Excited @WorldUnivAndSch to code for all 342 million Americans (from https://t.co/ClkQ3z2OaL a #WikidataPIN #
— WorldUnivandSch (@WorldUnivAndSch) November 27, 2025
& potentially for #AvatarAgentElectronicHealthRecords for #ExtremeLongevity & #AgingReversal #GeneDrugs as part of the ~50 US online #WUaSMedSchs https://t.co/uXwz76vzn1~ https://t.co/uiBh6266vC
The United States of America is the richest country in the history of the world. It is time for us to make good on the statement that health care is a basic human right.
— Elizabeth Warren (@ewarren) November 26, 2025
We need health care for everyone. I’m staying in that fight all the way.
*
And potentially in all 200 countries, eg in Sri Lanka for all 22 million Sri Lankans and at Sri Lanka World Univ & Sch
- https://wiki.
and - https://wiki.
* * *
Since #IF1ProteinControlsAgingRate, how best @Forrest_PhD w @geochruch as an advisor to dev. related #ExtremeLongevity & #AgingReversal #GeneDrugs' therapies @Cambridge_Univ &in #RealisticVirtualEarthForGenes #RealisticVirtualEarthForMultiomics #RealisticVirtualEarthForSpecies? https://t.co/vFkzfUoQRd
— WorldUnivandSch (@WorldUnivAndSch) November 27, 2025
https://x.com/WorldUnivAndSch/
https://x.com/TheOpenBand/
https://x.com/WUaSPress/
*
Since #IF1ProteinControlsAgingRate, how best @Forrest_PhD w @geochruch as an advisor to dev. related #ExtremeLongevity & #AgingReversal #GeneDrugs' therapies @ #CambridgeUniv &in #RealisticVirtualEarthForGenes #
Since #IF1ProteinControlsAgingRate, how best @Forrest_PhD w @geochruch as an advisor to dev. related #ExtremeLongevity & #AgingReversal #GeneDrugs' therapies @ #CambridgeUniv &in #RealisticVirtualEarthForGenes #RealisticVirtualEarthForMultiomics #RealisticVirtualEarthForSpecies? https://t.co/vFkzfUoQRd
— WorldUnivandSch (@WorldUnivAndSch) November 27, 2025
https://x.com/WorldUnivAndSch/
https://x.com/WUaSPress/
https://x.com/sgkmacleod/
https://x.com/HarbinBook/
https://x.com/scottmacleod/
https://x.com/Q_YogaMacFlower/
Retweeting -
New Results Follow this preprint
IF1 Protein Controls Aging Rate
View ORCID Profile
Michael David Forrest
doi: https://doi.org/10.1101/2021.
ABSTRACT
IF1 protein inhibits F1F0 ATP hydrolysis (and not F1F0 ATP synthesis). Across investigated species more IF1 protein, and less F1F0 ATP hydrolysis, correlates with greater maximal lifespan....
— george church (@geochurch) November 24, 2025
https://x.com/geochurch/
Wow: "#IF1ProteinControlsAgingRate"
— WorldUnivandSch (@WorldUnivAndSch) November 25, 2025
"aging is modifiable. But how? A clue might be body size: smaller mammal species tend to age faster than larger ones" How best to add initially #IF1ProteinMolecule processes to a #RealisticVirtualEarthForSpecies? #FilmTo3DApp @ #GMoleculeLevel? https://t.co/vFkzfUoQRd
IF1 Protein Controls Aging Rate
ABSTRACT
IF1 protein inhibits F1F0 ATP hydrolysis (and not F1F0 ATP synthesis). Across investigated species more IF1 protein, and less F1F0 ATP hydrolysis, correlates with greater maximal lifespan. Increased IF1 protein, and decreased F1F0 ATP hydrolysis, safely reduces a biomarker of aging in mice. Body temperature decrease, in mice administered with a small molecule drug that selectively inhibits F1F0 ATP hydrolysis (which doesn’t inhibit F1F0 ATP synthesis), is evidence that F1F0 ATP hydrolysis is used for metabolic heat generation in vivo. Instrumental to homeothermy, which is a new fundamental discovery. A further discovery is that cancer cells subvert F1F0 ATP hydrolysis to drive their distinctive Warburg metabolism and so selective drug inhibition of F1F0 ATP hydrolysis exerts potent anticancer activity. When the body is in an ambient temperature of 37°C (or more), no metabolic heat generation is needed for the body to be at 37°C, and so a large dose of a F1F0 ATP hydrolysis inhibiting anticancer drug may be administered, which may slow aging. So, here might be an entirely new class of anticancer drugs that may (when appropriately used) help, instead of harm, normal cells. Distinct from present anticancer drugs, which greatly harm normal cells, causing horrific side-effects, which kill many and cause many others to abandon cancer treatment.
Im short, this paper teaches how mammals metabolically generate heat, why different mammal species have different maximal lifespans, and new anticancer drugs, that are predicted to slow aging.
SIGNIFICANCE Has nature taught us how to slow aging?
Is the if1 protein, a gene & a molecule ? - Yes, the term IF1 refers to a protein (a type of molecule) that is encoded by a gene ...
You reposted
Michael Forrest
@Forrest_PhD
·
May 12
Drug (predicted) to Slow Aging
https://x.com/Forrest_PhD/
- Function: IF1's main role is to prevent the wasteful reversal of the ATP synthase, which would consume ATP instead of producing it.
- Location: It is found in the mitochondria of many organisms, from yeast to humans.
- Regulation: Its activity is regulated by pH, and it forms different oligomeric states (dimers and tetramers) that affect its ability to bind to ATP synthase.
- Relevance: IF1 is involved in protecting cells during stress and has been linked to conditions like cancer, where its upregulation can be associated with a worse prognosis. [1, 2, 3, 4, 5]
*
https://en.wikipedia.org/wiki/Ipsea_speciosa
https://commons.wikimedia.org/wiki/Ipsea_speciosa
...
Posts
No comments:
Post a Comment