1st #UnitarianUniversalist Church of Pittsburgh choir in 2012 on 12/24
Here's the 1st #UnitarianUniversalist Church of Pittsburgh choir in 2012 on 12/24 (I think my mother #JanieMacLeod is in the soprano section front left; I sang in this choir in 2006+2007 & my father's #GordonKMacLeodMD memorial service was here after he passed away on 11/25/07) pic.twitter.com/02b0iAA10y
— WorldUnivandSch (@WorldUnivAndSch) December 24, 2023
Here's the 1st #UnitarianUniversalist Church of Pittsburgh choir in 2012 on 12/24 (I think my mother #JanieMacLeod is in the soprano section front left; I sang in this choir in 2006+2007 & my father's #GprdonKMacLeodMD memorial service was here after he passed away on 11/25/07) pic.twitter.com/jGkbSC8dEC
— Scott_GK_MacLeod_WUaS_worlduniversityandschool.org (@scottmacleod) December 24, 2023
#Xmas 2 years ago 12/23/21 near #UPittMed school where my father taught #GrandRounds for many years & #PublicHealth -Remembering #GordonKMacLeodMD (plaque at #UPittGradSchPublicHealth) with my mother #JanieMacLeod & brother #SandyMacLeod #PghPA > #RealisticVirtualEarthForHistory? pic.twitter.com/Y8ZdPBqL4l
— Scott_GK_MacLeod_WUaS_worlduniversityandschool.org (@scottmacleod) December 23, 2023
* * *
#SkinFibroblastCells In what ways can a #RealisticVirtualEarthForGenetics think #GStreetView w #TimeSlider #GCellView #GMoleculeView help identify #WUaSPromisingTargets for #AgingReversal even w #FilmTo3DApps re #SRSF1 https://t.co/dOP0udzGmG in #WUaSLongevityGeneticsInstitute? https://t.co/0Xv2GRtqze
— WorldUnivandSch (@WorldUnivAndSch) December 24, 2023
https://twitter.com/
https://twitter.com/
But does this work in living organisms? - It does, at least in the skin!
We showed that SRSF1 gene therapy rejuvenates old skin and reverses its wound healing ability to youthful levels in
@justsaysinmice
. Oh, and it’s also linked to longevity in worms 6/8
But does this work in living organisms? - It does, at least in the skin!
— Alex Plesa (@amplesa) December 21, 2023
We showed that SRSF1 gene therapy rejuvenates old skin and reverses its wound healing ability to youthful levels in 🐁 @justsaysinmice. Oh, and it’s also linked to longevity in worms 🪱 6/8 pic.twitter.com/16zY4EiYea
https://twitter.com/amplesa/
In what ways can a #RealisticVirtualEarthForGenetics think #GStreetView w #TimeSlider #GCellView #GMoleculeView help identify #WUaSPromisingTargets for #AgingReversal even w #FilmTo3DApps w #SkinFibroblastCells re #SRSF1 https://t.co/dOP0udzGmG in #WUaSLongevityGeneticsInstitute?
— WorldUnivandSch (@WorldUnivAndSch) December 24, 2023
https://twitter.com/
Can we reverse aging?
— Alex Plesa (@amplesa) December 21, 2023
7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, https://t.co/7ZXhqHYDAD we used 🧬 screens to find new rejuvenation factors🧵1/8 pic.twitter.com/4npP6FVDnc
Can we reverse aging? In what ways can a #RealisticVirtualEarthForGenetics think #GStreetView w #TimeSlider #GCellView #GMoleculeView identify #WUaSPromisingTargets for #AgingReversal such as #SRSF1 https://t.co/dOP0udzGmG in #Canyon94516 #WUaSLongevityGeneticsInstitute #wuAsVR? https://t.co/QoVHXYFqnK
— WorldUnivandSch (@WorldUnivAndSch) December 24, 2023
https://twitter.com/
https://twitter.com/
Retweeting -
Alex Plesa
@amplesa
In search for new rejuvenation factors, we tested our top 90 genes by overexpressing them in human aged skin fibroblasts. Using the resulting gene expression profiles, we mapped out a landscape of fibroblast aging and rejuvenation, and identified SRSF1 as a promising target. 4/8
In search for new rejuvenation factors, we tested our top 90 genes by overexpressing them in human aged skin fibroblasts. Using the resulting gene expression profiles, we mapped out a landscape of fibroblast aging and rejuvenation, and identified SRSF1 as a promising target. 4/8 pic.twitter.com/TWYniYTNBO
— Alex Plesa (@amplesa) December 21, 2023
https://twitter.com/amplesa/
Can we reverse aging?
— Alex Plesa (@amplesa) December 21, 2023
7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, https://t.co/7ZXhqHYDAD we used 🧬 screens to find new rejuvenation factors🧵1/8 pic.twitter.com/4npP6FVDnc
With 1000s of genes changing throughout aging, how do we know which ones to target? - Networks!
— Alex Plesa (@amplesa) December 21, 2023
To increase our odds of finding the right targets and comprehensively rejuvenating cells, we decided to focus on the central nodes in the aged gene regulatory networks. 2/8 pic.twitter.com/8YzYO7EdiN
Next, to measure aging, we looked at gene expression changes in skin fibroblasts from donors aged 1-96yrs old. Assuming cells from young donors are healthier, we built transcriptomic functional indicators for 8 cellular processes and used them to measure overall cellular age. 3/8 pic.twitter.com/Z1oEuFaG7a
— Alex Plesa (@amplesa) December 21, 2023
In search for new rejuvenation factors, we tested our top 90 genes by overexpressing them in human aged skin fibroblasts. Using the resulting gene expression profiles, we mapped out a landscape of fibroblast aging and rejuvenation, and identified SRSF1 as a promising target. 4/8 pic.twitter.com/TWYniYTNBO
— Alex Plesa (@amplesa) December 21, 2023
Ok, so from a gene expression standpoint, SRSF1 induction makes these cells younger. Does that mean they also function better? - Yes, in certain aspects.
— Alex Plesa (@amplesa) December 21, 2023
We observed a reduction in cellular senescence, proteasome load, and an increase in collagen production. 5/8 pic.twitter.com/QAPNNT6Hzw
But does this work in living organisms? - It does, at least in the skin!
— Alex Plesa (@amplesa) December 21, 2023
We showed that SRSF1 gene therapy rejuvenates old skin and reverses its wound healing ability to youthful levels in 🐁 @justsaysinmice. Oh, and it’s also linked to longevity in worms 🪱 6/8 pic.twitter.com/16zY4EiYea
Cool. What next? Testing SRSF1 in age-related disease models and for healthspan extension in old 🐁.
— Alex Plesa (@amplesa) December 21, 2023
Also, larger screens in other cell types🩸. We think this is a viable approach for discovering new rejuvenation factors to serve as basis for future age reversal therapies🧬! 7/8
Thanks to @geochurch and all our amazing co-authors:
— Alex Plesa (@amplesa) December 21, 2023
Sascha Jung@wanghelenh
Fawad Omar@MichaelShadpour @Davetherobot
Maria Perez Matos
Naftali Horwitz
George Cai@NgianZhenKai @_Carol_Mag
Amy Wagers@William_Mair
Antonio del Sol
8/8
@LaurieGreen36
What does reverse aging mean exactly? Curious to know your take on it as it seems as if a lot of people have a different take on it
https://x.com/LaurieGreen36/
What does reverse aging mean exactly? Curious to know your take on it as it seems as if a lot of people have a different take on it
— Laurie Green (@LaurieGreen36) December 23, 2023
Alex Plesa
@amplesa
Ultimately, I think about it as converting a biological system (cell/tissue/organ/organism) to a more functional state, representative of a younger age.
https://x.com/amplesa/status/
Ultimately, I think about it as converting a biological system (cell/tissue/organ/organism) to a more functional state, representative of a younger age.
— Alex Plesa (@amplesa) December 23, 2023
https://twitter.com/amplesa/
* * *
Dear Dr Sowers, (Wesley Sowers MD, and all),Greetings and I hope this finds you well. Might we possibly please meet to talk early in the next week, or in the first week of January? I'm glad to have learned that I got active UPMC health care coverage on Wednesday or Thursday this week. I called and left a message on your office phone number message machine with Tom Honor (sp?) sharing the outgoing message.Some of my thoughts about talking potentially with you: Desiderata? https://www.desiderata.com/desiderata.html re "Speak your truth quietly and clearly; and listen to others ..." And I think I will learn much from you and as a knowledgeable and experienced MD psychiatrist. and regarding some of the issues in my emails, which you may have read. Talking (re Lacan's speech act) over even writing is part of my theoretical thinking in seeking to speak with you, and over something like 10 meetings if possible. The last psychiatrist MD I spoke with isJohn Sargent MD (and I spoke with John last about 10-15 years ago for ~1.5 years, while I was living in Canyon 94516, and he as a psychiatrist MD at Tufts Med Ctr was referred to me by Pgh PA family friend George Alexander MD a little more than 30 years ago, and having talked with John in his office SW of Philadelphia near Pendle Hill Quaker Center for Study and Contemplation in his office there initially)andEd Smyth MD (a friend and retired KP physician - and at whose wedding I played my bagpipes in around 2000)Both are the MDs most familiar with my issues I think.And Dr. Demoise is my UPMC primary care physician, (and Dr. Javier DeLeon is my PCP equivalent in the SF Bay Area at KP NorCal).Thank you, best regards, and happy new year,ScottChamomile (RU - National flower of Russia): Happy New Year 2023 Seasons Greetings Holiday Salutations Merry Christmas letter ~
https://scott-macleod.blogspot.com/2023/12/ chamomile-ru-national-flower- of-russia.html PSI started to update my CV and in applying for a Stanford Law Fellow position, with application due January 19, 2023, but which Stanford Law CodeX will start reading immediately - https://careersearch.stanford.edu/jobs/codex- residential-fellowship-2024- 25-23878 - and in growing MIT OCW-centric wiki World Univ & Sch's ~200 planned online law schools, in 200 countries and in their main languages, and as large language models, and 50 online Law Schools in US states and related regional ones in other countries too. PPSMy (great) mother is my main interlocutor these days ... and here's an example of our communications today -Hi Ma! Just called Penn Hills Lock and Door in Verona thanks to the Ace Hardware bag you gave me last time at Longwood which led to my going into the Oakmont Ace Hardware and asking about changing locks and they recommended this locksmith - they're open from Tu 12/26-F next week ... May have had another illegal entry yesterday into my place, with strange unfamiliar odor, and mud on my top most duvet cover sadly ... and after the possibly 3rd arson event symbolically with a pack of matches in an A frame on the street right in front of the house ... My changing locks if it works out would change the spare keys floating around ... and potentially prevent theft and sadly the threat of covert violence as well ... Glad to have gotten a Pinterest social media message this morning - from Pin or his networks? - one of a picture of the great RockAndRoll guitar player Duane Allman who died in around 1971 ... and saved this to my hippies 1960s Pinterest collection ... and after emailing Sen Elizabeth Warren, and Pin/Sid and Tym and Lobos Management about opening some US federal investigations into both LM Bryant Street Rentals and susan davis claus and family networks ... Changing the locks if possible with PHLAD locksmith would be great ... Seeking to talk too with smart Wes Sowers MD in the New Year if possible ... and think he would be very knowledgeable about many of my issues by then ... from my emails ... Could he be in communication with Peter Norvig of Google AI, also a Brown alum? I'd view this as a big positive for many reasons but particularly because I think Google and Alphabet themselves have navigated questions of criminality for some 25 years successfully and regarding the law and in many countries ... and regarding too growing MIT OCW-centric wiki World Univ & Sch. Love, abolitionally, see you soon, Merry Xmas, Scott (https://scott-macleod.blogspot.com/search/label/Law) PPSaHoliday Planning
Inbox
Jane MacLeod
11:44 AM (51 minutes ago)
Hi Scott,
So nice that you found a little live tree. How about that! What about this for an idea? When I come in tomorrow — Sunday the 24th - for a walk and tea at your place, we can enjoy the little bare tree together? Then, on Christmas day - Monday - when you come out here in the afternoon - you could bring it with you and you and Chris and I can decorate it. Then, you can take it home with you with its ornaments to enjoy in your apt. for as long as you like.
Also, on a completely different subject: I’ve made reservations for us at The Lot in Oakmont for a birthday celebration on Dec. 31st. The reservation is for 5:45. Hope that’s to your liking. (They have lots of vegetarian options)
Love, MaPPSbHi Ma,Thanks - good thinking! (I may add some of the pine cones you brought last time ... now a little less sappy ... and as an Xmas symbol of fertility too :)Would you like to come over around 2pm or ...?The little live tree is so small - but symbolically enormous - that there won't be many decorations or candles to put on it as we celebrate this tree donning event at your place ... this will be fun ...The Lot sounds good as well on Sunday 12/31/23 at 5:45 pm -On Thu, Dec 21, 2023 at 10:23 AM Scott MacLeod <sgkmacleod@worlduniversityandschool.org> wrote: Dear Dr. Sowers,Greetings and good morning. I hope this email finds you well. How are you?I just called My UPMC at 1 800 286 4242, spoke with Yavonne, and found I have active UPMC health care coverage and since Nov 21 2023. I"d like to explore scheduling a first meeting with youIn logging into https://myupmc.upmc.com/, and finding your information,I read that I should call your office to"Note: Please call the physician's office to verify insurance coverage." but it doesn't give a phone number.So I'll call this number soonto explore scheduling an appointment with you.How best to navigate privacy questions and issues in the information age (a question I learned much about from George Alexander MD, also formerly a clinician at Western Psych, as I think you may be)?Are you by any chance in communication with the great Peter Norvig (a head of Google AI, and his Lego Institute 2 ... and also a Brown Alum ... in one way or another)In my contacts, I recorded -Called Wes Sowers MD F April 21 2023 to explore scheduling first appointment
Calling Wes Th Dec 21 2023 to explore scheduling first appointmentThanks so much, best wishes, talk with you soon I hope,Scott--Society, Information Technology, and the Global University (2024, forthcoming)Scottish Small Piping album #2 - Honey Piobaireachd (2022)- https://twitter.com/TheOpenBand (Berkeley) Scottish Small Piping album #1 Honey in the Bag ~ Out of the Air tune (2020)Order Book #4 To the Dance or the Pools? ~ Virtually! How different it is to soak at Harbin Hot Springs, than to realize it in virtual reality (2019)Order Book #3 Winding Road Rainbow: Harbin, Wandering & the Poetry of Loving Bliss (2018)Order Book #2 Haiku-ish and Other Loving Hippie Harbin Poetry (2017)Order Actual-Virtual Ethnographic Book #1: Naked Harbin Ethnography (2016)- Scott GK MacLeodFounder, President, CEO & ProfessorCC-4 licensed MIT OCW-centric, Wiki,World University & School (WUaS)- PO Box 442, Canyon, CA 94516- 5816 Callowhill St., Pittsburgh, PA 152061) non-profit 501(c)(3) Public CharityMIT OCW-centric,World University and School - http://worlduniversityandschool.org 2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/ AcademicPress.html (o) 415 480 4577 - sgkmacleod@worlduniversiryandschool.org (m) 412 478 0116 - sgkmacleod@gmail.comWorld Univ & Sch Innovation Research - scottmacleod.com- https://twitter.com/sgkmacleod (all 7,168 known living languages at WUaS)
* * *
| Sat, Dec 23, 11:44 AM (1 day ago) | |||
So nice that you found a little live tree. How about that! What about this for an idea? When I come in tomorrow — Sunday the 24th - for a walk and tea at your place, we can enjoy the little bare tree together? Then, on Christmas day - Monday - when you come out here in the afternoon - you could bring it with you and you and Chris and I can decorate it. Then, you can take it home with you with its ornaments to enjoy in your apt. for as long as you like.
Also, on a completely different subject: I’ve made reservations for us at The Lot in Oakmont for a birthday celebration on Dec. 31st. The reservation is for 5:45. Hope that’s to you liking. (They have lots of vegetarian options)
Love, Ma
*
Hi Ma,
Love, See you soon!, Scott
*
| 8:38 AM (12 hours ago) | |||
*
| 9:12 AM (11 hours ago) | |||
*
Once climbing up a wee steep hill, the loop trail is somewhat level ...
https://twitter.com/
https://twitter.com/
https://twitter.com/
Retweeting -
Alex Plesa
@amplesa
In search for new rejuvenation factors, we tested our top 90 genes by overexpressing them in human aged skin fibroblasts. Using the resulting gene expression profiles, we mapped out a landscape of fibroblast aging and rejuvenation, and identified SRSF1 as a promising target. 4/8
https://twitter.com/amplesa/
With 1000s of genes changing throughout aging, how do we know which ones to target? - Networks!
— Alex Plesa (@amplesa) December 21, 2023
To increase our odds of finding the right targets and comprehensively rejuvenating cells, we decided to focus on the central nodes in the aged gene regulatory networks. 2/8 pic.twitter.com/8YzYO7EdiN
Next, to measure aging, we looked at gene expression changes in skin fibroblasts from donors aged 1-96yrs old. Assuming cells from young donors are healthier, we built transcriptomic functional indicators for 8 cellular processes and used them to measure overall cellular age. 3/8 pic.twitter.com/Z1oEuFaG7a
— Alex Plesa (@amplesa) December 21, 2023
In search for new rejuvenation factors, we tested our top 90 genes by overexpressing them in human aged skin fibroblasts. Using the resulting gene expression profiles, we mapped out a landscape of fibroblast aging and rejuvenation, and identified SRSF1 as a promising target. 4/8 pic.twitter.com/TWYniYTNBO
— Alex Plesa (@amplesa) December 21, 2023
Ok, so from a gene expression standpoint, SRSF1 induction makes these cells younger. Does that mean they also function better? - Yes, in certain aspects.
— Alex Plesa (@amplesa) December 21, 2023
We observed a reduction in cellular senescence, proteasome load, and an increase in collagen production. 5/8 pic.twitter.com/QAPNNT6Hzw
But does this work in living organisms? - It does, at least in the skin!
— Alex Plesa (@amplesa) December 21, 2023
We showed that SRSF1 gene therapy rejuvenates old skin and reverses its wound healing ability to youthful levels in 🐁 @justsaysinmice. Oh, and it’s also linked to longevity in worms 🪱 6/8 pic.twitter.com/16zY4EiYea
Cool. What next? Testing SRSF1 in age-related disease models and for healthspan extension in old 🐁.
— Alex Plesa (@amplesa) December 21, 2023
Also, larger screens in other cell types🩸. We think this is a viable approach for discovering new rejuvenation factors to serve as basis for future age reversal therapies🧬! 7/8
Thanks to @geochurch and all our amazing co-authors:
— Alex Plesa (@amplesa) December 21, 2023
Sascha Jung@wanghelenh
Fawad Omar@MichaelShadpour @Davetherobot
Maria Perez Matos
Naftali Horwitz
George Cai@NgianZhenKai @_Carol_Mag
Amy Wagers@William_Mair
Antonio del Sol
8/8
*
Ma,
*
https://en.wikipedia.org/wiki/Lilium_candidum
https://commons.wikimedia.org/wiki/Category:Lilium_candidum
https://en.wikipedia.org/wiki/Lilium
https://symbolhunt.com/national-flowers/
...
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