Tuesday, November 11, 2025

Rosa multiflora: Roche Manifold collaboration with @WorldUnivAndSch even, and in 1 iterating #RealisticVirtualEarth ??? * * * How to #DragAndDropAtWUaS the #FlywireConnectome https://flywire.ai/ which started as a #CitizenScience #FlyBrain #FlyWiringDiagram, > #GStreetView w #GTimeSlider >~ https://goo.gl/maps/7gSsSTweRCBo9gf87 to inquire about #DrosophilaFly #ConsciousnessReSubjectiveExperience? * * * WUaS knocking back International organized crime & growing abolition movement * * * Excited for the potential #WUaSPurchasingPower to lower costs at the #PhysicalDigital #WUaSEducationalServicesStores (for books, computers, robotics, groceries & think WM in 19/200 countries) @WUaSPress @WorldUnivAndSch in all ~200 countries & all 50 US states especially for Fruits, Vegetables, Grains, Legumes AND in coding for all 7.9B people to end poverty w #StanfordMinePiCrypto esp - https://minepi.com/sgkmac ~

 

Roche Manifold collaboration with @WorldUnivAndSch even, and in 1 iterating #RealisticVirtualEarth ???


#RocheManifold collab. w @WorldUnivAndSch in 1 iterating #RealisticVirtualEarth & see #PeterNorvig's INCREDIBLE #ToolifyAIWUaS art.  https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306#ForBrains #ForPharma #ForDrugDiscovery & think #GStreetView w #TimeSlider #GMaps #TensorflowAI @ #GMoleculeView & #GAtomView levels+?










Retweeting -

Very excited to announce Manifold's partnership with Roche to deliver the next generation of brain shuttled therapeutics for CNS diseases, using Manifold unique capabilties in AI + massively scaled in vivo measurment of drug molecules.

This deal is the culmination of over 6 years of effort building a technology to generate the data at a scale needed for AI model training, but to have that data be what has been the ultimate bottleneck for drug development and discovery: in vivo. 

We all know that AI requires massive data to enable the immense leaps in progress we have seen. The challenge with biology is most of the data is in vitro, or cells in a dish. A lot of groups are making excellent progress here, applying AI to very large datasets in vitro, and I hope that these results lead to better drugs. 

But the challenge is the humans are not cells in a dish. We've cured many diseases in petri dishes, only for those drugs to have unexpected results when put into the patients. Living systems are so complex that they are hard to reduce, despite how hard we try. 

This is what makes the Manifold approach so different, instead of simplifying the system down to a petri dish to generate the data we need for AI, we test millions of molecules in living systems so we can generate the relevant data we need for drug discovery.

We believe that this is the true unlock for AI in drug discovery. We are generating massive datasets of millions of potential drugs to hundreds of targets and asking the question of where do these molecules go, directly in animals. This allows us to build AI models of drug delivery, and eventually drug function. 

Delivery to the brain and this collaboration with Roche is just the start. We are rapidly scaling this approach to other tissues, and ultimately using it to understand drug affect on all organs in the body. 

If you are excited about AI, drug development, and totally novel data of drug function in animals, please reach out. We are hiring across many roles and always interested in collaboration with groups in AI and drug development as well!






Roche

Roche is a Swiss multinational healthcare company specializing in pharmaceuticals and diagnostics, founded in 1896. It operates globally with headquarters in Basel, Switzerland, and is known for developing scientifically researched pharmaceuticals and innovative diagnostic tools to improve patient health. 
  • Company Structure: Roche is a holding company, Roche, that oversees two main divisions: Pharmaceuticals and Diagnostics.
  • Pharmaceuticals: This division focuses on creating effective medicines through research, with partners including Genentech and Chugai. It is a leading provider of clinically differentiated medicines for diseases like cancer, neurological diseases, and cardiovascular-metabolic diseases.
  • Diagnostics: This division provides in-vitro diagnostic tools essential for identifying and monitoring diseases, screening, and determining treatment responses.
  • History: The company was one of the first to manufacture scientifically researched pharmaceuticals and has a history of evolving to meet medical needs.
  • Global Presence: Roche has a significant global presence, with operations and partnerships worldwid



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How to #DragAndDropAtWUaS the #FlywireConnectome https://flywire.ai/ which started as a #CitizenScience #FlyBrain #FlyWiringDiagram, > #GStreetView w #GTimeSlider  >~ https://goo.gl/maps/7gSsSTweRCBo9gf87 to inquire about #DrosophilaFly #ConsciousnessReSubjectiveExperience?


How to #DragAndDropAtWUaS the #FlywireConnectome https://flywire.ai/ which started as a #CitizenScience #FlyBrain #FlyWiringDiagram, > #GStreetView w #GTimeSlider >~ https://goo.gl/maps/7gSsSTweRCBo9gf87 to inquire about #DrosophilaFly #ConsciousnessReSubjectiveExperience @WorldUnivAndSch?

https://x.com/scottmacleod/status/1987978280440582342

https://x.com/WorldUnivAndSch/status/1987979211676831956

https://x.com/Q_YogaMacFlower/status/1987979280727605288








1
How can I drag and drop the current flywire connectome,which started as a #CitizenScience wiring diagram of a #FlyBrain, into Google Street View with a time slider to start asking questions about consciousness re subjective experience of #DrosophilaFly?


It is not currently possible to "drag and drop" the FlyWire connectome (a complex, high-resolution 3D map of a fly brain) into Google Street View. They are separate platforms designed for different types of data visualization and are not directly compatible in the way you describe. 
Here is a breakdown of why this is the case and how you can approach exploring the connectome:
Why It's Not Feasible
  • Fundamentally Different Data: Google Street View is designed to display ground-level, panoramic photographic imagery of real-world geographic locations. The FlyWire connectome, in contrast, is a microscopic, 3D neuroscientific dataset of neuron structures and connections, not tied to a physical location on Earth.
  • Technical Integration: There is no built-in functionality or simple drag-and-drop mechanism to merge complex, custom 3D scientific data directly into the proprietary Google Street View interface or its public APIs for general users.
  • Visualization Tools: FlyWire uses specialized infrastructure developed by Google Research and Janelia, such as Neuroglancer, for visualizing its massive dataset. These tools are optimized for navigating microscopic brain structures, which is fundamentally different from navigating a street using the Google Maps framework. 
How You Can Explore the FlyWire Connectome
You can directly explore the connectome and ask scientific questions using the dedicated FlyWire platform:
  1. Use the FlyWire Website: The entire connectome is publicly available on the FlyWire website (flywire.ai).
  2. Navigate the Brain: The platform allows you to pan, zoom, and step through slices of the brain data in 3D, similar to how you might navigate a 3D map, but optimized for the microscopic scale.
  3. Collaborate and Ask Questions: The platform is a citizen science project where researchers and the public can "proofread" and annotate neurons. You can use the built-in tools to select specific neurons, examine their connections, and share links to specific views with the community or researchers to ask specific questions about neural circuits and behavior. 
Addressing Consciousness Questions
Regarding your interest in consciousness and subjective experience in Drosophila:
The FlyWire connectome provides an anatomical "wiring diagram" of the fly brain. While this is a groundbreaking tool for understanding how neural circuits generate behavior, the link between a mere wiring diagram and the subjective experience of consciousness is a profound and active area of philosophical and scientific debate. Exploring the connectome can help inform hypotheses about how information is processed, but it doesn't offer a direct window into a fly's "inner world" or "subjective experience". 
You can use the connectome data to:
  • Identify new neural circuits and predict their function.
  • Build computational models of brain function based on real connectivity data.
  • Guide new experiments to test hypotheses about behavior and neural processing



2
are neurons cells?

Yes, neurons are specialized cells that are the fundamental building blocks of the nervous system. They are electrically excitable cells that transmit information to other cells through electrical and chemical signals. Like other cells, they have a cell body containing a nucleus and cytoplasm, but they also have a unique structure with long extensions called dendrites and an axon to send and receive messages over long distances. 
  • Cell body: The main part of the neuron that contains the nucleus and organelles, similar to other cells.
  • Dendrites: Branch-like extensions that receive signals from other neurons.
  • Axon: A long projection that transmits signals away from the cell body to other neurons or effector cells




3
What is subjective experience?



Subjective experience is an individual's personal, first-person perception of their own consciousness, encompassing unique feelings, thoughts, and interpretations of events. It is the internal, qualitative experience of a phenomenon, such as what it feels like to feel pain or see the color red, which cannot be objectively measured or fully understood by others. This is contrasted with objective reality, which is based on external facts that are the same for everyone. 
Key aspects of subjective experience
  • Personal and unique: Everyone's subjective experience is shaped by their own emotions, thoughts, memories, and interpretations, so the same event can be experienced differently by different people. For example, one person might feel intense sadness at a loss, while another feels anger and regret.
  • Internal and qualitative: It is the "what it's like" aspect of consciousness. For instance, a subjective experience of "pain" is a personal, internal feeling, even though the objective event (e.g., a cut) can be seen and measured by others.
  • Difficult to measure objectively: Because it is internal, subjective experience is hard to quantify or communicate to others in its entirety. Researchers can ask for a person's perspective through questionnaires or narratives, but this is a report of the experience, not the experience itself.
  • Influenced by memory and context: How an experience feels can depend on a person's memories, both implicit and explicit, as well as the context of the situation. The perception of a color, for example, can shift based on a person's assumptions about the lighting.
  • Contrasted with objective reality: Objective reality refers to things as they are, independent of any one person's perception, like the physical object a person mistakes for a snake when it is actually a rope. Subjective experience is one's personal interpretation of that rope




4

How far down the phylogenetic tree do species have consciousness or subjective experience ? Do drosophila flies have consciousness?


 The capacity for consciousness likely extends far down the phylogenetic tree, with a new declaration by scientists stating there is a "realistic possibility" of consciousness in insects, mollusks, and crustaceans. While they lack the self-reflection of humans, evidence suggests fruit flies (
image.gif
) and other invertebrates may possess basic forms of subjective experience and cognitive abilities. 
Evidence for consciousness in invertebrates 
  • Basic subjective experience: Some researchers argue that the insect brain has structures that perform functions analogous to the vertebrate midbrain, which are sufficient to support subjective experience.
  • Cognitive abilities: Studies have shown that fruit flies possess cognitive functions typically associated with more complex brains, such as memory formation and attention.
  • Sleep and dreams: Fruit flies show sleep-like states, including periods of "active sleep" where brain activity is similar to when they are awake, comparable to REM sleep in humans where vivid dreams—considered conscious experiences—occur.
  • Bodily awareness: Research suggests that even with a tiny brain, fruit flies have a basic sense of bodily awareness.
  • Response to stimuli: A fly avoiding your finger is a clear sign it is receiving, processing, and responding to stimuli, which indicates some level of conscious experience, even if it is very different from human experience. 
What is not supported by current evidence 
  • Pain: Some research suggests that the neural structures in the Drosophila brain are not complex enough to support subjective experience of pain, even though they can react to noxious stimuli.
  • Self-reflection: It is unlikely that flies are capable of the level of self-conscious awareness that humans have, which requires more complex cortical and midbrain structures









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Society, Information Technology, and the Global University (2025, forthcoming) 

- Scott GK MacLeod  
Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki, 
World University & School (WUaS) 
- USPS US Post Office, General Delivery, Canyon, CA 94516 


1) non-profit 501(c)(3) Public Charity 
best STEAM CC licensed OCW, Wiki, 
World University and School - http://worlduniversityandschool.org 

2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html

(m) 412 478 0116 - sgkmacleod@gmail.com 


World Univ & Sch Innovation Research - 






* * * 

WUaS knocking back international organized crime & growing abolition movement  


As @WorldUnivAndSch grows further a worldwide #WUaSAboltionMovement to protect people eg from #modernslavery & in #WUaScoding for all 7.9 billion people on planet w https://minepi.com/sgkmac to end poverty from https://wiki.worlduniversityandschool.org/wiki/You_at_World_University, WUaS is glad to be knocking back #InternationalOrganizedCrime & see Agenda item B
https://worlduniversityandschool.blogspot.com/2025/11/maroon-bells-snowmass-wilderness-c0-m.html &
https://scott-macleod.blogspot.com/2025/11/maroon-bells-snowmass-wilderness-c0.html ~


As @WorldUnivAndSch grows further a worldwide #WUaSAbolitionMovement to protect people eg from #ModernSlavery & in coding for all 7.9 B people on planet w https://minepi.com/sgkmac glad to be knocking back #InternationalOrganizedCrime & see Agenda item B
https://worlduniversityandschool.blogspot.com/2025/11/maroon-bells-snowmass-wilderness-c0-m.html ~


Not retweeting for example -

French Guyana

https://x.com/worldwidedays/status/1402991452095848449




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2025

Knocking back international organized crime ? ... Looking at what's happened over the last 21 years 8 years 2 years through legal lens of Intl org crime and also regarding abolition law 




international organized crime

#InternationalOrganizedCrime

#WUaSabolition movement is growing 

Coding for all 7.9 billion people on the planet 







--

Society, Information Technology, and the Global University (2025, forthcoming) 

- Scott GK MacLeod  
Founder, President, CEO & Professor
CC-4 licensed MIT OCW-centric, Wiki, 
World University & School (WUaS) 
- USPS US Post Office, General Delivery, Canyon, CA 94516 


1) non-profit 501(c)(3) Public Charity 
MIT OCW-centric, 
World University and School - http://worlduniversityandschool.org 

2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html

(m) 412 478 0116 - sgkmacleod@gmail.com 


World Univ & Sch Innovation Research - 






* * *


Excited for the potential #WUaSPurchasingPower to lower costs at the #PhysicalDigital #WUaSEducationalServicesStores (for books, computers, robotics, groceries, hospital technologies & think Walmart in 19/200 countries) @WUaSPress @WorldUnivAndSch in all ~200 countries & all 50 US states especially for Fruits, Vegetables, Grains, Legumes, AND in coding for all 7.9B people to end poverty w #StanfordMinePiCrypto esp - https://minepi.com/sgkmac ~



Excited for the potential #WUaSPurchasingPower to lower costs at the #PhysicalDigital #WUaSEducationalServicesStores (for books, computers, robotics, groceries & think WM in 19/200 countries) @WUaSPress @WorldUnivAndSch in all ~200 countries & all 50 US states especially for Fruits, Vegetables, Grains, Legumes AND in coding for all 7.9B people to end poverty w #StanfordMinePiCrypto esp - https://minepi.com/sgkmac ~



Excited for pot. #WUaSPurchasingPower to lower costs @ #PhysicalDigital #WUaSStores (for books, robotics, groceries) @WUaSPress @WorldUnivAndSch in #all200countries & all #50USstates, esp for Fruits, Vegetables +, AND in #WUaScoding for all 7.9B people w https://minepi.com/sgkmac~


https://x.com/WorldUnivAndSch/status/1988274969974108436?s=20

https://x.com/WUaSPress/status/1988275485747581188

https://x.com/sgkmacleod/status/1988276339405939102

https://x.com/Q_YogaMacFlower/status/1988276815665000778


Retweeting -

Elizabeth Warren
@ewarren

The American people want us to stand and fight to lower costs, and that's what I believe we must do.

https://x.com/ewarren/status/1988012834614018356?s=20




* 
Searched on 

purchasing power parity economically to bring costs & prices down for consumers regarding multinational companies is what



Purchasing power parity (PPP) is an economic theory used to bring costs and prices down for consumers of multinational companies by 
adjusting prices based on local purchasing power, ensuring a product costs roughly the same for customers in different countries after currency conversion. Instead of charging a single price, multinational companies can use PPP to lower prices in countries with lower wages so customers can afford the product. This makes goods more accessible to a global customer base and allows businesses to maximize profits by balancing affordability with their international pricing strategies. 
How PPP works to lower costs for consumers 
  • Principle: PPP is based on the idea that the price of an identical basket of goods should be the same across different countries when adjusted for currency exchange rates.
  • Price adjustments: Companies can adjust prices to a level that makes sense for the local market. For example, a software subscription costing 
    image.gif
     in the U.S. might be priced lower in a country with lower average wages to ensure customers can afford it.
  • Consumer accessibility: By lowering prices in some markets, companies make their products more accessible to a larger population, which benefits consumers in those regions.
  • Business strategy: Multinational companies use PPP to implement "parity pricing," which allows them to balance the goal of international pricing with the need to be competitive in different local markets.
  • Balancing act: PPP allows a company to be profitable in a country where a product might be too expensive at the U.S. price, while still capturing the higher price in countries where customers can afford i




--

--

Society, Information Technology, and the Global University (2025, forthcoming) 

- Scott GK MacLeod  
Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki, 
World University & School (WUaS) 
- USPS US Post Office, General Delivery, Canyon, CA 94516 


1) non-profit 501(c)(3) Public Charity 
best STEAM CC licensed OCW, Wiki, 
World University and School - http://worlduniversityandschool.org 

2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html

(m) 412 478 0116 - sgkmacleod@gmail.com 


World Univ & Sch Innovation Research - 




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https://en.wikipedia.org/wiki/Rosa_multiflora

https://commons.wikimedia.org/wiki/Rosa_multiflora

https://commons.wikimedia.org/wiki/Category:Rosa_multiflora

https://commons.wikimedia.org/wiki/Category:Rosa_multiflora_(flowers)


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