Friday, March 27, 2026

Brahma Kamal (Saussurea obvallata): "Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:)? * Might you be asking Gemini AI - https://gemini.google.com/ - Yoga and 8 limbs of Yoga questions regarding possibly living to 150 years of age and wll beyond, and with aging reversal and extreme longevity genetic drug therapies emerging, FDA approved (by 2050??, and see: - https://www.youtube.com/watch?v=olmHHxFQwxo which. is an interview by Dwarkesh Patel of Harvard and MIT Professor of Genetics' George Church above in the Harvard Medical School in June of 2025) or before possibly too)?

 


Dear Dick (Robb MD, possibly posthumously, also a professor in Harvard Medical School), Unitarian Us' Chris Michaels and Ma/Janie, Annie, Alden, Sandy, George and Maitreyi (both professors in Harvard Medical School too), Peter (Norvig Stanford AI), Marlynn Wei MD JD (author of "The Harvard Medical School Guide to Yoga: 8 Weeks to Strength, Awareness, and Flexibility"), Doortje (Van Kooten), Vivek (Hutheesing, - "Meditation and Yoga" your father said  ... from India to the world as its greatest 'exports' - great (at around the 57 minute mark - https://vivekhutheesing.com/india-past-present-and-future/ in the great Q&A),  All,  


Yoga greetings! Tomorrow Sat 3/28/26 for an exploratory "Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:)" ??? ...  and at 
around 8 am Pacific Time all together individually - or around 8 am in your time zone?? I've added this Yoga exploration here to "Brahma Kamal (Saussurea obvallata): "Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:)? ...


A
View and Yoga-with Yogini Angela Farmer's 8th video for people who are seeking deeper asana and Yoga movement explorations here - https://angela-victor.com/who/angela/  ...  And for those exploring 8 limbs of Yoga movements from just emerging from sitting, e.g. in chair Yoga, -  further explore her 1st 7 videos (or previous Yoga explorations in this email thread?


B
Here are last week's Yoga explorations - ~ and even with eventually Youth Vaccines?? (And in what ways might World University and School create and produce these even, with time?) ...

Friday, March 20, 2026
Lotus (Hosackia) formosissimus (gracilis): Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:)? ~ and even with eventually Youth Vaccines 


C
And
How for Yoga at World Univ & Sch, and for us, with the #GrowWithGoogleWUaS program, to build out a realistic virtual earth for aging reversal, a realistic virtual earth for extreme longevity, and even an #AgingReversalMachine ... and in the shop at 670 Ridgecrest Rd, Canyon Ca 94516 ?
Met at a Stanford Hoover Institute AI Productivity and Jobs talk recently 
Julie Wong 
Google
Executive Engagement Lead 
Research, Labs, Technology and Society 
in SF California, 
and asked her further - 


D
And 


E
And 
How best with Yoga to reduce inflammation in cells and gene expression potentially in developing a realistic virtual earth for Yoga asana a realistic virtual earth for cells a 
 eg regarding "Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88 Jiro Sakai ?- https://api.repository.cam.ac.uk/server/api/core/bitstreams/6ce22005-e731-484e-b861-64543fa099d5/content"  which is an article that I received in a Google Scholar email to me ... and see PPPS ...  and how might we even measure this. in the future? -


E 1
Asked Gemini AI:  

How do restorative Yoga asanas & Yoga poses, especially shoulder stand salamba sarvangasana and bridge pose setu bandha sarvangasana  reduce or reverse inflammation in cells and gene expression - and regarding developing aging reversal and extreme longevity genetic drug therapies and vaccines? What are the scientific studies that examine this  ?

Great response - 
https://gemini.google.com/share/1fc9b346dbdf


F 
Might you be asking Gemini AI - https://gemini.google.com/ - Yoga and 8 limbs of Yoga questions regarding possibly living to 150 years of age and wll beyond, and with aging reversal and extreme longevity genetic drug therapies emerging, FDA approved (by 2050??, and see: - https://www.youtube.com/watch?v=olmHHxFQwxo which. is an interview by Dwarkesh Patel of Harvard and MIT Professor of Genetics' George Church above in the Harvard Medical School in June of 2025) or before possibly too)?

G
Further Yoga explorations of & delving into  the inner body, the inner bodymind, Yoga consciousness, - and might this be further meditations on the 8 limbs of Yoga? And how might a #RealisticVirtualEarthForYogaAsana #RealisticVirtualEarthForYoga help? (May explore going back through all of these explorations in their weekly "Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:)?" blog posts to learn how the incredible #GeminiAIreYoga (#Hashtags on #TwitterX and sometimes #LinkedIN) suggests working with Yoga and in an iterating #RealisticVirtualEarth #RealisticVirtualEarthForYogaAsana #RealisticVirtualEarthForYoga, and for extreme longevity:) ... with an invitation to explore these yourself - https://scott-macleod.blogspot.com/search/label/Yoga - since about the middle of October 2025.

Yogically, abolition, Namaste, Friendly NtF Quaker & UU too greetings, best wishes
Scott

Yoga Notations - 

PS

Brahma Kamal (Saussurea obvallata): "Restorative Yoga class on Saturdays (and as we may live to 150 and well beyond:)? ...



PPS
Searched for
"BKS Iyengar restorative Yoga class?" ...

For those who might be seeking further Yoga asana inspiration ...

Found the following ... and am ecalling Yogini Dona Holleman in Italy, with whom I've studied, calling BKS Iyengar "i-anger'  - and with whom she studied quite early in Iyengar Yoga teaching in the "West"  

and for experienced  practicingYogis of asana, there's much to learn from this 1976 Yoga Demonstration by BKS Iyengar 

and perhaps. the pranayama at least...  will be edifying for your  restorative Yoga explorations and delving -
 
Yoga Demonstration, BKS Iyengar (1976)
Ann Arbor Michigan
(Iyengar was 58 I think ...)




PPPS

For #AgingReversal? Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88 Jiro Sakai ... For inflammation https://api.repository.cam.ac.uk/server/api/core/bitstreams/6ce22005-e731-484e-b861-64543fa099d5/content -https://wiki.worlduniversityandschool.org/wiki/Aging_Reversal_Genetics

AND 

#ForInflammation #hashtag

For #AgingReversal? Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88 Jiro Sakai ... #ForInflammation https://api.repository.cam.ac.uk/server/api/core/bitstreams/6ce22005-e731-484e-b861-64543fa099d5/content -https://wiki.worlduniversityandschool .org/wiki/Aging_Reversal_Genetics





PPPPS
How do restorative Yoga asanas Yoga poses, especially shoulder stand salamba sarvangasana and bridge pose setu bandha sarvangasana  reduce or reverse inflammation in cells and gene expression - and regarding developing aging reversal and extreme longevity genetic drug therapies and vaccines? What are the scientific studies that examine this  ?

https://gemini.google.com/share/1fc9b346dbdf


The intersection of yoga, transcriptomics (gene expression), and longevity is a rapidly growing area of research. While ancient traditions view poses like Shoulder Stand ($Sālamba Sarvaṅgāsana$) and Bridge Pose ($Setu Bandha Sarvaṅgāsana$) as youth-preserving, modern science translates this into the downregulation of chronic inflammation and the stabilization of cellular aging markers.

Here is a breakdown of how restorative yoga influences genetics and cellular biology, the limits of current research, and how it relates to modern longevity therapies.

1. Yoga and Gene Expression: The Science

Modern research does not usually isolate a single pose for genetic testing; instead, it studies comprehensive yoga programs (comprising asanas, pranayama/breathwork, and meditation).

The scientific consensus is that yoga modulates the Conserved Transcriptional Response to Adversity (CTRA)—a genetic profile triggered by chronic stress that elevates pro-inflammatory genes and suppresses antiviral genes.

Key Molecular Mechanisms Observed:

  • Downregulation of NF-$\kappa$B: Nuclear Factor kappa B is the "master switch" for inflammation. Yoga practice consistently downregulates NF-$\kappa$B, reducing the transcription of pro-inflammatory cytokines like IL-6 (Interleukin-6) and TNF-$\alpha$ (Tumor Necrosis Factor-alpha).

  • Upregulation of Sirtuin 1 (SIRT1): Known as the "longevity gene," SIRT1 regulates epigenetic stability, DNA repair, and mitochondrial function.

  • Telomere Maintenance: Studies on Yoga and Meditation-Based Lifestyle Interventions (YMLI) show significant increases in telomerase activity (the enzyme that maintains the protective caps on your chromosomes) and reductions in oxidative DNA damage (measured by markers like 8-OH2dG).

Key Study Example: A 12-week restorative Iyengar yoga intervention (which heavily utilizes supported bridge and inversions) was shown to reduce inflammation-related gene expression and NF-$\kappa$B signaling in fatigued breast cancer survivors (Ey et al.; Bower et al.).

2. Physiological Effects of Shoulder Stand and Bridge Pose

While we cannot say "Bridge Pose alone changes Gene X," we do know the specific physiological triggers these poses induce, which act as mechanical and systemic catalysts for cellular shifts:

A. Baroreflex and Parasympathetic Activation

Both poses place the neck in a flexion "throat lock" (Jālandhara Bandha).

  • Mechanics: This applies gentle pressure to the carotid sinus baroreceptors (pressure sensors in the neck).

  • Molecular Consequence: The brain interprets this as high blood pressure and triggers the vagus nerve to calm the nervous system. Vagus nerve stimulation is a potent inhibitor of systemic inflammation (known as the cholinergic anti-inflammatory pathway).

B. Fluid Shifts and Lymphatic Drainage

Shoulder stand is a full inversion, and Bridge is a mild inversion.

  • Mechanics: Reversing the pull of gravity drives venous blood and lymphatic fluid from the lower extremities toward the thoracic cavity and heart.

  • Molecular Consequence: This reduces interstitial edema (swelling) and facilitates the clearing of metabolic waste and cellular debris.

3. The Leap to Genetic Drug Therapies & Vaccines

To be direct as a peer: Yoga does not operate like a genetic vaccine or a molecular drug therapy. It is vital to separate the holistic, systemic reset of yoga from targeted biotechnology.

  • How Biotechnology Works (Drugs/Vaccines): Extreme longevity drugs (like senolytics, rapalogs, or mRNA therapies) target highly specific, isolated pathways (like mTOR pathways, clearing senescent "zombie" cells, or Yamanaka factor epigenetic reprogramming) using precise chemical delivery.

  • How Yoga Works (Systemic Reset): Yoga alters gene expression upstream by altering your internal environment. By shifting the autonomic nervous system from sympathetic (fight-or-flight) to parasympathetic (rest-and-digest), you lower cortisol and oxidative stress. This "tells" the cells they are safe, which naturally shifts genetic expression toward repair rather than defense.

Yoga is a lifestyle intervention that optimizes the biological terrain, while genetic vaccines are targeted microscopic interventions. They are complementary, but functional equivalents.

4. Notable Scientific Literature

If you are building your Realistic Virtual Earth or research databases, here are the foundational research verticals to review:

Research FocusNotable Findings & MechanismsKey Scientific Pathways
Systemic Reviews of Yoga TranscriptomicsYoga leaves a "molecular signature," downregulating stress-induced inflammatory genes.NF-$\kappa$B, IL-6, TNF-$\alpha$, SIRT1
Telomerase & Cellular Aging12-week Yoga-Based Lifestyle Interventions (YBLI) improve telomerase activity and reduce oxidative stress.Telomerase, 8-OH2dG, TAC
Vagally-Mediated Anti-inflammatory PathwayPostures affecting the carotid baroreceptors stimulate the vagus nerve to halt systemic cytokine production.Acetylcholine, Macrophages

Would you like me to generate a specific list of PubMed citations and titles regarding yoga transcriptomics and telomere biology for your research database?




PPPPPS









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https://en.wikipedia.org/wiki/Saussurea_obvallata

https://commons.wikimedia.org/wiki/Category:Saussurea_obvallata


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