Dear Yoga friends, family in their 80s and 90s' ~ Ma/Janie, and Alden (Briscoe - who went to Quaker George School in Philadelphia before Harvard college), & Quakertarian & Veterinarian & cousin Annie (Brown in NE Oregon) in her 60s, Dick (Robb MD, possibly posthumously, also an ophthalmology professor in Harvard Medical School - and might you Dick have helped develop the ongoing clinical trials for ER-100, epigenetic reprogramming for open-angle Glaucoma, and one other Glaucoma condition?, and see - https://share.google/aimode/
Yoga greetings for the Restorative Yoga explorations on Saturday August 8, 2026 (and as we may live to 150 and well beyond:) ... around 8 am your time (until again I can start streaming some Yoga explorations from the shop, and in an iterating realistic virtual earth for Yoga, at 670 Ridgecrest Rd Canyon 94516) & Happy restorative Yoga explorations ... & potentially re independence or liberation or freedom due to extreme longevity and aging reversal genetic drug therapies emerging, FDA approved - and the divine?? willing too??? - and with a physical-digital #RealisticVir
Restorative Chair Yoga explorations to begin ...
A
Urdhva Hastasana (Upward Raised Hands) in a Chair ...
B
and then Urdhva Hastasana in Tadasana (Mountain pose) standing pose ...
Can you ease your inner arms up into the sky above you, as they stream up out of your outer arms, palms facing each other ... Find the spaces in your shoulders, in your elbow joints, in your wrists, hands and fingers ... and as you also root down through your feet and legs ... Upper inner body and arms stream up from the roots of your legs ...
C
and then lying on one's back, height under head (like a folded blanket) ... so prone on the floor, as if in savasana, but big toes touching slightly pigeon toes - or knees bent (per image below) - extend your arms straight up toward the sky, and then extend them, describing an arc with your fingertips, over your head toward the floor ..
D
My mother Janie, at 91, above, seeks to walk 2 miles per day, and with walking sticks, thinking these help her stand upright and less hunched over, and for the walking exercises benefits ... (I wonder if this actually contracts the muscles of the shoulder girdle and thus might make her more hunched upper body muscular-wise ... but also think the walking sticks are good for adding more movement while walking 2 miles ... ) ... And I also explore the 8 limbs of Yoga while walking with poles ... eg pratyahara (withdrawal of the senses, e.g. dharana - concentration, dhyana - meditation, as I find a rhythm walking with poles almost like tele-marking in skiing ... and release inwardly re both dharana and dhyana ...)
D 1
I wrote her this email this morning ...
"Upward
Hi Ma,
To keep from hunching over, explore doing
Upward Raised Hands Yoga pose restoratively and even meditatively, & daily ...
More later about this in today's 8/8/26 (for Saturday too) restorative Yoga explorations' email.
Love, Scott
D 2
Also asked Google AI Mode - What are 10 benefits of walking 3 miles a day in terms of eg calorie burning etc? "Walking 3 miles a day burns roughly 300 calories, strengthens your heart, and builds muscle" - https://share.google/aimode/
E
General Biological Intelligence AI - #GeneralBiologicalIntelligen
Further re last week re Yoga Sat 8/1/26 - and regarding Stanford PhD in machine learning Eric Nguyen -
This amazing interview of Eric Nguyen - https://x.com/mariogabriele/
Eric Nguyen @exnx · I sat down with @mariogabriele on the Generalist podcast to talk about why DNA is the most complicated and important language ever - https://x.com/mariogabriele/
So I asked ...
Eric, 'How best @exnx @GeoChurch @amyneurons to create a #
https://x.com/WorldUnivAndSch/
https://x.com/sgkmacleod/
https://x.com/WUaSPress/
https://x.com/Q_YogaMacFlower/
https://x.com/HarbinBook/
https://x.com/WorldUnivAndSch/
https://x.com/sgkmacleod/
https://x.com/WUaSPress/
https://x.com/Q_YogaMacFlower/
https://x.com/HarbinBook/
https://x.com/TheOpenBand/
Retweeting -
Mario Gabriele
@mariogabriele
What happens when AI can write the genetic code for life itself?
Eric Nguyen (@exnx) is the co-founder of
@RadicalNumerics, the lab behind the models that generated the first genome ever created entirely by AI, a bacteriophage that had never existed in nature until it wrote one. He believes DNA should be treated the way language is treated: something a model can read, then write.
With more DNA sitting in public databases than there is text on the entire internet, he sees an almost unmined field, one where the models built to make sense of it remain, by his own admission, no more sophisticated than linear regression.
Thank you to the partners who make this possible
@ahrefs
Brand Radar: Find your brand in AI results: https://ahrefs.com/
@brexHQ
: The intelligent finance platform: https://brex.com/
@Guru_HQ
: The AI source of truth for work:
(3:35) An overview of Radical Numerics
(11:08) Why they started with DNA
(26:24) The limits of language models in biology
(31:15) Eric’s free-range upbringing and path to his PhD program
(41:20) Applying long-context models to DNA and meeting his co-founders
(55:30) How better general LLMs benefit Radical Numerics
(1:02:05) Making biology more concrete
(1:18:09) Final meditations
https://x.com/mariogabriele/
F
Also, asked today re Yoga asana too, and potentially for aging reversal in the future and in a realistic virtual earth for genetics as well -
What genes or complex of genes control movement in human & mammal bodies & particularly that might inform or control #YogaAsana movements, for ex & re #AgingReversal?
Regarding genes, gene expression & genomics, what genes or complex of genes control movement in human & mammal bodies & particularly that might inform or control #YogaAsana movements, for ex & re #AgingReversal?
>https://wiki.
https://x.com/Q_YogaMacFlower/
https://x.com/scottmacleod/
https://x.com/WUaSPress/
https://x.com/TheOpenBand/
https://x.com/sgkmacleod/
https://x.com/HarbinBook/
https://x.com/WorldUnivAndSch/
https://x.com/scottmacleod/
https://x.com/WUaSPress/
https://x.com/TheOpenBand/
https://x.com/sgkmacleod/
https://x.com/HarbinBook/
https://x.com/WorldUnivAndSch/
Have any questions, thoughts, or similar you'd like to share? Please email yogamacflower@gmail.com ... and
in exploring a #YogaAndLongevityGeneticsConvo
exploring an 8/1/26 #YogaAndLongevityGeneticsConvo -https://scott-macleod.
How with #
How with #
https://x.com/Q_YogaMacFlower/
https://x.com/WorldUnivAndSch/
https://x.com/scottmacleod/
https://x.com/sgkmacleod/
https://x.com/WUaSPress/
https://x.com/HarbinBook/
https://x.com/TheOpenBand/
https://x.com/WorldUnivAndSch/
https://x.com/scottmacleod/
https://x.com/sgkmacleod/
https://x.com/WUaSPress/
https://x.com/HarbinBook/
https://x.com/TheOpenBand/
(from Yoga explorations on Sat 8/1/26 - -https://scott-macleod.
Yogically (as in 8 limbs of Yoga) re uniting seeing with seer envisioning - wise, Desiderata prose poem greetings (https://www.desiderata.com/
Scott
PS
A related Yoga consciousness question ... Philosopher of Consciousness David Chalmers (above)?
Is #consciousness as awareness, sentience, #SubjectiveExperience, a biological experience or phenomenon? And if so, how? How does it work? How is consciousness as awareness biological?
https://share.gemini.google/
https://x.com/WorldUnivAndSch/
https://x.com/Q_YogaMacFlower/
https://x.com/HarbinBook/
https://x.com/scottmacleod/
https://x.com/WUaSPress/
https://x.com/sgkmacleod/
https://x.com/TheOpenBand/
https://x.com/Q_YogaMacFlower/
https://x.com/HarbinBook/
https://x.com/scottmacleod/
https://x.com/WUaSPress/
https://x.com/sgkmacleod/
https://x.com/TheOpenBand/
PPS
Saturday, September 27, 2008
* *
AI Mode -
How best could we engage these gene complexes with Yoga asana to reverse aging NOW in these genes & their networks eg in the way exercise builds muscle in aging people this reversing muscle wasting due to aging - and with calorie restriction as well as eventual aging reversal vaccines FDA approved ?
Engaging these target gene complexes to slow or partially reverse age-related muscle wasting (sarcopenia) and tissue degradation relies on epigenetic remodeling—changing how accessible and active these genes are without altering the underlying DNA sequence. Combining dynamic physical loading (yoga asana) with biochemical stressors (nutrient sensing) creates a synergistic effect across these networks.
Strategy 1: Targeted Yoga Asana Loading (Mechanotransduction)
Physical movement forces cells to deform, triggering mechanotransduction—a process where mechanical stress on cell membranes gets converted into biochemical signals that remodel chromatin and alter nuclear architecture.
- Sustained Isometric Holds (e.g., Utkatasana / Chair Pose, Virabhadrasana / Warrior Holds):
- Gene Targets:
ACTN3,MSTN,mTORC1signaling. - Mechanism: Isometric tension under load downregulates Myostatin (
MSTN—the muscle-suppressing gene), while activatingmTORpathways. This mimics traditional resistance exercise to stimulate protein synthesis and halt sarcopenic atrophy.
- Gene Targets:
- Active End-Range Stretching (e.g., Paschimottanasana / Forward Bends, Hanumanasana):
- Gene Targets:
COL1A1,COL5A1,PIEZO2. - Mechanism: Tensile strain on muscle fascia triggers
PIEZO2ion channels, signaling structural remodeling in tendon and extracellular matrix (ECM) genes. Over time, this decreases pathological cross-linking of collagen, restoring tissue compliance without damaging matrix integrity.
- Gene Targets:
- Vinyasa & Dynamic Transitions:
- Gene Targets:
PGC-1α,SIRT1. - Mechanism: Rhythmic, flow-based movement drives calcium influx in skeletal muscle, activating the
CAMK/PGC-1αaxis. This stimulates mitochondrial biogenesis, clearing damaged mitochondria (mitophagy) and boosting cellular energy production.
- Gene Targets:
Strategy 2: Integration with Calorie Restriction (CR)
Calorie restriction (or intermittent fasting windowing) creates a nutrient-scarce state that alters histone modifications and DNA methylation profiles.
| Pathway / Complex | Action under Calorie Restriction | Interacting Yoga Synergy |
|---|---|---|
Sirtuins (SIRT1, SIRT3, SIRT6) | Upregulated due to elevated NAD^+ levels; deacetylates histones to protect genomic stability. | Practice during fasted states to amplify SIRT-driven mitochondrial repair and lipid oxidation. |
Autophagy / mTOR Suppression | Low amino acid availability turns off mTORC1, initiating cellular self-cleaning. | Post-practice refeeding resets mTOR sharply, maximizing muscle protein recovery while minimizing chronic inflammation. |
| DNA Methylation Drift Buffer | Attenuates age-associated epigenetic drift across tissue types. | Combined long-term CR and structured exercise yield compound reductions in biological age metrics. |
Strategy 3: The Role of Novel Age-Reversal Vaccines
While traditional vaccines train the immune system against external pathogens, emerging biogerontology therapies focus on therapeutic senolytic vaccines and epigenetic reprogramming.
- Senolytic Vaccines (Targeting Senescent Cells):
- Current Reality: As of mid-2026, no senolytic "aging reversal vaccine" has received full FDA approval for general anti-aging or sarcopenia.
- Mechanism in Trials: Experimental senolytic vaccines target surface antigens on Senescence-Associated Secretory Phenotype (SASP) cells—such as glycoprotein nonmetastatic melanoma protein B (GPNMB). By training the immune system's T-cells to remove these "zombie cells," tissue inflammation drops, allowing healthy muscle stem cells (satellite cells) to repair damaged muscle fibers.
- Partial Epigenetic Reprogramming (Yamanaka Factors):
- Vector-delivered transient expression of
OCT4,SOX2, andKLF4(OSK) can reset the epigenetic age clock of damaged tissues without causing dedifferentiation (tumorigenesis). These therapies remain in human clinical trials for localized conditions (such as optic neuropathies and muscle regeneration) and are not yet FDA-approved for systemic age reversal.
- Vector-delivered transient expression of
The Integrated "NOW" Protocol
Combining these modalities yields a non-pharmacological framework to optimize neuromuscular epigenetics:
- Fasted Movement Windows: Perform active, posture-focused yoga asana during an intermittent fasting window to maximize
SIRT1andPGC-1αexpression. - Targeted Resistance: Incorporate isometric holds at challenging joints/angles to suppress
MSTNand stimulate local growth signaling. - Nutrient Timing: Break calorie-restricted windows with essential amino acids to stimulate precise, episodic
mTORactivity, preserving lean muscle mass while gaining the epigenetic maintenance benefits of restriction.
*
https://www.ccgproject.org/species/fremontodendron-decumbens-pine-hill-flannelbush
https://saveplants.org/plant-profile/?CPCNum=1952
https://en.wikipedia.org/wiki/Fremontodendron_californicum
https://en.wikipedia.org/wiki/Fremontodendron
....
here we have #menthaaquatica and a late flowering #meadowsweet #wildflower 
both also very useful 
.jpg/1280px-Gentianella_anglica_Gentianella_amarella_subsp._anglica%2C_Freshwater_IOW_(52974293833).jpg)
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