Friday, November 30, 2018

Telomere: Stanford-Duke Cardiology Symposium - Thanks #HelenBlau for your excellent Stanford-Duke "The Long and the Short of it: Telomere Length as a Hallmark of Cardiac Failure" talk, Longevity research too?, Here's MIT Media Lab Director Joi Ito and per Harvard's George Church and gene editing-With regard to "Eternal youth, eternal old age, or having our cryogenically frozen brains thawed out 2,000 years," George Church is doing gene editing research now with dogs, having moved on from mice, as well as mentioning 9 main scientific approaches to longevity, The prospect of many people living beyond the 122 years of the longest known living person (Jeanne Calment) is fascinating, Google's Project Baseline research? * * * & Thanks @SvatiShah for your "Project Baseline: Return of Results" talk re Google Verily's Project Baseline


Telomere: Stanford-Duke Cardiology Symposium 



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Dear Helen,

Thank you for your excellent and far-reaching Stanford-Duke Cardiovascular Research Symposium talk "The Long and the Short of it: Telomere Length as a Hallmark of Cardiac Failure" yesterday - http://med.stanford.edu/cvi/mission/upcoming-events/stanford-duke-cv-research-symposium-2018.html (http://med.stanford.edu/content/dam/sm/cvi/documents/pdf/stanford-duke-program-2018.pdf).

Here's MIT Media Lab Director Joi Ito and per Harvard's George Church and gene editing - https://web.archive.org/web/20180605002848/https://www.wired.com/story/the-responsibility-of-immortality/ - and re longevity (and the wiki subject for this at MIT OCW-centric wiki World University and School - https://wiki.worlduniversityandschool.org/wiki/Longevity - of which I'm the startup founder), - re the longevity article mentioning telomeres which I mentioned. With regard to "Eternal youth, eternal old age, or having our cryogenically frozen brains thawed out 2,000 years," George Church is doing gene editing research now with dogs, having moved on from mice, as well as mentioning 9 main scientific approaches to longevity:

"He is currently experimenting with age reversal in dogs using gene therapy that has been successful in mice, a technique he believes is the most promising of nine broad approaches to mortality and aging—genome stability, telomere extension, epigenetics, proteostasis, caloric restriction, mitochondrial research, cell senescence, stem cell exhaustion, and intercellular communication"
(https://scott-macleod.blogspot.com/2018/08/cardoon-freeuniversaleducation-at-wuas.html).

The prospect of many people living beyond the 122 years of the longest known living person (Jeanne Calment) is fascinating in terms of especially emergent social problems per Joi Ito's article, "The Responsibility of Immortality: Welcome to the New Transhumanism" - https://web.archive.org/web/20180605002848/https://www.wired.com/story/the-responsibility-of-immortality/. I wonder if a realistic virtual earth with avatars bots for planning purposes could help (https://scott-macleod.blogspot.com/2018/08/auk-what-is-arcore-by-google-you-can.html), and am thinking here Google Street View with TIME Slider / Maps / Earth / TensorFlow - at the cellular and atomic levels with all species and even all individual organisms, conceptually - for STEM research, clinical care, and as medical school / research classrooms.

I'm curious especially how your approaches to studying telomeres, and the 8 other ways to study longevity mentioned in this article will all emerge in such a SINGLE realistic virtual earth for STEM research, and even in collaboration with something like Project Baseline.

What do you think? And what please is the name of the researcher you mentioned?

Very nice to talk with you and thank you for your excellent and exciting presentation.

Best regards, Scott

P.S.
Here are some related Tweets about your recent Stanford-Duke talks/work -


https://twitter.com/SeanM_Wu/status/1068568418587004928

https://twitter.com/SeanM_Wu/status/1068568418587004928

https://twitter.com/StanfordCVI/status/1068281117378150400

https://twitter.com/StanfordCVI/status/1068566820745932800

https://twitter.com/euanashley/status/1036845241511292928

https://twitter.com/hashtag/HelenBlau?src=hash

Thanks #HelenBlau for your excellent and far-reaching Stanford-Duke talk "The Long and the Short of it: Telomere Length as a Hallmark of Cardiac Failure" https://twitter.com/SeanM_Wu/status/1068568418587004928 - https://twitter.com/SeanM_Wu/status/1068568418587004928 -https://twitter.com/StanfordCVI/status/1068281117378150400 -https://twitter.com/StanfordCVI/status/1068566820745932800 Project Baseline research?



https://twitter.com/WorldUnivAndSch/status/1069002087353090048

--

--
- Scott MacLeod - Founder, President & Professor

- World University and School
- http://worlduniversityandschool.org

- 415 480 4577
- http://scottmacleod.com

- CC World University and School - like CC Wikipedia with best STEM-centric CC OpenCourseWare - incorporated as a nonprofit university and school in California, and is a U.S. 501 (c) (3) tax-exempt educational organization.




* * *

Dear Svati, Rob, and Bob,

Project Baseline: Return of Results - Seek and Ye Shall Find
Svati Shah, MD, MHS
Vice-Chair of Translational Research
Associate Professor of Medicine
Duke University
svati.shah@duke.edu
https://dmpi.duke.edu/faculty/svati-h-shah-md-mhs

Rob Califf MD - Duke
https://medicine.duke.edu/faculty/robert-m-califf

Bob Harrington MD - Stanford
https://profiles.stanford.edu/robert-harrington




Thank you, Svati, for your excellent and far-reaching Stanford-Duke Cardiovascular Research Symposium talk, "Project Baseline: Return of Results - Seek and Ye Shall Find" yesterday - http://med.stanford.edu/cvi/mission/upcoming-events/stanford-duke-cv-research-symposium-2018.html (http://med.stanford.edu/content/dam/sm/cvi/documents/pdf/stanford-duke-program-2018.pdf).

In talking with Svati after her great presentation about Project Baseline and communicating results, she encouraged me to email you, Rob, as co-founder of Project Baseline (and re our communication after your UCSF talk in April 2018 here - https://scott-macleod.blogspot.com/2018/04/lady-slipper-orchid-uscf-duke-univs-rob.html - too). 

What I was mentioning and curious about, Svati, has to do with exploring how 
A
i) Project Baseline might develop into online hospitals for clinical care in ~10 years (possibly longer or less time).

ii) How Baseline might develop into a comprehensive STEM Medical research site as well, and as a SINGLE realistic virtual earth (part of the Google platform/ecosystem - I'm thinking here Google Street View with time slider / Maps / Earth / Brain / TensorFlow - and at the cellular and atomic levels+) - for everything actually.

iii) And how Baseline might also develop into avatar bots eventually for actual-virtual, physical-digital direct correspondence, and for even tele-robotic surgery - and potentially for all species and all organisms, a ginormous data vision and project. This would include potentially eventually even the possibility of virtual gene editing (CRISPR into Baseline/StreetView?) and genomics, so that per Rob's recent Tweet that "Genetically Modified People Are Walking Among Us" - https://twitter.com/califf001/status/1069041413461962752 - this gene editing and these people could "walk" VIRTUALLY / DIGITALLY too (am thinking Second Life / OpenSimulator avatars here, but realistic ones, not cartoon-esque). (See too this blog post with an email to Dr. Helen Blau and her work on Telomeres from Friday, and re longevity questions - https://scott-macleod.blogspot.com/2018/12/telomere-thanks-helenblau-for-your.html - and where I hope to post some of this email as well).

Communication here would include completely new forms of publishing, including participant communications, as well as patient records, from within such a Project Baseline realistic virtual earth as hospital. 


B
I also mentioned, as a heads' up, Svati, the possibility of  

i) Project ECHO (MD specialists to rural populations with a mentoring aspect in group video) becoming online medical schools in ~10 years (more or less)

ii) with NEJM Continuing Education Modules (CME) as a basis for the first 2 years of online course ware - and subsequently translated into ~200 countries' official / main languages, for online Medical Schools


C)
In developing MIT OCW-centric World University and School (of which I'm the startup founder), WUaS seeks to develop online Medical Schools with online teaching hospitals for online clinical care. And in WUaS's new wiki, and in developing "World University and School: Online Medical Schools and Teaching Hospitals in ~200 countries’ official languages," and re - https://wiki.worlduniversityandschool.org/wiki/Nation_States - WUaS seeks to generate, conceptually, Medical Schools in each of all ~200 countries' official / main languages from a Template like this - http://worlduniversity.wikia.com/wiki/World_University_Medical_School - with CC-4 MIT OCW in 5 languages and CC Yale OYC course ware, but MIT and Yale don't have any Medicine OpenCourseWare for online medicine degrees (newly defined potentially). Linked to each of these medical schools would be an online teaching hospital, e.g. - http://worlduniversity.wikia.com/wiki/Hospital - for clinical care. As I've mentioned to Bob in our meeting in the autumn of 2017 in his office, Stanford Medicine in creating Medicine OCW could ask reimbursement from nation states' ministries of health, based on GDP, of something like and some percentage of the $63,080 per student per year that it costs to attend Dartmouth this year - https://geiselmed.dartmouth.edu/admissions/costs-and-financial-aid/ - for CC-4 Stanford Medicine OpenCourseWare in all ~200 countries' official / main languages where applicable. (Starting with Canada and California/North Carolina, for example, could have merit, since these are probably prosperous states).

D)
And here's an example of how this might work in Zimbabwe in Africa with a specific disease in this blog post:

Claytonia virginica: online Zimbabwe Medical School with online Teaching Hospital for Clinical Care, Stanford Africa Table "Human Papillomavirus Screening in Rural Zimbabwe," April 25 2018, Thanks too for replying, in response to my question, that Zimbabweans are hungry for medical education, Google/Verily's and Stanford and Duke's Project Baseline and eventually into a map for health for Zimbabweans, Concerning the realistic virtual earth for STEM research, I mentioned - think Google Street View with time slider / Maps / Earth / Translate / TensorFlow / Brain - and at the cellular and atomic levels too, possibly emerging out of Google's Project Baseline itself - online hospitals might emerge uniquely in this in the future, and even with avatar bots (that correspond to the 10,000 real participants in Project Baseline) for clinical care, research, bioengineering, genetic therapies, and eventually even actual-virtual remote tele-robotic surgery



E)
And such a Project Baseline hospital in a realistic virtual earth could even be developed for clinical trials - with speakers of all 7,097 living languages - https://scott-macleod.blogspot.com/2018/07/cypripedium-lady-slippers-orchid.html.
F) 
You'll find further, mostly Stanford, talks about Project Baseline and Project ECHO in this compendium blog post - https://scott-macleod.blogspot.com/2018/02/lithops-collaboration-between-stanford.html - as well. 

Very nice to talk with you Svati (and Bob), and looking forward to further communication about this re this remarkable Duke-Stanford collaboration and with great regard to Project Baseline. 

All the best, 
Scott


-- 
- Scott MacLeod - Founder, President & Professor

- World University and School

- 415 480 4577

- CC World University and School - like CC Wikipedia with best STEM-centric CC OpenCourseWare - incorporated as a nonprofit university and school in California, and is a U.S. 501 (c) (3) tax-exempt educational organization. 




* * *

Stanford-Duke & Project Baseline: Thanks @SvatiShah for your "Project Baseline: Return of Results" talk. And thanks #HelenBlau too for your "The Long and the Short of it: Telomere Length as a Hallmark of Cardiac Failure" talk, LONGEVITY research too? SEE https://scott-macleod.blogspot.com/2018/12/telomere-thanks-helenblau-for-your.html ~

https://twitter.com/WorldUnivAndSch/status/1069303323545632768



* * *

Glad to have heard back too from Stanford researcher Helen Blau Ph.D. (who's English, and has a Harvard PhD) - to this email in this blog post too:

https://scott-macleod.blogspot.com/2018/12/greater-coucal-4-billion-people-in.html


with ...

"Dear Scott,

Thank you for your warm and thoughtful message.  John Ramunas is my ex student and postdoc with whom I think you would greatly enjoy talking (cc:d).

So glad you enjoyed my talk and our work.

Warm regards,
Helen"


She gave a stellar talk at Stanford Medicine on telomere extension - which may be related to questions of extending life.



 * * *

Dear John, Helen and Bob,

Thanks so so much, Helen. And nice to meet you here, John. It would be great to talk further about questions relating to Telomere extension, longevity and potentially in a realistic virtual earth with species and individuals, John - and re "Telomere extension turns back aging clock in cultured human cells, study finds" - https://med.stanford.edu/news/all-news/2015/01/telomere-extension-turns-back-aging-clock-in-cultured-cells.html - for example. Have blogged a little about your presentation, Helen, and the Stanford-Duke Cardiology Symposium here - https://scott-macleod.blogspot.com/2018/12/telomere-thanks-helenblau-for-your.html - as well.

Would be available to meet for a cup of coffee around Stanford, John?

Warm regards, Scott

P.S.
Some related Tweets here -

Telomere extension, longevity & potentially in a #RealisticVirtualEarth with species and individuals (thinking Baseline / StreetView) - and re "Telomere extension turns back aging clock in cultured human cells, study finds" - https://med.stanford.edu/news/all-news/2015/01/telomere-extension-turns-back-aging-clock-in-cultured-cells.html ~ https://scott-macleod.blogspot.com/2018/12/telomere-thanks-helenblau-for-your.html ~

https://twitter.com/WorldUnivAndSch/status/1069636959465725952

- https://twitter.com/WorldUnivAndSch/status/1069002087353090048
- https://twitter.com/WorldUnivAndSch/status/1069303323545632768



*
Thanks, Bob Harrington @HeartBobH & #HelenBlau for the excellent & far-reaching #StanfordDuke2018 Cardiovascular Symposium http://med.stanford.edu/cvi/mission/upcoming-events/stanford-duke-cv-research-symposium-2018.html https://twitter.com/WorldUnivAndSch/status/1069002087353090048 & re Telomere & LONGEVITY questions too https://scott-macleod.blogspot.com/2018/12/telomere-thanks-helenblau-for-your.html HAPPY BIRTHDAY, Bob https://twitter.com/StanfordCVI/status/1068384691776974850 ~

https://twitter.com/WorldUnivAndSch/status/1069018294886137856


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Stanford-Duke Medicine symposium 11/29-30 http://med.stanford.edu/cvi/mission/upcoming-events/stanford-duke-cv-research-symposium-2018.html & re World University and School's planned online medical schools https://wiki.worlduniversityandschool.org/wiki/World_University_Medical_School with online teaching hospitals https://wiki.worlduniversityandschool.org/wiki/Hospital & especially with Google's Projects Baseline as well as Project ECHO


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Revolutionizing #HeartSurgery With #VirtualReality
#VR #AR #IoT #digitalhealth #MEDTECH #HealthTech #EmergingTech


https://twitter.com/Paula_Piccard/status/1069572244572037120



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