Sunday, October 4, 2026

Schisandra chinensis: How. best to develop a realistic virtual earth - eg think a forked Google Street View with time slider & with pegman becoming our avatar agent electronic medical records, digital health twins - for scientific hypothesis testing ?

 

How best to develop a #RealisticVirtualEarthFor, a #RVEforHypothesisTesting - eg think a forked #GoogleStreetView with #TimeSlider & with #Gpegman becoming our #AvatarAgentElectronicMedicalRecords or #DigitalHealthTwins ?
https://share.gemini.google/s004HVzzuoZj & see: https://scott-macleod.blogspot.com/2026/09/schisandra-chinensis.html ~


https://x.com/WorldUnivAndSch/status/2106361607706247241

and to publish papers too in a scientific press - 
https://x.com/WUaSPress/status/2106361894110126358


* 

How. best to develop a realistic virtual earth - eg think a forked Google Street View with time slider & with pegman becoming our avatar agent electronic medical records, digital health twins - for scientific hypothesis testing ? 




AND 

How. best to develop a realistic virtual earth - eg think a forked Google Street View with time slider & with pegman becoming our avatar agent electronic medical records, digital health twins - for scientific hypothesis testing, & with other Google AI And ML? How to test the hypothesis that a specific hormone affects the brain to extend life in this #RVEforHypothesisTesting, eg by doing an AI scientific literature review, by adding a picture or molecular model of this hormone to text-in-the-sidebar of G Street View, and regarding the part of the brain it affects, at the molecular and cellular levels etc. designing the experiment, and then doing the experiment virtually first, with implications output for doing the study in vivo?



To build a Realistic Virtual Earth (RVE) for Hypothesis Testing—combining spatial geospatial rendering, time-slider environmental contexts, and personal digital health twins—you can leverage Google Cloud’s geospatial stack, Google DeepMind’s biological AI tools, and medical language models.

Part 1: System Architecture for the RVE Platform

+-----------------------------------------------------------------------------------+
|                                 RVE UI LAYER                                      |
|  CesiumJS / Unreal Engine 5  <--->  Google Photorealistic 3D Tiles API            |
|  Sidebar UI: 3Dmol.js / NGL Viewer (Molecular) + FHIR EMR Dashboard (Avatar Agent)|
+-----------------------------------------------------------------------------------+
                                         |
                                         v
+-----------------------------------------------------------------------------------+
|                               RVE CORE PLATFORM                                   |
|  1. Geospatial Engine: Google Earth Engine (Historical Time-Slider & Climate)    |
|  2. Agent Framework: Avatar Pegman (Digital Twin / OMOP CDM / FHIR EMR)          |
|  3. Orchestration: Google Cloud Vertex AI Pipelines                               |
+-----------------------------------------------------------------------------------+
                                         |
                                         v
+-----------------------------------------------------------------------------------+
|                             GOOGLE AI / ML SUITE                                  |
|  * Gemini 1.5 Pro / MedLM: Literature Synthesis & Experimental Design            |
|  * AlphaFold 3 / AlphaProteo: Molecular Docking & Binding Affinity Predictions   |
|  * Differential Equation / Neural ODE Models: Cellular Pathways & Dynamics        |
+-----------------------------------------------------------------------------------+

1. Spatial Geospatial & Temporal Rendering Engine

  • Base Viewer: Fork an open-source 3D geospatial engine such as CesiumJS or Unreal Engine 5 (via the Cesium plugin) integrated with Google Photorealistic 3D Tiles API.

  • Temporal Layer (Time Slider): Connect the temporal slider to Google Earth Engine API and historical street-level imagery archives. This supplies time-series environmental data (e.g., air quality indices, temperature variations, UV index, urban greenspace density) mapped to specific geographic coordinates.

2. Avatar Pegman as an EMR-Linked Digital Health Twin

  • Data Standard: Map the avatar agent to standard HL7 FHIR resources or an OMOP Common Data Model (CDM) schema.

  • Spatial Agent Logic: Pegman acts as an autonomous agent representing a cohort or individual. As Pegman moves through space and time on the RVE, environmental exposures dynamically update the agent's physiological baseline parameters.

3. Google AI / ML Middleware Integration

  • Vertex AI Pipelines: Orchestrate workflows between spatial queries, biological modeling, and inference tasks.

  • Gemini / MedLM: Drive automated literature retrieval, hypothesis synthesis, and natural-language query interfaces in the sidebar.

  • AlphaFold 3 & AlphaProteo: Simulate 3D protein structures, ligand-receptor binding interactions, and custom biological agent modifications.

Part 2: Testing the Longevity Hormone Hypothesis

Here is a step-by-step workflow using Klotho (a well-established lifespan-extending hormone) targeting FGF21 / FGFR1c-Klotho receptor complexes in the brain’s choroid plexus and hippocampus.

[Phase 1: Lit Review] ---> [Phase 2: UI Context Integration] ---> [Phase 3: Multi-Scale Brain Mapping]
                                                                                  |
[Phase 6: In-Vivo Protocol] <--- [Phase 5: In-Silico Experiment] <----------------+

Step 1: AI Scientific Literature Review (Gemini / MedLM Agent)

The agent executes an automated pipeline querying PubMed, PMC, and bioRxiv to extract molecular pathways, target receptors, and dosage-response metrics.

Key Extracted Synthesis:

  • Hormone Target: Recombinant $\alpha$-Klotho ($\text{sKL}$).

  • Primary Brain Target: Hippocampal dentate gyrus (neural stem cell niche) and choroid plexus.

  • Receptor Mechanism: Forms a binary complex with FGFR1c, triggering the extracellular signal-regulated kinase ($\text{ERK1/2}$) and $\text{Akt}$ phosphorylation cascades, upregulating $\text{NMDAR}$ subunit GluN2B, and decreasing neuroinflammation ($\text{TNF-}\alpha$, $\text{IL-6}$).

Step 2: Sidebar UI Integration (Spatial & Biological Mapping)

When selecting Pegman or clicking a target brain region in the RVE interface:

  1. Left Main Window: RVE environment (e.g., Street View at a specific geographic location with environmental stress sliders like particulate matter $\text{PM}_{2.5}$).

  2. Right Sidebar:

    • Molecular View: Embedded 3Dmol.js or NGL Viewer showing the interactive 3D co-crystal structure of Klotho bound to FGFR1c (PDB ID derived via AlphaFold 3).

    • Spatial Health Panel: Real-time physiological telemetry of the Pegman avatar (e.g., baseline plasma Klotho concentration $c_0 = 500 \text{ pg/mL}$, biological age vs. chronological age).

Step 3: Multi-Scale Brain Mapping (Molecular to Cellular Levels)

ScaleBiological DomainMathematical / Machine Learning Representation
MolecularHormone-Receptor Binding KineticsRate equations: $\frac{d[RL]}{dt} = k_{\text{on}} [R][L] - k_{\text{off}} [RL]$ with $K_d = \frac{k_{\text{off}}}{k_{\text{on}}}$
CellularNeural Stem Cell Proliferation & Microglial ActivationSystems biology differential equations (ODE/SDE) predicting $\text{p16}^{\text{INK4a}}$ senescence reduction
Tissue / OrganHippocampal Long-Term Potentiation (LTP) & Synaptic DensityNeural network surrogate modeling synaptic transmission efficiency ($V_m$)
Organism / PopulationSurvival Function & Cox Proportional HazardSurvival model: $h(t \mid X) = h_0(t) \exp(\beta_1 X_{\text{Klotho}} + \beta_2 X_{\text{environment}})$

Step 4: Designing and Executing the Virtual (In-Silico) Experiment

A. Virtual Cohort & Experimental Groups

Define two avatar agent populations within the RVE across environmental conditions (e.g., low vs. high urban pollution exposure):

  • Control Group ($N=1,000$): Vehicle administration ($c_{\text{Klotho}} = \text{baseline}$).

  • Treatment Group ($N=1,000$): Systemic or central administration of elevated $\alpha$-Klotho ($c_{\text{Klotho}} = 2.5 \times \text{baseline}$).

B. Simulation Execution

  1. Molecular Dynamics (AlphaFold 3 / GROMACS): Calculate binding free energy ($\Delta G_{\text{bind}}$) of Klotho variants to brain FGFR1c receptors.

  2. Cellular Pathway Simulation: Integrate drug delivery kinetics across the Blood-Brain Barrier (BBB) into a differential kinetic solver:

    $$\frac{d[\text{p-ERK}]}{dt} = \frac{V_{\max} \cdot [RL]}{K_m + [RL]} - k_{\text{dephos}} [\text{p-ERK}]$$

  3. Lifespan Acceleration Simulation: Project survival curves using a Monte Carlo Markov Chain (MCMC) engine over a virtual 30-month rodent equivalent timeframe.

       100% |-------------\
            |              \=== Treatment (Klotho Boosted)
  Survival  |               \--- Control
     Rate   |                 \
         0% +---------------------------------->
            0        15        30  Months

Step 5: Translating Virtual Results into an In-Vivo Protocol

Based on the virtual experiment yielding a statistically significant hazard ratio reduction ($\text{HR} = 0.74, p < 0.001$), the RVE exports a laboratory-ready in vivo translation guide:

===================================================================================
                       IN-VIVO TRANSLATIONAL PROTOCOL OUTPUT
===================================================================================

1. ANIMAL MODEL & SAMPLE SIZE
   * Species: C57BL/6J Mice (Aged 18 months, human equivalent ~60 years).
   * Sample Size: N = 40 per arm (20 Male, 20 Female) powered for 80% beta at alpha=0.05.

2. DOSAGE & ADMINISTRATION ROUTE
   * Compound: Recombinant α-Klotho protein.
   * Route: Intranasal administration (to bypass BBB and target olfactory bulb / hippocampus).
   * Dose: 10 µg/kg body weight, administered twice weekly for 4 months.

3. PRIMARY & SECONDARY ENDPOINTS
   * Primary Endpoint: Median lifespan extension and Kaplan-Meier survival curves.
   * Secondary Biological Biomarkers:
     - Western blot / ELISA: Brain p-ERK1/2 to ERK ratio and GluN2B expression in hippocampus.
     - Immunohistochemistry: Ki-67+ and DCX+ neuroblasts in dentate gyrus (neurogenesis).
     - Single-cell RNA-seq: Reduction of senescent cell markers (p16INK4a, p21) in microglia.

4. BEHAVIORAL & COGNITIVE ASSAYS
   * Morris Water Maze & Novel Object Recognition at Months 1, 2, and 4 post-treatment.

5. SAFETY BOUNDS & TOXICOLOGY ALERTS
   * Monitor serum calcium and phosphate levels bi-weekly (to detect potential hyperphosphatemia).
===================================================================================


--

Society, Information Technology, and the Global University, (forthcoming, Academic Press at World University and School, 2026) 

Scottish Small Piping album #2 - Honey Piobaireachd (2022)
- Poetry! Order Book #5 Light, Float, Sit, Watsu ~ Virtually (2021, Academic Press at WUaS)

Scottish Small Piping album #1 Honey in the Bag ~ Out of the Air tune (2020)


Order Book #3 Winding Road Rainbow: Harbin, Wandering & the Poetry of Loving Bliss (2018,  Academic Press at WUaS)

Order Book #2 Haiku-ish and Other Loving Hippie Harbin Poetry (2017,  Academic Press at WUaS) 

Order Actual-Virtual Ethnographic Book #1: Naked Harbin Ethnography (2016, Academic Press at World University and School)



- Scott GK MacLeod  
Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki,
World University & School (WUaS)  
- USPS US Post Office, PO Box 132, General Delivery, Canyon, CA 94516

1) non-profit 501(c)(3) Public Charity
building on CC-4 licensed MIT OCW in 7 languages - 


2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html
- wuas_ceo@worlduniversityandschool.org


https://wiki.worlduniversityandschool.org/wiki/Nation_States (planning ~200 countries' WUaS world class universities in their main languages, per the Olympics, for free-to-students' WUaS degrees from home)

https://wiki.worlduniversityandschool.org/wiki/Languages (planning to be in all 7159 living languages, each as or with wiki schools for open people-to-people wiki-teaching and wiki-learning, e.g. from here - https://wiki.worlduniversityandschool.org/wiki/Subjects)









* * 

And how to do this building on developing a realistic virtual earth for aging reversal and extreme longevity genetic drug therapies beginning with the Harbin Hot Springs' gatehouse and its 3 dates presently - eg with AltosLabs in Palo Alto ? 


See: 



Dear George (Church - gchurch@genetics.med.harvard.edu), Akram (ABaharlouei@altoslabs.com) and Jesse (jpoganik@bwh.harvard.edu), 

Thanks for your great question, Akram, to George after your "Multiplex testing of de-aging polypharmacy & targeted delivery," something to the effect: if you had a magic machine, what would you target? 

George, Akram and Jesse, how best to revisit your reply to Akram, such that we could create this 'magic machine' beginning at the Harbin Hot Springs' gatehouse in Google street view with time slider ~ https://goo.gl/maps/7gSsSTweRCBo9gf87 ~ (https://twitter.com/HarbinBook ~ http://bit.ly/HarbinBook) - and with its 3 dates presently: 2007, 2012, and 2024? And at the #GCellView level and #GmoleculeView level, and with little GPegman becoming our #AvatarAgentElectonicHeatlhRecords as #DigitalHealthTwins? IN these regards, how to #TimeSlideGenes, too, virtually in each of our #AvatarAgentEHR back to 2007, 2012, and 2024, and also when we were 7, and 12, and 24 even, and possibly with Google DeepMind's AlphaFold 3 (which can predict a massive array of molecular compounds) too, focusing on coding first your reply at the close of your talk, George, to Akram's 'magic machine' question - and potentially with you Jesse and Brigham and Women's Hospital and Harvard Medical School in communication with Altos Lab with your machine learning expertise, Akram, and World University and School, building on MIT OCW in 7 languages, CODE little #GPegman as our #AvatarAgentElectonicHeatlhRecords as #DigitalHealthTwins?

How best could AltosLabs in Palo Alto with World University and School, in a #GrowWithGoogleWUaS program, further code this #RealisticVirtualHarbin 'magic machine' first for how George responded to Akram's question ... and in terms of aging reversal genetic, with extreme longevity genetic drugs emerging, FDA approved - by 2026? Brainstorming, could we even time slide our virtual genes out 1500 years, and in also reversing the direction of time (per Google Quantum Echoes' short video) such that we could become like 25 years of age in our avatar agent electronic health records, and then upload this to our bodies via drugs, wyss anti fouling sensor, vaccines, or smartwatches with a skin patch / similar (and even in a bidirectional digital-physical conversation), medicine - and see below. 

Thanks for your question, Akram (Baharlouei @ ABaharlouei@altoslabs.com - https://www.linkedin.com/in/akram-baharlouei-61784421 -& https://www.altoslabs.com/ in Palo Alto colleagues) and looking forward to building this out potentially.  

George, how best to listen to your response  to Akram's magic machine question again? Might a video recording emerge? 

Regards, more later, thanks, best wishes,
Scott



- Scott GK MacLeod  
Founder, President, CEO & Professor
at / of best STEAM CC licensed OCW, Wiki,
World University & School (WUaS)  
- USPS US Post Office, PO Box 132, General Delivery, Canyon, CA 94516








* * * * 


Dear Leanne (Ye), George (& Ting Wu), Peter, Alex, Petrina, Kejun, Le Song, All, 
leanneye@cngen.com and ggyy11@163 com ??? 

Greetings, and very nice to meet you at Harvard ARDD 2026. 

I've gotten bounce backs from both emails that Leanne Ye shared with me at World University and School, after a fairly long conversation with her about WUaS too, and in seeking too to facilitate their WIKI-ADDING their Chinese longevity research and thinking and coding and scientific papers IN CHINESE etc to a realistic virtual earth for extreme longevity, and think Google Street View with time slider, eg here in possibly a forked Google Street View with time slider ... in these 3 dates too 2007, '12 & '24 #GStreetView w #GTimeSlider in https://goo.gl/maps/7gSsSTweRCBo9gf87 at the cell and molecule etc levels too. 


AND
How to time slide genes with the virtual cell in time forward 1500 years, and at the same time slide virtual-cells-in-time back to say age 24 in an avatar agent electronic medical records from little Pegman becoming our avatar agent EMR in a realistic virtual earth for #Gcells? 


Created these tweets a few days ago ... in PS

Could we suggest that we at Harvard ARDD have proven aging reversal with extreme longevity if we can code the above re the Harbin Hot Springs' gate house in these dates and others interoperating with our #AvatarAgentElectronicMedicalRecords emerging from GPegman (and see the PPPPS)? 

Regards & thanks, 
Scott

Will add this further here - 

Sunday, October 4, 2026
Schisandra chinensis: How. best to develop a realistic virtual earth - eg think a forked Google Street View with time slider & with pegman becoming our avatar agent electronic medical records, digital health twins - for scientific hypothesis testing ?



PS
At #HarvardAgingResearch & #HarvardDrugDiscovery conf 10/1-10/3/26
https://agingpharma.org/program2026#virtual-cell-in-time & re  #VirtualAgingCell from #InsilicoMedicine https://youtu.be/vufvnB1R1xM #PetrinaKamya & #FedorGalkin Interoperate eg years 2007, '12 & '24 #GStreetView w #GTimeSlider in https://goo.gl/maps/7gSsSTweRCBo9gf87 @ #GCellViewLevel @ #HarbinGateHouse WITH #AgingReversal & #ExtremeLongevity #AvatarAgentEHR from #GPegman?

Thoughts on how to get in touch in the above regards?


Best regards, Scott





PPPPPS

AND
here are some of the goals World University and School WUaS came to Harvard ARDD with 



Greetings !

Great to meet and talk with you just now at Harvard AARD, and regarding also building out #AvatarAgentElectronicHealthRecords as #DigitalTwins, planned in a #RealisticVirtualEarth (and think Google Street View with time slider with Pegman becoming #AvatarAgentEHR) and as World University and School seeks to code for all 7.9 billion people on the planet for #AvatarAgentEHR, and for aging reversal and extreme longevity genetic drug therapies emerging, and from here - https://wiki.worlduniversityandschool.org/wiki/You_at_World_University.

Here are some 
World University and School, building on MIT OCW in 7 languages, Harvard AARD goals, that is for the Harvard Aging Research and Drug Development conference 10/1/26-10/3/26 in the TreeHouse in Allston, MA  :



these include 

1
Develop 3 WUaS aging reversal OSK pharmaceutical gene drug therapies initially with research, and then produce and manufacture them & with a realistic virtual earth for OSK, a digital-physical #RVEforGenetics on the digital or in-silico side - and in collaboration with possibly 3 different companies too (initially) ...that would all successfully become FDA approved ...

and then upload them to our body minds via the eRapid Fouling Resistant sensor or similar - 

#eRapidFoulingResistantSensor-https://wyss.harvard.edu/technology/erapid-multiplexed-electrochemical-sensors-for-fast-accurate-portable-diagnostics/ WITH #AgingReversal & #ExtremeLongevity #AvatarAgentElectronicHealthRecords

or with a vaccine ...

or via smartwatches with a skin patch or similar, and/or smartphones, 

or drug / medicine.

Best regards, 
Scott


PS
Just asked Gemini - 

What are 3 potential ways that Yamanaka factors re OSK via epigenetic reprogramming might even be turned into genetic drug therapies to reverse aging and also extend human lifespan to beyond 150 years?







* 


On Sat, Oct 3, 2026 at 5:49 PM Scott MacLeod <sgkmacleod@worlduniversityandschool.org> wrote:
Leanne, George (& Ting Wu),

Brainstorming, how best for your Chinese company and team and colleagues in Shanghai and all over to add your iterating longevity research to a realistic virtual earth for extreme longevity + ? 


Saturday, October 3, 2026
Schisandra chinensis: How. best to develop a realistic virtual earth - eg think a forked Google Street View with time slider & with pegman becoming our avatar agent electronic medical records, digital health twins - for scientific hypothesis testing + and different cultures and languages sharing their research and science, eg of longevity and eg aging reversal potentially too and re https://scott-macleod.blogspot.com/2026/09/schisandra-chinensis.html ?

Best regards, Scott




leanneye@cngen.com

ggyy11@163 com





Scott 





PS


10/3 - Harvard ARDD Aging Research and Drug Development conference 10/1/26-10/3/26 in the TreeHouse in Allston, MA

And Greetings !

Great to meet and talk with you just now at Harvard AARD, and regarding also building out #AvatarAgentElectronicHealthRecords as #DigitalTwins, planned in a #RealisticVirtualEarth (and think Google Street View with time slider with Pegman becoming #AvatarAgentEHR) and as World University and School seeks to code for all 7.9 billion people on the planet for #AvatarAgentEHR, and for aging reversal and extreme longevity genetic drug therapies emerging, and from here - https://wiki.worlduniversityandschool.org/wiki/You_at_World_University.

Here are some 
World University and School, building on MIT OCW in 7 languages, Harvard AARD goals, that is for the Harvard Aging Research and Drug Development conference 10/1/26-10/3/26 in the TreeHouse in Allston, MA  :



these include 

1
Develop 3 WUaS aging reversal OSK pharmaceutical gene drug therapies initially with research, and then produce and manufacture them & with a realistic virtual earth for OSK, a digital-physical #RVEforGenetics on the digital or in-silico side - and in collaboration with possibly 3 different companies too (initially) ...that would all successfully become FDA approved ...

and then upload them to our body minds via the eRapid Fouling Resistant sensor or similar - 

#eRapidFoulingResistantSensor-https://wyss.harvard.edu/technology/erapid-multiplexed-electrochemical-sensors-for-fast-accurate-portable-diagnostics/ WITH #AgingReversal & #ExtremeLongevity #AvatarAgentElectronicHealthRecords

or with a vaccine ...

or via smartwatches with a skin patch or similar, and/or smartphones, 

or drug/medicine.

Best regards, 
Scott


PS
Just asked Gemini - 

What are 3 potential ways that yamanaka factors re OSK via epigenetic reprogramming might even be turned into genetic drug therapies to reverse aging and also extend human lifespan to beyond 150 years?




On Sat, Oct 3, 2026 at 5:09 PM Scott MacLeod <sgkmacleod@worlduniversityandschool.org> wrote:
Nice to meet you

Leanne Ye

ggyy11@163 com

Scott 




* 












https://www.harvardmagazine.com/2017/12/rare-plants-in-china



https://en.wikipedia.org/wiki/Schisandra

https://en.wikipedia.org/wiki/Schisandra_chinensis

....


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