restore cognitive function in older adults.
  • Muscle Regeneration: Improving stem cell quality to restore grip strength and metabolic health.
Disclaimer: These technologies are largely in preclinical, animal-model, or early-stage development, with some experts aiming for functional aging vaccines within 7-10 years




* * * 

What will youth vaccines be made up of initially ... e.g. vaccines that could reverse organs in an 80 year old to a 30 year old, & in #AvatarAgentElectronicHealthRecords & as #DigitalTwinOrganisms, esp with #RealisticVirtualEarthForYogaAsana ?


What will youth vaccines be made up of initially eg vaccines that could reverse organs in an 80 year old to a 30 yo? How to begin to develop these in #AvatarAgentElectronicHealthRecords & as #DigitalTwinOrganisms, esp with #RealisticVirtualEarthForYogaAsana, a #RealisticVirtualEarthForYogaPoses, #RealisticVirtualEarthForVaccines in one iterating #RealisticVirtualEarth ?


https://gemini.google. com/share/6b6df75619e9 = https://gemini.google.com/share/6b6df75619e9


What will #YouthVaccinesWUaS be made up of initially eg vaccines that could #reverseOrgans in an 80 yo to a 30 yo? How to dev w #AvatarAgentElectronicHealthRecords & as #DigitalTwinOrganisms, esp with #RealisticVirtualEarthForYogaAsana & #RVEforVaccines?

https://gemini.google. com/share/6b6df75619e9 ~


https://x. com/Q_YogaMacFlower/status/2034708113010684294 = https://x.com/Q_YogaMacFlower/status/2034708113010684294 


https://x. com/WorldUnivAndSch/status/2034708275833520310 


https://x. com/WUaSPress/status/2034708380858949644


https://x. com/HarbinBook/status/2034709197070410111


https://x. com/scottmacleod/status/2034708686929895891


https://x. com/sgkmacleod/status/2034710015815426164


https://x. com/TheOpenBand/status/2034709617184579869


Gemini AI reply:


The concept of "youth vaccines"—more scientifically known as epigenetic reprogramming or senolytic therapy—is one of the most ambitious frontiers in longevity science. We aren't just talking about a flu shot for aging; we are talking about biological "software" updates.

Here is a breakdown of what these vaccines might contain and how your vision of Digital Twins and Virtual Earths could facilitate their development.


1. The Composition of a "Youth Vaccine"


To reverse an 80-year-old’s organs to a 30-year-old state, the vaccine wouldn't use dead viruses. Instead, it would likely consist of:

Yamanaka Factors (OSKM): These are four specific genes ($Oct4, Sox2, Klf4, c-Myc$) that can "reprogram" an adult cell back into a pluripotent stem cell state. Modern research focuses on "partial reprogramming" to reset the cellular clock without losing the cell's identity (e.g., keeping a heart cell a heart cell).

mRNA Delivery Systems: Similar to COVID-19 vaccines, mRNA would provide the instructions for cells to temporary produce reprogramming proteins or repair telomeres.


2. Developing via #AvatarAgentElectronicHealthRecords


3. The Role of #DigitalTwinOrganisms


4. #RealisticVirtualEarth for #Yoga and Vaccines ~


https://www.linkedin. com/posts/world-university-and-school_gemini-longevity-vaccines-digital-twins-activity-7440501935511777281-jC9D


How best can #WorldUniversityAndSchool building on #MITOCW in 7 languages proceed to develop such vaccines & in a #RealisticVirtualEarthForVaccines?






--


Society, Information Technology, and the Global University, (forthcoming, Academic Press at World University and School, 2026) 

Scottish Small Piping album #2 - Honey Piobaireachd (2022)
- Poetry! Order Book #5 Light, Float, Sit, Watsu ~ Virtually (2021, Academic Press at WUaS)

Scottish Small Piping album #1 Honey in the Bag ~ Out of the Air tune (2020)


Order Book #3 Winding Road Rainbow: Harbin, Wandering & the Poetry of Loving Bliss (2018,  Academic Press at WUaS)

Order Book #2 Haiku-ish and Other Loving Hippie Harbin Poetry (2017,  Academic Press at WUaS) 

Order Actual-Virtual Ethnographic Book #1: Naked Harbin Ethnography (2016, Academic Press at World University and School)

- Scott GK MacLeod  
Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki, 
World University & School (WUaS)  
- USPS US Post Office, PO Box 132, General Delivery, Canyon, CA 94516 


1) non-profit 501(c)(3) Public Charity 
best STEAM CC licensed OCW, Wiki, 
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2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html

(o) 415 480 4577 (Google voice #) - sgkmacleod@worlduniversityandschool.org 
(m) 412 478 0116 - sgkmacleod@gmail.com 


World Univ & Sch Innovation Research - 






* 


Hi Erica, 

I'm removing your email above from this email thread. How are you? 

What do you think of Harvard and MIT Professor of Genetics' George Church's heralding of aging reversal genetics, potentially 1st ones FDA approved by 2050?

Warm regards, abolition-ally, Yogically, kindly, 
Scott





- Scott GK MacLeod  
Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki, 
World University & School (WUaS)  
- USPS US Post Office, PO Box 132, General Delivery, Canyon, CA 94516 


1) non-profit 501(c)(3) Public Charity 
best STEAM CC licensed OCW, Wiki, 
World University and School - http://worlduniversityandschool.org 

2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html

(o) 415 480 4577 (Google voice #) - sgkmacleod@worlduniversityandschool.org 
(m) 412 478 0116 - sgkmacleod@gmail.com 


World Univ & Sch Innovation Research - 


 




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https://upload.wikimedia.org/wikipedia/commons/thumb/f/fd/Harlequin_lotus%2C_Hosackia_gracilis_%2849864385601%29.jpg/1920px-Harlequin_lotus%2C_Hosackia_gracilis_%2849864385601%29.jpg



https://en.wikipedia.org/wiki/Hosackia_gracilis

https://commons.wikimedia.org/wiki/Category:Hosackia_gracilis


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