Dear Dick (Robb MD, possibly posthumously, also a professor in Harvard Medical School), UU Chris Michaels, Annie, Alden, Donna, George and Maitreyi (both professors in Harvard Medical School too), Ma/Janie, Peter (Norvig AI), Marlynn Wei (author of the Harvard Medical School Guide to Yoga), Doortje Van Kooten (in the Netherlands and how would you say your father Victor, and Angela teach consciousness or awareness - or the inner body - and regarding the 8 Limbs of Yoga? and see the PS too), Yogis, All,
Yoga and longevity genetics' conversation further ~
A
Added this week's Restorative Yoga explorations here with Yoga and longevity genetics' conversation - https://scott-macleod.
B
Great to find this recent LinkedIn post from Peter Norvig (above) - and regarding Google building out the Large Language models, I posit, for aging reversal and extreme longevity genetics ... and potentially with our #
Peter Norvig
Education Fellow at Stanford / Researcher at GoogleEducation Fellow at Stanford / Researcher at Google
I am now done comparing three LLMs to my own coding on the Advent of Code problems. The LLMs did great! They couldn't have done it last year. See my analysis here:
https://lnkd.in/gCc2iuPK
https://www.linkedin.com/
Education Fellow at Stanford / Researcher at GoogleEducation Fellow at Stanford / Researcher at Google
I am now done comparing three LLMs to my own coding on the Advent of Code problems. The LLMs did great! They couldn't have done it last year. See my analysis here:
https://lnkd.in/gCc2iuPK
https://www.linkedin.com/
C
TweetedX and LinkedIn about this Yoga exploration invitation this morning too here -
A free & open #RestorativeYogaExploration this morning ~ https://scott-macleod.
https://x.com/Q_YogaMacFlower/
https://x.com/WorldUnivAndSch/
https://x.com/sgkmacleod/
https://x.com/scottmacleod/
https://x.com/HarbinBook/
https://x.com/WUaSPress/
https://x.com/TheOpenBand/
https://x.com/WorldUnivAndSch/
https://x.com/sgkmacleod/
https://x.com/scottmacleod/
https://x.com/HarbinBook/
https://x.com/WUaSPress/
https://x.com/TheOpenBand/
https://www.linkedin.com/
https://www.linkedin.com/
https://www.linkedin.com/
https://www.linkedin.com/
https://www.linkedin.com/
D
Jason Meija, great to meet and talk with you in the Berkeley Claremont public library yesterday ... and with your UC Davis genetics' & SF State university cell biology degrees, how might we explore further building out on the digital side a realistic virtual earth for Aging Reversal, for Yoga Asana, for Extreme Longevity and that's group buildable (with STEM-wiki-virtual-world-
E
And with these approaches to the study of the problem of consciousness from a western philosophy perspective -
https://loewchristian.
Enjoying Angela's first 4 Yoga movement exploration videos here this morning - https://angela-victor.com/
Friendly regards, Namaste, Yogically,
Scott
* *
Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:)? ~ Want to explore these Angela Farmer Yoga asana explorations (in the videos to the left) on Saturday, March 14, 2026 ~
(selecting from some of these 8 short videos - https://angela-victor.com/who/angela/}
AND
AND
AND
Angela Farmer Loving Kindness
https://angela-victor.com/who/
and check out their Yoga teaching 'self-studies' (svadhyaya s, I'll call this, the Sanskrit word for study of the Self, as Victor & Angela translate Yoga from the East to the West emerging out of the 1960s and 1970s in their Yoga teachings) on these pages
from - https://angela-victor.com/who/ ?
B
3-4 yoga movement explorations / poses in about 15 minutes on Saturdays at around 8am ... ?
C
Appreciating 8 Limbs of Yoga ~ How best to #celebrateYoga in exploring #YogaConsciousness #YogaMeditation in #8LimbsOfYoga ?
Dear Dick (Robb MD, possibly posthumously, also a professor in Harvard Medical School), UU Chris Michaels, Annie, Alden, Donna, George and Maitreyi (both professors in Harvard Medical School too), Ma/Janie, Peter (Norvig AI), Marlynn Wei (author of the Harvard Medical School Guide to Yoga), Doortje Van Kooten (in the Netherlands and how would you say your father Victor, and Angela teach consciousness or awareness - or the inner body - and regarding the 8 Limbs of Yoga? and see the PS too), Yogis, All,
Want to explore these Angela Farmer Yoga asana explorations (in the videos to the left) on Saturday, March 14, 2026 ~
https://angela-victor.com/who/
and check out their Yoga teaching 'self-studies' (svadhyaya s, I'll call this, the Sanskrit word for study of the Self, as Victor & Angela translate Yoga from the East to the West emerging out of the 1960s and 1970s in their Yoga teachings) on these pages
from - https://angela-victor.com/who/ ?
B
3-4 yoga movement explorations / poses in about 15 minutes on Saturdays at around 8am ... ?
C
Appreciating 8 Limbs of Yoga
How best to #celebrateYoga in exploring #YogaConsciousness #YogaMeditation in #8LimbsOfYoga
#Yama
#Niyama
#Asana
#Pranayama
#Pratyahara
#Dharana
#Dhyana
#Samadhi
#AngelaAndVictorInspiredYoga ~ https://angela-victor.com/
How best to #celebrateYoga in exploring #YogaConsciousness #YogaMeditation in #8LimbsOfYoga#Yama #Niyama #Asana #Pranayama #Pratyahara #Dharana #Dhyana #Samadhi #AngelaAndVictorInspiredYoga ~ https://t.co/ozyvJCZksj?
— WorldUnivandSch (@WorldUnivAndSch) March 12, 2026
~https://wiki.worlduniversityandschool. org/wiki/Yoga!
https://x.com/WorldUnivAndSch/
https://x.com/sgkmacleod/
https://x.com/Q_YogaMacFlower/
https://x.com/WUaSPress/
https://x.com/scottmacleod/
https://x.com/HarbinBook/
https://x.com/TheOpenBand/
https://x.com/sgkmacleod/
https://x.com/Q_YogaMacFlower/
https://x.com/WUaSPress/
https://x.com/scottmacleod/
https://x.com/HarbinBook/
https://x.com/TheOpenBand/
***
How best to celebrate in exploring #YogaConsciousness in #8LimbsOfYoga
#Yama:
#Niyama:
#Asana: (Posture)
#Pranayama: (Breath Control)
#Pratyahara: (Withdrawal of Senses)
#Dharana: (Concentration)
#Dhyana: (Meditation)
#Samadhi: (Pure Contemplation, Absorption)
#AngelaAndVictorInspiredYoga ?
D
And how will or might we celebrate exploring #YogaConsciousness in #8LimbsOfYoga if we live until age 150 or well beyond and as new ways to Yoga-celebrate emerge ... in this #Yoga And Longevity Yoga Convo Conversation ?
Found this perspective from Gemini AI in asking about your research Professor George Church (above) -
"George Church, a Harvard geneticist, is pioneering anti-aging research aimed at reversing aging in human cells and animals using gene therapy, specifically CRISPR technology and partial cellular reprogramming. His work focuses on targeting the epigenome to potentially extend healthy human lifespan, with animal trials for rejuvenation already showing success.
Key details of George Church's age reversal research:
...
- Goal: The ultimate goal is to extend the healthy human lifespan beyond 100 years.
And what if we live beyond 200 years, with longevity genetic drug therapies emerging, FDA approved, first ones possibly by 2050?
E
Also, George (Church), David (Sun Kong), other researchers (above) in synthetic biology and longevity and aging reversal, I asked Yogically Gemini AI about Principal Investigators / scientists in about 4 countries who might have doubled the lifespan of the fruit fly ... re approaches too to longevity genetics that might be extrapolated to humans (as challenging as this is inter-species-wise) with time ... and as World University and School seeks to build out further a #
Longevity genetics' science in Drosophila fruit fly country by country & PI scientists?
A
British isles
B
Japan
C
In the 3 German language countries (auf Deutsch)
who are principal investigators and scientists in Germany Austria and Switzerland in the German language who are studying longevity and regarding drosophila melanogaster the fruit fly as experimental lab animal and even who might have double lifespan already?
AND SEE the PPS
E 1
And see the beginnings of adding a fruit flies' body to the Flywire Connectome project here -
Michael Andregg
@michaelandregg
·
Mar 8
We've uploaded a fruit fly. We took the @FlyWireNews connectome of the fruit fly brain, applied a simple neuron model (@Philip_Shiu Nature 2024) and used it to control a MuJoCo physics-simulated body, closing the loop from neural activation to action.
A few things I want to say about what this means and where we're going at
@eonsys
.
We've uploaded a fruit fly. We took the @FlyWireNews connectome of the fruit fly brain, applied a simple neuron model (@Philip_Shiu Nature 2024) and used it to control a MuJoCo physics-simulated body, closing the loop from neural activation to action.
— Michael Andregg (@michaelandregg) March 8, 2026
A few things I want to… pic.twitter.com/Qnlu3INs33
https://x.com/michaelandregg/
which is at the top of this TwitterX feed presently - https://x.com/FlyWireNews .
F
Asked Gemini AI
How do the "Harvard Medical School Guide to Yoga : Strength Awareness & Flexibility," Yogis' Angela & Victor, Hippy-anjali Yoga Notations, & World University and School teach about Yoga awareness or consciousness?
and see the PS
G
Happy Birthday, Yogi Matt (King), - https://scott-macleod.
H
Seeking to get started at developing further. a #
How best to #celebrateYoga (could this be samadhi or oneness in yoga meditation? ... OR ? :) in exploring #YogaConsciousness in #8LimbsOfYoga in Yoga explorations on this Saturday 3/14/26 morning? (Please let me or us know - perhaps by wiki-editing this Yoga wiki subject - https://wiki.
Thoughts, questions, suggestions??
Namaste, Yogically, Warm regards,
Scott
PS
How do the "Harvard Medical School Guide to Yoga : Strength Awareness & Flexibility," Yogis' Angela & Victor, Hippy-anjali Yoga Notations, & World University and School teach about Yoga awareness or consciousness?
How does "The #HarvardMedSch #GuideToYoga: 8 Weeks to Strength, Awareness, & Flexibility" teach about #YogaAwareness?
How do Yoga
@WorldUnivAndSch
https://wiki.
http://scottmacleod.com/
https://x.com/WorldUnivAndSch/
https://x.com/Q_YogaMacFlower/
https://x.com/scottmacleod/
https://x.com/HarbinBook/
https://x.com/sgkmacleod/
https://x.com/WUaSPress/
https://x.com/TheOpenBand/
How do Yoga
@WorldUnivAndSch
https://wiki.
http://scottmacleod.com/
https://x.com/WorldUnivAndSch/
https://x.com/Q_YogaMacFlower/
https://x.com/scottmacleod/
https://x.com/HarbinBook/
https://x.com/sgkmacleod/
https://x.com/WUaSPress/
https://x.com/TheOpenBand/
*
How does the "Harvard Medical School Guide to Yoga : Strength Awareness & Flexibility" teach about Yoga awareness or consciousness?
see pp 54-55 and
How does '8 Limbs of Yoga' teach about awareness or consciousness?
How does Yogini Angela Farmer and Yogi Victor Van Kooten teach about awareness or consciousness & regarding for example https://angela-victor.
in taking a course with Yogis' Angela and Victor rather than asking how they teach about yoga awareness or consciousness ...
how does Yogini Angela Farmer and Yogi Victor Van Kooten teach about awareness or consciousness & regarding for example https://angela-victor.com/who/ and http://scottmacleod.com/
?
How do Yoga @ World University and School -
and Scott MacLeod's Hippy-anjali Yoga Notations -
http://www.scottmacleod.com/
(in English presently, & in all 7159 living languages with time)
How to do Yoga @ World University and School -
and with Scott MacLeod's Hippy-anjali Yoga Notations - http://www.scottmacleod.com/
PPS
A
Asked -
Who are 10 key drosophila fly longevity genetics principal investigator scientists in England and the British Isles and what are some of their Publications? What are their names too?
Drosophila Longevity Genetics Researchers
https://gemini.google.com/
Created with Fast March 12, 2026 at 01:29 PM
Published March 12, 2026
https://gemini.google.com/
Created with Fast March 12, 2026 at 01:29 PM
Published March 12, 2026
Several leading scientists in England and the British Isles specialize in the genetics of longevity using Drosophila.
Key Principal Investigators and Labs
| Name | Institution | Research Focus |
| Linda Partridge | University College London (UCL) | Insulin/IGF signaling, dietary restriction, and the pharmacology of aging. |
| Stephen Goodwin | University of Oxford | Neural circuitry, sexual dimorphism, and how social environment mediates lifespan. |
| Alex Gould | Francis Crick Institute | Metabolic programming, lipid metabolism, and how early-life diet affects adult lifespan. |
| Alicia Hidalgo | University of Birmingham | Neurotrophins, structural brain plasticity, and CNS repair in relation to aging. |
| Richard Baines | University of Manchester | Homeostatic mechanisms, neuronal excitability, and critical periods in development. |
| Matthew Piper | Monash (formerly UCL) | Nutritional geometry and the molecular basis of dietary-induced lifespan extension. |
| Sebastian Grönke | UCL / Max Planck | Genetic interventions in the insulin signaling pathway and mitochondrial function. |
| Cathy Slack | University of Warwick | Ras/MAPK signaling and the role of protein synthesis in healthy aging. |
| James Hodge | University of Bristol | Circadian rhythms, potassium channels, and age-related memory loss. |
| Nazif Alic | UCL | RNA polymerase III and transcriptional regulation of longevity. |
Notable Publications
Partridge, L. et al. (2011). "Diet and Aging." Cell. Focuses on how nutrient sensing pathways (mTOR, AMPK) govern lifespan.
Gould, A. P. et al. (2017). "Developmental diet regulates Drosophila lifespan via lipid autotoxins." Nature Communications. Explores how early-life protein intake impacts adult mortality.
Goodwin, S. F. et al. (2018). "Interactions between the sexual identity of the nervous system and the social environment mediate lifespan in Drosophila melanogaster." Proc Biol Sci.
Alic, N. & Partridge, L. (2024). "Trametinib ameliorates aging-associated gut pathology." PNAS. Investigates pharmacological interventions for lifespan extension.
Would you like me to find specific contact information or current project descriptions for any of these labs?
B
who are the principal investigators & scientists in Japan who were studying longevity and regarding drosophila melanogaster the fruit fly as experimental lab animal and even who might have doubled lifespan already in the drosophila fly?
Japanese Longevity Research: Drosophila melanogaster
https://gemini.google.com/
Created with Fast March 12, 2026 at 01:33 PM
Published March 12, 2026
https://gemini.google.com/
Created with Fast March 12, 2026 at 01:33 PM
Published March 12, 2026
Key researchers in Japan investigating Drosophila melanogaster (fruit fly) longevity include Professor Masayuki Miura and Project Assistant Professor Fumiaki Obata at the University of Tokyo. Their research identified that enhancing the metabolism of S-adenosylmethionine (SAM) via the enzyme GNMT significantly extends lifespan and mediates the benefits of dietary restriction.
While researchers like Michael Rose (USA) and the team behind the Indy (I'm Not Dead Yet) gene at the University of Connecticut are famous for doubling fly lifespans, Japanese research has produced significant extensions (often 30–50%) through various genetic and dietary interventions:
Leading Researchers & Institutions
Masayuki Miura & Fumiaki Obata (University of Tokyo): Focus on metabolic pathways, specifically SAM catabolism and its role in dietary restriction-induced longevity.
Aya Takahashi (Tokyo Metropolitan University): Studies the genetic links between circadian rhythms (the timeless gene) and survival strategies like reproductive diapause.
Kazuhiko Kume (Nagoya University): Investigates the relationship between sleep, metabolism, and lifespan, recently testing compounds like 4-Galactosylkojibiose.
Kazutaka Akagi (National Center for Geriatrics and Gerontology): Developed "DR-evolved flies" through 100+ generations of dietary restriction to identify novel longevity factors related to intestinal health.
The "Double Lifespan" Context
True doubling (a 100% increase) is rare and typically requires specific selective breeding or high-impact mutations like the Indy gene mutation. Most high-profile Japanese studies focus on specific molecular mechanisms that offer robust but more moderate increases, such as:
GNMT Enhancement: Suppresses age-related metabolic shifts.
Dietary Shifts: Research at the University of Tokyo shows that switching to low-calorie diets, even late in life, can reduce mortality rates by over 35%.
Would you like me to find the specific syllabus for a course on longevity genetics based on these Japanese findings?
C
Who are principal investigators and scientists in Germany Austria and Switzerland in the German language who are studying longevity and regarding drosophila melanogaster the fruit fly as experimental lab animal and even who might have double lifespan already?
In Deutschland, Österreich und der Schweiz (DACH-Region) gibt es führende Expertinnen und Experten, die die Taufliege Drosophila melanogaster nutzen, um die Geheimnisse des Alterns zu entschlüsseln.
Führende Wissenschaftler in der DACH-Region
| Name | Institution | Forschungsschwerpunkt |
| Linda Partridge | Max-Planck-Institut für Biologie des Alterns (Köln) | Insulin-Signalisierung, Diätetische Restriktion und pharmakologische Interventionen. |
| Thomas Flatt | Universität Freiburg (CH) | Evolutionäre Genetik der Langlebigkeit und die Rolle des Immunsystems beim Altern. |
| Christian Schlötterer | Vetmeduni Vienna (Wien) | Populationsgenetik und experimentelle Evolution von Lebensspanne und Fitness. |
| Adam Antebi | Max-Planck-Institut (Köln) | Molekulare Genetik des Alterns, Stoffwechselwege und hormonelle Steuerung. |
| Eduardo Moreno | Universität Bern (CH) | Zellfitness und "Zellauswahl" (Cell Selection) zur Verjüngung von Gewebe. |
Verdopplung der Lebensspanne
Eine echte Verdopplung der Lebensspanne (100% Steigerung) ist extrem selten und meist nur unter sehr spezifischen Laborbedingungen oder durch die Kombination mehrerer Eingriffe möglich.
Zellauswahl (Bern): Das Team von Eduardo Moreno an der Universität Bern konnte durch die Optimierung der Qualitätskontrolle von Zellen (Eliminierung weniger fitter Zellen) die Lebensspanne von Fliegen um etwa 50–60 % verlängern.
Kombinierte Interventionen: Während Einzelmutationen oft nur moderate Zunahmen bewirken, erreichen Forscher wie Linda Partridge signifikante Verlängerungen durch die Hemmung des mTOR-Signalwegs oder der Insulin-Signalisierung, oft in Verbindung mit gezielter Ernährung.
Selektionsversuche: In der Evolutionsbiologie (z. B. bei Thomas Flatt oder Christian Schlötterer) werden Fliegen über hunderte Generationen auf Langlebigkeit selektiert. Diese "Methusalem-Fliegen" leben teils massiv länger als Wildtypen, allerdings oft auf Kosten ihrer frühen Fortpflanzungsfähigkeit.
Möchten Sie, dass ich nach spezifischen aktuellen Publikationen dieser Institute zum Thema Lebensverlängerung suche?
PPPS
On Fri, Mar 6, 2026 at 7:42 AM Scott Yoga Mac Flower MacLeod <yogamacflower@gmail.com> wrote:
Dear Dick (Robb MD, possibly posthumously, also a professor in Harvard Medical School), UU Chris Michaels, Annie, Alden, Donna, George and Maitreyi (both professors in Harvard Medical School too), Ma/Janie, Peter (Norvig AI), Yogis, All,Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:) Greetings!A8 limb Yoga Tree re Yoga philosophy -great Yoga tree of 8 limb Yoga in Pinterest ... and with its allusions to genetics even, implied -BFurther chair Yoga (with parallels to sitting in Friendly unprogrammed NtF Quaker Meeting - and Friendly leadings too) with breathing explorations per inspirations Yogini Angela's pranayama videos ... in your Yoga explorations on Sat 3/7/26 at 8 am PT, 11 am ET, 8:30 or 9:30 pm India Time? Invitation to continue to explore the Yoga asana and pranayama videos we've visited in the past few months (since, say - https://scott-macleod.blogspot.com/2025/10/red- hibiscus.html - Friday, October 17, 2025
CAs I sat in Yoga Mudrasana (cross-legged seated forward bend - explorable from chair yoga, as a forward bend - and see the AI Overview PS) this morning, Jnana Yoga-wise, and Svadhyaya -wise too (knowledge Yoga here, & the 4th Niyama), I was meditating (dhyana) on ways in which breathing (pranayama) could act as an intervention, or trigger even, to turn on Gene Expression of meditation (inner releasing action / relaxation response) ... which some could construe as even the divine, or oneness, sometimes 'bliss,' - samadhi? - and how we could study / learn further about this genetics, and with a #RealisticVirtualEarthForYogaAs ana #RealisticVirtualEarthForYoga in one iterating #RealisticVirtualEarth (#TwitterX #LinkedIn) connected with our electronic health records, or our # AvatarAgentElectronicHealthRec ords even in the future ... and (and as we may live to 150 and well beyond:) ... Explore some of this as you explore Yoga meditation, asana and breathing tomorrow?C iRe related gene expression, I asked AI overview. -What are the gene expressions that are turned on, potentially with pranayama as a trigger / intervention, and in what part of our bodyminds, when we Yoga meditate (dhyana) and regarding the inner releasing actions or the relaxation response? ... And got another incredible response ... and see PPSDSo how could we '8 limbs of Yoga explorers' who may live to 150 and beyond, use new Bayesian inference developments from Google Deep Mind -Google Research
@GoogleResearch
Mar 4
Introducing a new method to teach LLMs to reason like Bayesians. By training models to mimic optimal probabilistic inference, we improved their ability to update their predictions and generalize across new domains. Learn more: https://goo.gle/4ue4eqj
https://x.com/GoogleResearch/status/2029295018972778883?s= 20 ... to identify new genes, possibly for vaccines, new cellular, cell transition (through different life phases eg from embryo, 10, 20, 30 to 150 years old) & molecular processes and a myriad of other aging reversal and longevity genetics' biology processes & similar and in order to develop further aging reversal genetics and extreme longevity genetics, drug therapies, and that would be good candidates even for clinical trials, that might achieve FDA approval? How could a realistic virtual earth for genetics, a realistic virtual earth for synthetic biology, a realistic virtual earth for biomedical engineering, a realistic virtual earth for Yoga all interoperable with our #AvatarAgentElectronicHealthRec ords as digital twins make this happen? And how further to develop this #RealisticVirtualEarth in Google Street View with time slider at the #GCellView and #GMoleculeView levels in a #WUaSHospitalMultimediaRoom with "How to view street View in a Smart Meeting room - https://www.youtube.com/watch?v=q9FBhEAXRY4 - and with little Pegman becoming our # AvatarAgentElectronicHealthRec ords ... and in which we could further ask Bayesian inference questions toward aging reversal and extreme longevity genetic drug therapies emerging with 8 limb Yoga too? Until our next Yoga meditation asana pranayama explorations around 8am Pacific Time on Sat 3/7/26 individually all together ... un about 24 hours from now.Namaste, Yogically, Friendly best regards,ScottOur Restorative Yoga classes are in my daily blog (and posted usually on Saturdays or Fridays), and here's a first one -Friday, October 17, 2025
ANDsee too -Friday, October 10, 2025
PSYoga Mudrasana (Psychic Union Pose) is a powerful, seated forward-bending yoga posture that releases tension in the back, hips, and shoulders while fostering introspection. Practiced from a lotus or cross-legged position, it involves folding forward to bring the forehead to the floor, often with hands bound behind the backPPSYoga meditation (dhyana) and pranayama (yogic breathing) act as triggers that activate the "relaxation response," a physiological state that reverses stress-related molecular changes. These practices downregulate genes associated with inflammation and stress, while upregulating genes involved in immune function, energy metabolism, and DNA repair.These genetic changes are primarily observed in peripheral blood mononuclear cells (PBMCs) (immune cells in the blood), which act as a marker for the body's overall systemic response to the intervention.Key Gene Expressions Turned On (Upregulated)The relaxation response, induced by dhyana and pranayama, stimulates the following genetic pathways:
- Immune System & Antiviral Defense: Increased expression of genes involved in innate immunity, particularly interferon signaling (e.g., IFIT1, HERC5, MX1, XAF1, ISG15), boosting the body's antiviral response.
- Mitochondrial Function & Metabolism: Upregulation of genes related to energy metabolism and mitochondrial function, such as AMPK (adenosine monophosphate-activated protein kinase) and SIRT-1 (sirtuin 1), which improve metabolic health.
- DNA Repair & Longevity: Activation of genes involved in DNA repair (e.g., OGG1 or 8-oxoguanine DNA glycosylase) and increased telomerase activity, which helps maintain telomere length, promoting cellular longevity.
- Immune Regulation: Increased expression of anti-inflammatory and regulatory genes, including TGF-β (Transforming Growth Factor-beta) and FoxP3.
- Neuroprotection: Upregulation of genes linked to brain health and neuronal protection.
Key Gene Expressions Turned Off (Downregulated)
- Inflammatory Pathways (NF-κB): The most consistent finding is the downregulation of the Nuclear Factor kappa B (NF-κB) pathway, which is typically activated by stress and responsible for inflammation.
- Pro-inflammatory Cytokines: Decreased expression of genes that promote inflammation, such as RIPK2 and COX2, as well as cytokines like IL-6 and TNF-α.
- Oxidative Stress & Aging: Reduction in genes responsible for producing oxidative stress, which accelerates cellular damage and aging.
The Role of Pranayama and "Inner Releasing"Pranayama acts as a potent tool for triggering these genetic shifts by regulating the autonomic nervous system.
- Autonomic Shift: Pranayama increases parasympathetic activity ("rest and digest") and decreases sympathetic nervous system activity ("fight or flight"), reducing cortisol and adrenaline.
- Inner Releasing Actions: These actions involve deep, intentional, and slow breathing that directly signals the brain to reduce stress hormone production, resulting in decreased inflammatory gene expression.
Affected Areas of the "Bodymind"
- Peripheral Blood System (PBMCs): The primary site of study, showing rapid changes in gene expression in circulating immune cells.
- Neuroendocrine System: The hypothalamic-pituitary-adrenal (HPA) axis is modulated, reducing cortisol production.
- Brain Structure: Long-term meditation has been associated with increased cortical thickness in areas involved in emotion regulation.
- Cardiovascular System: Reduced blood pressure and improved hypertension control through altered gene expression in blood cells
PPPSOn Fri, Feb 27, 2026 at 8:40 PM Scott Yoga Mac Flower MacLeod <yogamacflower@gmail.com> wrote:Dear Dick (Robb MD, possibly posthumously, also a professor in Harvard Medical School), UU Chris Michaels, Annie, Alden, Donna, George and Maitreyi (both professors in Harvard Medical School too), Ma/Janie, Peter (Norvig AI), Yogis, All,Yoga greetings! A little restorative Yoga exploratoration tomorrow, Sat Feb 28, 2026 at around 8 am PT, 11 am ET 8:30 pm India time and in your zone ... Seeking to explore inside meditatively ~AExplore from this with Angela for 5 minutes or so at first -BAnd then explore some of this same video seating in easy cross-legged pose, or half-lotus, or especially sitting on a chair, for a few minutes -(adapting the video for sitting up?)CI found thisYoga tree of 8 limb Yoga great in Pinterest ... and with its allusions to genetics even, implied -A way to explore Yoga philosophy in many ways ~DAnd then another 5 minutes of so with a kind of introduction toPranayama - breathing explorations Yogically with Angela too -EAnd I found this book new Yoga book for me recently, and actually met one of its authors, Marlynn, whom I appreciated a lot, in a Data & Society webinar from near DC, yesterday morning, Th 2/26/26 -The #HarvardMedSch #GuideToYoga: 8 Weeks to Strength, Awareness, & Flexibility by #MarlynnWeiMDJD, & #JamesEGrovesMD, 2017.The #HarvardMedSch #GuideToYoga: 8 Weeks to Strength, Awareness, & Flexibilityby #MarlynnWeiMDJD, & #JamesEGrovesMD, 2017.Introduction to yoga: thechair sequenceModified Sun Salutation#HarvardHealthPubs #YogaWUaS: https://wiki.worlduniversityandschool.org/ wiki/Subjects ~ ANDhttps://www.linkedin.com/posts/scott-macleod-4691a011a_ harvardmedsch-guidetoyoga- marlynnweimdjd-activity- 7432884780775456768-ZR81
https://www.linkedin.com/posts/scottgkmacleod_ harvardmedsch-guidetoyoga- marlynnweimdjd-activity- 7432885023135125505-IkxR
https://www.linkedin.com/posts/world-university-and- school_subjects-world- university-and-school-wiki- activity-7432884248946278400- mZ4e FAnd Dick and Chris, and all, check out and do the first Harvard Yoga pose chair Yoga video -GAnd further, this Harvard Yoga pose might interest people who want to eventually try Sun SalutationModified Sun SalutationANDHAnd as we may live to 150 and well beyond:),I came to wonder further how we and scientists could Yogically even study or explore our cells relating to the Yoga poses and meditations we do and even the cells in our brains.And when Stanford Law and Bioethics' professor Hank Greely posted the following this morning, I asked the following too -how else is it possible to study brain cells & neuron cells w #brainwaveHeadsets, & in their cells, through the cranium, besides by EEG & MRI processes scientifically:https://g.co/gemini/share/1089acbe4a4a & how to add these data to an iterating # RealisticVirtualEarthForCells? #WUaScellBio ~ Retweeting -Long @undarkmag story on human neural organoids undark.org/2026/02/26/bra… Conflict of interest warning: it quotes me. A lot. Check out the Undarkmagazine article ...IHow to study the cells and neurons of the brain, and meditation and even loving bliss, and with headbands and brainwave headsets too, in my 2nd Harbin Hot Springs' ethnographic book project, while soaking in the Harbin warm pool or in our homes in a virtual Harbin hot springs, and with STEM research on the brain and body mind planned too - and re Yoga and asana and breathing and meditation?JAnd in these regards, here are some related research queries -
Which databases to draw from first @GeoChurch #PeterNorvig in dev #LLMmodels for "#CellularTransitions #AcrossHumanLifeStages" #RealisticVirtualEarth #RVEforExtremeLongevity #RVEforCells in our #PhysicalDigital #AvatarAgentElectronicHealthRec ords (& re
https://scott-macleod.blogspot.com/2026/02/kokio- keokeo-or-hawaiian-white- hibiscus.html ?)
https://x.com/Q_YogaMacFlower/status/2025267685572182468
https://x.com/WorldUnivAndSch/status/2025267346122985906 AND again -KHow to dev databases & #LLMmodels for "#CellularTransitions #AcrossHumanLifeStages" from #HarvardMedicalSchool @ embryo, 10, 20, - 90+ yo re dates @ #HarbinHotSprings' #GateHouse in #GStreetView w #GTimeSlider: 2007, 2012, 2024: https://goo.gl/maps/7gSsSTweRCBo9gf87 ? https://x.com/WorldUnivAndSch/status/2025750494682198267
https://x.com/WUaSPress/status/2025751095369404510 ANDLWhich databases to draw from first @GeoChurch #PeterNorvig in dev #LLMmodels for "#CellularTransitions #AcrossHumanLifeStages" #RealisticVirtualEarth #RVEforExtremeLongevity #RVEforCells in our #PhysicalDigital #AvatarAgentElectronicHealthRec ords (& re
https://scott-macleod.blogspot.com/2026/02/kokio- keokeo-or-hawaiian-white- hibiscus.html ?)
https://x.com/Q_YogaMacFlower/status/2025267685572182468
https://x.com/WorldUnivAndSch/status/2025267346122985906 MLooking forward to exploring some of this all together tomorrow as individuals on our own Yoga journeys ... and as we grow stronger, with awareness, and fitter too .. and as we may live to 150 years of age and well beyond. (And here's a fascinating rigorous clinical trial out of Brown University, with Brown Professor John Sedivy as the PI, I think, and other universities in New England studying slowing aging - https://scott-macleod.blogspot.com/2026/01/ asparagus-gharoensis.html). Know of other clinical trials in process in a related longevity vein, and with possible Yoga explorations too? Please let us know in this developing Yoga and Longevity conversation. Namaste, all the best, Happy Yoga explorations, warm regards,ScottOn Sun, Feb 22, 2026 at 9:51 AM Scott Yoga Mac Flower MacLeod <yogamacflower@gmail.com> wrote:
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