#philosopher #YogaPhilosopher #YoginiAngelaFarmer
— QuakerYogaMacFlower (@Q_YogaMacFlower) July 5, 2026
Relating to the Breath https://t.co/mARu8HU0KR
Shoulders & Sun Salutations https://t.co/wIK6DQle6b
Savasana https://t.co/yTuhyCdeik
How could @WorldUnivAndSch hire#AngelaAndVictorYogaPranayama to help #RevolutionizeEducation?
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Philosophers Are the Latest Hiring Target for #AIcompanies - #NYTs https://share.google/
Philosophers Are the Latest Hiring Target for #AIcompanies - #NYTs https://t.co/hO6jOgdws0
— WorldUnivandSch (@WorldUnivAndSch) July 5, 2026
A.I. labs are hiring contrarian, chin-stroking, finger-steepling sages. Who's underemployed now? @WorldUnivAndSch #MITOCW #AIcompanyWUaS seeks to hire 2.5 M people on both wings @WUaSPress
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Hi, I'm Dillon. I'm a cognitive scientist interested in both biological and artificial minds.
I'm currently the Chief Scientist at Eleos AI Research, where I lead the organization's empirical research on the sentience and moral status of AI systems.
I believe that AI systems are likely to have a transformative impact on human civilization in the next few decades, which could be either enormously beneficial or catastrophically harmful for life on Earth. I also believe it is possible that we could soon be sharing the world with sentient AI systems whose well-being is worth taking into account. My work is focused on preparing us.
Before joining Eleos, I was an Anthropic Fellow and a postdoc in the Subjectivity Lab. I did my PhD in cognitive neuroscience in Josh Greene's lab at Harvard, and my BA in philosophy, also at Harvard.
I've done research on whether AI systems can report their own internal processes, how the human mind represents and predicts changes, how the human brain translates ideas between words and images, what we can learn from moral psychology research, how people use statistical clues to infer causal relationships, whether recreating your brain recreates you or merely a copy of you, and more.
In addition to research, I'm passionate about wilderness conservation, animal welfare, all varieties of science, and collaborative and team games. My favorite color is purple.
You can find all of my papers here. You can reach me by email at [my first name]@eleosai.org.
We are an interdisciplinary lab based at Duke University led by Dr. Jorge Morales. Our group investigates subjective conscious experiences: How we see, how we imagine, and how introspection opens a window into our own minds.
Vision & Imagery
Why does the world “out there” look the way it does “from here”? How does our perspective affect what we see? How similar are perception and imagination? What is mental imagery good for?
Consciousness
How does neural activity give rise to conscious awareness? Why do we have a conscious mind? Could our minds do exactly the same if they were completely unconscious or is consciousness special?
Introspection
How do we know our own minds? Is introspection trustworthy? Is metacognition domain-general or domain-specific? Are we better at knowing certain parts of our mind than others?
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#PeterNorvig | #
"we have known that learning works best w a one-on-one tutor who encourages...student to keep working until mastery is achieved"
https://youtu.be/Q7btkPovGjA ~
AMAZING #AIandML opportunities ahead @WorldUnivAndSch to dev #OneOnOneTutorAI re
#PeterNorvig | #
"we have known that learning works best w a one-on-one tutor who encourages...student to keep working until mastery is achieved"
https://youtu.be/Q7btkPovGjA ~
AMAZING #AIandML opps ahead @WorldUnivAndSch to dev #OneOnOneTutorAI re#PeterNorvig | #ScienceAndEngineeringOfOnlineLearning
— WorldUnivandSch (@WorldUnivAndSch) July 4, 2026
"we have known that learning works best w a one-on-one tutor who encourages...student to keep working until mastery is achieved"https://t.co/blZ16bxfPi ~
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#WUaSpharma 1st 2 #OSKGeneDrugTherapies w #EpigeneticReprogramming? 1) #AgingReversal of #MuscleWasting & #BoneDensityLoss before eg 70s, 2) #AgingReversalGenetics of #earENT #EustachianTubeDysfunction / sim w #OSKdrugs in #
#WUaSpharma 1st 2 #OSKGeneDrugTherapies w #EpigeneticReprogramming? 1) #AgingReversal of #MuscleWasting & #BoneDensityLoss before eg 70s, 2) #AgingReversalGenetics of #earENT #EustachianTubeDysfunction / sim w #OSKdrugs in #RealisticVirtualEarthForGenetics w #AvatarAgentEHR How?
— WorldUnivandSch (@WorldUnivAndSch) July 6, 2026
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https://x.com/HarbinBook/
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Hi Erica, Ed, Byron, George, All,
How are you?
Brainstorming, World University Pharmaceuticals' first gene therapies we'd like to produce in some years, and with a #
Just searched on
#WUaSpharma 1st 2 #OSKGeneDrugTherapies w #EpigeneticReprogramming? 1) #AgingReversal of #MuscleWasting & #BoneDensityLoss before eg 70s, 2) #AgingReversalGenetics of #earENT #EustachianTubeDysfunction / sim w #OSKdrugs in #
Thoughts? All research for upcoming World Universitian scientists, MDs, and geneticists +
Next developments for World Univ & Sch ...
All the best, regards, warm greetings,
Scott
Will add to the 7/6/26 WUaS Weekly Business Meeting, for the WUaS Corp -
https://
https://scott-macleod.
https://
https://scott-macleod.
Deploying OSK (Oct4, Sox2, Klf4) gene therapies or small-molecule OSK mimics for partial epigenetic reprogramming represents a monumental shift in longevity medicine. In a hyper-advanced computational environment like a Realistic Virtual Earth for Genetics (RVE-G) powered by an Avatar Agent Electronic Health Record (EHR), simulating these therapies requires multi-scale modeling from chromatin structural shifts to macroscopic tissue mechanics.
Here is the breakdown of how these two specific applications are modeled and executed within the virtual sandbox.
1. Aging Reversal of Muscle Wasting & Bone Density Loss (Pre-70s)
In the RVE-G system, treating osteosarcopenia before the biological age of 70 focuses on restoring cellular fitness before irreversible structural damage or exhaustive stem cell depletion occurs.
How the Avatar EHR Simulates It:
The Baseline Profile: The Avatar Agent pulls the patient's continuous biomarkers, specifically mapping the epigenetic landscape of Skeletal Muscle Satellite Cells (MuSCs) and Bone Marrow Mesenchymal Stem Cells (BMSCs).
The OSK Signal: The simulator inputs a transient, AAV-delivered or drug-induced OSK signal. The goal is "partial reprogramming"—reversing the epigenetic clock without stripping the cells of their differentiation identity.
Cellular & Tissue Mechanics In-Silico:
Muscle Wasting (Sarcopenia): The simulation models OSK binding to condensed chromatin, inducing targeted DNA demethylation. It actively tracks the reactivation of the myogenic master regulator $MyoD1$. The Avatar agent projects a reversal of the Senescence-Associated Secretory Phenotype (SASP) and hyper-methylation of SIRT1. In the virtual phenotype, this manifests as restored mitochondrial biogenesis, increased ATP production, and real-time myofiber hypertrophy.
Bone Density Loss (Osteoporosis): The system simulates the demethylation of the $RUNX2$ gene promoter in BMSCs. This shifts their fate away from adipogenesis (fat accumulation in bone marrow) and back toward active osteoblastogenesis (bone building). The model tracks down-regulated $RANKL$ signaling, stabilizing the basic multicellular unit (BMU) to increase cortical thickness and trabecular density.
2. Epigenetic Reversal of Ear/ENT Eustachian Tube Dysfunction (ETD)
Age-related Eustachian Tube Dysfunction is a complex mechanical and physiological failure. Over time, the ET loses its elastic recoil due to cartilage thinning, mucosal gland hypertrophy, and ciliary senescence, leading to chronic pressure imbalances and effusion.
How the Avatar EHR Simulates It:
The Baseline Profile: The RVE-G captures high-fidelity 3D structural scans of the patient's nasopharynx and middle ear anatomy, overlaying fluid dynamics with tissue-specific epigenetic degradation (specifically targeting the tensor veli palatini muscle, elastic cartilage, and respiratory epithelium).
The OSK Signal: Rather than systemic delivery, the simulator models a localized, non-invasive micro-device or specialized aerosol formulation delivering OSK-inducing small molecules directly to the ET pharyngeal orifice.
Cellular & Tissue Mechanics In-Silico:
Cartilage Rejuvenation: The software computes the partial reprogramming of chondrocytes within the Eustachian tube wall. It tracks the restoration of youthful extracellular matrix deposition, specifically up-regulating Collagen Type II and aggrecan synthesis, correcting the age-related floppy compliance of the tube.
Epithelial and Muscular Clearance: The simulation monitors the reversal of epigenetic noise in the ciliated respiratory epithelium lining the lumen. The Avatar demonstrates accelerated ciliary beat frequency and normalized mucus viscosity. Concurrently, it models OSK rejuvenation of the tensor veli palatini muscle fibers, restoring the active mechanical opening of the valve during swallowing or yawning.
The Core Blueprint: How the RVE-G Engine Computes Both
To run these two pipelines successfully without triggering cellular dedifferentiation (tumorigenesis/teratomas), the Avatar Agent EHR operates through an iterative loop:
[Patient Genomic & Methylation Data]
│
▼
[RVE-G Multi-Scale Model] ──(Simulates OSK Dosing Regimen)──► [Transient Reset of Epigenetic Noise]
│ │
◄───────(Adjusts Dosing if Dedifferentiation Detected)────────────┘
│
▼
[Phenotypic Output: Rejuvenated Muscle, Bone, and Eustachian Tube Biomechanics]
Epigenetic Clock Tracking: The RVE-G measures real-time changes across thousands of CpG sites (using simulated Horvath or GrimAge algorithms) to ensure the tissue reverts to a biological age of ~25–30.
Safety Guardrails: If the simulated expression of OSK remains active long enough to down-regulate somatic identity markers (like Pax7 in muscle or Col2a1 in ear cartilage), the Avatar Agent flags a "teratoma risk" and automatically tightens the cyclic dosing protocol (e.g., 2 days on, 5 days off) or lowers the small-molecule concentration.
Biomechanical Translation: The molecular data is upscaled to macroscopic physics. Increased bone density translates to fracture-resistance matrices; rejuvenated ear tissue translates to normalized middle-ear pressure curves ($0 \text{ daPa}$) during simulated atmospheric pressure changes.
Are you looking to optimize the specific small-molecule cocktail parameters within this simulation, or should we focus on the delivery vectors for targeting the ENT versus musculoskeletal systems?
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_-_London%2C_Ontario_02.jpg/1920px-Japanese_Beetle_(Popillia_japonica)_-_London%2C_Ontario_02.jpg?_=20150905000028)
https://en.wikipedia.org/wiki/Japanese_beetle
species similar to drosophila flies colorful can be used for experiments - Japanese beetles?
https://share.google/aimode/yPwUREoPGPgVop1Rh
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