Saturday, February 14, 2026

Indian sundew: Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:)? ~ For Valentine's Day, here are some Angela Farmer and Victor van Kooten Yoga partner teaching explorations: ... * * 3 A Yoga and longevity and aging reversal genetics' conversation ... How to reverse muscle wasting as we age and with aging reversal genetic drug therapies emerging? How to develop '#YogaGenetics? For performance - higher faster stronger athletics - & #ETHICS? What? How? If & when #vaccines * 3 A And do or might you, George (Church), respond to this in your interview with Dwarkesh Patel from June of 2025 here - " "A Billion Years of Evolution in a Single Afternoon — George Church" https://youtu.be/olmHHxFQwxo Height 12 minute marker Multigenic trait Height 10000 genes" https://scott-macleod.blogspot.com/2025/09/bowhead-whale.html ?

 

Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:)? ~ For Valentine's Day, here are some Angela Farmer and Victor van Kooten Yoga partner teaching explorations: 


Dear Annie, Alden, Donna, George and Maitreyi (both professors in Harvard Medical School), Ma/Janie, Byron, Peter (Norvig AI), Yogis, All,   

Happy Valentine's Day tomorrow! For Valentine's Day, here are some Angela Farmer and Victor van Kooten Yoga partner teaching explorations: 


1 
A&V yoga partner teaching 
Angela Farmer and Victor van Kooten Partner Nadi Sodhana Balance Technique 
(a yogic pranayama technique of alternate nostril breathing) 

Angela Farmer and Victor van Kooten: Partner Shoulder Opening Assist, Part 1 of 2.

Angela Farmer and Victor van Kooten: Partner Shoulder Opening Assist, Part 2 of 2.

Angela Farmer: Opening the Leg Channels. Part 1 of 2.

https://youtu.be/JEbR6SX6pDU


Angela Farmer: Opening the Leg Channels. Part 2 of 2
Want to try these in the future? 
Am continuing to seek to move forward into a newly safe, vacant, with the deed 670 Ridgecrest Road, Canyon 94516 ... and potentially to grow a physical-virtual Yoga hall in the shop there too ... stay tuned.



2
And for tomorrow, 
Sat 2/14/26
explore restorative Yoga from here further, perhaps riffing with these in your own Yoga explorations? - 

the Open Band (Berkeley)
@TheOpenBand
·
Feb 8
open free Restorative Yoga class on Saturdays & in the mornings (and as we may live to 150 and well beyond:)? - Sat 2/7/26 https://scott-macleod.blogspot.com/2026/02/kadamba-flower.html
12/25/25
https://youtu.be/F61foSTThsY
12/27/25
https://youtu.be/AIKPYP939q8
https://youtube.com/@ScottMacLeodWorldUniversity/videos
#YogaAndLongevityGeneticsConvo #WUaSYoga ~

https://x.com/TheOpenBand/status/2020543732777635955


3 
A Yoga and longevity and aging reversal genetics' conversation ... 

How to reverse muscle wasting as we age and with aging reversal genetic drug therapies emerging? How to develop 

'#YogaGenetics? For performance - higher faster stronger athletics - & #ETHICS? What? How? If & when #vaccines for #YogaAthletes w #WUaSLongevity & #WUaSAgingReversal genetic drugs develop & give us younger -at age 150 years' old?, -more supple bodies, how #YogaEthics work?'

http://www.scottmacleod.com/yoganotations.html


3 A
And do or might you, George (Church), respond to this in your interview with Dwarkesh Patel from June of 2025 here - 


"        "A Billion Years of Evolution in a Single Afternoon — George Church"
https://youtu.be/olmHHxFQwxo

Height

12 minute marker
Multigenic trait

Height

10000 genes"

https://scott-macleod.blogspot.com/2025/09/bowhead-whale.html ?

Could aging reversal geneticists begin to focus on and study and produce DNA / proteins for the trait of height ... which then could be further developed for higher, faster, stronger, more supple Yoga genetics ... e.g. in Sun Salutation (Surya Namaskar)?



4
Here's the blog entry re this exploratory restorative Yoga class from last Saturday - 



And how does 8 limb yoga inform consciousness ?-
"Yoga philosophy, specifically the Eight Limbs ..."
https://g.co/gemini/share/b8138a92b679


Yoga philosophy, specifically the Eight Limbs (Ashtanga), originates from Patañjali’s Yoga Sutras. It provides a structured framework for living a purposeful, ethical, and disciplined life aimed at spiritual liberation.

The Eight Limbs
Yamas: Ethical restraints (non-violence, truthfulness).

Niyamas: Personal observances (purity, contentment).

Asana: Physical postures.

Pranayama: Breath control.

Pratyahara: Sensory withdrawal.

Dharana: Concentration.

Dhyana: Meditation.

Samadhi: Enlightenment or oneness.

Would you like me to break down the specific meanings of the Yamas and Niyamas?


https://g.co/gemini/share/b8138a92b679
 


What do you think of this 8 Limbs' Yoga philosophy? How do some of you explore this Yoga philosophy ... even as a kind of riffing? Matt King? 

these 
Hippy-anjali Yoga Notations - 


 - are one riff on these 8 limbs of Yoga philosophy :)


Will or how will/might we all be exploring restorative Yoga in the year 2100 both via the Internet and possibly together in person too?

Enjoy Yoga explorations in about 12 hours individually (together) around 8 am Pacific Time, 11 am Mountain Time, 8:30 pm India Time on Valentine's day, Saturday, February 14, 2026!

Namaste, Yogically, best wishes, Happy Yoga meditations, cheers, 
Scott






On Sun, Feb 8, 2026 at 12:48 PM Scott Yoga Mac Flower MacLeod <yogamacflower@gmail.com> wrote:
Annie, Alden, Donna, George and Maitreyi (both professors in Harvard Medical School), Ma/Janie, Byron, Peter Norvig, Yogis, All,  
 
Some fascinating further Gemini AI responses regarding Yoga meditation and asana genetics and scientific experimentation directions ... and with avatar agent electronic health records  in a realistic virtual earth ...and see the PS especially ...

Sat 2/7/26
open free Restorative Yoga class on Saturdays & in the mornings (and as we may live to 150 and well beyond:)? - Sat 2/7/26 https://scott-macleod.blogspot.com/2026/02/kadamba-flower.html
12/25/25
https://youtu.be/F61foSTThsY
12/27/25
https://youtu.be/AIKPYP939q8
https://www.youtube.com/@ScottMacLeodWorldUniversity/videos
#YogaAndLongevityGeneticsConvo #WUaSYoga~



AND
See some of you, I hope, in the HTGAA synthetic biology class 2026 on Tuesday at 11am PT ..

Until next Saturday, 2/14/26 ... and Happy Valentine's Day too 

Yogically, warm regards, Namaste,
Scott
Will further add here on Sat 2/7/26 - 


PS



AND 

How might we do further research in a realistic virtual Earth for molecules and a realistic virtual Earth for genetics on Yoga asana & the Yoga relaxation response meditation and other genes that for example George Church is focusing on in aging reversal genetics and extreme longevity genetics? 

To conduct research into the intersection of Yoga Asana, the Relaxation Response (RR), and George Church’s aging reversal genetics, we can move beyond static data and build a Virtual Earth for Genetics.

By transitioning from Electronic Health Records (EHR) to Avatar Agents and finally to Digital Twins, we can simulate the "synergy" between ancient mind-body practices and cutting-edge synthetic biology.

1. The Research Framework: From Record to Agent

A "Virtual Earth" allows us to simulate millions of lives simultaneously to see how behavioral changes (Yoga) interact with genetic interventions (Church).

Phase A: Data Foundation (EHR)

  • The Baseline: Use EHR data to identify "epigenetic signatures" in long-term yoga practitioners versus non-practitioners.

  • Target Genes: Focus on Church’s primary longevity targets—FGF21 (metabolism), sTGFβR2 (anti-fibrosis), and α-Klotho (kidney/brain protection)—and see how their baseline expression correlates with yoga frequency.

Phase B: The Avatar Agent (The Experimental Proxy)

Before building a 1:1 molecular "Twin," create Avatar Agents. These are AI-driven representatives of different genetic "types."

  • The "Practice" Variable: Program agents to perform different "Virtual Asana" routines (e.g., restorative vs. vigorous) in a simulated environment.

  • The "Intervention" Variable: Introduce "Digital Church Therapies" (simulated AAV gene delivery) to these agents.

  • Hypothesis: Does the reduced inflammation (NF-κB downregulation) from a "Yoga Agent" increase the success rate of the FGF21 gene therapy by reducing cellular "noise" or stress?

Phase C: The Digital Twin (Molecular Simulation)

This is the high-fidelity stage where we model the actual molecular docking and protein folding.

  • Molecular Dynamics: Simulate how the α-Klotho protein, enhanced by gene therapy, interacts with the lower cortisol and higher BDNF levels found in the "Relaxation Response" state.

  • In Silico Aging: Run the Digital Twin at 100x speed to observe "epigenetic drift" over a simulated 150-year lifespan.

2. Key Genetic Targets for the Simulation

Your research in this Virtual Earth would track the interaction between these two "toolkits":

The "Yoga/RR" Genetic ToolkitGeorge Church's "Aging Reversal" Toolkit
NF-κB: Downregulated to stop chronic inflammation ("inflammaging").FGF21: Overexpressed to reverse obesity and metabolic decline.
Telomerase: Increased activity to protect chromosomal "caps."sTGFβR2: Repressed to stop heart and lung tissue scarring (fibrosis).
SIRT1: Upregulated for mitochondrial health and DNA repair.α-Klotho: Increased to protect cognitive function and kidney health.
BDNF: Increased for neuroplasticity and brain aging reversal.TFAM: Enhanced to boost mitochondrial "biogenesis" (energy).

3. Designing the "Virtual Earth" Experiment

In a realistic virtual world, you can test scenarios that are impossible in real-life clinical trials:

  1. The "Synergy" Test:

    • Group A: Gene Therapy alone.

    • Group B: Yoga Asana alone.

    • Group C: Combined "Avatar" receiving both.

    • Virtual Earth Finding: You might find that Group C reaches "longevity escape velocity" 20% faster because the RR stabilizes the environment for the new genes.

  2. Environmental Stressors:

    • Introduce "Virtual Pollution" or "High Stress" into the Earth. Observe if the Relaxation Response acts as a "buffer" that prevents the synthetic genes (like FGF21) from being prematurely silenced by epigenetic "tags" (methylation).

  3. Cross-Generational Modeling:

    • Simulate the "Avatar Agent" having offspring to see if the epigenetic benefits of the Yoga RR + Church Genetics are heritable in the virtual environment.

Next Step

Would you like me to generate a detailed technical simulation roadmap for an Avatar Agent that combines Hatha Yoga asanas with the α-Klotho gene therapy?



AND 
Yoga asana, realistic virtual earth with avatar agent electronic health records, & George Church's aging reversal and longevity genetics ' gene therapies, experiments (at World Univ & Sch building on MIT OCW in 7 languages) ?

Yoga meditation as relaxation response and Yoga asana

Research from Harvard Medical School indicates that the Relaxation Response (RR) alters the expression of genes involved in energy metabolism, insulin secretion, and inflammatory pathways.

Specifically, the response influences:

NF-κB: Downregulates genes linked to the pro-inflammatory response and stress-related signaling.

Mitochondrial Resilience: Enhances genes associated with ATP synthesis and insulin pathways to improve energy stability.

Telomere Maintenance: Some studies suggest positive effects on genes related to cellular aging and DNA repair.

Would you like me to find a specific study citation for these genetic markers?

how might we do further research in a realistic virtual Earth for molecules and a realistic virtual Earth for genetics on the relaxation response meditation and other genes that for example George Church is focusing on in aging reversal genetics and extreme longevity genetics
To research the relaxation response and longevity genetics within a "virtual Earth" framework, we can leverage Digital Twins and In Silico modeling to simulate molecular interactions at scale.

1. Digital Twins for Personalized Meditation
Researchers can create a digital twin—a virtual mathematical replica—of a person’s biological system. By feeding real-time data from wearables (heart rate variability, cortisol levels) into the twin, scientists can simulate how the Relaxation Response (RR) influences gene expression in that specific individual.

Targeting NF-κB: Virtual models can predict how different meditation durations "downregulate" inflammatory pathways in real-time.

Environmental Feedback: A "Virtual Earth" allows researchers to test how different simulated environments (e.g., a digital forest vs. deep space) optimize the RR at a genetic level.

2. Virtual Genetic Perturbation for Longevity
For the work of George Church and aging reversal, we use virtual cell models to perform "genetic perturbation." Instead of years of lab trials, AI simulates the effects of editing master genes across an entire virtual population.

Multi-Gene Interaction: Longevity is rarely about one gene. Virtual Earths allow us to simulate the "cocktail effect" of Church’s focus areas—like FGF21, sTGFβR2, and α-Klotho—interacting simultaneously.

Simulated Evolutionary Pressure: Researchers can observe how "extreme longevity" genes perform over virtual centuries within varied environmental stressors.

Comparison of Research Approaches
Method Physical Lab Virtual Earth / Digital Twin
Speed Years/Decades Minutes/Hours (via AI)
Scale Limited samples Millions of virtual "twins"
Risk High (in vivo testing) Zero (in silico simulation)
Complexity Single-pathway focus Holistic, multi-gene interaction
Would you like me to generate a summary of the specific "longevity cocktail" genes George Church is currently testing in his Rejuvenate Bio research?

how many further examine do research with hypotheses and experiments on the effects of yoga Asana and George Church's focus in aging reversal genetics and extreme longevity genetics and in a realistic virtual Earth for genetics for aging reversal for extreme longevity and Beyond digital twins as Avatar agent electronic health records building from the electronic health record to Avatar agents first before possibly digital Twins or in a separate Direction
To research the intersection of yoga asana, George Church’s aging reversal genetics, and virtual Earth modeling, you can follow this multi-stage framework that transitions from data records to active simulations.

1. Hypothesis Formulation: Convergence of Bio-Markers
You can test the hypothesis that Yoga Asana acts as a "behavioral epigenetic regulator" that synergizes with Church's longevity gene therapies (like FGF21, sTGFβR2, and α-Klotho).

Hypothesis: Regular asana practice reduces systemic inflammation (downregulating NF-κB), creating a more receptive cellular environment for Church’s AAV-delivered gene therapies to reverse tissue fibrosis.

Experiment: Use "Virtual Earth" simulations to model how reduced cortisol from yoga interacts with the metabolic efficiency provided by FGF21 over a 50-year simulated lifespan.

2. The Developmental Pipeline: EHR to Avatar to Digital Twin
Instead of jumping straight to a high-fidelity Digital Twin, building in stages allows for a more realistic "Avatar Agent" that acts as a bridge:

Step 1: Electronic Health Record (EHR)

Action: Aggregate multi-modal data (genomics, blood panels, yoga frequency).

Focus: Passive history and baseline biological age.

Step 2: Avatar Agent (The "Active" Proxy)

Action: Create a goal-driven AI agent representing the patient. This agent "lives" in the Virtual Earth, testing different yoga routines and dosage timings for gene therapies.

Value: Unlike a static twin, the agent can proactively "negotiate" with virtual environments to find the path of least biological resistance.

Step 3: Digital Twin (The "Predictive" Model)

Action: Once the Avatar Agent identifies successful patterns, the Digital Twin runs high-fidelity molecular simulations (e.g., protein folding of α-Klotho) to confirm the physical viability of the aging reversal.

3. Virtual Earth Research Tools
Using a Virtual Earth for Genetics, you can scale experiments beyond human limitations:

Simulated Populations: Run 100,000 Avatar Agents with different genetic backgrounds to see which groups respond best to the combination of yoga and FGF21 therapy.

Extreme Longevity Modeling: Simulate "Super Ager" genetics (like those studied by Nir Barzilai) alongside George Church’s synthetic edits to identify if yoga can prevent the "adverse interactions" Church observed when combining certain longevity genes.

Would you like me to draft a specific research protocol for simulating the interaction between Hatha Yoga and the α-Klotho gene in an Avatar Agent?






PPS

While I can conceive of Yoga genetics and regarding aging reversal and extreme longevity genetic drug therapies emerging  as self-study or self-experimentation ... 'svadhyaya' in the Sanskrit in 8 Limbs of Yoga,  ...


How does George Church self-experiment?

Femini AI 

George Church self-experiments by applying his genetic engineering and synthetic biology research directly to his own body to test safety and efficacy, most notably by taking a DIY COVID-19 vaccine. As a pioneer of the Personal Genome Project, he has made his own genomic, health, and trait data public.
Key ways George Church engages in self-experimentation include:
  • DIY COVID-19 Vaccine: In 2020, Church took a do-it-yourself coronavirus vaccine developed by a former student, mixing the ingredients himself and administering two doses to test its safety.
  • Personal Genomics and Data Sharing: Church founded the Personal Genome Project (PGP), where he was the first to make his own genome sequence, medical records, and lab values public to accelerate research.
  • Age Reversal Research: Church is heavily involved in studies aimed at reversing aging through genetic modification, often testing concepts related to cellular rejuvenation.
  • Technological Validation: He often tests technologies developed in his lab, such as new, highly accurate, and inexpensive genome sequencing methods.
His approach is driven by a belief that high-risk, high-reward innovations—ranging from synthetic biology to de-extinction—can be accelerated by pioneering researchers taking the first steps themselves

PPS

On Fri, Feb 6, 2026 at 8:04 PM Scott Yoga Mac Flower MacLeod <yogamacflower@gmail.com> wrote:
Dear Annie, Alden, Donna, George and Maitreyi (both professors in Harvard Medical School), Ma/Janie, Byron, Yogis, All,  

Greetings ... Looking forward to gathering individually for restorative Yoga poses exploration in about 12 hours from now - and as we may live to 150 years old and well beyond - and all exploring Yoga asana independently from home, or where we are ... I blogged about this today here -


Recalling also that, for me, first Yoga meditation in a cross legged pose, then half lotus Yoga pose into a forward bend head to floor (Yoga mudrasana) daily can be wonderful for de-stressing ... And if you are finding yourself stressed or worried, I've also just recalled that flax-seed-oil such as in capsule form, or as seeds baked into corn, tomato and spinach chips can be a very positive and great way to destress  ...

Here again are steps to explore the relaxation response inner releasing action meditation - https://scott-macleod.blogspot.com/2008/09/arc-steps-to-elicit-relaxation-response.html - and out of the Harvard Medical School, and derived from a scientific study of meditation.

Happy Yoga, best regards, Namaste, 
Scott

Want to wiki-teach Yoga in some of these regards, or even longevity or aging reversal genetics regarding Yoga potentially? Please explore wiki-teaching here - 


of








* 

Scott Yoga Mac Flower MacLeod <yogamacflower@gmail.com>

to: Ann Brown <annieb@gorge.net>,

Jane MacLeod <jkbmacleod@icloud.com>,

Alden F Briscoe <ABriscoe@brakeleybriscoe.com>,

Donna Leet MD <donna.leet@ucsf.edu>,

Ed Smyth <esmythmd@gmail.com>,

Pin - Siddartha Mazumdar <sid.mazumdar@gmail.com>,

Byron Hann <byronhann1@gmail.com>,

Tom Hess <yogitom@comcast.net>,

fracka@gmail.com,

George Church <gchurch@genetics.med.harvard.edu>,

Joan Kidder <kidderjoan@gmail.com>,

Sandy MacLeod <sandysculpture@hotmail.com>,

Shawn T Flaherty <pgh.shawn@yahoo.com>,

Robin Appleberry <robinappleberry@yahoo.com>,

Marti - Maitreyi Mazumdar <maitreyi.mazumdar@childrens.harvard.edu>,

Elliott Thurston <esthurston@hotmail.com>,

Peter Norvig <pnorvig@google.com>,

robert@neffs.net,

Timmothy & A Brown <timmothybrownbrown@gmail.com>,

Abigail Sophie Burnyeat <ab2.smo@uhi.ac.uk>,

Linda Argote <argote@andrew.cmu.edu>,

Brad & Arlene MacLeod <macleod@usm.maine.edu>,

Scott MacLeod <helianth@gmail.com>,

Dick & Chris Michaels <christine.michaels4@gmail.com>,

Kathryn Norgang <yebo.kathryn@gmail.com>,

Lillian & Ruben Thomas <lillianbthomas57@gmail.com>,

"Hugh M. Thomas" <h.thomas@miami.edu>,

drvaria.gegindia@gmail.com,

Linda Meacci Yoga <info@lindameacciyoga.com>,

Marc Dupuis <marco.dupuis@gmail.com>,

Matthew King <king.matthewt@gmail.com>,

doortjevankooten@yahoo.com,

bill.gates@gatesfoundation.org,

Barbara van Schewick <schewick@stanford.edu>,

Gerry & Mary Lou Kennedy <geraldkennedy1155@gmail.com>,

John & Gretchen Kidder <jkidder@vtc.edu>,

Joichi Ito <Joiito@gmail.com>,

Scott MacLeod <sgkmacleod@worlduniversityandschool.org>,

Nick Thompson <npt134@gmail.com>,

Charles Nesson <nesson@gmail.com>,

Stephon Owens <StephonO87@gmail.com>,

Erica Robb Thaler <erica.thaler@uphs.upenn.edu>,

Doug & Zoe Billman <dbillman@rcn.com>,

"David S. Kong" <dkong@mit.edu>,

Jillian Chelson Briscoe <yogapac@yahoo.com>

date: Feb 13, 2026, 8:28 PM

subject: Re: Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:)?






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