Wednesday, May 26, 2021

Yosemite valley tunnel view: Getting one's mind around aging reversal genetically * Begin perfectly building an #ActualVirtual #PhysicalDigital> #RealisticVirtualEarthForGenetics #CRISPR + "possible to safely reverse the age of complex tissues" “If you wind the hands of the clock back, time also goes backward” #WUaSagingReversal #FilmTo3D App @ cell/atom levels * * A 'Realistic Virtual Earth for Biology' - and also to master biology?


Getting one's mind around aging reversal genetically

Dear Ma, Dick, Jean, Sandy, All, 

Some thinking about aging reversal genetically - which is pretty wild stuff ... 

Am seeking to further get my mind (Larry too) around how aging reversal genetically would work:

1
Here's a first Harvard Medical School article explaining how a mechanism might work (from Havard and MIT Professor of Genetics' George Church) ... 
https://hms.harvard.edu/news/vision-revision

2
And here's the Tweet where I found this - 
Transcription Factors, TFome:  aging forward & reverse

3
In conceiving of a single realistic virtual earth for everything (and building on Google Street View with time slider, Maps, Earth, TensorFlowAi, Translate, with avatar bot electronic medical records, with #FilmTo3D App at the cellular, atomic and street view levels too), here's what how World Univ & Sch might explore further coming into conversation with the above research: 

4

Begin perfectly building an #ActualVirtual #PhysicalDigital> #RealisticVirtualEarthForGenetics #CRISPR +

"possible to safely reverse the age of complex tissues" 

“If you wind the hands of the clock back, time also goes backward” #WUaSagingReversal #FilmTo3D App @ cell/atom levels


(all in yesterday's blog post - https://scott-macleod.blogspot.com/2021/05/wombat.html - the genes' label



5
A reply to George Church's Tweet, speculating on George becoming a teenager again ! ... 

Anopheles @Anophel50455039
Dec 5, 2020
Replying to
@geochurch
TFome... i love the sounds of that already.

When do we get to meet the teenage George Church?
https://twitter.com/Anophel50455039/status/1335326966443089923?s=20


6
See, too, the 5/15/21 World Univ & Sch Minutes - 
https://scott-macleod.blogspot.com/2021/05/araripe-manakin.html - where in Minute 9 I wonder too if George could become a 20 year old again ... 

Minute 9
How best to inspire young scientists to go into STEM fields, and regarding aging reversal (beyond longevity) genetic drug development questions, for example? See this George Church interview for one:

George Church just Tweeted this great video interview - https://youtu.be/WZwRe6ht8yg - of him, by a young interviewer - 
https://twitter.com/geochurch/status/1392899305485254657?s=20 - about STEM and much more, including aging reversal; Very inspiring for teenagers who are interested in science!

Could Harvard & MIT Professor of Genetics' George Church genetically engineer himself back to become a 20 year old again, eventually I wonder? 


7
Could we live to beyond 122 years old, and with reversal of ailments especially, as well? How to conceive of such possible futures? Living to 1,243 years of age - add some zeros to this? Pretty wild stuff ... 


8
Has the coronavirus pandemic of the past year majorly advanced the genetic engineering revolution (since DNA's discovery in 1953?)


Thoughts, ideas, questions, suggestions? 

Warm regards, 
Scott




*

Hi All, 


And a bit after emailing all of you, this Tweet from George Church appears (which I saw after it had been posted for 2 minutes). Am wondering how to make 'digital' or 'virtual'  - in one simulation of virtual reality (and part of a SINGLE realistic virtual earth for genetics, and even with plans for all 7.8 billion people's DNA in avatar bot electronic records, and with machine learning, so conceptually like Google Street View with time slider, Maps, Earth, TensorFlow AI ... with avatar bots ... and at the PARTICLE, so probably atomic, level ... )


Particle detection and tracking with DNA
https://arxiv.org/pdf/2105.11949.pdf

https://twitter.com/geochurch/status/1397647119759052800?s=20


From the abstract -
"Since the sequences of base pairs in nucleic acid molecules can be precisely amplified
and measured using polymerase chain reaction (PCR), the original spatial position of each broken strand inside
the detector can be reconstructed with nm precision."

This paper is all on the physical or actual side of science ... a remarkable opportunity to co-constitute virtually or digitally ... and track DNA particles as they potentially "GET YOUNGER" too - and per 
Transcription Factors, TFome:  aging forward & reverse
! :)

Further thoughts, ideas, questions, suggestions?
Thanks, George, for this Tweet :)

Fond regards (aging reversal-wise too, and esp.!:), 
Scott



PS
Seems as if Twitter is becoming part of this science conversation somehow! !

World Univ and Sch Twitter - http://twitter.com/WorldUnivandSch
WUaS Press - https://twitter.com/WUaSPress

Scott MacLeod - https://twitter.com/scottmacleod
Languages - World Univ - http://twitter.com/sgkmacleod

“Naked Harbin Ethnography” book (in Academic Press at WUaS) - http://twitter.com/HarbinBook
OpenBand (Berkeley) - https://twitter.com/TheOpenBand


 PPS
Thanks to Ian for this video about a long term Harvard happiness study - 

https://youtu.be/8KkKuTCFvzI

and my reply - 
Thanks, Ian - will check this out ... and extended long term happiness studies beyond 122 years of age - if - would be a good idea, and doable now online in new ways!

Cheers, Scott


PPPS
Thanks to Jim for the BEAUTIFUL eclipse photo, and for 

Jim Spohrer

1:55 PM (2 hours ago)
to me
Yes, but they still require extra hardware mostly - see https://www.ibm.com/blogs/research/2018/03/microscopic-reality-ai-microscopes/

PPPSa - 
And here's one exploration from 2018 of microscopy from a smartphone - https://scott-macleod.blogspot.com/2018/03/comfrey-hospital-in-smartphone-emerging.html - 

and, as I replied too to Jim - "Can we eventually add Apps to our smartphones that will allow us to do telescopy, create binoculars - all with photography - and related new functions (and even into a single realistic virtual earth into Google Poly, conceptually, and interactively, and for STEM field sites, 'classrooms,' and interactive learning too)?

I think there may be a few blog posts in these regards, but I will look further for only software telescopy and potentially from smartphones (without additional hardware!:)

and via - https://scott-macleod.blogspot.com/search/label/ethno-wiki-virtual-world-graphy - where I hope we'll be able to contribute to this science in a realistic virtual earth ... and possibly even to edit our own genome (with more blog posts about this) - and to the age reversal age we'd like? :))


" . . . and will we be able to edit our own genomes from our smartphones - https://twitter.com/hashtag/RealisticVirtualEarthForGenetics?src=hashtag_click - backwards and forward ... "I'd like my cheeks to look 10 years younger," kind of thing, totally hypothetically since the proof of aging reversal genetically is so so early per George Church's 1 minute video above ...)" ... 
with this idea here - https://scott-macleod.blogspot.com/2020/12/bluebell-barleria-barleria-cristata.html - :)

PPPPS
This wild axolotl - bird hybrid holds much potential for aging reversal genetics too - 


--


-- 
- Scott GK MacLeod  
Founder, President, CEO & Professor
World Univ & Sch (WUaS) - PO Box 442, Canyon, CA 94516 
1) non-profit World University and School - http://worlduniversityandschool.org  
2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html

(m) 412 478 0116 - sgkmacleod@gmail.com 

World Univ & Sch Innovation Research -  scottmacleod.com 

- CC World University and School - like CC Wikipedia with best STEM-centric CC OpenCourseWare - incorporated as a nonprofit university and school in California, and is a U.S. 501 (c) (3) tax-exempt educational organization. 




* * 

A 'Realistic Virtual Earth for Biology' - and also to master biology? 


Th May 27, 2021


Dear Ma, John, Joan, Sandy, Dick, Larry, All, 


Following up further on this "Getting one's mind around aging reversal genetically" thread, I put DNA atomic particles which potentially "GET YOUNGER" in QUOTES 
re ...
"... track DNA particles as they potentially "GET YOUNGER" too - and per 
Transcription Factors, TFome:  aging forward & reverse

... because I couldn't get my mind FURTHER around the concept of atoms "getting younger." 

But if there's a relationship between "Transcription Factors, TFome:  aging forward & reverse" and atoms or DNA particles, these atoms would have to do something that relates to cells getting younger, but in PHYSICS, rather than BIOLOGY ... and we may be able to further generate #ActualVirtual, #PhysicalDigital interoperability between these fields, and even in something like #GoogleStreetView with time slider, Maps, Earth, #TensorFlow AI and esp. #AvatarBotElectronicMedicalRecords. (This sounds like a great opportunity for particle physicists, in great numbers perhaps ...to come into communication with GENETICISTS and biologists!). WHY NOT IN A #REALISTIC VIRTUAL EARTH FOR GENETICS - AND STEM - https://twitter.com/hashtag/RealisticVirtualEarthForGenetics?src=hashtag_click ?

This may however also lead to an exploration about how best to MASTER biology, AND physics! . . . 


How best to master biology itself with 1 #RealisticVirtualEarth a #RealisticVirtualEarthForGenetics a #RealisticVirtualEarthForEvolutionaryBiology re #SDDS2021 w
@StanfordDeptMed for #COVID19 vaccines @ #WUaScellAtomLevels & w #AvatarBotElectronicMedicalRecords for 7.8 bil. peop?


https://twitter.com/WorldUnivAndSch/status/1384584211982536705?s=20



SO FURTHER, how could one model biology, AND physics in virtual reality VR this in a single #Realistic virtual earth for CRISPR and Genetics ... at the atomic level, and the cellular level ... and in 3D ... as if their discrete units were represented digitally in Google Poly, a library of 3D objects (closing this June, but conceptually - and actually especially, regarding what comes after) ... and thus interactively & digitally for subsequent VR modeling of biology, genetics  ... and even aging reversal genetics & drug therapies? ... and with a #FilmTo3D Application (not yet written) ... at the street view, cellular and atomic levels ... (given all the amazing videography at the atomic level these days, for example)?

Mastering biology and physics - and in a single 3D virtual earth for everything - might even lead to further developments in aging reversal genetics and genetic drug therapies ... not easy, however, to get my mind yet around mastering biology and physics in 1 realistic virtual earth . .. because it's not yet completed (but thanks Google Earth!:)

Thoughts, Tweets, ideas, questions, suggestions? 

Cheers, 
Scott

Some of the above ideas are #HashTags in Twitter ... if you'd like to 'riff' with these ideas yourselves, and further, and in the conversation or forum or dialogue space of social media like Twitter ... 

And check out this 1 minute video from George Church again about the 8 ways or so that aging reversal is proven: 

Harvard Medical School: "Treatment restores blood vessel growth, muscle vitality, boosts exercise endurance in aging animals" 3/22/18 https://hms.harvard.edu/news/rewinding-clock
How soon could humans reverse the aging process with genetic engineering?
https://youtu.be/bnCEIPQFNnk #WUaSAgingReversal ~

https://twitter.com/WorldUnivAndSch/status/1390027142642102272?s=20



 







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