Found this new
https://youtu.be/2b5xDVCNkTU
on #HarvardWebsite -
https://wyss.harvard.edu/
Into @WorldUnivAndSch's #
Igloo Vision:
https://youtu.be/q9FBhEAXRY4 ?
George Church vid pic
In a #WUaSHospitalMultimediaRoom? Found new @GeoChurch #LongevityWUaS videohttps://t.co/VRZvw5YUpg
— WUaSPress (@WUaSPress) November 15, 2025
on #HarvardWebsite -https://t.co/TCHy7fpw93
Into @WorldUnivAndSch's #RealisticVirtualEarthForGenetics & even an #AgingReversalMachine w
Igloo Vision:https://t.co/dfmAjVChwi ?
Street View in Smart Meeting Room pic
https://x.com/WorldUnivAndSch/
https://x.com/scottmacleod/
https://x.com/Q_YogaMacFlower/
Igloo Vision:
What's next for AI at DeepMind, Google's artificial intelligence lab | 60 Minutes
The proposed Realistic Virtual Earth (RVE) system—incorporating a time-slider-enabled Google Earth visualization, TensorFlow AI, and Pegman Avatar Agent Electronic Health Records (EHR) for the global population—would serve as the ultimate simulation, personalization, and operational scaling platform for the genetic and age reversal discoveries coming out of George Church’s lab in 2025.
It shifts Church's research from lab results and clinical trials into a globally predictive, personalized medicine system.
1. Operationalizing Genomic Data (Matter Bio)
George Church's involvement with Matter Bio (April 2025) is focused on identifying pro-longevity genes and molecular pathways by analyzing data from 10,000+ human centenarians. The RVE system provides the necessary infrastructure to take this massive genomic and metabolomic data and make it actionable for every person on Earth.
| RVE Component | Connection to Church's 2025 Work | Benefit |
| Pegman # | The Avatar Agent is the digital twin for the centenarian data. If Matter Bio identifies a key gene variant, the RVE instantaneously assigns that variant's potential impact to every Pegman on the map based on their personal EHR, genetics, and environment. | Global Predictive Modeling: Allows researchers to see the theoretical impact of a pro-longevity gene variant across all 7.9 billion people, accounting for demographic, lifestyle, and geographical factors immediately. |
| Google Street View with Time Slider | This feature allows for the longitudinal tracking of health and aging, which is critical for longevity research. It would visualize the rate of aging (e.g., epigenetic clocks) for the Pegman avatar over time, rather than just a static health snapshot. | Causal Inference: Helps identify environmental or lifestyle factors (visible on the Street View/Map layer) that either exacerbate or mitigate the effects of the longevity genes identified by Matter Bio. |
2. Simulating and Optimizing Gene Therapy (Rejuvenate Bio)
Church’s company, Rejuvenate Bio, is focused on creating combination gene therapies (e.g., AAV vectors delivering FGF21 and Klotho) to treat multiple age-related diseases simultaneously. The RVE’s #AgingReversalMachine component, powered by TensorFlow AI (akin to DeepMind’s work), would function as a massive, high-speed simulation engine to optimize these therapies.
Virtual Clinical Trials: The Aging Reversal Machine (ARM) would run in silico (computer) clinical trials on the 7.9 billion Pegman avatars. This bypasses the long, costly, and resource-intensive human trials.
Optimization: It could predict the precise combination and dose of Church’s gene therapies needed for an individual avatar based on their unique, complex EHR data. For instance, the AI could run billions of simulations to find the optimal combination of FGF21 and Klotho expression needed to treat a specific avatar's heart failure without causing adverse effects seen in earlier trials.
Safety Pre-check: The system could flag potential off-target effects or adverse interactions (like the issues that led to the retraction of the BioViva-related paper in August 2025) before the therapy is ever introduced in a live patient, drastically improving safety.
Epigenetic Reversal Modeling: Since Church supports the idea that much aging can be reversed by epigenetic reprogramming, the ARM would simulate the insertion of genes or factors to "reset the clock" in the virtual cells of the avatar, allowing researchers to visualize the degree of age reversal achieved in different organs and tissues on the map interface.
3. The Visualization and Collaboration Layer
The proposed #WUaSHospitalMultimediaRoom (using technology like Igloo Vision) represents the command center where researchers, clinicians, and students would view the RVE. This immersive visualization environment is crucial for translating the complex genetic data and AI simulations into human-interpretable insights.
It allows a global team of experts to:
Spot Trends: Identify macro-patterns of aging, disease, and therapy response that are only visible when viewing 7.9 billion avatars simultaneously on a global map.
Collaborative Diagnosis: Clinicians can "walk" a Pegman patient's avatar through their life history on the time-slider, view their specific genetic risks, and consult the ARM’s predicted optimal gene therapy in a shared, immersive space.
Educational Tool: For the "MIT OCW-centric wiki World University and School," the RVE becomes a real-time, living textbook on human genetics and aging, accelerating education and new breakthroughs
Gemini: George Church age reversal 2025
? Besides "As of October 2025, George Church has not announced full age reversal in humans, but he is actively involved in developing gene therapies and other technologies to combat age-related diseases and promote cellular rejuvenation" ?
As of October 2025, George Church's work on age reversal is primarily focused on gene therapy and large-scale data analysis to combat age-related decline, with several notable developments:
Research and Business Updates
Longevity Gene Therapy Platform: His work through the company Rejuvenate Bio continues to focus on developing combination gene therapies, often using adeno-associated virus (AAV) vectors, to deliver multiple longevity-associated genes (like FGF21, Klotho, and sTGF R2) in a single treatment. The goal is to address multiple age-related diseases simultaneously, a concept supported by earlier mouse studies. The strategy for human trials is anticipated to involve first developing a veterinary product for dogs.
Decoding Exceptional Longevity (Matter Bio): Dr. Church is a co-founder of Matter Bio, which in April 2025 announced a collaboration to decode exceptional longevity. This initiative involves analyzing multi-omics data (genomics, transcriptomics, proteomics, and metabolomics) from over 10,000 human centenarians and other long-lived species. The aim is to use AI to identify key pro-longevity genes and molecular pathways that can be targeted for future gene therapies to enhance cellular longevity.
Retraction of an Anti-Aging Paper: A 2022 anti-aging gene therapy paper co-authored by Dr. Church, which claimed to support a purported nasal spray treatment, was formally retracted in August 2025 due to "data discrepancies." Church, who served as an advisor for the company involved (BioViva), reportedly agreed to the retraction.
Philosophical and Media Statements
Hybrid Model of Aging: Church continues to advocate for a "hybrid model" of aging, suggesting that while some damage is irreparable, a "surprising amount" of aging can be reversed through epigenetic reprogramming by introducing certain genes or factors into the bloodstream via multiplex gene therapy.
Long-Term Projection: In recent discussions, he has maintained a long-term optimistic view, suggesting that with exponential advances in biotechnology and therapies moving into clinical trials, a point of "escape velocity" for aging—where life expectancy increases faster than one year for every year lived—is possible. However, he has offered a cautious estimate for the broader impact of full rejuvenation, saying he "wouldn't be surprised if 2050 would be a point."
Public Appearances: Dr. Church continues to be a prominent voice in the field, with a scheduled public discussion on age reversal and genetic engineering as recently as September 2025.
In summary, George Church's age reversal work in 2025 focuses on practical, multi-gene therapies targeting multiple diseases of aging, supported by a major project to analyze the genetics of centenarians, even while the field faces the scrutiny of a research retraction.
- Cellular Rejuvenation:Church's lab works on identifying genes that can reverse the "transcriptome clock" of a cell, returning it to a more youthful state, according to the Wyss Institute.
- Gene Therapy for Age-Related Diseases:A key focus is using gene therapy to boost specific proteins that decline with age. This aims to help organisms recover from age-related diseases rather than just extending lifespan, notes InsideTracker.
- Focus on Protein Delivery:Instead of delivering genetic material to every cell, Church's strategy involves delivering a small amount of genes to a few cells, which then produce and distribute the rejuvenating proteins throughout the body, explains the InsideTracker Blog.
- Ichor Project:This research initiative aims to reverse aging in hematopoietic stem cells (HSCs) to improve the outcomes of HSC transplants and increase the availability of viable cells for patients.
- Rejuvenate Bio:Church co-founded this company with the goal of developing full age-reversal gene therapies by targeting key genes involved in aging, reports Longevity.Technology.
- Early-Stage Reversal:While full age reversal in humans hasn't been achieved, experiments in animals have shown reversal of age-related biomarkers, and some therapies are in the initial stages of clinical trials, says the InsideTracker Blog
*
.jpg/1599px-Black-billed_magpie_on_cow_(40005944621).jpg)
.jpg/1599px-Pica_hudsonia_(35595622660).jpg)
_Smith_Rock_State_Park_3.jpg/1599px-Black-billed_magpie_(Pica_hudsonia)_Smith_Rock_State_Park_3.jpg?20220629034219)
https://en.wikipedia.org/wiki/Black-billed_magpie
https://commons.wikimedia.org/wiki/Category:Pica_hudsonia
...
Posts
No comments:
Post a Comment